Large vision-language models (LVLMs) have shown remarkable capabilities in visual-language understanding for downstream multi-modal tasks. Despite their success, LVLMs still suffer from generating hallucinations in complex generation tasks, leading to inconsistencies between visual inputs and generated content. To address this issue, some approaches have introduced inference-time interventions, such as contrastive decoding and attention rectification, to reduce overreliance on language priors. However, these approaches overlook hallucinations stemming from spurious inter-modality correlations. In this paper, we propose an Inter-Modality Correlation Calibration Decoding (IMCCD) method to mitigate hallucinations in LVLMs in a training-free manner. In this method, we design a Cross-Modal Value-Enhanced Decoding(CMVED) module to alleviate hallucination by a novel contrastive decoding mechanism. During the estimation of distorted distribution, CMVED masks the value vectors associated with significant cross-modal attention weights, which address both uni-modality overreliance and misleading inter-modality correlations. Additionally, a Content-Driven Attention Refinement(CDAR) module refines cross-modal attention weights, guiding LVLMs to focus on important visual content. Experimental results on diverse hallucination benchmarks validate the superiority of our method over existing state-of-the-art techniques in reducing hallucinations in LVLM text generation. Our code will be available at https://github.com/lijm48/IMCCD.

LLM routers aim to balance quality and cost of generation by classifying queries and routing them to a cheaper or more expensive LLM depending on their complexity. Routers represent one type of what we call LLM control planes: systems that orchestrate use of one or more LLMs. In this paper, we investigate routers' adversarial robustness. We first define LLM control plane integrity, i.e., robustness of LLM orchestration to adversarial inputs, as a distinct problem in AI safety. Next, we demonstrate that an adversary can generate query-independent token sequences we call ``confounder gadgets'' that, when added to any query, cause LLM routers to send the query to a strong LLM. Our quantitative evaluation shows that this attack is successful both in white-box and black-box settings against a variety of open-source and commercial routers, and that confounding queries do not affect the quality of LLM responses. Finally, we demonstrate that gadgets can be effective while maintaining low perplexity, thus perplexity-based filtering is not an effective defense. We finish by investigating alternative defenses.

The increasing use of machine learning in learning analytics (LA) has raised significant concerns around algorithmic fairness and privacy. Synthetic data has emerged as a dual-purpose tool, enhancing privacy and improving fairness in LA models. However, prior research suggests an inverse relationship between fairness and privacy, making it challenging to optimize both. This study investigates which synthetic data generators can best balance privacy and fairness, and whether pre-processing fairness algorithms, typically applied to real datasets, are effective on synthetic data. Our results highlight that the DEbiasing CAusal Fairness (DECAF) algorithm achieves the best balance between privacy and fairness. However, DECAF suffers in utility, as reflected in its predictive accuracy. Notably, we found that applying pre-processing fairness algorithms to synthetic data improves fairness even more than when applied to real data. These findings suggest that combining synthetic data generation with fairness pre-processing offers a promising approach to creating fairer LA models.

The integration of Internet of Things (IoT) technology in various domains has led to operational advancements, but it has also introduced new vulnerabilities to cybersecurity threats, as evidenced by recent widespread cyberattacks on IoT devices. Intrusion detection systems are often reactive, triggered by specific patterns or anomalies observed within the network. To address this challenge, this work proposes a proactive approach to anticipate and preemptively mitigate malicious activities, aiming to prevent potential damage before it occurs. This paper proposes an innovative intrusion prediction framework empowered by Pre-trained Large Language Models (LLMs). The framework incorporates two LLMs: a fine-tuned Bidirectional and AutoRegressive Transformers (BART) model for predicting network traffic and a fine-tuned Bidirectional Encoder Representations from Transformers (BERT) model for evaluating the predicted traffic. By harnessing the bidirectional capabilities of BART the framework then identifies malicious packets among these predictions. Evaluated using the CICIoT2023 IoT attack dataset, our framework showcases a notable enhancement in predictive performance, attaining an impressive 98% overall accuracy, providing a powerful response to the cybersecurity challenges that confront IoT networks.

This study proposes a novel lightweight neural network model leveraging features extracted from electrocardiogram (ECG) and respiratory signals for early OSA screening. ECG signals are used to generate feature spectrograms to predict sleep stages, while respiratory signals are employed to detect sleep-related breathing abnormalities. By integrating these predictions, the method calculates the apnea-hypopnea index (AHI) with enhanced accuracy, facilitating precise OSA diagnosis. The method was validated on three publicly available sleep apnea databases: the Apnea-ECG database, the UCDDB dataset, and the MIT-BIH Polysomnographic database. Results showed an overall OSA detection accuracy of 0.978, highlighting the model's robustness. Respiratory event classification achieved an accuracy of 0.969 and an area under the receiver operating characteristic curve (ROC-AUC) of 0.98. For sleep stage classification, in UCDDB dataset, the ROC-AUC exceeded 0.85 across all stages, with recall for Sleep reaching 0.906 and specificity for REM and Wake states at 0.956 and 0.937, respectively. This study underscores the potential of integrating lightweight neural networks with multi-signal analysis for accurate, portable, and cost-effective OSA screening, paving the way for broader adoption in home-based and wearable health monitoring systems.

How can we use the novel capacities of large language models (LLMs) in empirical research? And how can we do so while accounting for their limitations, which are themselves only poorly understood? We develop an econometric framework to answer this question that distinguishes between two types of empirical tasks. Using LLMs for prediction problems (including hypothesis generation) is valid under one condition: no ``leakage'' between the LLM's training dataset and the researcher's sample. No leakage can be ensured by using open-source LLMs with documented training data and published weights. Using LLM outputs for estimation problems to automate the measurement of some economic concept (expressed either by some text or from human subjects) requires the researcher to collect at least some validation data: without such data, the errors of the LLM's automation cannot be assessed and accounted for. As long as these steps are taken, LLM outputs can be used in empirical research with the familiar econometric guarantees we desire. Using two illustrative applications to finance and political economy, we find that these requirements are stringent; when they are violated, the limitations of LLMs now result in unreliable empirical estimates. Our results suggest the excitement around the empirical uses of LLMs is warranted -- they allow researchers to effectively use even small amounts of language data for both prediction and estimation -- but only with these safeguards in place.

Coronary artery disease (CAD), one of the leading causes of mortality worldwide, necessitates effective risk assessment strategies, with coronary artery calcium (CAC) scoring via computed tomography (CT) being a key method for prevention. Traditional methods, primarily based on UNET architectures implemented on pre-built models, face challenges like the scarcity of annotated CT scans containing CAC and imbalanced datasets, leading to reduced performance in segmentation and scoring tasks. In this study, we address these limitations by incorporating the self-supervised learning (SSL) technique of DINO (self-distillation with no labels), which trains without requiring CAC-specific annotations, enhancing its robustness in generating distinct features. The DINO-LG model, which leverages label guidance to focus on calcified areas, achieves significant improvements, with a sensitivity of 89% and specificity of 90% for detecting CAC-containing CT slices, compared to the standard DINO model's sensitivity of 79% and specificity of 77%. Additionally, false-negative and false-positive rates are reduced by 49% and 59%, respectively, instilling greater confidence in clinicians when ruling out calcification in low-risk patients and minimizing unnecessary imaging reviews by radiologists. Further, CAC scoring and segmentation tasks are conducted using a basic UNET architecture, applied specifically to CT slices identified by the DINO-LG model as containing calcified areas. This targeted approach enhances CAC scoring accuracy by feeding the UNET model with relevant slices, significantly improving diagnostic precision, reducing both false positives and false negatives, and ultimately lowering overall healthcare costs by minimizing unnecessary tests and treatments, presenting a valuable advancement in CAD risk assessment.

Recent advances in techniques for monitoring and perturbing neural populations have greatly enhanced our ability to study circuits in the brain. In particular, two-photon holographic optogenetics now enables precise photostimulation of experimenter-specified groups of individual neurons, while simultaneous two-photon calcium imaging enables the measurement of ongoing and induced activity across the neural population. Despite the enormous space of potential photostimulation patterns and the time-consuming nature of photostimulation experiments, very little algorithmic work has been done to determine the most effective photostimulation patterns for identifying the neural population dynamics. Here, we develop methods to efficiently select which neurons to stimulate such that the resulting neural responses will best inform a dynamical model of the neural population activity. Using neural population responses to photostimulation in mouse motor cortex, we demonstrate the efficacy of a low-rank linear dynamical systems model, and develop an active learning procedure which takes advantage of low-rank structure to determine informative photostimulation patterns. We demonstrate our approach on both real and synthetic data, obtaining in some cases as much as a two-fold reduction in the amount of data required to reach a given predictive power. Our active stimulation design method is based on a novel active learning procedure for low-rank regression, which may be of independent interest.

Parkinson's disease (PD), the second most common neurodegenerative disorder, is characterized by dopaminergic neuron loss and the accumulation of abnormal synuclein. PD presents both motor and non-motor symptoms that progressively impair daily functioning. The severity of these symptoms is typically assessed using the MDS-UPDRS rating scale, which is subjective and dependent on the physician's experience. Additionally, PD shares symptoms with other neurodegenerative diseases, such as progressive supranuclear palsy (PSP) and multiple system atrophy (MSA), complicating accurate diagnosis. To address these diagnostic challenges, we propose a machine learning-based system for differential diagnosis of PD, PSP, MSA, and healthy controls (HC). This system utilizes a kinematic feature-based hierarchical feature extraction and selection approach. Initially, 18 kinematic features are extracted, including two newly proposed features: Thumb-to-index vector velocity and acceleration, which provide insights into motor control patterns. In addition, 41 statistical features were extracted here from each kinematic feature, including some new approaches such as Average Absolute Change, Rhythm, Amplitude, Frequency, Standard Deviation of Frequency, and Slope. Feature selection is performed using One-way ANOVA to rank features, followed by Sequential Forward Floating Selection (SFFS) to identify the most relevant ones, aiming to reduce the computational complexity. The final feature set is used for classification, achieving a classification accuracy of 66.67% for each dataset and 88.89% for each patient, with particularly high performance for the MSA and HC groups using the SVM algorithm. This system shows potential as a rapid and accurate diagnostic tool in clinical practice, though further data collection and refinement are needed to enhance its reliability.

Super-resolution ultrasound (SR-US) is a powerful imaging technique for capturing microvasculature and blood flow at high spatial resolution. However, accurate microbubble (MB) localization remains a key challenge, as errors in localization can propagate through subsequent stages of the super-resolution process, affecting overall performance. In this paper, we explore the potential of ensemble learning techniques to enhance MB localization by increasing detection sensitivity and reducing false positives. Our study evaluates the effectiveness of ensemble methods on both in vivo and simulated outputs of a Deformable DEtection TRansformer (Deformable DETR) network. As a result of our study, we are able to demonstrate the advantages of these ensemble approaches by showing improved precision and recall in MB detection and offering insights into their application in SR-US.