Myocardial infarction (MI) is the leading cause of mortality in the world that occurs due to a blockage of the coronary arteries feeding the myocardium. An early diagnosis of MI and its localization can mitigate the extent of myocardial damage by facilitating early therapeutic interventions. Following the blockage of a coronary artery, the regional wall motion abnormality (RWMA) of the ischemic myocardial segments is the earliest change to set in. Echocardiography is the fundamental tool to assess any RWMA. Assessing the motion of the left ventricle (LV) wall only from a single echocardiography view may lead to missing the diagnosis of MI as the RWMA may not be visible on that specific view. Therefore, in this study, we propose to fuse apical 4-chamber (A4C) and apical 2-chamber (A2C) views in which a total of 11 myocardial segments can be analyzed for MI detection. The proposed method first estimates the motion of the LV wall by Active Polynomials (APs), which extract and track the endocardial boundary to compute myocardial segment displacements. The features are extracted from the A4C and A2C view displacements, which are fused and fed into the classifiers to detect MI. The main contributions of this study are 1) creation of a new benchmark dataset by including both A4C and A2C views in a total of 260 echocardiography recordings, which is publicly shared with the research community, 2) improving the performance of the prior work of threshold-based APs by a Machine Learning based approach, and 3) a pioneer MI detection approach via multi-view echocardiography by fusing the information of A4C and A2C views. Experimental results show that the proposed method achieves 90.91% sensitivity and 86.36% precision for MI detection over multi-view echocardiography.

Motivated by neuroscientific and clinical applications, we empirically examine whether observational measures of information flow can suggest interventions. We do so by performing experiments on artificial neural networks in the context of fairness in machine learning, where the goal is to induce fairness in the system through interventions. Using our recently developed $M$-information flow framework, we measure the flow of information about the true label (responsible for accuracy, and hence desirable), and separately, the flow of information about a protected attribute (responsible for bias, and hence undesirable) on the edges of a trained neural network. We then compare the flow magnitudes against the effect of intervening on those edges by pruning. We show that pruning edges that carry larger information flows about the protected attribute reduces bias at the output to a greater extent. This demonstrates that $M$-information flow can meaningfully suggest targets for interventions, answering the title's question in the affirmative. We also evaluate bias-accuracy tradeoffs for different intervention strategies, to analyze how one might use estimates of desirable and undesirable information flows (here, accuracy and bias flows) to inform interventions that preserve the former while reducing the latter.

University campuses are essentially a microcosm of a city. They comprise diverse facilities such as residences, sport centres, lecture theatres, parking spaces, and public transport stops. Universities are under constant pressure to improve efficiencies while offering a better experience to various stakeholders including students, staff, and visitors. Nonetheless, anecdotal evidence indicates that campus assets are not being utilised efficiently, often due to the lack of data collection and analysis, thereby limiting the ability to make informed decisions on the allocation and management of resources. Advances in the Internet of Things (IoT) technologies that can sense and communicate data from the physical world, coupled with data analytics and Artificial intelligence (AI) that can predict usage patterns, have opened up new opportunities for organisations to lower cost and improve user experience. This thesis explores this opportunity via theory and experimentation using UNSW Sydney as a living laboratory.

An ensemble of decision trees is known as Random Forest. As suggested by Breiman, the strength of unstable learners and the diversity among them are the ensemble models' core strength. In this paper, we propose two approaches known as oblique and rotation double random forests. In the first approach, we propose a rotation based double random forest. In rotation based double random forests, transformation or rotation of the feature space is generated at each node. At each node different random feature subspace is chosen for evaluation, hence the transformation at each node is different. Different transformations result in better diversity among the base learners and hence, better generalization performance. With the double random forest as base learner, the data at each node is transformed via two different transformations namely, principal component analysis and linear discriminant analysis. In the second approach, we propose oblique double random forest. Decision trees in random forest and double random forest are univariate, and this results in the generation of axis parallel split which fails to capture the geometric structure of the data. Also, the standard random forest may not grow sufficiently large decision trees resulting in suboptimal performance. To capture the geometric properties and to grow the decision trees of sufficient depth, we propose oblique double random forest. The oblique double random forest models are multivariate decision trees. At each non-leaf node, multisurface proximal support vector machine generates the optimal plane for better generalization performance. Also, different regularization techniques (Tikhonov regularisation and axis-parallel split regularisation) are employed for tackling the small sample size problems in the decision trees of oblique double random forest.

Machine learning is a field of artificial intelligence in which a system is designed to learn automatically given a set of input data. After the system has learnt (we say that the system has been trained), we can use it to make predictions for new data, unseen before. This approach makes it possible to solve complex problems which are difficult or impossible to solve with traditional sequential programming. Recognizing handwritten text is a problem that traces back to the first automatic machines that needed to recognize individual characters in handwritten documents. Think about, for example, the ZIP codes on letters at the post office and the automation needed to recognize these five digits.

We establish a broad methodological foundation for mixed-integer optimization with learned constraints. We propose an end-to-end pipeline for data-driven decision making in which constraints and objectives are directly learned from data using machine learning, and the trained models are embedded in an optimization formulation. We exploit the mixed-integer optimization-representability of many machine learning methods, including linear models, decision trees, ensembles, and multi-layer perceptrons. The consideration of multiple methods allows us to capture various underlying relationships between decisions, contextual variables, and outcomes. We also characterize a decision trust region using the convex hull of the observations, to ensure credible recommendations and avoid extrapolation. We efficiently incorporate this representation using column generation and clustering. In combination with domain-driven constraints and objective terms, the embedded models and trust region define a mixed-integer optimization problem for prescription generation. We implement this framework as a Python package (OptiCL) for practitioners. We demonstrate the method in both chemotherapy optimization and World Food Programme planning. The case studies illustrate the benefit of the framework in generating high-quality prescriptions, the value added by the trust region, the incorporation of multiple machine learning methods, and the inclusion of multiple learned constraints.

Solving Constraint Optimization Problems (COPs) can be dramatically simplified by boundary estimation, that is, providing tight boundaries of cost functions. By feeding a supervised Machine Learning (ML) model with data composed of known boundaries and extracted features of COPs, it is possible to train the model to estimate boundaries of a new COP instance. In this paper, we first give an overview of the existing body of knowledge on ML for Constraint Programming (CP) which learns from problem instances. Second, we introduce a boundary estimation framework that is applied as a tool to support a CP solver. Within this framework, different ML models are discussed and evaluated regarding their suitability for boundary estimation, and countermeasures to avoid unfeasible estimations that avoid the solver to find an optimal solution are shown. Third, we present an experimental study with distinct CP solvers on seven COPs. Our results show that near-optimal boundaries can be learned for these COPs with only little overhead. These estimated boundaries reduce the objective domain size by 60-88% and can help the solver to find near-optimal solutions early during search.

Even skilled fantasy football managers can be disappointed by their mid-season rosters as some players inevitably fall short of draft day expectations. Team managers can quickly discover that their team has a low score ceiling even if they start their best active players. A novel and diverse combinatorial optimization system proposes high volume and unique player trades between complementary teams to balance trade fairness. Several algorithms create the valuation of each fantasy football player with an ensemble of computing models such as Quantum Support Vector Classifier with Permutation Importance (QSVC-PI), Quantum Support Vector Classifier with Accumulated Local Effects (QSVC-ALE), Variational Quantum Circuit with Permutation Importance (VQC-PI), Hybrid Quantum Neural Network with Permutation Importance (HQNN-PI), eXtreme Gradient Boosting Classifier (XGB), and Subject Matter Expert (SME) rules. The valuation of each player is personalized based on league rules, roster, and selections. Similarly, the cost of trading away a player is related to a team's roster, such as the depth at a position, slot count, position importance, etc. Teams are paired together for trading based on a cosine dissimilarity score so that teams can offset their respective strengths and weaknesses. A knapsack 0-1 algorithm computes outgoing players for each team. Postprocessors apply analytics and deep learning models to measure 6 different objective measures about each trade, such as parity, pain, and fairness. Over the 2020 and 2021 National Football League (NFL) seasons, a group of 24 experts from IBM and ESPN evaluated trade quality through 10 Football Error Analysis Tool (FEAT) sessions. Our system started with 76.9% of high-quality trades and was deployed for the 2021 season with 97.3% of high-quality trades. To increase trade quantity, our quantum, classical, and rules-based computing have 100% trade uniqueness. This paper will discuss our diverse computing paradigms that value players, cost determinations, personalization experience, knapsack 0-1 algorithm and our experimental results. Throughout the 2020 season, we served over 239 million trade proposals and insights with over 55 million user interactions. In 2021, we introduced trade personalization so that the trade proposals were created around user preferences.

In this chapter two programs are presented: fit_func_esvr.py and fit_func_nusvr.py In fact through the argument --svrparams the user passes a series of hyper-parameters to adjust the behavior of the'underlying SVR algorithm and others to configure its learning phase. In addition to the parameters of the underlying regressor the program supports its own arguments to allow the user to pass the training dataset and on which file to save the trained model. The format of the input datasets is in csv format (with header), with $n m$ columns, of which the first $n$ columns contain the values of the $n$ independent variables and the last $m$ containing the values of the dependent variables. In this chapter the program predict_func.py is presented and which purpose is to make predictions on a test dataset applying it to a previously trained e-SVR or nu-SVR model respectively via the program fit_func_esvr.py or fit_func_nusvr.py,

This work explores the evaluation of a machine learning anomaly detector using custom-made parameterizable malware in an Internet of Things (IoT) Ecosystem. It is assumed that the malware has infected, and resides on, the Linux router that serves other devices on the network, as depicted in Figure 1. This IoT Ecosystem was developed as a testbed to evaluate the efficacy of a behavior-based anomaly detector. The malware consists of three types of custom-made malware: ransomware, cryptominer, and keylogger, which all have exfiltration capabilities to the network. The parameterization of the malware gives the malware samples multiple degrees of freedom, specifically relating to the rate and size of data exfiltration. The anomaly detector uses feature sets crafted from system calls and network traffic, and uses a Support Vector Machine (SVM) for behavioral-based anomaly detection. The custom-made malware is used to evaluate the situations where the SVM is effective, as well as the situations where it is not effective.