Manifold learning has been successfully applied to a variety of medical imaging problems. Its use in real-time applications requires fast projection onto the low-dimensional space. To this end, out-of-sample extensions are applied by constructing an interpolation function that maps from the input space to the low-dimensional manifold. Commonly used approaches such as the Nystr\"{o}m extension and kernel ridge regression require using all training points. We propose an interpolation function that only depends on a small subset of the input training data. Consequently, in the testing phase each new point only needs to be compared against a small number of input training data in order to project the point onto the low-dimensional space. We interpret our method as an out-of-sample extension that approximates kernel ridge regression. Our method involves solving a simple convex optimization problem and has the attractive property of guaranteeing an upper bound on the approximation error, which is crucial for medical applications. Tuning this error bound controls the sparsity of the resulting interpolation function. We illustrate our method in two clinical applications that require fast mapping of input images onto a low-dimensional space.

During the past years there has been an explosion of interest in learning methods based on sparsity regularization. In this paper, we discuss a general class of such methods, in which the regularizer can be expressed as the composition of a convex function $\omega$ with a linear function. This setting includes several methods such the group Lasso, the Fused Lasso, multi-task learning and many more. We present a general approach for solving regularization problems of this kind, under the assumption that the proximity operator of the function $\omega$ is available. Furthermore, we comment on the application of this approach to support vector machines, a technique pioneered by the groundbreaking work of Vladimir Vapnik.

We investigate a family of poisoning attacks against Support Vector Machines (SVM). Such attacks inject specially crafted training data that increases the SVM's test error. Central to the motivation for these attacks is the fact that most learning algorithms assume that their training data comes from a natural or well-behaved distribution. However, this assumption does not generally hold in security-sensitive settings. As we demonstrate, an intelligent adversary can, to some extent, predict the change of the SVM's decision function due to malicious input and use this ability to construct malicious data. The proposed attack uses a gradient ascent strategy in which the gradient is computed based on properties of the SVM's optimal solution. This method can be kernelized and enables the attack to be constructed in the input space even for non-linear kernels. We experimentally demonstrate that our gradient ascent procedure reliably identifies good local maxima of the non-convex validation error surface, which significantly increases the classifier's test error.

Time series modeling and forecasting has fundamental importance to various practical domains. Thus a lot of active research works is going on in this subject during several years. Many important models have been proposed in literature for improving the accuracy and effectiveness of time series forecasting. The aim of this dissertation work is to present a concise description of some popular time series forecasting models used in practice, with their salient features. In this thesis, we have described three important classes of time series models, viz. the stochastic, neural networks and SVM based models, together with their inherent forecasting strengths and weaknesses. We have also discussed about the basic issues related to time series modeling, such as stationarity, parsimony, overfitting, etc. Our discussion about different time series models is supported by giving the experimental forecast results, performed on six real time series datasets. While fitting a model to a dataset, special care is taken to select the most parsimonious one. To evaluate forecast accuracy as well as to compare among different models fitted to a time series, we have used the five performance measures, viz. MSE, MAD, RMSE, MAPE and Theil's U-statistics. For each of the six datasets, we have shown the obtained forecast diagram which graphically depicts the closeness between the original and forecasted observations. To have authenticity as well as clarity in our discussion about time series modeling and forecasting, we have taken the help of various published research works from reputed journals and some standard books.

Support vector machine (SVM) training is an active research area since the dawn of the method. In recent years there has been increasing interest in specialized solvers for the important case of linear models. The algorithm presented by Hsieh et al., probably best known under the name of the "liblinear" implementation, marks a major breakthrough. The method is analog to established dual decomposition algorithms for training of non-linear SVMs, but with greatly reduced computational complexity per update step. This comes at the cost of not keeping track of the gradient of the objective any more, which excludes the application of highly developed working set selection algorithms. We present an algorithmic improvement to this method. We replace uniform working set selection with an online adaptation of selection frequencies. The adaptation criterion is inspired by modern second order working set selection methods. The same mechanism replaces the shrinking heuristic. This novel technique speeds up training in some cases by more than an order of magnitude.

We describe a method for predicting a classification of an object given classifications of the objects in the training set, assuming that the pairs object/classification are generated by an i.i.d. process from a continuous probability distribution. Our method is a modification of Vapnik's support-vector machine; its main novelty is that it gives not only the prediction itself but also a practicable measure of the evidence found in support of that prediction. We also describe a procedure for assigning degrees of confidence to predictions made by the support vector machine. Some experimental results are presented, and possible extensions of the algorithms are discussed.

Stochastic Gradient Descent (SGD) has become popular for solving large scale supervised machine learning optimization problems such as SVM, due to their strong theoretical guarantees. While the closely related Dual Coordinate Ascent (DCA) method has been implemented in various software packages, it has so far lacked good convergence analysis. This paper presents a new analysis of Stochastic Dual Coordinate Ascent (SDCA) showing that this class of methods enjoy strong theoretical guarantees that are comparable or better than SGD. This analysis justifies the effectiveness of SDCA for practical applications.

It is shown that bootstrap approximations of support vector machines (SVMs) based on a general convex and smooth loss function and on a general kernel are consistent. This result is useful to approximate the unknown finite sample distribution of SVMs by the bootstrap approach.

We define a generalized likelihood function based on uncertainty measures and show that maximizing such a likelihood function for different measures induces different types of classifiers. In the probabilistic framework, we obtain classifiers that optimize the cross-entropy function. In the possibilistic framework, we obtain classifiers that maximize the interclass margin. Furthermore, we show that the support vector machine is a sub-class of these maximum-margin classifiers.

Incorporating feature selection into a classification or regression method often carries a number of advantages. In this paper we formalize feature selection specifically from a discriminative perspective of improving classification/regression accuracy. The feature selection method is developed as an extension to the recently proposed maximum entropy discrimination (MED) framework. We describe MED as a flexible (Bayesian) regularization approach that subsumes, e.g., support vector classification, regression and exponential family models. For brevity, we restrict ourselves primarily to feature selection in the context of linear classification/regression methods and demonstrate that the proposed approach indeed carries substantial improvements in practice. Moreover, we discuss and develop various extensions of feature selection, including the problem of dealing with example specific but unobserved degrees of freedom -- alignments or invariants.