Out-of-distribution (OOD) detection attempts to distinguish outlier samples to prevent models trained on the in-distribution (ID) dataset from producing unavailable outputs. Most OOD detection methods require many IID samples for training, which seriously limits their real-world applications. To this end, we target a challenging setting: few-shot OOD detection, where {Only a few {\em labeled ID} samples are available.} Therefore, few-shot OOD detection is much more challenging than the traditional OOD detection setting. Previous few-shot OOD detection works ignore the distinct diversity between different classes. In this paper, we propose a novel network: Adaptive Multi-prompt Contrastive Network (AMCN), which adapts the ID-OOD separation boundary by learning inter- and intra-class distribution. To compensate for the absence of OOD and scarcity of ID {\em image samples}, we leverage CLIP, connecting text with images, engineering learnable ID and OOD {\em textual prompts}. Specifically, we first generate adaptive prompts (learnable ID prompts, label-fixed OOD prompts and label-adaptive OOD prompts). Then, we generate an adaptive class boundary for each class by introducing a class-wise threshold. Finally, we propose a prompt-guided ID-OOD separation module to control the margin between ID and OOD prompts. Experimental results show that AMCN outperforms other state-of-the-art works.

Personalized precision radiation therapy requires more than simple classification, it demands the identification of prognostic, spatially informative features and the ability to adapt treatment based on individual response. This study compares three approaches for predicting treatment response: standard radiomics, gradient based features, and convolutional neural networks enhanced with Class Activation Mapping. We analyzed 69 brain metastases from 39 patients treated with Gamma Knife radiosurgery. An integrated autoencoder classifier model was used to predict whether tumor volume would shrink by more than 20 percent at a three months follow up, framed as a binary classification task. The results highlight their strength in hierarchical feature extraction and the classifiers discriminative capacity. Among the models, pixel wise CAM provides the most detailed spatial insight, identifying lesion specific regions rather than relying on fixed patterns, demonstrating strong generalization. In non responding lesions, the activated regions may indicate areas of radio resistance. Pixel wise CAM outperformed both radiomics and gradient based methods in classification accuracy. Moreover, its fine grained spatial features allow for alignment with cellular level data, supporting biological validation and deeper understanding of heterogeneous treatment responses. Although further validation is necessary, these findings underscore the promise in guiding personalized and adaptive radiotherapy strategies for both photon and particle therapies.

The task of data integration for multi-omics data has emerged as a powerful strategy to unravel the complex biological underpinnings of cancer. Recent advancements in graph neural networks (GNNs) offer an effective framework to model heterogeneous and structured omics data, enabling precise representation of molecular interactions and regulatory networks. This systematic review explores several recent studies that leverage GNN-based architectures in multi-omics cancer research. We classify the approaches based on their targeted omics layers, graph neural network structures, and biological tasks such as subtype classification, prognosis prediction, and biomarker discovery. The analysis reveals a growing trend toward hybrid and interpretable models, alongside increasing adoption of attention mechanisms and contrastive learning. Furthermore, we highlight the use of patient-specific graphs and knowledge-driven priors as emerging directions. This survey serves as a comprehensive resource for researchers aiming to design effective GNN-based pipelines for integrative cancer analysis, offering insights into current practices, limitations, and potential future directions.

Understanding the relationship between mild cognitive impairment (MCI) and driving behavior is essential for enhancing road safety, particularly among older adults. This study introduces a novel approach by incorporating specific trip destinations-such as home, work, medical appointments, social activities, and errands-using geohashing to analyze the driving habits of older drivers in Nebraska. We employed a two-fold methodology that combines data visualization with advanced machine learning models, including C5.0, Random Forest, and Support Vector Machines, to assess the effectiveness of these location-based variables in predicting cognitive impairment. Notably, the C5.0 model showed a robust and stable performance, achieving a median recall of 0.68, which indicates that our methodology accurately identifies cognitive impairment in drivers 68\% of the time. This emphasizes our model's capacity to reduce false negatives, a crucial factor given the profound implications of failing to identify impaired drivers. Our findings underscore the innovative use of life-space variables in understanding and predicting cognitive decline, offering avenues for early intervention and tailored support for affected individuals.

We studied a generalized question: chronic diseases like ME/CFS and long COVID exhibit high heterogeneity with multifactorial etiology and progression, complicating diagnosis and treatment. To address this, we developed BioMapAI, an explainable Deep Learning framework using the richest longitudinal multi-omics dataset for ME/CFS to date. This dataset includes gut metagenomics, plasma metabolome, immune profiling, blood labs, and clinical symptoms. By connecting multi-omics to a symptom matrix, BioMapAI identified both disease- and symptom-specific biomarkers, reconstructed symptoms, and achieved state-of-the-art precision in disease classification. We also created the first connectivity map of these omics in both healthy and disease states and revealed how microbiome-immune-metabolome crosstalk shifted from healthy to ME/CFS.

Benchmark datasets for network intrusion detection commonly rely on synthetically generated traffic, which fails to reflect the statistical variability and temporal drift encountered in operational environments. This paper introduces MAWIFlow, a flow-based benchmark derived from the MAWILAB v1.1 dataset, designed to enable realistic and reproducible evaluation of anomaly detection methods. A reproducible preprocessing pipeline is presented that transforms raw packet captures into flow representations conforming to the CICFlowMeter format, while preserving MAWILab's original anomaly labels. The resulting datasets comprise temporally distinct samples from January 2011, 2016, and 2021, drawn from trans-Pacific backbone traffic. To establish reference baselines, traditional machine learning methods, including Decision Trees, Random Forests, XGBoost, and Logistic Regression, are compared to a deep learning model based on a CNN-BiLSTM architecture. Empirical results demonstrate that tree-based classifiers perform well on temporally static data but experience significant performance degradation over time. In contrast, the CNN-BiLSTM model maintains better performance, thus showing improved generalization. These findings underscore the limitations of synthetic benchmarks and static models, and motivate the adoption of realistic datasets with explicit temporal structure. All datasets, pipeline code, and model implementations are made publicly available to foster transparency and reproducibility.

Large language models (LLMs) offer promising opportunities for organizational research. However, their built-in moderation systems can create problems when researchers try to analyze harmful content, often refusing to follow certain instructions or producing overly cautious responses that undermine validity of the results. This is particularly problematic when analyzing organizational conflicts such as microaggressions or hate speech. This paper introduces an Elo rating-based method that significantly improves LLM performance for harmful content analysis In two datasets, one focused on microaggression detection and the other on hate speech, we find that our method outperforms traditional LLM prompting techniques and conventional machine learning models on key measures such as accuracy, precision, and F1 scores. Advantages include better reliability when analyzing harmful content, fewer false positives, and greater scalability for large-scale datasets. This approach supports organizational applications, including detecting workplace harassment, assessing toxic communication, and fostering safer and more inclusive work environments.

Background: Patients with both diabetes mellitus (DM) and atrial fibrillation (AF) face elevated mortality in intensive care units (ICUs), yet models targeting this high-risk group remain limited. Objective: To develop an interpretable machine learning (ML) model predicting 28-day mortality in ICU patients with concurrent DM and AF using early-phase clinical data. Methods: A retrospective cohort of 1,535 adult ICU patients with DM and AF was extracted from the MIMIC-IV database. Data preprocessing involved median/mode imputation, z-score normalization, and early temporal feature engineering. A two-step feature selection pipeline-univariate filtering (ANOVA F-test) and Random Forest-based multivariate ranking-yielded 19 interpretable features. Seven ML models were trained with stratified 5-fold cross-validation and SMOTE oversampling. Interpretability was assessed via ablation and Accumulated Local Effects (ALE) analysis. Results: Logistic regression achieved the best performance (AUROC: 0.825; 95% CI: 0.779-0.867), surpassing more complex models. Key predictors included RAS, age, bilirubin, and extubation. ALE plots showed intuitive, non-linear effects such as age-related risk acceleration and bilirubin thresholds. Conclusion: This interpretable ML model offers accurate risk prediction and clinical insights for early ICU triage in patients with DM and AF.

Recent advances in model pre-training give rise to task adaptation-based few-shot learning (FSL), where the goal is to adapt a pre-trained task-agnostic model for capturing task-specific knowledge with a few-labeled support samples of the target task.Nevertheless, existing approaches may still fail in the open world due to the inevitable in-distribution (ID) and out-of-distribution (OOD) noise from both support and query samples of the target task. With limited support samples available, i) the adverse effect of the dual noises can be severely amplified during task adaptation, and ii) the adapted model can produce unreliable predictions on query samples in the presence of the dual noises. In this work, we propose DEnoised Task Adaptation (DETA++) for reliable FSL. DETA++ uses a Contrastive Relevance Aggregation (CoRA) module to calculate image and region weights for support samples, based on which a clean prototype loss and a noise entropy maximization loss are proposed to achieve noise-robust task adaptation. Additionally,DETA++ employs a memory bank to store and refine clean regions for each inner-task class, based on which a Local Nearest Centroid Classifier (LocalNCC) is devised to yield noise-robust predictions on query samples. Moreover, DETA++ utilizes an Intra-class Region Swapping (IntraSwap) strategy to rectify ID class prototypes during task adaptation, enhancing the model's robustness to the dual noises. Extensive experiments demonstrate the effectiveness and flexibility of DETA++.

Predictive artificial intelligence (AI) offers an opportunity to improve clinical practice and patient outcomes, but risks perpetuating biases if fairness is inadequately addressed. However, the definition of "fairness" remains unclear. We conducted a scoping review to identify and critically appraise fairness metrics for clinical predictive AI. We defined a "fairness metric" as a measure quantifying whether a model discriminates (societally) against individuals or groups defined by sensitive attributes. We searched five databases (2014-2024), screening 820 records, to include 41 studies, and extracted 62 fairness metrics. Metrics were classified by performance-dependency, model output level, and base performance metric, revealing a fragmented landscape with limited clinical validation and overreliance on threshold-dependent measures. Eighteen metrics were explicitly developed for healthcare, including only one clinical utility metric. Our findings highlight conceptual challenges in defining and quantifying fairness and identify gaps in uncertainty quantification, intersectionality, and real-world applicability.