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Towards a Multimodal MRI-Based Foundation Model for Multi-Level Feature Exploration in Segmentation, Molecular Subtyping, and Grading of Glioma

arXiv.org Artificial Intelligence

Accurate, noninvasive glioma characterization is crucial for effective clinical management. Traditional methods, dependent on invasive tissue sampling, often fail to capture the spatial heterogeneity of the tumor. While deep learning has improved segmentation and molecular profiling, few approaches simultaneously integrate tumor morphology and molecular features. Foundation deep learning models, which learn robust, task-agnostic representations from large-scale datasets, hold great promise but remain underutilized in glioma imaging biomarkers. We propose the Multi-Task SWIN-UNETR (MTS-UNET) model, a novel foundation-based framework built on the BrainSegFounder model, pretrained on large-scale neuroimaging data. MTS-UNET simultaneously performs glioma segmentation, histological grading, and molecular subtyping (IDH mutation and 1p/19q co-deletion). It incorporates two key modules: Tumor-Aware Feature Encoding (TAFE) for multi-scale, tumor-focused feature extraction and Cross-Modality Differential (CMD) for highlighting subtle T2-FLAIR mismatch signals associated with IDH mutation. The model was trained and validated on a diverse, multi-center cohort of 2,249 glioma patients from seven public datasets. MTS-UNET achieved a mean Dice score of 84% for segmentation, along with AUCs of 90.58% for IDH mutation, 69.22% for 1p/19q co-deletion prediction, and 87.54% for grading, significantly outperforming baseline models (p<=0.05). Ablation studies validated the essential contributions of the TAFE and CMD modules and demonstrated the robustness of the framework. The foundation-based MTS-UNET model effectively integrates tumor segmentation with multi-level classification, exhibiting strong generalizability across diverse MRI datasets. This framework shows significant potential for advancing noninvasive, personalized glioma management by improving predictive accuracy and interpretability.


Privacy Auditing of Large Language Models

arXiv.org Artificial Intelligence

Current techniques for privacy auditing of large language models (LLMs) have limited efficacy -- they rely on basic approaches to generate canaries which leads to weak membership inference attacks that in turn give loose lower bounds on the empirical privacy leakage. We develop canaries that are far more effective than those used in prior work under threat models that cover a range of realistic settings. We demonstrate through extensive experiments on multiple families of fine-tuned LLMs that our approach sets a new standard for detection of privacy leakage. For measuring the memorization rate of non-privately trained LLMs, our designed canaries surpass prior approaches. For example, on the Qwen2.5-0.5B model, our designed canaries achieve $49.6\%$ TPR at $1\%$ FPR, vastly surpassing the prior approach's $4.2\%$ TPR at $1\%$ FPR. Our method can be used to provide a privacy audit of $\varepsilon \approx 1$ for a model trained with theoretical $\varepsilon$ of 4. To the best of our knowledge, this is the first time that a privacy audit of LLM training has achieved nontrivial auditing success in the setting where the attacker cannot train shadow models, insert gradient canaries, or access the model at every iteration.


On the Mutual Influence of Gender and Occupation in LLM Representations

arXiv.org Artificial Intelligence

We examine LLM representations of gender for first names in various occupational contexts to study how occupations and the gender perception of first names in LLMs influence each other mutually. We find that LLMs' first-name gender representations correlate with real-world gender statistics associated with the name, and are influenced by the co-occurrence of stereotypically feminine or masculine occupations. Additionally, we study the influence of first-name gender representations on LLMs in a downstream occupation prediction task and their potential as an internal metric to identify extrinsic model biases. While feminine first-name embeddings often raise the probabilities for female-dominated jobs (and vice versa for male-dominated jobs), reliably using these internal gender representations for bias detection remains challenging.


Interpretable Model Drift Detection

arXiv.org Artificial Intelligence

Data in the real world often has an evolving distribution. Thus, machine learning models trained on such data get outdated over time. This phenomenon is called model drift. Knowledge of this drift serves two purposes: (i) Retain an accurate model and (ii) Discovery of knowledge or insights about change in the relationship between input features and output variable w.r.t. the model. Most existing works focus only on detecting model drift but offer no interpretability. In this work, we take a principled approach to study the problem of interpretable model drift detection from a risk perspective using a feature-interaction aware hypothesis testing framework, which enjoys guarantees on test power. The proposed framework is generic, i.e., it can be adapted to both classification and regression tasks. Experiments on several standard drift detection datasets show that our method is superior to existing interpretable methods (especially on real-world datasets) and on par with state-of-the-art black-box drift detection methods. We also quantitatively and qualitatively study the interpretability aspect including a case study on USENET2 dataset. We find our method focuses on model and drift sensitive features compared to baseline interpretable drift detectors.


Privacy Protection in Prosumer Energy Management Based on Federated Learning

arXiv.org Artificial Intelligence

With the booming development of prosumers, there is an urgent need for a prosumer energy management system to take full advantage of the flexibility of prosumers and take into account the interests of other parties. However, building such a system will undoubtedly reveal users' privacy. In this paper, by solving the non-independent and identical distribution of data (Non-IID) problem in federated learning with federated cluster average(FedClusAvg) algorithm, prosumers' information can efficiently participate in the intelligent decision making of the system without revealing privacy. In the proposed FedClusAvg algorithm, each client performs cluster stratified sampling and multiple iterations. Then, the average weight of the parameters of the sub-server is determined according to the degree of deviation of the parameter from the average parameter. Finally, the sub-server multiple local iterations and updates, and then upload to the main server. The advantages of FedClusAvg algorithm are the following two parts. First, the accuracy of the model in the case of Non-IID is improved through the method of clustering and parameter weighted average. Second, local multiple iterations and three-tier framework can effectively reduce communication rounds.


MOB-GCN: A Novel Multiscale Object-Based Graph Neural Network for Hyperspectral Image Classification

arXiv.org Artificial Intelligence

This paper introduces a novel multiscale object-based graph neural network called MOB-GCN for hyperspectral image (HSI) classification. The central aim of this study is to enhance feature extraction and classification performance by utilizing multiscale object-based image analysis (OBIA). Traditional pixel-based methods often suffer from low accuracy and speckle noise, while single-scale OBIA approaches may overlook crucial information of image objects at different levels of detail. MOB-GCN addresses this issue by extracting and integrating features from multiple segmentation scales to improve classification results using the Multiresolution Graph Network (MGN) architecture that can model fine-grained and global spatial patterns. By constructing a dynamic multiscale graph hierarchy, MOB-GCN offers a more comprehensive understanding of the intricate details and global context of HSIs. Experimental results demonstrate that MOB-GCN consistently outperforms single-scale graph convolutional networks (GCNs) in terms of classification accuracy, computational efficiency, and noise reduction, particularly when labeled data is limited. The implementation of MOB-GCN is publicly available at https://github.com/HySonLab/MultiscaleHSI


Fairness-aware organ exchange and kidney paired donation

arXiv.org Artificial Intelligence

The kidney paired donation (KPD) program provides an innovative solution to overcome incompatibility challenges in kidney transplants by matching incompatible donor-patient pairs and facilitating kidney exchanges. To address unequal access to transplant opportunities, there are two widely used fairness criteria: group fairness and individual fairness. However, these criteria do not consider protected patient features, which refer to characteristics legally or ethically recognized as needing protection from discrimination, such as race and gender. Motivated by the calibration principle in machine learning, we introduce a new fairness criterion: the matching outcome should be conditionally independent of the protected feature, given the sensitization level. We integrate this fairness criterion as a constraint within the KPD optimization framework and propose a computationally efficient solution. Theoretically, we analyze the associated price of fairness using random graph models. Empirically, we compare our fairness criterion with group fairness and individual fairness through both simulations and a real-data example.


VesselSAM: Leveraging SAM for Aortic Vessel Segmentation with LoRA and Atrous Attention

arXiv.org Artificial Intelligence

Medical image segmentation is crucial for clinical diagnosis and treatment planning, especially when dealing with complex anatomical structures such as vessels. However, accurately segmenting vessels remains challenging due to their small size, intricate edge structures, and susceptibility to artifacts and imaging noise. In this work, we propose VesselSAM, an enhanced version of the Segment Anything Model (SAM), specifically tailored for aortic vessel segmentation. VesselSAM incorporates AtrousLoRA, a novel module integrating Atrous Attention and Low-Rank Adaptation (LoRA), to enhance segmentation performance. Atrous Attention enables the model to capture multi-scale contextual information, preserving both fine-grained local details and broader global context. Additionally, LoRA facilitates efficient fine-tuning of the frozen SAM image encoder, reducing the number of trainable parameters and thereby enhancing computational efficiency. We evaluate VesselSAM using two challenging datasets: the Aortic Vessel Tree (AVT) dataset and the Type-B Aortic Dissection (TBAD) dataset. VesselSAM achieves state-of-the-art performance, attaining DSC scores of 93.50\%, 93.25\%, 93.02\%, and 93.26\% across multi-center datasets. Our results demonstrate that VesselSAM delivers high segmentation accuracy while significantly reducing computational overhead compared to existing large-scale models. This development paves the way for enhanced AI-based aortic vessel segmentation in clinical environments. The code and models will be released at https://github.com/Adnan-CAS/AtrousLora.


Swift Hydra: Self-Reinforcing Generative Framework for Anomaly Detection with Multiple Mamba Models

arXiv.org Machine Learning

Despite a plethora of anomaly detection models developed over the years, their ability to generalize to unseen anomalies remains an issue, particularly in critical systems. This paper aims to address this challenge by introducing Swift Hydra, a new framework for training an anomaly detection method based on generative AI and reinforcement learning (RL). Through featuring an RL policy that operates on the latent variables of a generative model, the framework synthesizes novel and diverse anomaly samples that are capable of bypassing a detection model. These generated synthetic samples are, in turn, used to augment the detection model, further improving its ability to handle challenging anomalies. Swift Hydra also incorporates Mamba models structured as a Mixture of Experts (MoE) to enable scalable adaptation of the number of Mamba experts based on data complexity, effectively capturing diverse feature distributions without increasing the model's inference time. Empirical evaluations on ADBench benchmark demonstrate that Swift Hydra outperforms other state-of-the-art anomaly detection models while maintaining a relatively short inference time. From these results, our research highlights a new and auspicious paradigm of integrating RL and generative AI for advancing anomaly detection.


Universality of Layer-Level Entropy-Weighted Quantization Beyond Model Architecture and Size

arXiv.org Artificial Intelligence

We present a novel approach to selective model quantization that transcends the limitations of architecture-specific and size-dependent compression methods for Large Language Models (LLMs) using Entropy-Weighted Quantization (EWQ). By analyzing the entropy distribution across transformer blocks, EWQ determines which blocks can be safely quantized without causing significant performance degradation, independent of model architecture or size. Our method outperforms uniform quantization approaches, maintaining Massive Multitask Language Understanding (MMLU) accuracy scores within 0.5% of unquantized models while reducing memory usage by up to 18%. We demonstrate the effectiveness of EWQ across multiple architectures -- from 1.6B to 70B parameters -- and showcase consistent improvements in the quality-compression trade-off regardless of model scale or architectural design. A surprising finding of EWQ is its ability to reduce perplexity compared to unquantized models, suggesting the presence of beneficial regularization through selective precision reduction. This improvement holds across different model families, indicating a fundamental relationship between layer-level entropy and optimal precision requirements. Additionally, we introduce FastEWQ, a rapid method for entropy distribution analysis that eliminates the need for loading model weights. This technique leverages universal characteristics of entropy distribution that persist across various architectures and scales, enabling near-instantaneous quantization decisions while maintaining 80% classification accuracy with full entropy analysis. Our results demonstrate that effective quantization strategies can be developed independently of specific architectural choices or model sizes, opening new possibilities for efficient LLM deployment.