Data sets with imbalanced class sizes, often where one class size is much smaller than that of others, occur extremely often in various applications, including those with biological foundations, such as drug discovery and disease diagnosis. Thus, it is extremely important to be able to identify data elements of classes of various sizes, as a failure to detect can result in heavy costs. However, many data classification algorithms do not perform well on imbalanced data sets as they often fail to detect elements belonging to underrepresented classes. In this paper, we propose the BTDT-MBO algorithm, incorporating Merriman-Bence-Osher (MBO) techniques and a bidirectional transformer, as well as distance correlation and decision threshold adjustments, for data classification problems on highly imbalanced molecular data sets, where the sizes of the classes vary greatly. The proposed method not only integrates adjustments in the classification threshold for the MBO algorithm in order to help deal with the class imbalance, but also uses a bidirectional transformer model based on an attention mechanism for self-supervised learning. Additionally, the method implements distance correlation as a weight function for the similarity graph-based framework on which the adjusted MBO algorithm operates. The proposed model is validated using six molecular data sets, and we also provide a thorough comparison to other competing algorithms. The computational experiments show that the proposed method performs better than competing techniques even when the class imbalance ratio is very high.

Within the machine learning community, reconstruction attacks are a principal attack of concern and have been identified even in federated learning, which was designed with privacy preservation in mind. In federated learning, it has been shown that an adversary with knowledge of the machine learning architecture is able to infer the exact value of a training element given an observation of the weight updates performed during stochastic gradient descent. In response to these threats, the privacy community recommends the use of differential privacy in the stochastic gradient descent algorithm, termed DP-SGD. However, DP has not yet been formally established as an effective countermeasure against reconstruction attacks. In this paper, we formalise the reconstruction threat model using the information-theoretic framework of quantitative information flow. We show that the Bayes' capacity, related to the Sibson mutual information of order infinity, represents a tight upper bound on the leakage of the DP-SGD algorithm to an adversary interested in performing a reconstruction attack. We provide empirical results demonstrating the effectiveness of this measure for comparing mechanisms against reconstruction threats.

Recent research has explored how Language Models (LMs) can be used for feature representation and prediction in tabular machine learning tasks. This involves employing text serialization and supervised fine-tuning (SFT) techniques. Despite the simplicity of these techniques, significant gaps remain in our understanding of the applicability and reliability of LMs in this context. Our study assesses how emerging LM technologies compare with traditional paradigms in tabular machine learning and evaluates the feasibility of adopting similar approaches with these advanced technologies. At the data level, we investigate various methods of data representation and curation of serialized tabular data, exploring their impact on prediction performance. At the classification level, we examine whether text serialization combined with LMs enhances performance on tabular datasets (e.g. class imbalance, distribution shift, biases, and high dimensionality), and assess whether this method represents a state-of-the-art (SOTA) approach for addressing tabular machine learning challenges. Our findings reveal current pre-trained models should not replace conventional approaches.

We introduce an evidential model for time-to-event prediction with censored data. In this model, uncertainty on event time is quantified by Gaussian random fuzzy numbers, a newly introduced family of random fuzzy subsets of the real line with associated belief functions, generalizing both Gaussian random variables and Gaussian possibility distributions. Our approach makes minimal assumptions about the underlying time-to-event distribution. The model is fit by minimizing a generalized negative log-likelihood function that accounts for both normal and censored data. Comparative experiments on two real-world datasets demonstrate the very good performance of our model as compared to the state-of-the-art.

Synthesizing electronic health records (EHR) data has become a preferred strategy to address data scarcity, improve data quality, and model fairness in healthcare. However, existing approaches for EHR data generation predominantly rely on state-of-the-art generative techniques like generative adversarial networks, variational autoencoders, and language models. These methods typically replicate input visits, resulting in inadequate modeling of temporal dependencies between visits and overlooking the generation of time information, a crucial element in EHR data. Moreover, their ability to learn visit representations is limited due to simple linear mapping functions, thus compromising generation quality. To address these limitations, we propose a novel EHR data generation model called EHRPD. It is a diffusion-based model designed to predict the next visit based on the current one while also incorporating time interval estimation. To enhance generation quality and diversity, we introduce a novel time-aware visit embedding module and a pioneering predictive denoising diffusion probabilistic model (PDDPM). Additionally, we devise a predictive U-Net (PU-Net) to optimize P-DDPM.We conduct experiments on two public datasets and evaluate EHRPD from fidelity, privacy, and utility perspectives. The experimental results demonstrate the efficacy and utility of the proposed EHRPD in addressing the aforementioned limitations and advancing EHR data generation.

Recent results show that vanilla gradient descent can be accelerated for smooth convex objectives, merely by changing the stepsize sequence. We show that this can lead to surprisingly large errors indefinitely, and therefore ask: Is there any stepsize schedule for gradient descent that accelerates the classic $\mathcal{O}(1/T)$ convergence rate, at \emph{any} stopping time $T$?

Binary Classification plays an important role in machine learning. For linear classification, SVM is the optimal binary classification method. For nonlinear classification, the SVM algorithm needs to complete the classification task by using the kernel function. Although the SVM algorithm with kernel function is very effective, the selection of kernel function is empirical, which means that the kernel function may not be optimal. Therefore, it is worth studying how to obtain an optimal binary classifier. In this paper, the problem of finding the optimal binary classifier is considered as a variational problem. We design the objective function of this variational problem through the max-min problem of the (Euclidean) distance between two classes. For linear classification, it can be deduced that SVM is a special case of this variational problem framework. For Euclidean distance, it is proved that the proposed variational problem has some limitations for nonlinear classification. Therefore, how to design a more appropriate objective function to find the optimal binary classifier is still an open problem. Further, it's discussed some challenges and problems in finding the optimal classifier.

Recent advancements in off-policy Reinforcement Learning (RL) have significantly improved sample efficiency, primarily due to the incorporation of various forms of regularization that enable more gradient update steps than traditional agents. However, many of these techniques have been tested in limited settings, often on tasks from single simulation benchmarks and against well-known algorithms rather than a range of regularization approaches. This limits our understanding of the specific mechanisms driving RL improvements. To address this, we implemented over 60 different off-policy agents, each integrating established regularization techniques from recent state-of-the-art algorithms. We tested these agents across 14 diverse tasks from 2 simulation benchmarks, measuring training metrics related to overestimation, overfitting, and plasticity loss -- issues that motivate the examined regularization techniques. Our findings reveal that while the effectiveness of a specific regularization setup varies with the task, certain combinations consistently demonstrate robust and superior performance. Notably, a simple Soft Actor-Critic agent, appropriately regularized, reliably finds a better-performing policy within the training regime, which previously was achieved mainly through model-based approaches.

Graph representation learning (GRL) is to encode graph elements into informative vector representations, which can be used in downstream tasks for analyzing graph-structured data and has seen extensive applications in various domains. However, the majority of extant studies on GRL are geared towards generating node representations, which cannot be readily employed to perform edge-based analytics tasks in edge-attributed bipartite graphs (EABGs) that pervade the real world, e.g., spam review detection in customer-product reviews and identifying fraudulent transactions in user-merchant networks. Compared to node-wise GRL, learning edge representations (ERL) on such graphs is challenging due to the need to incorporate the structure and attribute semantics from the perspective of edges while considering the separate influence of two heterogeneous node sets U and V in bipartite graphs. To our knowledge, despite its importance, limited research has been devoted to this frontier, and existing workarounds all suffer from sub-par results. Motivated by this, this paper designs EAGLE, an effective ERL method for EABGs. Building on an in-depth and rigorous theoretical analysis, we propose the factorized feature propagation (FFP) scheme for edge representations with adequate incorporation of long-range dependencies of edges/features without incurring tremendous computation overheads. We further ameliorate FFP as a dual-view FFP by taking into account the influences from nodes in U and V severally in ERL. Extensive experiments on 5 real datasets showcase the effectiveness of the proposed EAGLE models in semi-supervised edge classification tasks. In particular, EAGLE can attain a considerable gain of at most 38.11% in AP and 1.86% in AUC when compared to the best baselines.

Social media enables activists to directly communicate with the public and provides a space for movement leaders, participants, bystanders, and opponents to collectively construct and contest narratives. Focusing on Twitter messages from social movements surrounding three issues in 2018-2019 (guns, immigration, and LGBTQ rights), we create a codebook, annotated dataset, and computational models to detect diagnostic (problem identification and attribution), prognostic (proposed solutions and tactics), and motivational (calls to action) framing strategies. We conduct an in-depth unsupervised linguistic analysis of each framing strategy, and uncover cross-movement similarities in associations between framing and linguistic features such as pronouns and deontic modal verbs. Finally, we compare framing strategies across issues and other social, cultural, and interactional contexts. For example, we show that diagnostic framing is more common in replies than original broadcast posts, and that social movement organizations focus much more on prognostic and motivational framing than journalists and ordinary citizens.