Leveraging artificial intelligence (AI)-driven electronic design and automation (EDA) tools, high-performance computing, and parallelized algorithms are essential for next-generation microprocessor innovation, ensuring continued progress in computing, AI, and semiconductor technology. Machine learning-based design rule checking (DRC) and lithography hotspot detection can improve first-pass silicon success. However, conventional ML and neural network (NN)-based models use supervised learning and require a large balanced dataset (in terms of positive and negative classes) and training time. This research addresses those key challenges by proposing the first-ever unsupervised DRC violation prediction methodology. The proposed model can be built using any unbalanced dataset using only one class and set a threshold for it, then fitting any new data querying if they are within the boundary of the model for classification. This research verified the proposed model by implementing different computational cores using CMOS 28 nm technology and Synopsys Design Compiler and IC Compiler II tools. Then, layouts were divided into virtual grids to collect about 60k data for analysis and verification. The proposed method has 99.95% prediction test accuracy, while the existing support vector machine (SVM) and neural network (NN) models have 85.44\% and 98.74\% accuracy, respectively. In addition, the proposed methodology has about 26.3x and up to 6003x lower training times compared to SVM and NN-models, respectively.

We present a novel mathematical optimization framework for outlier detection in multimodal datasets, extending Support Vector Data Description approaches. We provide a primal formulation, in the shape of a Mixed Integer Second Order Cone model, that constructs Euclidean hyperspheres to identify anomalous observations. Building on this, we develop a dual model that enables the application of the kernel trick, thus allowing for the detection of outliers within complex, non-linear data structures. An extensive computational study demonstrates the effectiveness of our exact method, showing clear advantages over existing heuristic techniques in terms of accuracy and robustness.

Quantitative Structure-Activity Relationship ( QSAR) modeling is key in drug discovery, but classical methods face limitations when handling high-dimensional data and capturing complex molecular interactions. This research proposes enhancing QSAR techniques through Quantum Support Vector Machines ( QSVMs), which leverage quantum computing principles to process information in Hilbert spaces. By using quantum data encoding and quantum kernel functions, we aim to develop more accurate and efficient predictive models.

Inconsistencies between clinical and omics data may arise within medical cohorts. The identification, annotation and explanation of anomalous omics-based patients or individuals may become crucial to better reshape the disease, e.g., by detecting early onsets signaled by the omics and undetectable from observable symptoms. Here, we developed MLASDO (Machine Learning based Anomalous Sample Detection on Omics), a new method and software tool to identify, characterize and automatically describe anomalous samples based on omics data. Its workflow is based on three steps: (1) classification of healthy and cases individuals using a support vector machine algorithm; (2) detection of anomalous samples within groups; (3) explanation of anomalous individuals based on clinical data and expert knowledge. We showcase MLASDO using transcriptomics data of 317 healthy controls (HC) and 465 Parkinson's disease (PD) cases from the Parkinson's Progression Markers Initiative. In this cohort, MLASDO detected 15 anomalous HC with a PD-like transcriptomic signature and PD-like clinical features, including a lower proportion of CD4/CD8 naive T-cells and CD4 memory T-cells compared to HC (P<3.5*10^-3). MLASDO also identified 22 anomalous PD cases with a transcriptomic signature more similar to that of HC and some clinical features more similar to HC, including a lower proportion of mature neutrophils compared to PD cases (P<6*10^-3). In summary, MLASDO is a powerful tool that can help the clinician to detect and explain anomalous HC and cases of interest to be followed up. MLASDO is an open-source R package available at: https://github.com/JoseAdrian3/MLASDO.

Active learning for classification seeks to reduce the cost of labeling samples by finding unlabeled examples about which the current model is least certain and sending them to an annotator/expert to label. Bayesian theory can provide a probabilistic view of deep neural network models by asserting a prior distribution over model parameters and estimating the uncertainties by posterior distribution over these parameters. This paper proposes two novel active learning approaches to label one million malware examples belonging to different unknown modern malware families. The first model is Inception-V4+PCA combined with several support vector machine (SVM) algorithms (UTSVM, PSVM, SVM-GSU, TBSVM). The second model is Vision Transformer based Bayesian Neural Networks ViT-BNN. Our proposed ViT-BNN is a state-of-the-art active learning approach that differs from current methods and can apply to any particular task. The experiments demonstrate that the ViT-BNN is more stable and robust in handling uncertainty.

We consider the following classification problem: Given a population of individuals characterized by a set of attributes represented as a vector in ${\mathbb R}^N$, the goal is to find a hyperplane in ${\mathbb R}^N$ that separates two sets of points corresponding to two distinct classes. This problem, with a history dating back to the perceptron model, remains central to machine learning. In this paper we propose a novel approach by searching for a vector of parameters in a bounded $N$-dimensional hypercube centered at the origin and a positive vector in ${\mathbb R}^M$, obtained through the minimization of an entropy-based function defined over the space of unknown variables. The method extends to polynomial surfaces, allowing the separation of data points by more complex decision boundaries. This provides a robust alternative to traditional linear or quadratic optimization techniques, such as support vector machines and gradient descent. Numerical experiments demonstrate the efficiency and versatility of the method in handling diverse classification tasks, including linear and non-linear separability.

With current advancement in hybermedia knowledges, the privacy of digital information has developed a critical problem. To overawed the susceptibilities of present security protocols, scholars tend to focus mainly on efforts on alternation of current protocols. Over past decade, various proposed encoding models have been shown insecurity, leading to main threats against significant data. Utilizing the suitable encryption model is very vital means of guard against various such, but algorithm is selected based on the dependency of data which need to be secured. Moreover, testing potentiality of the security assessment one by one to identify the best choice can take a vital time for processing. For faster and precisive identification of assessment algorithm, we suggest a security phase exposure model for cipher encryption technique by invoking Support Vector Machine (SVM). In this work, we form a dataset using usual security components like contrast, homogeneity. To overcome the uncertainty in analysing the security and lack of ability of processing data to a risk assessment mechanism. To overcome with such complications, this paper proposes an assessment model for security issues using fuzzy evidential reasoning (ER) approaches. Significantly, the model can be utilised to process and assemble risk assessment data on various aspects in systematic ways. To estimate the performance of our framework, we have various analyses like, recall, F1 score and accuracy.

This study addresses the problem of authorship attribution for Romanian texts using the ROST corpus, a standard benchmark in the field. We systematically evaluate six machine learning techniques: Support Vector Machine (SVM), Logistic Regression (LR), k-Nearest Neighbors (k-NN), Decision Trees (DT), Random Forests (RF), and Artificial Neural Networks (ANN), employing character n-gram features for classification. Among these, the ANN model achieved the highest performance, including perfect classification in four out of fifteen runs when using 5-gram features. These results demonstrate that lightweight, interpretable character n-gram approaches can deliver state-of-the-art accuracy for Romanian authorship attribution, rivaling more complex methods. Our findings highlight the potential of simple stylometric features in resource, constrained or under-studied language settings.

According to the data, the percent of women who underwent screening for cervical cancer, breast and oral cancer in Telangana in the year 2020 was 3.3 percent, 0.3 percent and 2.3 percent respectively. Although early detection is the only way to reduce morbidity and mortality, people have very low awareness about cervical and breast cancer signs and symptoms and screening practices. We developed an ML classification model to predict if a person is susceptible to breast or cervical cancer based on demographic factors. We devised a system to provide suggestions for the nearest hospital or Cancer treatment centres based on the users location or address. In addition to this, we can integrate the health card to maintain medical records of all individuals and conduct awareness drives and campaigns. For ML classification models, we used decision tree classification and support vector classification algorithms for cervical cancer susceptibility and breast cancer susceptibility respectively. Thus, by devising this solution we come one step closer to our goal which is spreading cancer awareness, thereby, decreasing the cancer mortality and increasing cancer literacy among the people of Telangana.

In this study, we apply machine learning and software engineering in analyzing air pollution levels in City of Baltimore. The data model was fed with three primary data sources: 1) a biased method of estimating insurance risk used by homeowners loan corporation, 2) demographics of Baltimore residents, and 3) census data estimate of NO2 and PM2.5 concentrations. The dataset covers 650,643 Baltimore residents in 44.7 million residents in 202 major cities in US. The results show that air pollution levels have a clear association with the biased insurance estimating method. Great disparities present in NO2 level between more desirable and low income blocks. Similar disparities exist in air pollution level between residents' ethnicity. As Baltimore population consists of a greater proportion of people of color, the finding reveals how decades old policies has continued to discriminate and affect quality of life of Baltimore citizens today.