Existing state-of-the-art 3D point clouds understanding methods only perform well in a fully supervised manner. To the best of our knowledge, there exists no unified framework which simultaneously solves the downstream high-level understanding tasks, especially when labels are extremely limited. This work presents a general and simple framework to tackle point clouds understanding when labels are limited. We propose a novel unsupervised region expansion based clustering method for generating clusters. More importantly, we innovatively propose to learn to merge the over-divided clusters based on the local low-level geometric property similarities and the learned high-level feature similarities supervised by weak labels. Hence, the true weak labels guide pseudo labels merging taking both geometric and semantic feature correlations into consideration. Finally, the self-supervised reconstruction and data augmentation optimization modules are proposed to guide the propagation of labels among semantically similar points within a scene. Experimental Results demonstrate that our framework has the best performance among the three most important weakly supervised point clouds understanding tasks including semantic segmentation, instance segmentation, and object detection even when limited points are labeled, under the data-efficient settings for the large-scale 3D semantic scene parsing. The developed techniques have postentials to be applied to downstream tasks for better representations in robotic manipulation and robotic autonomous navigation. Codes and models are publicly available at: https://github.com/KangchengLiu.

Discovering reliable and informative interactions among brain regions from functional magnetic resonance imaging (fMRI) signals is essential in neuroscientific predictions of cognition. Most of the current methods fail to accurately characterize those interactions because they only focus on pairwise connections and overlook the high-order relationships of brain regions. We delve into this problem and argue that these high-order relationships should be maximally informative and minimally redundant (MIMR). However, identifying such high-order relationships is challenging and highly under-explored. Methods that can be tailored to our context are also non-existent. In response to this gap, we propose a novel method named HyBRiD that aims to extract MIMR high-order relationships from fMRI data. HyBRiD employs a Constructor to identify hyperedge structures, and a Weighter to compute a weight for each hyperedge. HyBRiD achieves the MIMR objective through an innovative information bottleneck framework named multi-head drop-bottleneck with theoretical guarantees. Our comprehensive experiments demonstrate the effectiveness of our model. Our model outperforms the state-of-the-art predictive model by an average of 12.1%, regarding the quality of hyperedges measured by CPM, a standard protocol for studying brain connections.

Major advancements in computer vision can primarily be attributed to the use of labeled datasets. However, acquiring labels for datasets often results in errors which can harm model performance. Recent works have proposed methods to automatically identify mislabeled images, but developing strategies to effectively implement them in real world datasets has been sparsely explored. Towards improved data-centric methods for cleaning real world vision datasets, we first conduct more than 200 experiments carefully benchmarking recently developed automated mislabel detection methods on multiple datasets under a variety of synthetic and real noise settings with varying noise levels. We compare these methods to a Simple and Efficient Mislabel Detector (SEMD) that we craft, and find that SEMD performs similarly to or outperforms prior mislabel detection approaches. We then apply SEMD to multiple real world computer vision datasets and test how dataset size, mislabel removal strategy, and mislabel removal amount further affect model performance after retraining on the cleaned data. With careful design of the approach, we find that mislabel removal leads per-class performance improvements of up to 8% of a retrained classifier in smaller data regimes.

The integration of multi-omics data has emerged as a promising approach for gaining comprehensive insights into complex diseases such as cancer. This paper proposes a novel approach to identify cancer subtypes through the integration of multi-omics data for clustering. The proposed method, named LIDAF utilises affinity matrices based on linear relationships between and within different omics datasets (Linear Inter and Intra Dataset Affinity Fusion (LIDAF)). Canonical Correlation Analysis is in this paper employed to create distance matrices based on Euclidean distances between canonical variates. The distance matrices are converted to affinity matrices and those are fused in a three-step process. The proposed LIDAF addresses the limitations of the existing method resulting in improvement of clustering performance as measured by the Adjusted Rand Index and the Normalized Mutual Information score. Moreover, our proposed LIDAF approach demonstrates a notable enhancement in 50% of the log10 rank p-values obtained from Cox survival analysis, surpassing the performance of the best reported method, highlighting its potential of identifying distinct cancer subtypes.

Untrusted data used to train a model might have been manipulated to endow the learned model with hidden properties that the data contributor might later exploit. Data purification aims to remove such manipulations prior to training the model. We propose Mendata, a novel framework to purify manipulated training data. Starting from a small reference dataset in which a large majority of the inputs are clean, Mendata perturbs the training inputs so that they retain their utility but are distributed similarly (as measured by Wasserstein distance) to the reference data, thereby eliminating hidden properties from the learned model. A key challenge is how to find such perturbations, which we address by formulating a min-max optimization problem and developing a two-step method to iteratively solve it. We demonstrate the effectiveness of Mendata by applying it to defeat state-of-the-art data poisoning and data tracing techniques.

The escalating drug addiction crisis in the United States underscores the urgent need for innovative therapeutic strategies. This study embarked on an innovative and rigorous strategy to unearth potential drug repurposing candidates for opioid and cocaine addiction treatment, bridging the gap between transcriptomic data analysis and drug discovery. We initiated our approach by conducting differential gene expression analysis on addiction-related transcriptomic data to identify key genes. We propose a novel topological differentiation to identify key genes from a protein-protein interaction (PPI) network derived from DEGs. This method utilizes persistent Laplacians to accurately single out pivotal nodes within the network, conducting this analysis in a multiscale manner to ensure high reliability. Through rigorous literature validation, pathway analysis, and data-availability scrutiny, we identified three pivotal molecular targets, mTOR, mGluR5, and NMDAR, for drug repurposing from DrugBank. We crafted machine learning models employing two natural language processing (NLP)-based embeddings and a traditional 2D fingerprint, which demonstrated robust predictive ability in gauging binding affinities of DrugBank compounds to selected targets. Furthermore, we elucidated the interactions of promising drugs with the targets and evaluated their drug-likeness. This study delineates a multi-faceted and comprehensive analytical framework, amalgamating bioinformatics, topological data analysis and machine learning, for drug repurposing in addiction treatment, setting the stage for subsequent experimental validation. The versatility of the methods we developed allows for applications across a range of diseases and transcriptomic datasets.

Existing state-of-the-art 3D point cloud understanding methods merely perform well in a fully supervised manner. To the best of our knowledge, there exists no unified framework that simultaneously solves the downstream high-level understanding tasks including both segmentation and detection, especially when labels are extremely limited. This work presents a general and simple framework to tackle point cloud understanding when labels are limited. The first contribution is that we have done extensive methodology comparisons of traditional and learned 3D descriptors for the task of weakly supervised 3D scene understanding, and validated that our adapted traditional PFH-based 3D descriptors show excellent generalization ability across different domains. The second contribution is that we proposed a learning-based region merging strategy based on the affinity provided by both the traditional/learned 3D descriptors and learned semantics. The merging process takes both low-level geometric and high-level semantic feature correlations into consideration. Experimental results demonstrate that our framework has the best performance among the three most important weakly supervised point clouds understanding tasks including semantic segmentation, instance segmentation, and object detection even when very limited number of points are labeled. Our method, termed Region Merging 3D (RM3D), has superior performance on ScanNet data-efficient learning online benchmarks and other four large-scale 3D understanding benchmarks under various experimental settings, outperforming current arts by a margin for various 3D understanding tasks without complicated learning strategies such as active learning.

Optical tactile sensors have recently become popular. They provide high spatial resolution, but struggle to offer fine temporal resolutions. To overcome this shortcoming, we study the idea of replacing the RGB camera with an event-based camera and introduce a new event-based optical tactile sensor called Evetac. Along with hardware design, we develop touch processing algorithms to process its measurements online at 1000 Hz. We devise an efficient algorithm to track the elastomer's deformation through the imprinted markers despite the sensor's sparse output. Benchmarking experiments demonstrate Evetac's capabilities of sensing vibrations up to 498 Hz, reconstructing shear forces, and significantly reducing data rates compared to RGB optical tactile sensors. Moreover, Evetac's output and the marker tracking provide meaningful features for learning data-driven slip detection and prediction models. The learned models form the basis for a robust and adaptive closed-loop grasp controller capable of handling a wide range of objects. We believe that fast and efficient event-based tactile sensors like Evetac will be essential for bringing human-like manipulation capabilities to robotics. The sensor design is open-sourced at https://sites.google.com/view/evetac .

The block diagonal structure of an affinity matrix is a commonly desired property in cluster analysis because it represents clusters of feature vectors by non-zero coefficients that are concentrated in blocks. However, recovering a block diagonal affinity matrix is challenging in real-world applications, in which the data may be subject to outliers and heavy-tailed noise that obscure the hidden cluster structure. To address this issue, we first analyze the effect of different fundamental outlier types in graph-based cluster analysis. A key idea that simplifies the analysis is to introduce a vector that represents a block diagonal matrix as a piece-wise linear function of the similarity coefficients that form the affinity matrix. We reformulate the problem as a robust piece-wise linear fitting problem and propose a Fast and Robust Sparsity-Aware Block Diagonal Representation (FRS-BDR) method, which jointly estimates cluster memberships and the number of blocks. Comprehensive experiments on a variety of real-world applications demonstrate the effectiveness of FRS-BDR in terms of clustering accuracy, robustness against corrupted features, computation time and cluster enumeration performance.

Temporal event forecasting aims to predict what will happen next given the observed events in history. Previous formulations of temporal event are unstructured, atomic, or lacking full temporal information, thus largely restricting the representation quality and forecasting ability of temporal events. To address these limitations, we introduce a novel formulation for Structured, Complex, and Time-complete Temporal Event (SCTc-TE). Based on this new formulation, we develop a simple and fully automated pipeline for constructing such SCTc-TEs from a large amount of news articles. Furthermore, we propose a novel model that leverages both Local and Global contexts for SCTc-TE forecasting, named LoGo. To evaluate our model, we construct two large-scale datasets named MidEast-TE and GDELT-TE. Extensive evaluations demonstrate the advantages of our datasets in multiple aspects, while experimental results justify the effectiveness of our forecasting model LoGo. We release the code and dataset via https://github.com/yecchen/GDELT-ComplexEvent.