-- Bone fractures are a leading cause of morbidity and disability worldwide, imposing significant clinical and economic burdens on healthcare systems. Traditional X - ray inter pretation is time - consuming and error - prone, while existing machine learning and deep learning solutions often demand extensive feature engineering, large, annotated datasets, and high computational resources. To address these challenges, a distributed hyb rid quantum - classical pipeline is proposed that first applies Principal Component Analysis (PCA) for dimensionality reduction and then leverages a 4 - qubit quantum amplitude - encoding circuit for feature enrichment. By fusing eight PCA - derived features with eight quantum - enhanced features into a 16 - dimensional vector and then classifying with different machine learning models achieving 99% accuracy using a public multi - region X - ray dataset on par with state - of - the - art transfer learning models -- while reducing feature extraction time by 82%. I. INTRODUCTION one fractures present a major challenge in orthopedic and trauma care, where accurate and timely diagnosis is critical for effective trea tment and patient recovery. These may result from trauma, accidents, or conditions like osteoporosis, and if fractures are misdiagnosed or undiagnosed, patients may suffer complications such as improper heali ng or long - term disability [1]. Globally, the fractures contribute substantially to morbidity, disability, and healthcare costs [1 ], [ 2]. X - ray imaging remains the most common diagnostic tool due to its accessibility and non - invasive nature.

Jailbreak attacks to Large audio-language models (LALMs) are studied recently, but they achieve suboptimal effectiveness, applicability, and practicability, particularly, assuming that the adversary can fully manipulate user prompts. In this work, we first conduct an extensive experiment showing that advanced text jailbreak attacks cannot be easily ported to end-to-end LALMs via text-to speech (TTS) techniques. We then propose AudioJailbreak, a novel audio jailbreak attack, featuring (1) asynchrony: the jailbreak audio does not need to align with user prompts in the time axis by crafting suffixal jailbreak audios; (2) universality: a single jailbreak perturbation is effective for different prompts by incorporating multiple prompts into perturbation generation; (3) stealthiness: the malicious intent of jailbreak audios will not raise the awareness of victims by proposing various intent concealment strategies; and (4) over-the-air robustness: the jailbreak audios remain effective when being played over the air by incorporating the reverberation distortion effect with room impulse response into the generation of the perturbations. In contrast, all prior audio jailbreak attacks cannot offer asynchrony, universality, stealthiness, or over-the-air robustness. Moreover, AudioJailbreak is also applicable to the adversary who cannot fully manipulate user prompts, thus has a much broader attack scenario. Extensive experiments with thus far the most LALMs demonstrate the high effectiveness of AudioJailbreak. We highlight that our work peeks into the security implications of audio jailbreak attacks against LALMs, and realistically fosters improving their security robustness. The implementation and audio samples are available at our website https://audiojailbreak.github.io/AudioJailbreak.

Former United States President Joe Biden was not diagnosed with prostate cancer before last week, and received his "last known" blood test for the disease more than a decade ago, his office has said. The Biden camp's statement on Tuesday came as critics, including current President Donald Trump, stoked scepticism over the timing of the diagnosis, which has reanimated questions about whether the former president misled the public about his health while in office. "President Biden's last known PSA was in 2014," Biden's office said in the brief statement, referring to the prostate-specific antigen test used to detect prostate cancer. "Prior to Friday, President Biden had never been diagnosed with prostate cancer." On Monday, Trump said he was "surprised" that the public had not been notified about Biden's diagnosis "a long time ago".

High-risk industries like nuclear and aviation use real-time monitoring to detect dangerous system conditions. Similarly, Large Language Models (LLMs) need monitoring safeguards. We propose a real-time framework to predict harmful AI outputs before they occur by using an unsupervised approach that treats normal behavior as the baseline and harmful outputs as outliers. Our study focuses specifically on backdoor-triggered responses -- where specific input phrases activate hidden vulnerabilities causing the model to generate unsafe content like violence, pornography, or hate speech. We address two key challenges: (1) identifying true causal indicators rather than surface correlations, and (2) preventing advanced models from deception -- deliberately evading monitoring systems. Hence, we approach this problem from an unsupervised lens by drawing parallels to human deception: just as humans exhibit physical indicators while lying, we investigate whether LLMs display distinct internal behavioral signatures when generating harmful content. Our study addresses two critical challenges: 1) designing monitoring systems that capture true causal indicators rather than superficial correlations; and 2)preventing intentional evasion by increasingly capable "Future models''. Our findings show that models can produce harmful content through causal mechanisms and can become deceptive by: (a) alternating between linear and non-linear representations, and (b) modifying feature relationships. To counter this, we developed Safety-Net -- a multi-detector framework that monitors different representation dimensions, successfully detecting harmful behavior even when information is shifted across representational spaces to evade individual monitors. Our evaluation shows 96% accuracy in detecting harmful cases using our unsupervised ensemble approach.

Large Language Models (LLMs) are increasingly integrated into critical systems in industries like healthcare and finance. Users can often submit queries to LLM-enabled chatbots, some of which can enrich responses with information retrieved from internal databases storing sensitive data. This gives rise to a range of attacks in which a user submits a malicious query and the LLM-system outputs a response that creates harm to the owner, such as leaking internal data or creating legal liability by harming a third-party. While security tools are being developed to counter these threats, there is little formal evaluation of their effectiveness and usability. This study addresses this gap by conducting a thorough comparative analysis of LLM security tools. We identified 13 solutions (9 closed-source, 4 open-source), but only 7 were evaluated due to a lack of participation by proprietary model owners.To evaluate, we built a benchmark dataset of malicious prompts, and evaluate these tools performance against a baseline LLM model (ChatGPT-3.5-Turbo). Our results show that the baseline model has too many false positives to be used for this task. Lakera Guard and ProtectAI LLM Guard emerged as the best overall tools showcasing the tradeoff between usability and performance. The study concluded with recommendations for greater transparency among closed source providers, improved context-aware detections, enhanced open-source engagement, increased user awareness, and the adoption of more representative performance metrics.

Decision-focused learning (DFL) is an increasingly popular paradigm for training predictive models whose outputs are used in decision-making tasks. Instead of merely optimizing for predictive accuracy, DFL trains models to directly minimize the loss associated with downstream decisions. This end-to-end strategy holds promise for tackling complex combinatorial problems; however, existing studies focus solely on scenarios where a fixed batch of data is available and the objective function does not change over time. We instead investigate DFL in dynamic environments where the objective function and data distribution evolve over time. This setting is challenging because the objective function has zero or undefined gradients -- which prevents the use of standard first-order optimization methods -- and is generally non-convex. To address these difficulties, we (i) regularize the objective to make it differentiable and (ii) make use of the optimism principle, based on a near-optimal oracle along with an appropriate perturbation. This leads to a practical online algorithm for which we establish bounds on the expected dynamic regret, both when the decision space is a simplex and when it is a general bounded convex polytope. Finally, we demonstrate the effectiveness of our algorithm by comparing its performance with a classic prediction-focused approach on a simple knapsack experiment.

Bootstrap methods have long been a cornerstone of ensemble learning in machine learning. This paper presents a theoretical analysis of bootstrap techniques applied to the Least Square Support Vector Machine (LSSVM) ensemble in the context of large and growing sample sizes and feature dimensionalities. Leveraging tools from Random Matrix Theory, we investigate the performance of this classifier that aggregates decision functions from multiple weak classifiers, each trained on different subsets of the data. We provide insights into the use of bootstrap methods in high-dimensional settings, enhancing our understanding of their impact. Based on these findings, we propose strategies to select the number of subsets and the regularization parameter that maximize the performance of the LSSVM. Empirical experiments on synthetic and real-world datasets validate our theoretical results.

This paper addresses the covariate shift problem in the context of nonparametric regression within reproducing kernel Hilbert spaces (RKHSs). Covariate shift arises in supervised learning when the input distributions of the training and test data differ, presenting additional challenges for learning. Although kernel methods have optimal statistical properties, their high computational demands in terms of time and, particularly, memory, limit their scalability to large datasets. To address this limitation, the main focus of this paper is to explore the trade-off between computational efficiency and statistical accuracy under covariate shift. We investigate the use of random projections where the hypothesis space consists of a random subspace within a given RKHS. Our results show that, even in the presence of covariate shift, significant computational savings can be achieved without compromising learning performance.

Imbalanced data poses a significant obstacle in machine learning, as an unequal distribution of class labels often results in skewed predictions and diminished model accuracy. To mitigate this problem, various resampling strategies have been developed, encompassing both oversampling and undersampling techniques aimed at modifying class proportions. Conventional oversampling approaches like SMOTE enhance the representation of the minority class, whereas undersampling methods focus on trimming down the majority class. Advances in deep learning have facilitated the creation of more complex solutions, such as Generative Adversarial Networks (GANs) and Variational Autoencoders (VAEs), which are capable of producing high-quality synthetic examples. This paper reviews a broad spectrum of data balancing methods, classifying them into categories including synthetic oversampling, adaptive techniques, generative models, ensemble-based strategies, hybrid approaches, undersampling, and neighbor-based methods. Furthermore, it highlights current developments in resampling techniques and discusses practical implementations and case studies that validate their effectiveness. The paper concludes by offering perspectives on potential directions for future exploration in this domain.

This study investigates the multifaceted factors influencing wildfire risk in Iran, focusing on the interplay between climatic conditions and human activities. Utilizing advanced remote sensing, geospatial information system (GIS) processing techniques such as cloud computing, and machine learning algorithms, this research analyzed the impact of climatic parameters, topographic features, and human-related factors on wildfire susceptibility assessment and prediction in Iran. Multiple scenarios were developed for this purpose based on the data sampling strategy. The findings revealed that climatic elements such as soil moisture, temperature, and humidity significantly contribute to wildfire susceptibility, while human activities-particularly population density and proximity to powerlines-also played a crucial role. Furthermore, the seasonal impact of each parameter was separately assessed during warm and cold seasons. The results indicated that human-related factors, rather than climatic variables, had a more prominent influence during the seasonal analyses. This research provided new insights into wildfire dynamics in Iran by generating high-resolution wildfire susceptibility maps using advanced machine learning classifiers. The generated maps identified high risk areas, particularly in the central Zagros region, the northeastern Hyrcanian Forest, and the northern Arasbaran forest, highlighting the urgent need for effective fire management strategies.