Selecting the right drugs for the right patients is a primary goal of precision medicine. In this manuscript, we consider the problem of cancer drug selection in a learning-to-rank framework. We have formulated the cancer drug selection problem as to accurately predicting 1). the ranking positions of sensitive drugs and 2). the ranking orders among sensitive drugs in cancer cell lines based on their responses to cancer drugs. We have developed a new learning-to-rank method, denoted as pLETORg , that predicts drug ranking structures in each cell line via using drug latent vectors and cell line latent vectors. The pLETORg method learns such latent vectors through explicitly enforcing that, in the drug ranking list of each cell line, the sensitive drugs are pushed above insensitive drugs, and meanwhile the ranking orders among sensitive drugs are correct. Genomics information on cell lines is leveraged in learning the latent vectors. Our experimental results on a benchmark cell line-drug response dataset demonstrate that the new pLETORg significantly outperforms the state-of-the-art method in prioritizing new sensitive drugs.

Modeling the Point Spread Function (PSF) of wide-field surveys is vital for many astrophysical applications and cosmological probes including weak gravitational lensing. The PSF smears the image of any recorded object and therefore needs to be taken into account when inferring properties of galaxies from astronomical images. In the case of cosmic shear, the PSF is one of the dominant sources of systematic errors and must be treated carefully to avoid biases in cosmological parameters. Recently, forward modeling approaches to calibrate shear measurements within the Monte-Carlo Control Loops ($MCCL$) framework have been developed. These methods typically require simulating a large amount of wide-field images, thus, the simulations need to be very fast yet have realistic properties in key features such as the PSF pattern. Hence, such forward modeling approaches require a very flexible PSF model, which is quick to evaluate and whose parameters can be estimated reliably from survey data. We present a PSF model that meets these requirements based on a fast deep-learning method to estimate its free parameters. We demonstrate our approach on publicly available SDSS data. We extract the most important features of the SDSS sample via principal component analysis. Next, we construct our model based on perturbations of a fixed base profile, ensuring that it captures these features. We then train a Convolutional Neural Network to estimate the free parameters of the model from noisy images of the PSF. This allows us to render a model image of each star, which we compare to the SDSS stars to evaluate the performance of our method. We find that our approach is able to accurately reproduce the SDSS PSF at the pixel level, which, due to the speed of both the model evaluation and the parameter estimation, offers good prospects for incorporating our method into the $MCCL$ framework.

Recent advances show that two-dimensional linear discriminant analysis (2DLDA) is a successful matrix based dimensionality reduction method. However, 2DLDA may encounter the singularity issue theoretically and the sensitivity to outliers. In this paper, a generalized Lp-norm 2DLDA framework with regularization for an arbitrary $p>0$ is proposed, named G2DLDA. There are mainly two contributions of G2DLDA: one is G2DLDA model uses an arbitrary Lp-norm to measure the between-class and within-class scatter, and hence a proper $p$ can be selected to achieve the robustness. The other one is that by introducing an extra regularization term, G2DLDA achieves better generalization performance, and solves the singularity problem. In addition, G2DLDA can be solved through a series of convex problems with equality constraint, and it has closed solution for each single problem. Its convergence can be guaranteed theoretically when $1\leq p\leq2$. Preliminary experimental results on three contaminated human face databases show the effectiveness of the proposed G2DLDA.

We present an algorithm for approximating a function defined over a $d$-dimensional manifold utilizing only noisy function values at locations sampled from the manifold with noise. To produce the approximation we do not require any knowledge regarding the manifold other than its dimension $d$. The approximation scheme is based upon the Manifold Moving Least-Squares (MMLS). The proposed algorithm is resistant to noise in both the domain and function values. Furthermore, the approximant is shown to be smooth and of approximation order of $\mathcal{O}(h^{m+1})$ for non-noisy data, where $h$ is the mesh size with respect to the manifold domain, and $m$ is the degree of a local polynomial approximation utilized in our algorithm. In addition, the proposed algorithm is linear in time with respect to the ambient-space's dimension. Thus, in case of extremely large ambient space dimension, we are able to avoid the curse of dimensionality without having to perform non-linear dimension reduction, which introduces distortions to the manifold data. Using numerical experiments, we compare the presented method to state-of-the-art algorithms for regression over manifolds and show its potential.

Consider a structured matrix factorization model where one factor is restricted to have its columns lying in the unit simplex. This simplex-structured matrix factorization (SSMF) model and the associated factorization techniques have spurred much interest in research topics over different areas, such as hyperspectral unmixing in remote sensing, topic discovery in machine learning, to name a few. In this paper we develop a new theoretical SSMF framework whose idea is to study a maximum volume ellipsoid inscribed in the convex hull of the data points. This maximum volume inscribed ellipsoid (MVIE) idea has not been attempted in prior literature, and we show a sufficient condition under which the MVIE framework guarantees exact recovery of the factors. The sufficient recovery condition we show for MVIE is much more relaxed than that of separable non-negative matrix factorization (or pure-pixel search); coincidentally it is also identical to that of minimum volume enclosing simplex, which is known to be a powerful SSMF framework for non-separable problem instances. We also show that MVIE can be practically implemented by performing facet enumeration and then by solving a convex optimization problem. The potential of the MVIE framework is illustrated by numerical results.

When food delivery services talk breathlessly about machine learning, feel free to roll your eyes: it's baked salmon they're dropping off, not Bayesian statistics. Insurance is another kettle of fish altogether. The birth of statistics is usually dated to 1662, when John Graunt calculated the probabilities of Londoners surviving to a given age. Lloyds of London started shortly thereafter, and advances in statistics and insurance have been inseparable ever since. Insurers, of course, have machines too, but the machine's'secret power' is its ability to extract prophetic insights from inhuman quantities of data.

This guide gets you started programming in TensorFlow. Before using this guide, install TensorFlow. The lowest level API--TensorFlow Core-- provides you with complete programming control. We recommend TensorFlow Core for machine learning researchers and others who require fine levels of control over their models. The higher level APIs are built on top of TensorFlow Core.

Machine learning topic is definitely popular these days. Some get wrong assumptions about it -- they think machine could learn by itself and its kind of magic. The truth is -- there is no magic, but math behind it. Machine will learn the way math model is defined for learning process. In my opinion, the best solution is a combination of machine learning math and algorithms.

In machine learning, there's something called the "No Free Lunch" theorem. In a nutshell, it states that no one algorithm works best for every problem, and it's especially relevant for supervised learning (i.e. For example, you can't say that neural networks are always better than decision trees or vice-versa. There are many factors at play, such as the size and structure of your dataset. As a result, you should try many different algorithms for your problem, while using a hold-out "test set" of data to evaluate performance and select the winner.

So what were the answers popping in your head? Random forest, SVM, K means, Knn or even Deep Learning and its variants? Now some of you might laugh and say how on earth can you predict so far ahead, predicting things 100 yrs into future is crazy. Well the answer is Lindy effect. Yes, the heuristic I am using to predict this is Lindy Effect.