This study introduces a new approach to addressing positive and unlabeled (PU) data through the double exponential tilting model (DETM). Traditional methods often fall short because they only apply to selected completely at random (SCAR) PU data, where the labeled positive and unlabeled positive data are assumed to be from the same distribution. In contrast, our DETM's dual structure effectively accommodates the more complex and underexplored selected at random PU data, where the labeled and unlabeled positive data can be from different distributions. We rigorously establish the theoretical foundations of DETM, including identifiability, parameter estimation, and asymptotic properties. Additionally, we move forward to statistical inference by developing a goodness-of-fit test for the SCAR condition and constructing confidence intervals for the proportion of positive instances in the target domain. We leverage an approximated Bayes classifier for classification tasks, demonstrating DETM's robust performance in prediction. Through theoretical insights and practical applications, this study highlights DETM as a comprehensive framework for addressing the challenges of PU data.

Graph clustering, which aims to divide a graph into several homogeneous groups, is a critical area of study with applications that span various fields such as social network analysis, bioinformatics, and image segmentation. This paper explores both traditional and more recent approaches to graph clustering. Firstly, key concepts and definitions in graph theory are introduced. The background section covers essential topics, including graph Laplacians and the integration of Deep Learning in graph analysis. The paper then delves into traditional clustering methods, including Spectral Clustering and the Leiden algorithm. Following this, state-of-the-art clustering techniques that leverage deep learning are examined. A comprehensive comparison of these methods is made through experiments. The paper concludes with a discussion of the practical applications of graph clustering and potential future research directions.

Non-stationary systems are found throughout the world, from climate patterns under the influence of variation in carbon dioxide concentration, to brain dynamics driven by ascending neuromodulation. Accordingly, there is a need for methods to analyze non-stationary processes, and yet most time-series analysis methods that are used in practice, on important problems across science and industry, make the simplifying assumption of stationarity. One important problem in the analysis of non-stationary systems is the problem class that we refer to as Parameter Inference from a Non-stationary Unknown Process (PINUP). Given an observed time series, this involves inferring the parameters that drive non-stationarity of the time series, without requiring knowledge or inference of a mathematical model of the underlying system. Here we review and unify a diverse literature of algorithms for PINUP. We formulate the problem, and categorize the various algorithmic contributions. This synthesis will allow researchers to identify gaps in the literature and will enable systematic comparisons of different methods. We also demonstrate that the most common systems that existing methods are tested on - notably the non-stationary Lorenz process and logistic map - are surprisingly easy to perform well on using simple statistical features like windowed mean and variance, undermining the practice of using good performance on these systems as evidence of algorithmic performance. We then identify more challenging problems that many existing methods perform poorly on and which can be used to drive methodological advances in the field. Our results unify disjoint scientific contributions to analyzing non-stationary systems and suggest new directions for progress on the PINUP problem and the broader study of non-stationary phenomena.

[See paper for full abstract] Meta-analysis is a crucial tool for answering scientific questions. It is usually conducted on a relatively small amount of ``trusted'' data -- ideally from randomized, controlled trials -- which allow causal effects to be reliably estimated with minimal assumptions. We show how to answer causal questions much more precisely by making two changes. First, we incorporate untrusted data drawn from large observational databases, related scientific literature and practical experience -- without sacrificing rigor or introducing strong assumptions. Second, we train richer models capable of handling heterogeneous trials, addressing a long-standing challenge in meta-analysis. Our approach is based on conformal prediction, which fundamentally produces rigorous prediction intervals, but doesn't handle indirect observations: in meta-analysis, we observe only noisy effects due to the limited number of participants in each trial. To handle noise, we develop a simple, efficient version of fully-conformal kernel ridge regression, based on a novel condition called idiocentricity. We introduce noise-correcting terms in the residuals and analyze their interaction with a ``variance shaving'' technique. In multiple experiments on healthcare datasets, our algorithms deliver tighter, sounder intervals than traditional ones. This paper charts a new course for meta-analysis and evidence-based medicine, where heterogeneity and untrusted data are embraced for more nuanced and precise predictions.

The factor model, a pivotal tool for analyzing large panel data, has become a significant topic in finance and economics research (e.g., Chamberlain and Rothschild, 1983; Fama and French, 1993; Stock and Watson, 2002; Bai and Ng, 2002; Giglio and Xiu, 2021; Fan et al., 2021b). The estimation and inference for factor models are crucial in economic studies, particularly in areas like asset pricing and return forecasting. In the era of big data, the factor model has gained increased prominence in capturing the latent common structure for large panel data, where both the cross-sectional and temporal dimensions are ultra-high (see, e.g., recent surveys Bai and Wang, 2016; Fan et al., 2021a). Principal component analysis (PCA), known for its simplicity and effectiveness, is closely connected with the factor model and has long been a key research topic of interest in the econometric community (e.g., Stock and Watson, 2002; Bai and Ng, 2002; Bai, 2003; Onatski, 2012; Fan et al., 2013; Bai and Ng, 2013, 2023). As pointed out by Giglio et al. (2023), most theoretical guarantees for the PCA approach to factor analysis rely on the pervasiveness assumption (e.g., Bai and Ng, 2002; Bai, 2003). This assumption requires the signalto-noise ratio (SNR), which measures the factor strength relative to the noise level, to grow with the rate of N - the square root of the cross-sectional dimension. However, many real datasets in economics do not exhibit sufficiently strong factors to meet this pervasiveness assumption. When the SNR grows slower than N, the resulting model is often called the weak factor model (e.g., Onatski, 2009, 2010). Extensive research has been dedicated to the weak factor model (e.g., Onatski, 2012; Bailey et al., 2021; Freyaldenhoven, 2022; Uematsu and Yamagata, 2022a,b; Bai and Ng, 2023; Jiang et al., 2023; Choi and Yuan, 2024), among which

Parallel Continual Learning (PCL) tasks investigate the training methods for continual learning with multi-source input, where data from different tasks are learned as they arrive. PCL offers high training efficiency and is well-suited for complex multi-source data systems, such as autonomous vehicles equipped with multiple sensors. However, at any time, multiple tasks need to be trained simultaneously, leading to severe training instability in PCL. This instability manifests during both forward and backward propagation, where features are entangled and gradients are conflict. This paper introduces Stable Parallel Continual Learning (SPCL), a novel approach that enhances the training stability of PCL for both forward and backward propagation. For the forward propagation, we apply Doubly-block Toeplit (DBT) Matrix based orthogonality constraints to network parameters to ensure stable and consistent propagation. For the backward propagation, we employ orthogonal decomposition for gradient management stabilizes backpropagation and mitigates gradient conflicts across tasks. By optimizing gradients by ensuring orthogonality and minimizing the condition number, SPCL effectively stabilizing the gradient descent in complex optimization tasks. Experimental results demonstrate that SPCL outperforms state-of-the-art methjods and achieve better training stability.

Pathogenic chromosome abnormalities are very common among the general population. While numerical chromosome abnormalities can be quickly and precisely detected, structural chromosome abnormalities are far more complex and typically require considerable efforts by human experts for identification. This paper focuses on investigating the modeling of chromosome features and the identification of chromosomes with structural abnormalities. Most existing data-driven methods concentrate on a single chromosome and consider each chromosome independently, overlooking the crucial aspect of homologous chromosomes. In normal cases, homologous chromosomes share identical structures, with the exception that one of them is abnormal. Therefore, we propose an adaptive method to align homologous chromosomes and diagnose structural abnormalities through homologous similarity. Inspired by the process of human expert diagnosis, we incorporate information from multiple pairs of homologous chromosomes simultaneously, aiming to reduce noise disturbance and improve prediction performance. Extensive experiments on real-world datasets validate the effectiveness of our model compared to baselines.

This work explores how to fine-tune large language models using prompt engineering techniques with contextual information for generating an accurate text description of the full story, ready to be forwarded to off-the-shelve speech synthesis tools. We propose to use existing computer vision and optical character recognition techniques to build a grounded context from the comic strip image content, such as panels, characters, text, reading order and the association of bubbles and characters. Then we infer character identification and generate comic book script with context-aware panel description including character's appearance, posture, mood, dialogues etc. We believe that such enriched content description can be easily used to produce audiobook and eBook with various voices for characters, captions and playing sound effects. Keywords: comics understanding large language model prompt engineering character identification comic book script accessible comics.

Neural networks (NN) achieve remarkable results in various tasks, but lack key characteristics: interpretability, support for categorical features, and lightweight implementations suitable for edge devices. While ongoing efforts aim to address these challenges, Gradient Boosting Trees (GBT) inherently meet these requirements. As a result, GBTs have become the go-to method for supervised learning tasks in many real-world applications and competitions. However, their application in online learning scenarios, notably in reinforcement learning (RL), has been limited. In this work, we bridge this gap by introducing Gradient-Boosting RL (GBRL), a framework that extends the advantages of GBT to the RL domain. Using the GBRL framework, we implement various actor-critic algorithms and compare their performance with their NN counterparts. Inspired by shared backbones in NN we introduce a tree-sharing approach for policy and value functions with distinct learning rates, enhancing learning efficiency over millions of interactions. GBRL achieves competitive performance across a diverse array of tasks, excelling in domains with structured or categorical features. Additionally, we present a high-performance, GPU-accelerated implementation that integrates seamlessly with widely-used RL libraries (available at https://github.com/NVlabs/gbrl). GBRL expands the toolkit for RL practitioners, demonstrating the viability and promise of GBT within the RL paradigm, particularly in domains characterized by structured or categorical features.

A profound gap persists between artificial intelligence (AI) and clinical practice in medicine, primarily due to the lack of rigorous and cost-effective evaluation methodologies. State-of-the-art and state-of-the-practice AI model evaluations are limited to laboratory studies on medical datasets or direct clinical trials with no or solely patient-centered controls. Moreover, the crucial role of clinicians in collaborating with AI, pivotal for determining its impact on clinical practice, is often overlooked. For the first time, we emphasize the critical necessity for rigorous and cost-effective evaluation methodologies for AI models in clinical practice, featuring patient/clinician-centered (dual-centered) AI randomized controlled trials (DC-AI RCTs) and virtual clinician-based in-silico trials (VC-MedAI) as an effective proxy for DC-AI RCTs. Leveraging 7500 diagnosis records from two-phase inaugural DC-AI RCTs across 14 medical centers with 125 clinicians, our results demonstrate the necessity of DC-AI RCTs and the effectiveness of VC-MedAI. Notably, VC-MedAI performs comparably to human clinicians, replicating insights and conclusions from prospective DC-AI RCTs. We envision DC-AI RCTs and VC-MedAI as pivotal advancements, presenting innovative and transformative evaluation methodologies for AI models in clinical practice, offering a preclinical-like setting mirroring conventional medicine, and reshaping development paradigms in a cost-effective and fast-iterative manner. Chinese Clinical Trial Registration: ChiCTR2400086816.