Are you trying to teach yourself machine learning from scratch, but aren't sure where to start? Or maybe you've taken an online course or two, but have hit a roadblock in your learning journey and don't know how to proceed. I was in a similar position just two years ago. I had spent over $25K in university fees, but was still inexperienced and unprepared for the job market. It took a lot of trial and error for me to come up with a machine learning roadmap.

The use of training, validation and test datasets is common but not easily understood. In this post, I attempt to clarify this concept. The post is part of my forthcoming book on learning Artificial Intelligence, Machine Learning and Deep Learning based on high school maths. And then comes up with an important statement: Reference to a "validation dataset" disappears if the practitioner is choosing to tune model hyperparameters using k-fold cross-validation with the training dataset. Model selection: involves selecting optimal parameters or a model.

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Most of the advanced control systems use sensor-based feedback for robust control. Tilt angle estimation is key feedback for many robotics and mechatronics applications in order to stabilize a system. Tilt angle cannot be directly measured when the system in consideration is not attached to a stationary frame. it is usually estimated through indirect measurements in such systems. The precision of this estimation depends on the measurements; hence it can get expensive and complicated as the precision requirement increases. This research is aimed at developing a novel and economic method to estimate tilt angle with a relatively less sophisticated and complicated system, while maintaining precision in estimating tilt angle. The method is developed to explore a pendulum as an inertial measurement sensor and estimates tilt angle based on dynamics of pendulum and parameter estimation models. Further, algorithms are developed with varying order of complexity and accuracy to have customization for different applications. Furthermore, this study will validate the developed algorithms by experimental testing. This method focuses on developing algorithms to reduce the input measurement error in the Kalman filter.

Facial recognition tools are becoming exceptionally accurate in identifying people from images. However, this comes at the cost of privacy for users of online services with photo management (e.g. social media platforms). Particularly troubling is the ability to leverage unsupervised learning to recognize faces even when the user has not labeled their images. In this paper we propose Ulixes, a strategy to generate visually non-invasive facial noise masks that yield adversarial examples, preventing the formation of identifiable user clusters in the embedding space of facial encoders. This is applicable even when a user is unmasked and labeled images are available online. We demonstrate the effectiveness of Ulixes by showing that various classification and clustering methods cannot reliably label the adversarial examples we generate. We also study the effects of Ulixes in various black-box settings and compare it to the current state of the art in adversarial machine learning. Finally, we challenge the effectiveness of Ulixes against adversarially trained models and show that it is robust to countermeasures.

Patient-derived extracellular vesicles (EVs) that contains a complex biological cargo is a valuable source of liquid biopsy diagnostics to aid in early detection, cancer screening, and precision nanotherapeutics. In this study, we predicted that coupling cancer patient blood-derived EVs to time-resolved spectroscopy and artificial intelligence (AI) could provide a robust cancer screening and follow-up tools. Methods: Fluorescence correlation spectroscopy (FCS) measurements were performed on 24 blood samples-derived EVs. Blood samples were obtained from 15 cancer patients (presenting 5 different types of cancers), and 9 healthy controls (including patients with benign lesions). The obtained FCS autocorrelation spectra were processed into power spectra using the Fast-Fourier Transform algorithm and subjected to various machine learning algorithms to distinguish cancer spectra from healthy control spectra. Results and Applications: The performance of AdaBoost Random Forest (RF) classifier, support vector machine, and multilayer perceptron, were tested on selected frequencies in the N=118 power spectra. The RF classifier exhibited a 90% classification accuracy and high sensitivity and specificity in distinguishing the FCS power spectra of cancer patients from those of healthy controls. Further, an image convolutional neural network (CNN), ResNet network, and a quantum CNN were assessed on the power spectral images as additional validation tools. All image-based CNNs exhibited a nearly equal classification performance with an accuracy of roughly 82% and reasonably high sensitivity and specificity scores. Our pilot study demonstrates that AI-algorithms coupled to time-resolved FCS power spectra can accurately and differentially classify the complex patient-derived EVs from different cancer samples of distinct tissue subtypes.

Approximating probability distributions can be a challenging task, particularly when they are supported over regions of high geometrical complexity or exhibit multiple modes. Annealing can be used to facilitate this task which is often combined with constant a priori selected increments in inverse temperature. However, using constant increments limit the computational efficiency due to the inability to adapt to situations where smooth changes in the annealed density could be handled equally well with larger increments. We introduce AdaAnn, an adaptive annealing scheduler that automatically adjusts the temperature increments based on the expected change in the Kullback-Leibler divergence between two distributions with a sufficiently close annealing temperature. AdaAnn is easy to implement and can be integrated into existing sampling approaches such as normalizing flows for variational inference and Markov chain Monte Carlo. We demonstrate the computational efficiency of the AdaAnn scheduler for variational inference with normalizing flows on a number of examples, including density approximation and parameter estimation for dynamical systems.

The efficiency of Markov Chain Monte Carlo (MCMC) depends on how the underlying geometry of the problem is taken into account. For distributions with strongly varying curvature, Riemannian metrics help in efficient exploration of the target distribution. Unfortunately, they have significant computational overhead due to e.g. repeated inversion of the metric tensor, and current geometric MCMC methods using the Fisher information matrix to induce the manifold are in practice slow. We propose a new alternative Riemannian metric for MCMC, by embedding the target distribution into a higher-dimensional Euclidean space as a Monge patch and using the induced metric determined by direct geometric reasoning. Our metric only requires first-order gradient information and has fast inverse and determinants, and allows reducing the computational complexity of individual iterations from cubic to quadratic in the problem dimensionality. We demonstrate how Lagrangian Monte Carlo in this metric efficiently explores the target distributions.

Optimization is a ubiquitous modeling tool and is often deployed in settings which repeatedly solve similar instances of the same problem. Amortized optimization methods use learning to predict the solutions to problems in these settings. This leverages the shared structure between similar problem instances. In this tutorial, we will discuss the key design choices behind amortized optimization, roughly categorizing 1) models into fully-amortized and semi-amortized approaches, and 2) learning methods into regression-based and objectivebased. We then view existing applications through these foundations to draw connections between them, including for manifold optimization, variational inference, sparse coding, meta-learning, control, reinforcement learning, convex optimization, and deep equilibrium networks. This framing enables us easily see, for example, that the amortized inference in variational autoencoders is conceptually identical to value gradients in control and reinforcement learning as they both use fully-amortized models with an objective-based loss.

Paraphrase generation is a fundamental and long-standing task in natural language processing. In this paper, we concentrate on two contributions to the task: (1) we propose Retrieval Augmented Prompt Tuning (RAPT) as a parameter-efficient method to adapt large pre-trained language models for paraphrase generation; (2) we propose Novelty Conditioned RAPT (NC-RAPT) as a simple model-agnostic method of using specialized prompt tokens for controlled paraphrase generation with varying levels of lexical novelty. By conducting extensive experiments on four datasets, we demonstrate the effectiveness of the proposed approaches for retaining the semantic content of the original text while inducing lexical novelty in the generation.