Within the current sphere of deep learning research, despite the extensive application of optimization algorithms such as Stochastic Gradient Descent (SGD) and Adaptive Moment Estimation (Adam), there remains a pronounced inadequacy in their capability to address fluctuations in learning efficiency, meet the demands of complex models, and tackle non-convex optimization issues. These challenges primarily arise from the algorithms' limitations in handling complex data structures and models, for instance, difficulties in selecting an appropriate learning rate, avoiding local optima, and navigating through high-dimensional spaces. To address these issues, this paper introduces a novel optimization algorithm named DWMGrad. This algorithm, building on the foundations of traditional methods, incorporates a dynamic guidance mechanism reliant on historical data to dynamically update momentum and learning rates. This allows the optimizer to flexibly adjust its reliance on historical information, adapting to various training scenarios. This strategy not only enables the optimizer to better adapt to changing environments and task complexities but also, as validated through extensive experimentation, demonstrates DWMGrad's ability to achieve faster convergence rates and higher accuracies under a multitude of scenarios.

Radiomics-based machine learning models show promise for clinical decision support but are vulnerable to distribution shifts caused by variations in imaging protocols, positioning, and segmentation. This study systematically investigates the robustness of radiomics-based machine learning models under distribution shifts across five MRI sequences. We evaluated how different acquisition protocols and segmentation strategies affect model reliability in terms of predictive power and uncertainty-awareness. Using a phantom of 16 fruits, we evaluated distribution shifts through: (1) protocol variations across T2-HASTE, T2-TSE, T2-MAP, T1-TSE, and T2-FLAIR sequences; (2) segmentation variations (full, partial, rotated); and (3) inter-observer variability. We trained XGBoost classifiers on 8 consistent robust features versus sequence-specific features, testing model performance under in-domain and out-of-domain conditions. Results demonstrate that models trained on protocol-invariant features maintain F1-scores >0.85 across distribution shifts, while models using all features showed 40% performance degradation under protocol changes. Dataset augmentation substantially improved the quality of uncertainty estimates and reduced the expected calibration error (ECE) by 35% without sacrificing accuracy. Temperature scaling provided minimal calibration benefits, confirming XGBoost's inherent reliability. Our findings reveal that protocol-aware feature selection and controlled phantom studies effectively predict model behavior under distribution shifts, providing a framework for developing robust radiomics models resilient to real-world protocol variations.

In recent years, machine learning has become an increasingly powerful tool for supporting seizure detection and monitoring in epilepsy care. Traditional approaches focus on identifying seizures only after they begin, which limits the opportunity for early intervention and proactive treatment. In this study, we propose a novel approach that integrates both real-time seizure detection and prediction, aiming to capture subtle temporal patterns in EEG data that may indicate an upcoming seizure. Our approach was evaluated using the CHB-MIT Scalp EEG Database, which includes 969 hours of recordings and 173 seizures collected from 23 pediatric and young adult patients with drug-resistant epilepsy. To support seizure detection, we implemented a range of supervised machine learning algorithms, including K-Nearest Neighbors, Logistic Regression, Random Forest, and Support Vector Machine. The Logistic Regression achieved 90.9% detection accuracy with 89.6% recall, demonstrating balanced performance suitable for clinical screening. Random Forest and Support Vector Machine models achieved higher accuracy (94.0%) but with 0% recall, failing to detect any seizures, illustrating that accuracy alone is insufficient for evaluating medical ML models with class imbalance. For seizure prediction, we employed Long Short-Term Memory (LSTM) networks, which use deep learning to model temporal dependencies in EEG data. The LSTM model achieved 89.26% prediction accuracy. These results highlight the potential of developing accessible, real-time monitoring tools that not only detect seizures as traditionally done, but also predict them before they occur. This ability to predict seizures marks a significant shift from reactive seizure management to a more proactive approach, allowing patients to anticipate seizures and take precautionary measures to reduce the risk of injury or other complications.

Diffusion policies are competitive for offline reinforcement learning (RL) but are typically guided at sampling time by heuristics that lack a statistical notion of risk. We introduce LRT-Diffusion, a risk-aware sampling rule that treats each denoising step as a sequential hypothesis test between the unconditional prior and the state-conditional policy head. Concretely, we accumulate a log-likelihood ratio and gate the conditional mean with a logistic controller whose threshold tau is calibrated once under H0 to meet a user-specified Type-I level alpha. This turns guidance from a fixed push into an evidence-driven adjustment with a user-interpretable risk budget. Importantly, we deliberately leave training vanilla (two heads with standard epsilon-prediction) under the structure of DDPM. LRT guidance composes naturally with Q-gradients: critic-gradient updates can be taken at the unconditional mean, at the LRT-gated mean, or a blend, exposing a continuum from exploitation to conservatism. We standardize states and actions consistently at train and test time and report a state-conditional out-of-distribution (OOD) metric alongside return. On D4RL MuJoCo tasks, LRT-Diffusion improves the return-OOD trade-off over strong Q-guided baselines in our implementation while honoring the desired alpha. Theoretically, we establish level-alpha calibration, concise stability bounds, and a return comparison showing when LRT surpasses Q-guidance-especially when off-support errors dominate. Overall, LRT-Diffusion is a drop-in, inference-time method that adds principled, calibrated risk control to diffusion policies for offline RL.

We consider the problem of payoff division in indivisible coalitional games, where the value of the grand coalition is a natural number. This number represents a certain quantity of indivisible objects, such as parliamentary seats, kidney exchanges, or top features contributing to the outcome of a machine learning model. The goal of this paper is to propose a fair method for dividing these objects among players. To achieve this, we define the indivisible Shapley value and study its properties. We demonstrate our proposed technique using three case studies, in particular, we use it to identify key regions of an image in the context of an image classification task.

Benchmarks for out-of-distribution (OOD) generalization frequently show a strong positive correlation between in-distribution (ID) and OOD accuracy across models, termed "accuracy-on-the-line." This pattern is often taken to imply that spurious correlations - correlations that improve ID but reduce OOD performance - are rare in practice. We find that this positive correlation is often an artifact of aggregating heterogeneous OOD examples. Using a simple gradient-based method, OODSelect, we identify semantically coherent OOD subsets where accuracy on the line does not hold. Across widely used distribution shift benchmarks, the OODSelect uncovers subsets, sometimes over half of the standard OOD set, where higher ID accuracy predicts lower OOD accuracy. Our findings indicate that aggregate metrics can obscure important failure modes of OOD robustness. We release code and the identified subsets to facilitate further research.

Machine learning models increasingly map biological sequence-fitness landscapes to predict mutational effects. Effective evaluation of these models requires benchmarks curated from empirical data. Despite their impressive scales, existing benchmarks lack topographical information regarding the underlying fitness landscapes, which hampers interpretation and comparison of model performance beyond averaged scores. Here, we introduce GraphFLA, a Python framework that constructs and analyzes fitness landscapes from mutagensis data in diverse modalities (e.g., DNA, RNA, protein, and beyond) with up to millions of mutants. GraphFLA calculates 20 biologically relevant features that characterize 4 fundamental aspects of landscape topography. By applying GraphFLA to over 5,300 landscapes from ProteinGym, RNAGym, and CIS-BP, we demonstrate its utility in interpreting and comparing the performance of dozens of fitness prediction models, highlighting factors influencing model accuracy and respective advantages of different models. In addition, we release 155 combinatorially complete empirical fitness landscapes, encompassing over 2.2 million sequences across various modalities. All the codes and datasets are available at https://github.com/COLA-Laboratory/GraphFLA.

Assessing fish freshness is vital for ensuring food safety and minimizing economic losses in the seafood industry. However, traditional sensory evaluation remains subjective, time-consuming, and inconsistent. Although recent advances in deep learning have automated visual freshness prediction, challenges related to accuracy and feature transparency persist. This study introduces a unified three-stage framework that refines and leverages deep visual representations for reliable fish freshness assessment. First, five state-of-the-art vision architectures - ResNet-50, DenseNet-121, EfficientNet-B0, ConvNeXt-Base, and Swin-Tiny - are fine-tuned to establish a strong baseline. Next, multi-level deep features extracted from these backbones are used to train seven classical machine learning classifiers, integrating deep and traditional decision mechanisms. Finally, feature selection methods based on Light Gradient Boosting Machine (LGBM), Random Forest, and Lasso identify a compact and informative subset of features. Experiments on the Freshness of the Fish Eyes (FFE) dataset demonstrate that the best configuration combining Swin-Tiny features, an Extra Trees classifier, and LGBM-based feature selection achieves an accuracy of 85.99%, outperforming recent studies on the same dataset by 8.69-22.78%. These findings confirm the effectiveness and generalizability of the proposed framework for visual quality evaluation tasks.

Recently, graph-based semi-supervised learning and pseudo-labeling have gained attention due to their effectiveness in reducing the need for extensive data annotations. Pseudo-labeling uses predictions from unlabeled data to improve model training, while graph-based methods are characterized by processing data represented as graphs. However, the lack of clear graph structures in images combined with the complexity of multi-view data limits the efficiency of traditional and existing techniques. Moreover, the integration of graph structures in multi-view data is still a challenge. In this paper, we propose Re-node Self-taught Graph-based Semi-supervised Learning for Multi-view Data (RSGSLM). Our method addresses these challenges by (i) combining linear feature transformation and multi-view graph fusion within a Graph Convolutional Network (GCN) framework, (ii) dynamically incorporating pseudo-labels into the GCN loss function to improve classification in multi-view data, and (iii) correcting topological imbalances by adjusting the weights of labeled samples near class boundaries. Additionally, (iv) we introduce an unsupervised smoothing loss applicable to all samples. This combination optimizes performance while maintaining computational efficiency. Experimental results on multi-view benchmark image datasets demonstrate that RSGSLM surpasses existing semi-supervised learning approaches in multi-view contexts.

Y et, despite this progress, the point clouds acquired by MLS systems operating in real-world environments inevitably contain uncertainty arising from various error sources during acquisition and processing. Although MLS systems have advanced rapidly in both data collection and post-processing, research on uncertainty evaluation has received comparatively less attention and remains underdeveloped (Xu et al., 2025b). From a user's perspective, the quality of point clouds from MLS systems is a critical concern. As the foundational input for many downstream tasks, inadequate assessment of MLS point clouds' quality can easily impact high-precision applications such as navigation and change analysis. This will not only undermine reliability but also result in substantial waste of time and resources, which is unacceptable in real-world applications. There is a clear need for automated and reliable solutions for uncertainty evaluation. In MLS systems, four main categories of error sources contribute to uncertainty: instrumental errors, atmospheric errors, object-and geometry-related errors, and trajectory estimation errors (Habib et al., 2009, Schenk, 2001). Considering the characteristics of these error sources, existing uncertainty evaluation methods can be broadly divided into two categories: forward modeling and backward modeling (Shi et al., 2021). The core idea of forward modeling is grounded in variance-covariance propagation, which involves detailed theoretical analysis of MLS system errors.