In machine learning, ensemble methods [10] aim to combine hypotheses to make predictive models more robust and accurate. A weighted majority vote learning procedure is an ensemble method for classification where each voter/hypothesis is assigned a weight (i.e., its influence in the final voting). Among the most famous majority vote methods, we can cite Boosting [13], Bagging [5], or Random Forest [6]. Interestingly, most of the kernel-based classifiers, like Support Vector Machines [3, 7], can be seen as majority vote of kernel functions. Understanding when and why weighted majority votes perform better than a single hypothesis is challenging. To study the generalization abilities of such majority votes, the PAC-Bayesian framework [34, 25] offers powerful tools to obtain Probably Approximately Correct (PAC) generalization bounds. Motivated by the fact that PAC-Bayesian analyses can lead to tight bounds (see e.g., [28]), developing algorithms to minimize such bounds is an important direction (e.g., [14, 11, 15, 24]). We focus on a class of PAC-Bayesian algorithms minimizing an upper bound on the majority vote's risk called the C-Bound

An important goal across most scientific fields is the discovery of causal structures underling a set of observations. Unfortunately, causal discovery methods which are based on correlation or mutual information can often fail to identify causal links in systems which exhibit dynamic relationships. Such dynamic systems (including the famous coupled logistic map) exhibit `mirage' correlations which appear and disappear depending on the observation window. This means not only that correlation is not causation but, perhaps counter-intuitively, that causation may occur without correlation. In this paper we describe Neural Shadow-Mapping, a neural network based method which embeds high-dimensional video data into a low-dimensional shadow representation, for subsequent estimation of causal links. We demonstrate its performance at discovering causal links from video-representations of dynamic systems.

Prediction of diabetes and its various complications has been studied in a number of settings, but a comprehensive overview of problem setting for diabetes prediction and care management has not been addressed in the literature. In this document we seek to remedy this omission in literature with an encompassing overview of diabetes complication prediction as well as situating this problem in the context of real world healthcare management. We illustrate various problems encountered in real world clinical scenarios via our own experience with building and deploying such models. In this manuscript we illustrate a Machine Learning (ML) framework for addressing the problem of predicting Type 2 Diabetes Mellitus (T2DM) together with a solution for risk stratification, intervention and management. These ML models align with how physicians think about disease management and mitigation, which comprises these four steps: Identify, Stratify, Engage, Measure.

High-dimensional biomarkers such as genomics are increasingly being measured in randomized clinical trials. Consequently, there is a growing interest in developing methods that improve the power to detect biomarker-treatment interactions. We adapt recently proposed two-stage interaction detecting procedures in the setting of randomized clinical trials. We also propose a new stage 1 multivariate screening strategy using ridge regression to account for correlations among biomarkers. For this multivariate screening, we prove the asymptotic between-stage independence, required for family-wise error rate control, under biomarker-treatment independence. Simulation results show that in various scenarios, the ridge regression screening procedure can provide substantially greater power than the traditional one-biomarker-at-a-time screening procedure in highly correlated data. We also exemplify our approach in two real clinical trial data applications.

With populations ageing, the number of people with dementia worldwide is expected to triple to 152 million by 2050. Seventy percent of cases are due to Alzheimer's disease (AD) pathology and there is a 10-20 year 'pre-clinical' period before significant cognitive decline occurs. We urgently need, cost effective, objective methods to detect AD, and other dementias, at an early stage. Risk factor modification could prevent 40% of cases and drug trials would have greater chances of success if participants are recruited at an earlier stage. Currently, detection of dementia is largely by pen and paper cognitive tests but these are time consuming and insensitive to pre-clinical phases. Specialist brain scans and body fluid biomarkers can detect the earliest stages of dementia but are too invasive or expensive for widespread use. With the advancement of technology, Artificial Intelligence (AI) shows promising results in assisting with detection of early-stage dementia. Existing AI-aided methods and potential future research directions are reviewed and discussed.

Graph structural information such as topologies or connectivities provides valuable guidance for graph convolutional networks (GCNs) to learn nodes' representations. Existing GCN models that capture nodes' structural information weight in- and out-neighbors equally or differentiate in- and out-neighbors globally without considering nodes' local topologies. We observe that in- and out-neighbors contribute differently for nodes with different local topologies. To explore the directional structural information for different nodes, we propose a GCN model with weighted structural features, named WGCN. WGCN first captures nodes' structural fingerprints via a direction and degree aware Random Walk with Restart algorithm, where the walk is guided by both edge direction and nodes' in- and out-degrees. Then, the interactions between nodes' structural fingerprints are used as the weighted node structural features. To further capture nodes' high-order dependencies and graph geometry, WGCN embeds graphs into a latent space to obtain nodes' latent neighbors and geometrical relationships. Based on nodes' geometrical relationships in the latent space, WGCN differentiates latent, in-, and out-neighbors with an attention-based geometrical aggregation. Experiments on transductive node classification tasks show that WGCN outperforms the baseline models consistently by up to 17.07% in terms of accuracy on five benchmark datasets.

Over the last years, machine learning techniques have been applied to more and more application domains, including software engineering and, especially, software quality assurance. Important application domains have been, e.g., software defect prediction or test case selection and prioritization. The ability to predict which components in a large software system are most likely to contain the largest numbers of faults in the next release helps to better manage projects, including early estimation of possible release delays, and affordably guide corrective actions to improve the quality of the software. However, developing robust fault prediction models is a challenging task and many techniques have been proposed in the literature. Closely related to estimating defect-prone parts of a software system is the question of how to select and prioritize test cases, and indeed test case prioritization has been extensively researched as a means for reducing the time taken to discover regressions in software. In this survey, we discuss various approaches in both fault prediction and test case prioritization, also explaining how in recent studies deep learning algorithms for fault prediction help to bridge the gap between programs' semantics and fault prediction features. We also review recently proposed machine learning methods for test case prioritization (TCP), and their ability to reduce the cost of regression testing without negatively affecting fault detection capabilities.

While the predictive performance of modern statistical dependency parsers relies heavily on the availability of expensive expert-annotated treebank data, not all annotations contribute equally to the training of the parsers. In this paper, we attempt to reduce the number of labeled examples needed to train a strong dependency parser using batch active learning (AL). In particular, we investigate whether enforcing diversity in the sampled batches, using determinantal point processes (DPPs), can improve over their diversity-agnostic counterparts. Simulation experiments on an English newswire corpus show that selecting diverse batches with DPPs is superior to strong selection strategies that do not enforce batch diversity, especially during the initial stages of the learning process. Additionally, our diversityaware strategy is robust under a corpus duplication setting, where diversity-agnostic sampling strategies exhibit significant degradation.

Many reinforcement learning algorithms rely on value estimation. However, the most widely used algorithms -- namely temporal difference algorithms -- can diverge under both off-policy sampling and nonlinear function approximation. Many algorithms have been developed for off-policy value estimation which are sound under linear function approximation, based on the linear mean-squared projected Bellman error (PBE). Extending these methods to the non-linear case has been largely unsuccessful. Recently, several methods have been introduced that approximate a different objective, called the mean-squared Bellman error (BE), which naturally facilities nonlinear approximation. In this work, we build on these insights and introduce a new generalized PBE, that extends the linear PBE to the nonlinear setting. We show how this generalized objective unifies previous work, including previous theory, and obtain new bounds for the value error of the solutions of the generalized objective. We derive an easy-to-use, but sound, algorithm to minimize the generalized objective which is more stable across runs, is less sensitive to hyperparameters, and performs favorably across four control domains with neural network function approximation.

Few-shot semantic segmentation aims to segment novel-class objects in a query image with only a few annotated examples in support images. Most of advanced solutions exploit a metric learning framework that performs segmentation through matching each pixel to a learned foreground prototype. However, this framework suffers from biased classification due to incomplete construction of sample pairs with the foreground prototype only. To address this issue, in this paper, we introduce a complementary self-contrastive task into few-shot semantic segmentation. Our new model is able to associate the pixels in a region with the prototype of this region, no matter they are in the foreground or background. To this end, we generate self-contrastive background prototypes directly from the query image, with which we enable the construction of complete sample pairs and thus a complementary and auxiliary segmentation task to achieve the training of a better segmentation model. Extensive experiments on PASCAL-5$^i$ and COCO-20$^i$ demonstrate clearly the superiority of our proposal. At no expense of inference efficiency, our model achieves state-of-the results in both 1-shot and 5-shot settings for few-shot semantic segmentation.