Osteoporosis is a common condition that increases fracture risk, especially in older adults. Early diagnosis is vital for preventing fractures, reducing treatment costs, and preserving mobility. However, healthcare providers face challenges like limited labeled data and difficulties in processing medical images. This study presents a novel multi-modal learning framework that integrates clinical and imaging data to improve diagnostic accuracy and model interpretability. The model utilizes three pre-trained networks-VGG19, InceptionV3, and ResNet50-to extract deep features from X-ray images. These features are transformed using PCA to reduce dimensionality and focus on the most relevant components. A clustering-based selection process identifies the most representative components, which are then combined with preprocessed clinical data and processed through a fully connected network (FCN) for final classification. A feature importance plot highlights key variables, showing that Medical History, BMI, and Height were the main contributors, emphasizing the significance of patient-specific data. While imaging features were valuable, they had lower importance, indicating that clinical data are crucial for accurate predictions. This framework promotes precise and interpretable predictions, enhancing transparency and building trust in AI-driven diagnoses for clinical integration.

Software-defined network (SDN) is a new approach that allows network control to become directly programmable, and the underlying infrastructure can be abstracted from applications and network services. Control plane). When it comes to security, the centralization that this demands is ripe for a variety of cyber threats that are not typically seen in other network architectures. The authors in this research developed a novel machine-learning method to capture infections in networks. We applied the classifier to the UNSW-NB 15 intrusion detection benchmark and trained a model with this data. Random Forest and Decision Tree are classifiers used to assess with Gradient Boosting and AdaBoost. Out of these best-performing models was Gradient Boosting with an accuracy, recall, and F1 score of 99.87%,100%, and 99.85%, respectively, which makes it reliable in the detection of intrusions for SDN networks. The second best-performing classifier was also a Random Forest with 99.38% of accuracy, followed by Ada Boost and Decision Tree. The research shows that the reason that Gradient Boosting is so effective in this task is that it combines weak learners and creates a strong ensemble model that can predict if traffic belongs to a normal or malicious one with high accuracy. This paper indicates that the GBDT-IDS model is able to improve network security significantly and has better features in terms of both real-time detection accuracy and low false positive rates. In future work, we will integrate this model into live SDN space to observe its application and scalability. This research serves as an initial base on which one can make further strides forward to enhance security in SDN using ML techniques and have more secure, resilient networks.

A large amount of information in today's world is now stored in knowledge bases. Named Entity Recognition (NER) is a process of extracting, disambiguation, and linking an entity from raw text to insightful and structured knowledge bases. More concretely, it is identifying and classifying entities in the text that are crucial for Information Extraction, Semantic Annotation, Question Answering, Ontology Population, and so on. The process of NER has evolved in the last three decades since it first appeared in 1996. In this survey, we study the evolution of techniques employed for NER and compare the results, starting from supervised to the developing unsupervised learning methods.

In this paper, we design an exclusive Metaverse network traffic classifier, named Discern-XR, to help Internet service providers (ISP) and router manufacturers enhance the quality of Metaverse services. Leveraging segmented learning, the Frame Vector Representation (FVR) algorithm and Frame Identification Algorithm (FIA) are proposed to extract critical frame-related statistics from raw network data having only four application-level features. A novel Augmentation, Aggregation, and Retention Online Training (A2R-OT) algorithm is proposed to find an accurate classification model through online training methodology. In addition, we contribute to the real-world Metaverse dataset comprising virtual reality (VR) games, VR video, VR chat, augmented reality (AR), and mixed reality (MR) traffic, providing a comprehensive benchmark. Discern-XR outperforms state-of-the-art classifiers by 7% while improving training efficiency and reducing false-negative rates. Our work advances Metaverse network traffic classification by standing as the state-of-the-art solution.

The classification of genetic variants, particularly Variants of Uncertain Significance (VUS), poses a significant challenge in clinical genetics and precision medicine. Large Language Models (LLMs) have emerged as transformative tools in this realm. These models can uncover intricate patterns and predictive insights that traditional methods might miss, thus enhancing the predictive accuracy of genetic variant pathogenicity. This study investigates the integration of state-of-the-art LLMs, including GPN-MSA, ESM1b, and AlphaMissense, which leverage DNA and protein sequence data alongside structural insights to form a comprehensive analytical framework for variant classification. Our approach evaluates these integrated models using the well-annotated ProteinGym and ClinVar datasets, setting new benchmarks in classification performance. The models were rigorously tested on a set of challenging variants, demonstrating substantial improvements over existing state-of-the-art tools, especially in handling ambiguous and clinically uncertain variants. The results of this research underline the efficacy of combining multiple modeling approaches to significantly refine the accuracy and reliability of genetic variant classification systems. These findings support the deployment of these advanced computational models in clinical environments, where they can significantly enhance the diagnostic processes for genetic disorders, ultimately pushing the boundaries of personalized medicine by offering more detailed and actionable genetic insights.

Object-centric learning (OCL) aims to learn representations of individual objects within visual scenes without manual supervision, facilitating efficient and effective visual reasoning. Traditional OCL methods primarily employ bottom-up approaches that aggregate homogeneous visual features to represent objects. However, in complex visual environments, these methods often fall short due to the heterogeneous nature of visual features within an object. To address this, we propose a novel OCL framework incorporating a top-down pathway. This pathway first bootstraps the semantics of individual objects and then modulates the model to prioritize features relevant to these semantics. By dynamically modulating the model based on its own output, our top-down pathway enhances the representational quality of objects. Our framework achieves state-of-the-art performance across multiple synthetic and real-world object-discovery benchmarks.

Human-in-the-loop (HITL) feedback mechanisms can significantly enhance machine learning models, particularly in financial fraud detection, where fraud patterns change rapidly, and fraudulent nodes are sparse. Even small amounts of feedback from Subject Matter Experts (SMEs) can notably boost model performance. This paper examines the impact of HITL feedback on both traditional and advanced techniques using proprietary and publicly available datasets. Our results show that HITL feedback improves model accuracy, with graph-based techniques benefiting the most. We also introduce a novel feedback propagation method that extends feedback across the dataset, further enhancing detection accuracy. By leveraging human expertise, this approach addresses challenges related to evolving fraud patterns, data sparsity, and model interpretability, ultimately improving model robustness and streamlining the annotation process.

Inspired by the success of Geographically Weighted Regression and its accounting for spatial variations, we propose GeogGNN -- A graph neural network model that accounts for geographical latitude and longitudinal points. Using a synthetically generated dataset, we apply the algorithm for a 4-class classification problem in cybersecurity with seemingly realistic geographic coordinates centered in the Gulf Cooperation Council region. We demonstrate that it has higher accuracy than standard neural networks and convolutional neural networks that treat the coordinates as features. Encouraged by the speed-up in model accuracy by the GeogGNN model, we provide a general mathematical result that demonstrates that a geometrically weighted neural network will, in principle, always display higher accuracy in the classification of spatially dependent data by making use of spatial continuity and local averaging features.

Robustness is a fundamental aspect for developing safe and trustworthy models, particularly when they are deployed in the open world. In this work we analyze the inherent capability of one-stage object detectors to robustly operate in the presence of out-of-distribution (OoD) data. Specifically, we propose a novel detection algorithm for detecting unknown objects in image data, which leverages the features extracted by the model from each sample. Differently from other recent approaches in the literature, our proposal does not require retraining the object detector, thereby allowing for the use of pretrained models. Our proposed OoD detector exploits the application of supervised dimensionality reduction techniques to mitigate the effects of the curse of dimensionality on the features extracted by the model. Furthermore, it utilizes high-resolution feature maps to identify potential unknown objects in an unsupervised fashion. Our experiments analyze the Pareto trade-off between the performance detecting known and unknown objects resulting from different algorithmic configurations and inference confidence thresholds. We also compare the performance of our proposed algorithm to that of logits-based post-hoc OoD methods, as well as possible fusion strategies. Finally, we discuss on the competitiveness of all tested methods against state-of-the-art OoD approaches for object detection models over the recently published Unknown Object Detection benchmark. The obtained results verify that the performance of avant-garde post-hoc OoD detectors can be further improved when combined with our proposed algorithm.

Content moderation typically combines the efforts of human moderators and machine learning models. However, these systems often rely on data where significant disagreement occurs during moderation, reflecting the subjective nature of toxicity perception. Rather than dismissing this disagreement as noise, we interpret it as a valuable signal that highlights the inherent ambiguity of the content,an insight missed when only the majority label is considered. In this work, we introduce a novel content moderation framework that emphasizes the importance of capturing annotation disagreement. Our approach uses multitask learning, where toxicity classification serves as the primary task and annotation disagreement is addressed as an auxiliary task. Additionally, we leverage uncertainty estimation techniques, specifically Conformal Prediction, to account for both the ambiguity in comment annotations and the model's inherent uncertainty in predicting toxicity and disagreement.The framework also allows moderators to adjust thresholds for annotation disagreement, offering flexibility in determining when ambiguity should trigger a review. We demonstrate that our joint approach enhances model performance, calibration, and uncertainty estimation, while offering greater parameter efficiency and improving the review process in comparison to single-task methods.