Microarray cancer gene expression data comprise of very high dimensions. Reducing the dimensions helps in improving the overall analysis and classification performance. We propose two hybrid techniques, Biogeography - based Optimization - Random Forests (BBO - RF) and BBO - SVM (Support Vector Machines) with gene ranking as a heuristic, for microarray gene expression analysis. This heuristic is obtained from information gain filter ranking procedure. The BBO algorithm generates a population of candidate subset of genes, as part of an ecosystem of habitats, and employs the migration and mutation processes across multiple generations of the population to improve the classification accuracy. The fitness of each gene subset is assessed by the classifiers - SVM and Random Forests. The performances of these hybrid techniques are evaluated on three cancer gene expression datasets retrieved from the Kent Ridge Biomedical datasets collection and the libSVM data repository. Our results demonstrate that genes selected by the proposed techniques yield classification accuracies comparable to previously reported algorithms.

Methods for analysis of principal components in discrete data have existed for some time under various names such as grade of membership modelling, probabilistic latent semantic analysis, and genotype inference with admixture. In this paper we explore a number of extensions to the common theory, and present some application of these methods to some common statistical tasks. We show that these methods can be interpreted as a discrete version of ICA. We develop a hierarchical version yielding components at different levels of detail, and additional techniques for Gibbs sampling. We compare the algorithms on a text prediction task using support vector machines, and to information retrieval.

Diabetes management is a difficult task for patients, who must monitor and control their blood glucose levels in order to avoid serious diabetic complications. It is a difficult task for physicians, who must manually interpret large volumes of blood glucose data to tailor therapy to the needs of each patient. This paper describes three emerging applications that employ AI to ease this task: (1) case-based decision support for diabetes management; (2) machine learning classification of blood glucose plots; and (3) support vector regression for blood glucose prediction. The first application provides decision support by detecting blood glucose control problems and recommending therapeutic adjustments to correct them. The second provides an automated screen for excessive glycemic variability. The third aims to build a hypoglycemia predictor that could alert patients to dangerously low blood glucose levels in time to take preventive action. All are products of the 4 Diabetes Support SystemTM project, which uses AI to promote the health and wellbeing of people with type 1 diabetes. These emerging applications could potentially benefit 20 million patients who are at risk for devastating complications, thereby improving quality of life and reducing health care cost expenditures.

NewsFinder automates the steps involved in finding, selecting, categorizing, and publishing news stories that meet relevance criteria for the Artificial Intelligence community. The software combines a broad search of online news sources with topic-specific trained models and heuristics. Since August 2010, the program has been used to operate the AI in the News service that is part of the AAAI AITopics website.

With the advent of kernel methods, automating the task of specifying a suitable kernel has become increasingly important. In this context, the Multiple Kernel Learning (MKL) problem of finding a combination of pre-specified base kernels that is suitable for the task at hand has received significant attention from researchers. In this paper we show that Multiple Kernel Learning can be framed as a standard binary classification problem with additional constraints that ensure the positive definiteness of the learned kernel. Framing MKL in this way has the distinct advantage that it makes it easy to leverage the extensive research in binary classification to develop better performing and more scalable MKL algorithms that are conceptually simpler, and, arguably, more accessible to practitioners. Experiments on nine data sets from different domains show that, despite its simplicity, the proposed technique compares favorably with current leading MKL approaches.

Functional neuroimaging can measure the brain?s response to an external stimulus. It is used to perform brain mapping: identifying from these observations the brain regions involved. This problem can be cast into a linear supervised learning task where the neuroimaging data are used as predictors for the stimulus. Brain mapping is then seen as a support recovery problem. On functional MRI (fMRI) data, this problem is particularly challenging as i) the number of samples is small due to limited acquisition time and ii) the variables are strongly correlated. We propose to overcome these difficulties using sparse regression models over new variables obtained by clustering of the original variables. The use of randomization techniques, e.g. bootstrap samples, and clustering of the variables improves the recovery properties of sparse methods. We demonstrate the benefit of our approach on an extensive simulation study as well as two fMRI datasets.

Discriminative linear models are a popular tool in machine learning. These can be generally divided into two types: The first is linear classifiers, such as support vector machines, which are well studied and provide state-of-the-art results. One shortcoming of these models is that their output (known as the 'margin') is not calibrated, and cannot be translated naturally into a distribution over the labels. Thus, it is difficult to incorporate such models as components of larger systems, unlike probabilistic based approaches. The second type of approach constructs class conditional distributions using a nonlinearity (e.g. log-linear models), but is occasionally worse in terms of classification error. We propose a supervised learning method which combines the best of both approaches. Specifically, our method provides a distribution over the labels, which is a linear function of the model parameters. As a consequence, differences between probabilities are linear functions, a property which most probabilistic models (e.g. log-linear) do not have. Our model assumes that classes correspond to linear subspaces (rather than to half spaces). Using a relaxed projection operator, we construct a measure which evaluates the degree to which a given vector 'belongs' to a subspace, resulting in a distribution over labels. Interestingly, this view is closely related to similar concepts in quantum detection theory. The resulting models can be trained either to maximize the margin or to optimize average likelihood measures. The corresponding optimization problems are semidefinite programs which can be solved efficiently. We illustrate the performance of our algorithm on real world datasets, and show that it outperforms 2nd order kernel methods.

In this paper we propose a unified framework for structured prediction with latent variables which includes hidden conditional random fields and latent structured support vector machines as special cases. We describe a local entropy approximation for this general formulation using duality, and derive an efficient message passing algorithm that is guaranteed to converge. We demonstrate its effectiveness in the tasks of image segmentation as well as 3D indoor scene understanding from single images, showing that our approach is superior to latent structured support vector machines and hidden conditional random fields.

In this paper, we address the problem of embedded feature selection for ranking on top of the list problems. We pose this problem as a regularized empirical risk minimization with $p$-norm push loss function ($p=\infty$) and sparsity inducing regularizers. We leverage the issues related to this challenging optimization problem by considering an alternating direction method of multipliers algorithm which is built upon proximal operators of the loss function and the regularizer. Our main technical contribution is thus to provide a numerical scheme for computing the infinite push loss function proximal operator. Experimental results on toy, DNA microarray and BCI problems show how our novel algorithm compares favorably to competitors for ranking on top while using fewer variables in the scoring function.

We show that the multi-class support vector machine (MSVM) proposed by Lee et. al. (2004), can be viewed as a MAP estimation procedure under an appropriate probabilistic interpretation of the classifier. We also show that this interpretation can be extended to a hierarchical Bayesian architecture and to a fully-Bayesian inference procedure for multi-class classification based on data augmentation. We present empirical results that show that the advantages of the Bayesian formalism are obtained without a loss in classification accuracy.