A major challenge in single-particle cryo-electron microscopy (cryo-EM) is that the orientations adopted by the 3D particles prior to imaging are unknown; yet, this knowledge is essential for high-resolution reconstruction. We present a method to recover these orientations directly from the acquired set of 2D projections. Our approach consists of two steps: (i) the estimation of distances between pairs of projections, and (ii) the recovery of the orientation of each projection from these distances. In step (i), pairwise distances are estimated by a Siamese neural network trained on synthetic cryo-EM projections from resolved bio-structures. In step (ii), orientations are recovered by minimizing the difference between the distances estimated from the projections and the distances induced by the recovered orientations. We evaluated the method on synthetic cryo-EM datasets. Current results demonstrate that orientations can be accurately recovered from projections that are shifted and corrupted with a high level of noise. The accuracy of the recovery depends on the accuracy of the distance estimator. While not yet deployed in a real experimental setup, the proposed method offers a novel learning-based take on orientation recovery in SPA. Our code is available at https://github.com/JelenaBanjac/protein-reconstruction

We solve a weakly supervised regression problem. Under "weakly" we understand that for some training points the labels are known, for some unknown, and for others uncertain due to the presence of random noise or other reasons such as lack of resources. The solution process requires to optimize a certain objective function (the loss function), which combines manifold regularization and low-rank matrix decomposition techniques. These low-rank approximations allow us to speed up all matrix calculations and reduce storage requirements. This is especially crucial for large datasets. Ensemble clustering is used for obtaining the co-association matrix, which we consider as the similarity matrix. The utilization of these techniques allows us to increase the quality and stability of the solution. In the numerical section, we applied the suggested method to artificial and real datasets using Monte-Carlo modeling.

This paper presents a Gaussian process (GP) model for estimating piecewise continuous regression functions. In scientific and engineering applications of regression analysis, the underlying regression functions are piecewise continuous in that data follow different continuous regression models for different regions of the data with possible discontinuities between the regions. However, many conventional GP regression approaches are not designed for piecewise regression analysis. We propose a new GP modeling approach for estimating an unknown piecewise continuous regression function. The new GP model seeks for a local GP estimate of an unknown regression function at each test location, using local data neighboring to the test location. To accommodate the possibilities of the local data from different regions, the local data is partitioned into two sides by a local linear boundary, and only the local data belonging to the same side as the test location is used for the regression estimate. This local split works very well when the input regions are bounded by smooth boundaries, so the local linear approximation of the smooth boundaries works well. We estimate the local linear boundary jointly with the other hyperparameters of the GP model, using the maximum likelihood approach. Its computation time is as low as the local GP's time. The superior numerical performance of the proposed approach over the conventional GP modeling approaches is shown using various simulated piecewise regression functions.

Random Fourier Features (RFF) demonstrate wellappreciated performance in kernel approximation for largescale situations but restrict kernels to be stationary and positive definite. And for non-stationary kernels, the corresponding RFF could be converted to that for stationary indefinite kernels when the inputs are restricted to the unit sphere. Numerous methods provide accessible ways to approximate stationary but indefinite kernels. However, they are either biased or possess large variance. In this article, we propose the generalized orthogonal random features, an unbiased estimation with lower variance.Experimental results on various datasets and kernels verify that our algorithm achieves lower variance and approximation error compared with the existing kernel approximation methods. With better approximation to the originally selected kernels, improved classification accuracy and regression ability is obtained with our approximation algorithm in the framework of support vector machine and regression.

Federated Learning is an emerging privacy-preserving distributed machine learning approach to building a shared model by performing distributed training locally on participating devices (clients) and aggregating the local models into a global one. As this approach prevents data collection and aggregation, it helps in reducing associated privacy risks to a great extent. However, the data samples across all participating clients are usually not independent and identically distributed (noni.i.d.), and Out of Distribution (OOD) generalization for the learned models can be poor. Besides this challenge, federated learning also remains vulnerable to various attacks on security wherein a few malicious participating entities work towards inserting backdoors, degrading the generated aggregated model as well as inferring the data owned by participating entities. In this paper, we propose an approach for learning invariant (causal) features common to all participating clients in a federated learning setup and analyse empirically how it enhances the Out of Distribution (OOD) accuracy as well as the privacy of the final learned model.

Emotion is a complicated notion present in music that is hard to capture even with fine-tuned feature engineering. In this paper, we investigate the utility of state-of-the-art pre-trained deep audio embedding methods to be used in the Music Emotion Recognition (MER) task. Deep audio embedding methods allow us to efficiently capture the high dimensional features into a compact representation. We implement several multi-class classifiers with deep audio embeddings to predict emotion semantics in music. We investigate the effectiveness of L3-Net and VGGish deep audio embedding methods for music emotion inference over four music datasets. The experiments with several classifiers on the task show that the deep audio embedding solutions can improve the performances of the previous baseline MER models. We conclude that deep audio embeddings represent musical emotion semantics for the MER task without expert human engineering.

Since the number of elderly and patients who are in hospitals and healthcare centers are growing, providing efficient remote healthcare services seems very important. Currently, most such systems benefit from the distribution and autonomy features of multiagent systems and the structure of wireless sensor networks. On the one hand, securing the data of remote healthcare systems is one of the most significant concerns; particularly recent types of research about the security of remote healthcare systems keep them secure from eavesdropping and data modification. On the other hand, existing remote healthcare systems are still vulnerable against other common attacks of healthcare networks such as Denial of Service (DoS) and User to Root (U2R) attacks, because they are managed remotely and based on the Internet. Therefore, in this paper, we propose a secure framework for remote healthcare systems that consists of two phases. First, we design a healthcare system base on multiagent technology to collect data from a sensor network. Then, in the second phase, a layered architecture of intrusion detection systems that uses Support Vector Machine to learn the behavior of network traffic is applied. Based on our framework, we implement a secure remote healthcare system and evaluate this system against the frequent attacks of healthcare networks such as Smurf, Buffer overflow, Neptune, and Pod attacks. In the end, evaluation parameters of the layered architecture of intrusion detection systems prove the efficiency and correctness of our proposed framework.

Artificial Intelligence (AI) has a tremendous impact on the unexpected growth of technology in almost every aspect. AI-powered systems are monitoring and deciding about sensitive economic and societal issues. The future is towards automation, and it must not be prevented. However, this is a conflicting viewpoint for a lot of people, due to the fear of uncontrollable AI systems. This concern could be reasonable if it was originating from considerations associated with social issues, like gender-biased, or obscure decision-making systems. Explainable AI (XAI) is recently treated as a huge step towards reliable systems, enhancing the trust of people to AI. Interpretable machine learning (IML), a subfield of XAI, is also an urgent topic of research. This paper presents a small but significant contribution to the IML community, focusing on a local-based, neural-specific interpretation process applied to textual and time-series data. The proposed methodology introduces new approaches to the presentation of feature importance based interpretations, as well as the production of counterfactual words on textual datasets. Eventually, an improved evaluation metric is introduced for the assessment of interpretation techniques, which supports an extensive set of qualitative and quantitative experiments.

In this paper we describe a parameterized family of first-order distributed optimization algorithms that enable a network of agents to collaboratively calculate a decision variable that minimizes the sum of cost functions at each agent. These algorithms are self-healing in that their correctness is guaranteed even if they are initialized randomly, agents drop in or out of the network, local cost functions change, or communication packets are dropped. Our algorithms are the first single-Laplacian methods to exhibit all of these characteristics. We achieve self-healing by sacrificing internal stability, a fundamental trade-off for single-Laplacian methods.

The problem of inhomogeneous cluster densities has been a long-standing issue for distance-based and density-based algorithms in clustering and anomaly detection. These algorithms implicitly assume that all clusters have approximately the same density. As a result, they often exhibit a bias towards dense clusters in the presence of sparse clusters. Many remedies have been suggested; yet, we show that they are partial solutions which do not address the issue satisfactorily. To match the implicit assumption, we propose to transform a given dataset such that the transformed clusters have approximately the same density while all regions of locally low density become globally low density -- homogenising cluster density while preserving the cluster structure of the dataset. We show that this can be achieved by using a new multi-dimensional Cumulative Distribution Function in a transform-and-shift method. The method can be applied to every dataset, before the dataset is used in many existing algorithms to match their implicit assumption without algorithmic modification. We show that the proposed method performs better than existing remedies.