In the last few decades, Machine Learning (ML) has achieved significant success across domains ranging from healthcare, sustainability, and the social sciences, to criminal justice and finance. But its deployment in increasingly sophisticated, critical, and sensitive areas affecting individuals, the groups they belong to, and society as a whole raises critical concerns around fairness, transparency, robustness, and privacy, among others. As the complexity and scale of ML systems and of the settings in which they are deployed grow, so does the need for responsible ML methods that address these challenges while providing guaranteed performance in deployment. Mixed-integer optimization (MIO) offers a powerful framework for embedding responsible ML considerations directly into the learning process while maintaining performance. For example, it enables learning of inherently transparent models that can conveniently incorporate fairness or other domain specific constraints. This tutorial paper provides an accessible and comprehensive introduction to this topic discussing both theoretical and practical aspects. It outlines some of the core principles of responsible ML, their importance in applications, and the practical utility of MIO for building ML models that align with these principles. Through examples and mathematical formulations, it illustrates practical strategies and available tools for efficiently solving MIO problems for responsible ML. It concludes with a discussion on current limitations and open research questions, providing suggestions for future work.

Engagement between client and therapist is a critical determinant of therapeutic success. We propose a multi-dimensional natural language processing (NLP) framework that objectively classifies engagement quality in counseling sessions based on textual transcripts. Using 253 motivational interviewing transcripts (150 high-quality, 103 low-quality), we extracted 42 features across four domains: conversational dynamics, semantic similarity as topic alignment, sentiment classification, and question detection. Classifiers, including Random Forest (RF), Cat-Boost, and Support Vector Machines (SVM), were hyperparameter tuned and trained using a stratified 5-fold cross-validation and evaluated on a holdout test set. On balanced (non-augmented) data, RF achieved the highest classification accuracy (76.7%), and SVM achieved the highest AUC (85.4%). After SMOTE-Tomek augmentation, performance improved significantly: RF achieved up to 88.9% accuracy, 90.0% F1-score, and 94.6% AUC, while SVM reached 81.1% accuracy, 83.1% F1-score, and 93.6% AUC. The augmented data results reflect the potential of the framework in future larger-scale applications. Feature contribution revealed conversational dynamics and semantic similarity between clients and therapists were among the top contributors, led by words uttered by the client (mean and standard deviation). The framework was robust across the original and augmented datasets and demonstrated consistent improvements in F1 scores and recall. While currently text-based, the framework supports future multimodal extensions (e.g., vocal tone, facial affect) for more holistic assessments. This work introduces a scalable, data-driven method for evaluating engagement quality of the therapy session, offering clinicians real-time feedback to enhance the quality of both virtual and in-person therapeutic interactions.

This dissertation considers Open-world Robot Manipulation, a manipulation problem where a robot must generalize or quickly adapt to new objects, scenes, or tasks for which it has not been pre-programmed or pre-trained. This dissertation tackles the problem using a methodology of efficient sensorimotor learning. The key to enabling efficient sensorimotor learning lies in leveraging regular patterns that exist in limited amounts of demonstration data. These patterns, referred to as ``regularity,'' enable the data-efficient learning of generalizable manipulation skills. This dissertation offers a new perspective on formulating manipulation problems through the lens of regularity. Building upon this notion, we introduce three major contributions. First, we introduce methods that endow robots with object-centric priors, allowing them to learn generalizable, closed-loop sensorimotor policies from a small number of teleoperation demonstrations. Second, we introduce methods that constitute robots' spatial understanding, unlocking their ability to imitate manipulation skills from in-the-wild video observations. Last but not least, we introduce methods that enable robots to identify reusable skills from their past experiences, resulting in systems that can continually imitate multiple tasks in a sequential manner. Altogether, the contributions of this dissertation help lay the groundwork for building general-purpose personal robots that can quickly adapt to new situations or tasks with low-cost data collection and interact easily with humans. By enabling robots to learn and generalize from limited data, this dissertation takes a step toward realizing the vision of intelligent robotic assistants that can be seamlessly integrated into everyday scenarios.

One of the fundamental problems within the field of machine learning is dimensionality reduction. Dimensionality reduction methods make it possible to combat the so-called curse of dimensionality, visualize high-dimensional data and, in general, improve the efficiency of storing and processing large data sets. One of the best-known nonlinear dimensionality reduction methods is Diffusion Maps. However, despite their virtues, both Diffusion Maps and many other manifold learning methods based on the spectral decomposition of kernel matrices have drawbacks such as the inability to apply them to data outside the initial set, their computational complexity, and high memory costs for large data sets. In this work, we propose to alleviate these problems by resorting to deep learning. Specifically, a new formulation of Diffusion Maps embedding is offered as a solution to a certain unconstrained minimization problem and, based on it, a cost function to train a neural network which computes Diffusion Maps embedding -- both inside and outside the training sample -- without the need to perform any spectral decomposition. The capabilities of this approach are compared on different data sets, both real and synthetic, with those of Diffusion Maps and the Nystrom method.

This study presents an integrated methodology for fault detection in wind turbine blades using 3D-printed scaled models, finite element simulations, experimental modal analysis, and machine learning techniques. A scaled model of the NREL 5MW blade was fabricated using 3D printing, and crack-type damages were introduced at critical locations. Finite Element Analysis was employed to predict the impact of these damages on the natural frequencies, with the results validated through controlled hammer impact tests. Vibration data was processed to extract both time-domain and frequency-domain features, and key discriminative variables were identified using statistical analyses (ANOVA). Machine learning classifiers, including Support Vector Machine and K-Nearest Neighbors, achieved classification accuracies exceeding 94%. The results revealed that vibration modes 3, 4, and 6 are particularly sensitive to structural anomalies for this blade. This integrated approach confirms the feasibility of combining numerical simulations with experimental validations and paves the way for structural health monitoring systems in wind energy applications.

Split Learning (SL) has emerged as a promising paradigm for distributed deep learning, allowing resource-constrained clients to offload portions of their model computation to servers while maintaining collaborative learning. However, recent research has demonstrated that SL remains vulnerable to a range of privacy and security threats, including information leakage, model inversion, and adversarial attacks. While various defense mechanisms have been proposed, a systematic understanding of the attack landscape and corresponding countermeasures is still lacking. In this study, we present a comprehensive taxonomy of attacks and defenses in SL, categorizing them along three key dimensions: employed strategies, constraints, and e ffectiveness. Furthermore, we identify key open challenges and research gaps in SL based on our systematization, highlighting potential future directions. Keywords: split learning, collaborative learning, distributed machine learning, privacy-preserving ...

Open set label shift (OSLS) occurs when label distributions change from a source to a target distribution, and the target distribution has an additional out-of-distribution (OOD) class. In this work, we build estimators for both source and target open set label distributions using a source domain in-distribution (ID) classifier and an ID/OOD classifier . With reasonable assumptions on the ID/OOD classifier, the estimators are assembled into a sequence of three stages: 1) an estimate of the source label distribution of the OOD class, 2) an EM algorithm for Maximum Likelihood estimates (MLE) of the target label distribution, and 3) an estimate of the target label distribution of OOD class under relaxed assumptions on the OOD classifier . The sampling errors of estimates in 1) and 3) are quantified with a concentration inequality. The estimation result allows us to correct the ID classifier trained on the source distribution to the target distribution without retraining. Experiments on a variety of open set label shift settings demonstrate the effectiveness of our model.

Knots in wood are critical to both aesthetics and structural integrity, making their detection and pairing essential in timber processing. However, traditional manual annotation was labor-intensive and inefficient, necessitating automation. This paper proposes a lightweight and fully automated pipeline for knot detection and pairing based on machine learning techniques. In the detection stage, high-resolution surface images of wooden boards were collected using industrial-grade cameras, and a large-scale dataset was manually annotated and preprocessed. After the transfer learning, the YOLOv8l achieves an mAP@0.5 of 0.887. In the pairing stage, detected knots were analyzed and paired based on multidimensional feature extraction. A triplet neural network was used to map the features into a latent space, enabling clustering algorithms to identify and pair corresponding knots. The triplet network with learnable weights achieved a pairing accuracy of 0.85. Further analysis revealed that he distances from the knot's start and end points to the bottom of the wooden board, and the longitudinal coordinates play crucial roles in achieving high pairing accuracy. Our experiments validate the effectiveness of the proposed solution, demonstrating the potential of AI in advancing wood science and industry.

When training classification models, it expects that the learned features are compact within classes, and can well separate different classes. As the dominant loss function for training classification models, minimizing cross-entropy (CE) loss maximizes the compactness and distinctiveness, i.e., reaching neural collapse (NC). The recent works show that binary CE (BCE) performs also well in multi-class tasks. In this paper, we compare BCE and CE in deep feature learning. For the first time, we prove that BCE can also maximize the intra-class compactness and inter-class distinctiveness when reaching its minimum, i.e., leading to NC. We point out that CE measures the relative values of decision scores in the model training, implicitly enhancing the feature properties by classifying samples one-by-one. In contrast, BCE measures the absolute values of decision scores and adjust the positive/negative decision scores across all samples to uniformly high/low levels. Meanwhile, the classifier biases in BCE present a substantial constraint on the decision scores to explicitly enhance the feature properties in the training. The experimental results are aligned with above analysis, and show that BCE could improve the classification and leads to better compactness and distinctiveness among sample features. The codes will be released.

Diabetic macular edema (DME) significantly contributes to visual impairment in diabetic patients. Treatment responses to intravitreal therapies vary, highlighting the need for patient stratification to predict therapeutic benefits and enable personalized strategies. To our knowledge, this study is the first to explore pre-treatment stratification for predicting DME treatment responses. To advance this research, we organized the 2nd Asia-Pacific Tele-Ophthalmology Society (APTOS) Big Data Competition in 2021. The competition focused on improving predictive accuracy for anti-VEGF therapy responses using ophthalmic OCT images. We provided a dataset containing tens of thousands of OCT images from 2,000 patients with labels across four sub-tasks. This paper details the competition's structure, dataset, leading methods, and evaluation metrics. The competition attracted strong scientific community participation, with 170 teams initially registering and 41 reaching the final round. The top-performing team achieved an AUC of 80.06%, highlighting the potential of AI in personalized DME treatment and clinical decision-making.