Diseases such as autism, cardiovascular disease, and the autoimmune disorders are difficult to treat because of the remarkable degree of variation among affected individuals. Subtyping research seeks to refine the definition of such complex, multi-organ diseases by identifying homogeneous patient subgroups. In this paper, we propose the Probabilistic Subtyping Model (PSM) to identify subgroups based on clustering individual clinical severity markers. This task is challenging due to the presence of nuisance variability — variations in measurements that are not due to disease subtype — which, if not accounted for, generate biased estimates for the group-level trajectories. Measurement sparsity and irregular sampling patterns pose additional challenges in clustering such data. PSM uses a hierarchical model to account for these different sources of variability. Our experiments demonstrate that by accounting for nuisance variability, PSM is able to more accurately model the marker data. We also discuss novel subtypes discovered using PSM and the resulting clinical hypotheses that are now the subject of follow up clinical experiments.

College students often struggle to balance their work with personal wellness. In part, this occurs because students work when they are unable to focus. We hypothesize that we can adapt the Experience Sampling Method (ESM) to build a model of users’ efficacy and predict when they will be most likely to experience flow, a state of motivation and immersion. We also hypothesize that we can present this information effectively to users, allowing them to understand when they are most likely to achieve flow. In order to test these hypotheses, we introduce the Productivity and Wellness Pal (PaWPal), a smartphone-based application that seeks to make users aware of their efficacy at various tasks as well as which courses of action are likely to lead to immersive experiences.

Spectral clustering, a graph partitioning technique, has gained immense popularity in machine learning in the context of unsupervised learning. This is due to convincing empirical studies, elegant approaches involved and the theoretical guarantees provided in the literature. To tackle some challenging problems that arose in computer vision etc., recently, a need to develop spectral methods that incorporate multi-way similarity measures surfaced. This, in turn, leads to a hypergraph partitioning problem. In this paper, we formulate a criterion for partitioning uniform hypergraphs, and show that a relaxation of this problem is related to the multilinear singular value decomposition (SVD) of symmetric tensors. Using this, we provide a spectral technique for clustering based on higher order affinities, and derive a theoretical bound on the error incurred by this method. We also study the complexity of the algorithm and use Nystr ̈om’s method and column sampling techniques to develop approximate methods with significantly reduced complexity. Experiments on geometric grouping and motion segmentation demonstrate the practical significance of the proposed methods.

In particular, we investigate demographic business. Banks, telecommunication companies, airlines, Internet churn indicators (obtained from users of microposts), service providers, pay TV companies, and insurance content churn indicators (obtained from the textual firms etc., utilize customer churn or attrition rates as one of content of micro-posts), and context churn indicators (obtained their key business metrics. This metric is important as the from threads containing the micro-posts). We examine churn rate of a business is a good indicator of customer response factors that make this problem more challenging and investigate to services, pricing, and competitions. The ability to the performance of several state-of-the-art machine identify churny contents / behaviors can enable early intervention learning techniques on this problem. A challenging aspect processes (as part of retention campaigns) and ultimately of such classification task is that churny contents can be expressed a reduction in customer churn.

In this paper we propose a wrapper based PSO method for gene selection in microarray datasets, where we gradually refine the feature (gene) space from a very coarse level to a fine grained one, by reducing the gene set at each step of the algorithm. We use the linear support vector machine weight vector to serve as the initial gene pool selection. In addition, we also examine integration of other filter based ranking methods with our proposed approach. Experiments on publicly available datasets, Colon, Leukemia and T2D show that our approach selects only a very small subset of genes while yielding substantial improvements in accuracy over state-of-the-art evolutionary methods.

Metric learning has become a widespreadly used tool in machine learning. To reduce expensive costs brought in by increasing dimensionality, low-rank metric learning arises as it can be more economical in storage and computation. However, existing low-rank metric learning algorithms usually adopt nonconvex objectives, and are hence sensitive to the choice of a heuristic low-rank basis. In this paper, we propose a novel low-rank metric learning algorithm to yield bilinear similarity functions. This algorithm scales linearly with input dimensionality in both space and time, therefore applicable to high-dimensional data domains. A convex objective free of heuristics is formulated by leveraging trace norm regularization to promote low-rankness. Crucially, we prove that all globally optimal metric solutions must retain a certain low-rank structure, which enables our algorithm to decompose the high-dimensional learning task into two steps: an SVD-based projection and a metric learning problem with reduced dimensionality. The latter step can be tackled efficiently through employing a linearized Alternating Direction Method of Multipliers. The efficacy of the proposed algorithm is demonstrated through experiments performed on four benchmark datasets with tens of thousands of dimensions.

Subset selection from massive data with noised information is increasingly popular for various applications. This problem is still highly challenging as current methods are generally slow in speed and sensitive to outliers. To address the above two issues, we propose an accelerated robust subset selection (ARSS) method. Extensive experiments on ten benchmark datasets verify that our method not only outperforms state of the art methods, but also runs 10,000+ times faster than the most related method.

In the real-world applications, heterogeneous interdependent attributes that consist of both discrete and numerical variables can be observed ubiquitously. The usual representation of these data sets is an information table, assuming the independence of attributes. However, very often, they are actually interdependent on one another, either explicitly or implicitly. Limited research has been conducted in analyzing such attribute interactions, which causes the analysis results to be more local than global. This paper proposes the coupled heterogeneous attribute analysis to capture the interdependence among mixed data by addressing coupling context and coupling weights in unsupervised learning. Such global couplings integrate the interactions within discrete attributes, within numerical attributes and across them to form the coupled representation for mixed type objects based on dimension conversion and feature selection. This work makes one step forward towards explicitly modeling the interdependence of heterogeneous attributes among mixed data, verified by the applications in data structure analysis, data clustering evaluation, and density comparison. Substantial experiments on 12 UCI data sets show that our approach can effectively capture the global couplings of heterogeneous attributes and outperforms the state-of-the-art methods, supported by statistical analysis.

Massive Open Online Courses (MOOCs) have received widespread attention for their potential to scale higher education, with multiple platforms such as Coursera, edX and Udacity recently appearing. Despite their successes, a major problem faced by MOOCs is low completion rates. In this paper, we explore the accurate early identification of students who are at risk of not completing courses. We build predictive models weekly, over multiple offerings of a course. Furthermore, we envision student interventions that present meaningful probabilities of failure, enacted only for marginal students.To be effective, predicted probabilities must be both well-calibrated and smoothed across weeks.Based on logistic regression, we propose two transfer learning algorithms to trade-off smoothness and accuracy by adding a regularization term to minimize the difference of failure probabilities between consecutive weeks. Experimental results on two offerings of a Coursera MOOC establish the effectiveness of our algorithms.

Topic modeling of textual corpora is an important and challenging problem. In most previous work, the “bag-of-words” assumption is usually made which ignores the ordering of words. This assumption simplifies the computation, but it unrealistically loses the ordering information and the semantic of words in the context. In this paper, we present a Gaussian Mixture Neural Topic Model (GMNTM) which incorporates both the ordering of words and the semantic meaning of sentences into topic modeling. Specifically, we represent each topic as a cluster of multi-dimensional vectors and embed the corpus into a collection of vectors generated by the Gaussian mixture model. Each word is affected not only by its topic, but also by the embedding vector of its surrounding words and the context. The Gaussian mixture components and the topic of documents, sentences and words can be learnt jointly. Extensive experiments show that our model can learn better topics and more accurate word distributions for each topic. Quantitatively, comparing to state-of-the-art topic modeling approaches, GMNTM obtains significantly better performance in terms of perplexity, retrieval accuracy and classification accuracy.