In the last years, artificial intelligence (AI) in clinical decision support systems (CDSS) played a key role in harnessing machine learning and deep learning architectures. Despite their promising capabilities, the lack of transparency and explainability of AI models poses significant challenges, particularly in medical contexts where reliability is a mandatory aspect. Achieving transparency without compromising predictive accuracy remains a key challenge. This paper presents a novel method, namely Rad4XCNN, to enhance the predictive power of CNN-derived features with the interpretability inherent in radiomic features. Rad4XCNN diverges from conventional methods based on saliency map, by associating intelligible meaning to CNN-derived features by means of Radiomics, offering new perspectives on explanation methods beyond visualization maps. Using a breast cancer classification task as a case study, we evaluated Rad4XCNN on ultrasound imaging datasets, including an online dataset and two in-house datasets for internal and external validation. Some key results are: i) CNN-derived features guarantee more robust accuracy when compared against ViT-derived and radiomic features; ii) conventional visualization map methods for explanation present several pitfalls; iii) Rad4XCNN does not sacrifice model accuracy for their explainability; iv) Rad4XCNN provides global explanation insights enabling the physician to analyze the model outputs and findings. In addition, we highlight the importance of integrating interpretability into AI models for enhanced trust and adoption in clinical practice, emphasizing how our method can mitigate some concerns related to explainable AI methods.

Clinical trial outcome prediction seeks to estimate the likelihood that a clinical trial will successfully reach its intended endpoint. This process predominantly involves the development of machine learning models that utilize a variety of data sources such as descriptions of the clinical trials, characteristics of the drug molecules, and specific disease conditions being targeted. Accurate predictions of trial outcomes are crucial for optimizing trial planning and prioritizing investments in a drug portfolio. While previous research has largely concentrated on small-molecule drugs, there is a growing need to focus on biologics-a rapidly expanding category of therapeutic agents that often lack the well-defined molecular properties associated with traditional drugs. Additionally, applying conventional methods like graph neural networks to biologics data proves challenging due to their complex nature. To address these challenges, we introduce the Language Interaction Network (LINT), a novel approach that predicts trial outcomes using only the free-text descriptions of the trials. We have rigorously tested the effectiveness of LINT across three phases of clinical trials, where it achieved ROC-AUC scores of 0.770, 0.740, and 0.748 for phases I, II, and III, respectively, specifically concerning trials involving biologic interventions.

Empirical defenses for machine learning privacy forgo the provable guarantees of differential privacy in the hope of achieving higher utility while resisting realistic adversaries. We identify severe pitfalls in existing empirical privacy evaluations (based on membership inference attacks) that result in misleading conclusions. In particular, we show that prior evaluations fail to characterize the privacy leakage of the most vulnerable samples, use weak attacks, and avoid comparisons with practical differential privacy baselines. In 5 case studies of empirical privacy defenses, we find that prior evaluations underestimate privacy leakage by an order of magnitude. Under our stronger evaluation, none of the empirical defenses we study are competitive with a properly tuned, high-utility DP-SGD baseline (with vacuous provable guarantees).

Digital pathology and the integration of artificial intelligence (AI) models have revolutionized histopathology, opening new opportunities. With the increasing availability of Whole Slide Images (WSIs), there's a growing demand for efficient retrieval, processing, and analysis of relevant images from vast biomedical archives. However, processing WSIs presents challenges due to their large size and content complexity. Full computer digestion of WSIs is impractical, and processing all patches individually is prohibitively expensive. In this paper, we propose an unsupervised patching algorithm, Sequential Patching Lattice for Image Classification and Enquiry (SPLICE). This novel approach condenses a histopathology WSI into a compact set of representative patches, forming a "collage" of WSI while minimizing redundancy. SPLICE prioritizes patch quality and uniqueness by sequentially analyzing a WSI and selecting non-redundant representative features. We evaluated SPLICE for search and match applications, demonstrating improved accuracy, reduced computation time, and storage requirements compared to existing state-of-the-art methods. As an unsupervised method, SPLICE effectively reduces storage requirements for representing tissue images by 50%. This reduction enables numerous algorithms in computational pathology to operate much more efficiently, paving the way for accelerated adoption of digital pathology.

Accurately measuring the cycle lifetime of commercial lithium-ion batteries is crucial for performance and technology development. We introduce a novel hybrid approach combining a physics-based equation with a self-attention model to predict the cycle lifetimes of commercial lithium iron phosphate graphite cells via early-cycle data. After fitting capacity loss curves to this physics-based equation, we then use a self-attention layer to reconstruct entire battery capacity loss curves. Our model exhibits comparable performances to existing models while predicting more information: the entire capacity loss curve instead of cycle life. This provides more robustness and interpretability: our model does not need to be retrained for a different notion of end-of-life and is backed by physical intuition.

Feature selection aims to identify the optimal feature subset for enhancing downstream models. Effective feature selection can remove redundant features, save computational resources, accelerate the model learning process, and improve the model overall performance. However, existing works are often time-intensive to identify the effective feature subset within high-dimensional feature spaces. Meanwhile, these methods mainly utilize a single downstream task performance as the selection criterion, leading to the selected subsets that are not only redundant but also lack generalizability. To bridge these gaps, we reformulate feature selection through a neuro-symbolic lens and introduce a novel generative framework aimed at identifying short and effective feature subsets. More specifically, we found that feature ID tokens of the selected subset can be formulated as symbols to reflect the intricate correlations among features. Thus, in this framework, we first create a data collector to automatically collect numerous feature selection samples consisting of feature ID tokens, model performance, and the measurement of feature subset redundancy. Building on the collected data, an encoder-decoder-evaluator learning paradigm is developed to preserve the intelligence of feature selection into a continuous embedding space for efficient search. Within the learned embedding space, we leverage a multi-gradient search algorithm to find more robust and generalized embeddings with the objective of improving model performance and reducing feature subset redundancy. These embeddings are then utilized to reconstruct the feature ID tokens for executing the final feature selection. Ultimately, comprehensive experiments and case studies are conducted to validate the effectiveness of the proposed framework.

Clustering of motion trajectories is highly relevant for human-robot interactions as it allows the anticipation of human motions, fast reaction to those, as well as the recognition of explicit gestures. Further, it allows automated analysis of recorded motion data. Many clustering algorithms for trajectories build upon distance metrics that are based on pointwise Euclidean distances. However, our work indicates that focusing on salient characteristics is often sufficient. We present a novel distance measure for motion plans consisting of state and control trajectories that is based on a compressed representation built from their main features. This approach allows a flexible choice of feature classes relevant to the respective task. The distance measure is used in agglomerative hierarchical clustering. We compare our method with the widely used dynamic time warping algorithm on test sets of motion plans for the Furuta pendulum and the Manutec robot arm and on real-world data from a human motion dataset. The proposed method demonstrates slight advantages in clustering and strong advantages in runtime, especially for long trajectories.

Electricity generated from renewable energy sources has been established as an efficient remedy for both energy shortages and the environmental pollution stemming from conventional energy production methods. Solar and wind power are two of the most dominant renewable energy sources. The accurate forecasting of the energy generation of those sources facilitates their integration into electric grids, by minimizing the negative impact of uncertainty regarding their management and operation. This paper proposes a novel methodology for deterministic wind and solar energy generation forecasting for multiple generation sites, utilizing multi-location weather forecasts. The method employs a U-shaped Temporal Convolutional Auto-Encoder (UTCAE) architecture for temporal processing of weather-related and energy-related time-series across each site. The Multi-sized Kernels convolutional Spatio-Temporal Attention (MKST-Attention), inspired by the multi-head scaled-dot product attention mechanism, is also proposed aiming to efficiently transfer temporal patterns from weather data to energy data, without a priori knowledge of the locations of the power stations and the locations of provided weather data. The conducted experimental evaluation on a day-ahead solar and wind energy forecasting scenario on five datasets demonstrated that the proposed method achieves top results, outperforming all competitive time-series forecasting state-of-the-art methods.

Common artefacts such as baseline drift, rescaling, and noise critically limit the performance of machine learningbased automated ECG analysis and interpretation. This study proposes Derived Peak (DP) encoding, a non-parametric method that generates signed spikes corresponding to zero crossings of the signals first and second-order time derivatives. Notably, DP encoding is invariant to shift and scaling artefacts, and its implementation is further simplified by the absence of userdefined parameters. DP encoding was used to encode the 12-lead ECG data from the PTB-XL dataset (n=18,869 participants) and was fed to 1D-ResNet-18 models trained to identify myocardial infarction, conductive deficits and ST-segment abnormalities. Robustness to artefacts was assessed by corrupting ECG data with sinusoidal baseline drift, shift, rescaling and noise, before encoding. The addition of these artefacts resulted in a significant drop in accuracy for seven other methods from prior art, while DP encoding maintained a baseline AUC of 0.88 under drift, shift and rescaling. DP achieved superior performance to unencoded inputs in the presence of shift (AUC under 1mV shift: 0.91 vs 0.62), and rescaling artefacts (AUC 0.91 vs 0.79). Thus, DP encoding is a simple method by which robustness to common ECG artefacts may be improved for automated ECG analysis and interpretation.

We propose a novel clustering pipeline to detect and characterize influence campaigns from documents. This approach clusters parts of document, detects clusters that likely reflect an influence campaign, and then identifies documents linked to an influence campaign via their association with the high-influence clusters. Our approach outperforms both the direct document-level classification and the direct document-level clustering approach in predicting if a document is part of an influence campaign. We propose various novel techniques to enhance our pipeline, including using an existing event factuality prediction system to obtain document parts, and aggregating multiple clustering experiments to improve the performance of both cluster and document classification. Classifying documents after clustering not only accurately extracts the parts of the documents that are relevant to influence campaigns, but also captures influence campaigns as a coordinated and holistic phenomenon. Our approach makes possible more fine-grained and interpretable characterizations of influence campaigns from documents.