Recent extensions of Cellular Automata (CA) have incorporated key ideas from modern deep learning, dramatically extending their capabilities and catalyzing a new family of Neural Cellular Automata (NCA) techniques. Inspired by Transformer-based architectures, our work presents a new class of $\textit{attention-based}$ NCAs formed using a spatially localized$\unicode{x2014}$yet globally organized$\unicode{x2014}$self-attention scheme. We introduce an instance of this class named $\textit{Vision Transformer Cellular Automata}$ (ViTCA). We present quantitative and qualitative results on denoising autoencoding across six benchmark datasets, comparing ViTCA to a U-Net, a U-Net-based CA baseline (UNetCA), and a Vision Transformer (ViT). When comparing across architectures configured to similar parameter complexity, ViTCA architectures yield superior performance across all benchmarks and for nearly every evaluation metric. We present an ablation study on various architectural configurations of ViTCA, an analysis of its effect on cell states, and an investigation on its inductive biases. Finally, we examine its learned representations via linear probes on its converged cell state hidden representations, yielding, on average, superior results when compared to our U-Net, ViT, and UNetCA baselines.

Purpose: we evaluated the generalization capability of deep neural networks (DNNs), trained to classify chest X-rays as Covid-19, normal or pneumonia, using a relatively small and mixed dataset. Methods: we proposed a DNN to perform lung segmentation and classification, stacking a segmentation module (U-Net), an original intermediate module and a classification module (DenseNet201). To evaluate generalization, we tested the DNN with an external dataset (from distinct localities) and used Bayesian inference to estimate probability distributions of performance metrics. Results: our DNN achieved 0.917 AUC on the external test dataset, and a DenseNet without segmentation, 0.906. Bayesian inference indicated mean accuracy of 76.1% and [0.695, 0.826] 95% HDI (highest density interval, which concentrates 95% of the metric's probability mass) with segmentation and, without segmentation, 71.7% and [0.646, 0.786]. Conclusion: employing a novel DNN evaluation technique, which uses LRP and Brixia scores, we discovered that areas where radiologists found strong Covid-19 symptoms are the most important for the stacked DNN classification. External validation showed smaller accuracies than internal, indicating difficulty in generalization, which is positively affected by segmentation. Finally, the performance in the external dataset and the analysis with LRP suggest that DNNs can be trained in small and mixed datasets and still successfully detect Covid-19.

We present an automatic multilayer power plane generation method to accelerate the design of printed circuit boards (PCB). In PCB design, while automatic solvers have been developed to predict important indicators such as the IR-drop, power integrity, and signal integrity, the generation of the power plane itself still largely relies on laborious manual methods. Our automatic power plane generation approach is based on genetic optimization combined with a multilayer perceptron and is able to automatically generate power planes across a diverse set of problems with varying levels of difficulty. Our method GOMLP consists of an outer loop genetic optimizer (GO) and an inner loop multi-layer perceptron (MLP) that generate power planes automatically. The critical elements of our approach include contour detection, feature expansion, and a distance measure to enable island-minimizing complex power plane generation. We compare our approach to a baseline solution based on A*. The A* method consisting of a sequential island generation and merging process which can produce less than ideal solutions. Our experimental results show that on single layer power plane problems, our method outperforms A* in 71% of the problems with varying levels of board layout difficulty. We further describe H-GOMLP, which extends GOMLP to multilayer power plane problems using hierarchical clustering and net similarities based on the Hausdorff distance.

This work proposes a new data-driven model devised to integrate process knowledge into its structure to increase the human-machine synergy in the process industry. The proposed Contextual Mixture of Experts (cMoE) explicitly uses process knowledge along the model learning stage to mold the historical data to represent operators' context related to the process through possibility distributions. This model was evaluated in two real case studies for quality prediction, including a sulfur recovery unit and a polymerization process. The contextual mixture of experts was employed to represent different contexts in both experiments. The results indicate that integrating process knowledge has increased predictive performance while improving interpretability by providing insights into the variables affecting the process's different regimes.

Fetal growth restriction (FGR) is a prevalent pregnancy condition characterised by failure of the fetus to reach its genetically predetermined growth potential. We explore the application of model fitting techniques, linear regression machine learning models, deep learning regression, and Haralick textured features from multi-contrast MRI for multi-fetal organ analysis of FGR. We employed T2 relaxometry and diffusion-weighted MRI datasets (using a combined T2-diffusion scan) for 12 normally grown and 12 FGR gestational age (GA) matched pregnancies. We applied the Intravoxel Incoherent Motion Model and novel multi-compartment models for MRI fetal analysis, which exhibit potential to provide a multi-organ FGR assessment, overcoming the limitations of empirical indicators - such as abnormal artery Doppler findings - to evaluate placental dysfunction. The placenta and fetal liver presented key differentiators between FGR and normal controls (decreased perfusion, abnormal fetal blood motion and reduced fetal blood oxygenation. This may be associated with the preferential shunting of the fetal blood towards the fetal brain. These features were further explored to determine their role in assessing FGR severity, by employing simple machine learning models to predict FGR diagnosis (100\% accuracy in test data, n=5), GA at delivery, time from MRI scan to delivery, and baby weight. Moreover, we explored the use of deep learning to regress the latter three variables. Image texture analysis of the fetal organs demonstrated prominent textural variations in the placental perfusion fractions maps between the groups (p$<$0.0009), and spatial differences in the incoherent fetal capillary blood motion in the liver (p$<$0.009). This research serves as a proof-of-concept, investigating the effect of FGR on fetal organs.

Financial domain tasks, such as trading in market exchanges, are challenging and have long attracted researchers. The recent achievements and the consequent notoriety of Reinforcement Learning (RL) have also increased its adoption in trading tasks. RL uses a framework with well-established formal concepts, which raises its attractiveness in learning profitable trading strategies. However, RL use without due attention in the financial area can prevent new researchers from following standards or failing to adopt relevant conceptual guidelines. In this work, we embrace the seminal RL technical fundamentals, concepts, and recommendations to perform a unified, theoretically-grounded examination and comparison of previous research that could serve as a structuring guide for the field of study. A selection of twenty-nine articles was reviewed under our classification that considers RL's most common formulations and design patterns from a large volume of available studies. This classification allowed for precise inspection of the most relevant aspects regarding data input, preprocessing, state and action composition, adopted RL techniques, evaluation setups, and overall results. Our analysis approach organized around fundamental RL concepts allowed for a clear identification of current system design best practices, gaps that require further investigation, and promising research opportunities. Finally, this review attempts to promote the development of this field of study by facilitating researchers' commitment to standards adherence and helping them to avoid straying away from the RL constructs' firm ground.

We develop an implementable stochastic proximal point (SPP) method for a class of weakly convex, composite optimization problems. The proposed stochastic proximal point algorithm incorporates a variance reduction mechanism and the resulting SPP updates are solved using an inexact semismooth Newton framework. We establish detailed convergence results that take the inexactness of the SPP steps into account and that are in accordance with existing convergence guarantees of (proximal) stochastic variance-reduced gradient methods. Numerical experiments show that the proposed algorithm competes favorably with other state-of-the-art methods and achieves higher robustness with respect to the step size selection.

As in-the-wild data are increasingly involved in the training stage, machine learning applications become more susceptible to data poisoning attacks. Such attacks typically lead to test-time accuracy degradation or controlled misprediction. In this paper, we investigate the third type of exploitation of data poisoning - increasing the risks of privacy leakage of benign training samples. To this end, we demonstrate a set of data poisoning attacks to amplify the membership exposure of the targeted class. We first propose a generic dirty-label attack for supervised classification algorithms. We then propose an optimization-based clean-label attack in the transfer learning scenario, whereby the poisoning samples are correctly labeled and look "natural" to evade human moderation. We extensively evaluate our attacks on computer vision benchmarks. Our results show that the proposed attacks can substantially increase the membership inference precision with minimum overall test-time model performance degradation. To mitigate the potential negative impacts of our attacks, we also investigate feasible countermeasures.

Background: Mild cognitive impairment (MCI) is often considered a precursor to Alzheimer's disease (AD) due to the high rate of progression from MCI to AD. Sensitive neural biomarkers may provide a tool for an accurate MCI diagnosis, enabling earlier and perhaps more effective treatment. Despite the availability of numerous neuroscience techniques, electroencephalography (EEG) is the most popular and frequently used tool among researchers due to its low cost and superior temporal resolution. Objective: We conducted a scoping review of EEG and MCI between 2012 and 2022 to track the progression of research in this field. Methods: In contrast to previous scoping reviews, the data charting was aided by co-occurrence analysis using VOSviewer, while data reporting adopted a Patterns, Advances, Gaps, Evidence of Practice, and Research Recommendations (PAGER) framework to increase the quality of the results. Results: Event-related potentials (ERPs) and EEG, epilepsy, quantitative EEG (QEEG), and EEG-based machine learning were the research themes addressed by 2310 peer-reviewed articles on EEG and MCI. Conclusion: Our review identified the main research themes in EEG and MCI with high-accuracy detection of seizure and MCI performed using ERP/EEG, QEEG and EEG-based machine learning frameworks.

Accurately forecasting patient arrivals at Urgent Care Clinics (UCCs) and Emergency Departments (EDs) is important for effective resourcing and patient care. However, correctly estimating patient flows is not straightforward since it depends on many drivers. The predictability of patient arrivals has recently been further complicated by the COVID-19 pandemic conditions and the resulting lockdowns. This study investigates how a suite of novel quasi-real-time variables like Google search terms, pedestrian traffic, the prevailing incidence levels of influenza, as well as the COVID-19 Alert Level indicators can both generally improve the forecasting models of patient flows and effectively adapt the models to the unfolding disruptions of pandemic conditions. This research also uniquely contributes to the body of work in this domain by employing tools from the eXplainable AI field to investigate more deeply the internal mechanics of the models than has previously been done. The Voting ensemble-based method combining machine learning and statistical techniques was the most reliable in our experiments. Our study showed that the prevailing COVID-19 Alert Level feature together with Google search terms and pedestrian traffic were effective at producing generalisable forecasts. The implications of this study are that proxy variables can effectively augment standard autoregressive features to ensure accurate forecasting of patient flows. The experiments showed that the proposed features are potentially effective model inputs for preserving forecast accuracies in the event of future pandemic outbreaks.