Healthcare professionals have long envisioned using the enormous processing powers of computers to discover new facts and medical knowledge locked inside electronic health records. These vast medical archives contain time-resolved information about medical visits, tests and procedures, as well as outcomes, which together form individual patient journeys. By assessing the similarities among these journeys, it is possible to uncover clusters of common disease trajectories with shared health outcomes. The assignment of patient journeys to specific clusters may in turn serve as the basis for personalized outcome prediction and treatment selection. This procedure is a non-trivial computational problem, as it requires the comparison of patient data with multi-dimensional and multi-modal features that are captured at different times and resolutions. In this review, we provide a comprehensive overview of the tools and methods that are used in patient similarity analysis with longitudinal data and discuss its potential for improving clinical decision making.

In Canada, financial advisors and dealers are required by provincial securities commissions and self-regulatory organizations--charged with direct regulation over investment dealers and mutual fund dealers--to respectively collect and maintain Know Your Client (KYC) information, such as their age or risk tolerance, for investor accounts. With this information, investors, under their advisor's guidance, make decisions on their investments which are presumed to be beneficial to their investment goals. Our unique dataset is provided by a financial investment dealer with over 50,000 accounts for over 23,000 clients. We use a modified behavioural finance recency, frequency, monetary model for engineering features that quantify investor behaviours, and machine learning clustering algorithms to find groups of investors that behave similarly. We show that the KYC information collected does not explain client behaviours, whereas trade and transaction frequency and volume are most informative. We believe the results shown herein encourage financial regulators and advisors to use more advanced metrics to better understand and predict investor behaviours.

Interpretability of learning-to-rank models is a crucial yet relatively under-examined research area. Recent progress on interpretable ranking models largely focuses on generating post-hoc explanations for existing black-box ranking models, whereas the alternative option of building an intrinsically interpretable ranking model with transparent and self-explainable structure remains unexplored. Developing fully-understandable ranking models is necessary in some scenarios (e.g., due to legal or policy constraints) where post-hoc methods cannot provide sufficiently accurate explanations. In this paper, we lay the groundwork for intrinsically interpretable learning-to-rank by introducing generalized additive models (GAMs) into ranking tasks. Generalized additive models (GAMs) are intrinsically interpretable machine learning models and have been extensively studied on regression and classification tasks. We study how to extend GAMs into ranking models which can handle both item-level and list-level features and propose a novel formulation of ranking GAMs. To instantiate ranking GAMs, we employ neural networks instead of traditional splines or regression trees. We also show that our neural ranking GAMs can be distilled into a set of simple and compact piece-wise linear functions that are much more efficient to evaluate with little accuracy loss. We conduct experiments on three data sets and show that our proposed neural ranking GAMs can achieve significantly better performance than other traditional GAM baselines while maintaining similar interpretability.

Large-scale population-based studies in medicine are a key resource towards better diagnosis, monitoring, and treatment of diseases. They also serve as enablers of clinical decision support systems, in particular Computer Aided Diagnosis (CADx) using machine learning (ML). Numerous ML approaches for CADx have been proposed in literature. However, these approaches assume full data availability, which is not always feasible in clinical data. To account for missing data, incomplete data samples are either removed or imputed, which could lead to data bias and may negatively affect classification performance. As a solution, we propose an end-to-end learning of imputation and disease prediction of incomplete medical datasets via Multigraph Geometric Matrix Completion (MGMC). MGMC uses multiple recurrent graph convolutional networks, where each graph represents an independent population model based on a key clinical meta-feature like age, sex, or cognitive function. Graph signal aggregation from local patient neighborhoods, combined with multigraph signal fusion via self-attention, has a regularizing effect on both matrix reconstruction and classification performance. Our proposed approach is able to impute class relevant features as well as perform accurate classification on two publicly available medical datasets. We empirically show the superiority of our proposed approach in terms of classification and imputation performance when compared with state-of-the-art approaches. MGMC enables disease prediction in multimodal and incomplete medical datasets. These findings could serve as baseline for future CADx approaches which utilize incomplete datasets.

With the emergence of IoT, there is a rising interest in applying Internet of Things (IoT) technology in the smart homes for making occupants' life more convenient. The convenience is underpinned by the principle of the least effort, i.e. the premise that humans would usually want to achieve goals with the least cognitive and physical efforts [2]. IoT refers to the networked interconnection of everyday things, which are augmented with capabilities such as sensing, actuating, and communication [21]. The availability of IoT devices including switch sensors, infrared motion sensors, pressure sensor, wearable sensors, accelerators, temperature, humidity, and light sensors have the potential to realize the convenience. It is a challenge that IoT devices are highly diverse in supporting infrastructure such as different programming language and communication protocols [5].

We propose a novel activity learning framework based on Edge Cloud architecture for the purpose of recognizing and predicting human activities. Although activity recognition has been vastly studied by many researchers, the temporal features that constitute an activity, which can provide useful insights for activity models, have not been exploited to their full potentials by mining algorithms. In this paper, we utilize temporal features for activity recognition and prediction in a single smart home setting. We discover activity patterns and temporal relations such as the order of activities from real data to develop a prompting system. Analysis of real data collected from smart homes was used to validate the proposed method.

Variants of Gradient Descent What is Gradient Descent? Gradient Descent is an iterative process that finds the minima of a function. This is an optimisation algorithm that finds the parameters or coefficients of a function where the function has a minimum value. The post An easy guide to Gradient Descent appeared first on GreatLearning.

We study the efficient learnability of high-dimensional Gaussian mixtures in the outlier-robust setting, where a small constant fraction of the data is adversarially corrupted. We resolve the polynomial learnability of this problem when the components are pairwise separated in total variation distance. Specifically, we provide an algorithm that, for any constant number of components $k$, runs in polynomial time and learns the components of an $\epsilon$-corrupted $k$-mixture within information theoretically near-optimal error of $\tilde{O}(\epsilon)$, under the assumption that the overlap between any pair of components $P_i, P_j$ (i.e., the quantity $1-TV(P_i, P_j)$) is bounded by $\mathrm{poly}(\epsilon)$. Our separation condition is the qualitatively weakest assumption under which accurate clustering of the samples is possible. In particular, it allows for components with arbitrary covariances and for components with identical means, as long as their covariances differ sufficiently. Ours is the first polynomial time algorithm for this problem, even for $k=2$. Our algorithm follows the Sum-of-Squares based proofs to algorithms approach. Our main technical contribution is a new robust identifiability proof of clusters from a Gaussian mixture, which can be captured by the constant-degree Sum of Squares proof system. The key ingredients of this proof are a novel use of SoS-certifiable anti-concentration and a new characterization of pairs of Gaussians with small (dimension-independent) overlap in terms of their parameter distance.

Traditional machine learning applications, such as optical character recognition, arose from the inability to explicitly program a computer to perform a routine task. In this context, learning algorithms usually derive a model exclusively from the evidence present in a massive dataset. Yet in some scientific disciplines, obtaining an abundance of data is an impractical luxury, however; there is an explicit model of the domain based upon previous scientific discoveries. Here we introduce a new approach to machine learning that is able to leverage prior scientific discoveries in order to improve generalizability over a scientific model. We show its efficacy in predicting the entire energy spectrum of a Hamiltonian on a superconducting quantum device, a key task in present quantum computer calibration. Our accuracy surpasses the current state-of-the-art by over $20\%.$ Our approach thus demonstrates how artificial intelligence can be further enhanced by "standing on the shoulders of giants."

Optimizing parameters with momentum, normalizing data values, and using rectified linear units (ReLUs) are popular choices in neural network (NN) regression. Although ReLUs are popular, they can collapse to a constant function and "die", effectively removing their contribution from the model. While some mitigations are known, the underlying reasons of ReLUs dying during optimization are currently poorly understood. In this paper, we consider the effects of target normalization and momentum on dying ReLUs. We find empirically that unit variance targets are well motivated and that ReLUs die more easily, when target variance approaches zero. To further investigate this matter, we analyze a discrete-time linear autonomous system, and show theoretically how this relates to a model with a single ReLU and how common properties can result in dying ReLU. We also analyze the gradients of a single-ReLU model to identify saddle points and regions corresponding to dying ReLU and how parameters evolve into these regions when momentum is used. Finally, we show empirically that this problem persist, and is aggravated, for deeper models including residual networks.