The Context-Content Uncertainty Principle (CCUP) proposes that inference under uncertainty is governed by an entropy asymmetry between context and content: high-entropy contexts must be interpreted through alignment with low-entropy, structured content. In this paper, we develop a layered computational framework that derives operational principles from this foundational asymmetry. At the base level, CCUP formalizes inference as directional entropy minimization, establishing a variational gradient that favors content-first structuring. Building upon this, we identify four hierarchical layers of operational principles: (\textbf{L1}) \emph{Core Inference Constraints}, including structure-before-specificity, asymmetric inference flow, cycle-consistent bootstrapping, and conditional compression, all shown to be mutually reducible; (\textbf{L2}) \emph{Resource Allocation Principles}, such as precision-weighted attention, asymmetric learning rates, and attractor-based memory encoding; (\textbf{L3}) \emph{Temporal Bootstrapping Dynamics}, which organize learning over time via structure-guided curricula; and (\textbf{L4}) \emph{Spatial Hierarchical Composition}, which integrates these mechanisms into self-organizing cycles of memory, inference, and planning. We present formal equivalence theorems, a dependency lattice among principles, and computational simulations demonstrating the efficiency gains of CCUP-aligned inference. This work provides a unified theoretical foundation for understanding how brains and machines minimize uncertainty through recursive structure-specificity alignment. The brain is not just an inference machine. It is a cycle-consistent entropy gradient resolver, aligning structure and specificity via path-dependent, content-seeded simulation.

The advent of single-cell multi-omics technologies has enabled the simultaneous profiling of diverse omics layers within individual cells. Integrating such multimodal data provides unprecedented insights into cellular identity, regulatory processes, and disease mechanisms. However, it remains challenging, as current methods often rely on selecting highly variable genes or peaks during preprocessing, which may inadvertently discard crucial biological information. Here, we present scMamba, a foundation model designed to integrate single-cell multi-omics data without the need for prior feature selection while preserving genomic positional information. scMamba introduces a patch-based cell tokenization strategy that treats genomics regions as words (tokens) and cells as sentences. Building upon the concept of state space duality, scMamba distills rich biological insights from high-dimensional, sparse single-cell multi-omics data. Additionally, our novel contrastive learning approach, enhanced with cosine similarity regularization, enables superior alignment across omics layers compared to traditional methods. Systematic benchmarking across multiple datasets demonstrates that scMamba significantly outperforms state-of-the-art methods in preserving biological variation, aligning omics layers, and enhancing key downstream tasks such as clustering, cell type annotation, and trajectory inference. Our findings position scMamba as a powerful tool for large-scale single-cell multi-omics integration, capable of handling large-scale atlases and advancing biological discovery.

Graph neural networks (GNNs) have achieved significant success in graph representation learning and have been applied to various domains. However, many real-world graphs contain sensitive personal information, such as user profiles in social networks, raising serious privacy concerns when graph learning is performed using GNNs. To address this issue, locally private graph learning protocols have gained considerable attention. These protocols leverage the privacy advantages of local differential privacy (LDP) and the effectiveness of GNN's message-passing in calibrating noisy data, offering strict privacy guarantees for users' local data while maintaining high utility (e.g., node classification accuracy) for graph learning. Despite these advantages, such protocols may be vulnerable to data poisoning attacks, a threat that has not been considered in previous research. Identifying and addressing these threats is crucial for ensuring the robustness and security of privacy-preserving graph learning frameworks. This work introduces the first data poisoning attack targeting locally private graph learning protocols. The attacker injects fake users into the protocol, manipulates these fake users to establish links with genuine users, and sends carefully crafted data to the server, ultimately compromising the utility of private graph learning. The effectiveness of the attack is demonstrated both theoretically and empirically. In addition, several defense strategies have also been explored, but their limited effectiveness highlights the need for more robust defenses.

Modern cyberattacks in cyber-physical systems (CPS) rapidly evolve and cannot be deterred effectively with most current methods which focused on characterizing past threats. Adaptive anomaly detection (AAD) is among the most promising techniques to detect evolving cyberattacks focused on fast data processing and model adaptation. AAD has been researched in the literature extensively; however, to the best of our knowledge, our work is the first systematic literature review (SLR) on the current research within this field. We present a comprehensive SLR, gathering 397 relevant papers and systematically analyzing 65 of them (47 research and 18 survey papers) on AAD in CPS studies from 2013 to 2023 (November). We introduce a novel taxonomy considering attack types, CPS application, learning paradigm, data management, and algorithms. Our analysis indicates, among other findings, that reviewed works focused on a single aspect of adaptation (either data processing or model adaptation) but rarely in both at the same time. We aim to help researchers to advance the state of the art and help practitioners to become familiar with recent progress in this field. We identify the limitations of the state of the art and provide recommendations for future research directions.

Detecting deceptive conversations on dynamic platforms is increasingly difficult due to evolving language patterns and Concept Drift (CD)-i.e., semantic or topical shifts that alter the context or intent of interactions over time. These shifts can obscure malicious intent or mimic normal dialogue, making accurate classification challenging. While Large Language Models (LLMs) show strong performance in natural language tasks, they often struggle with contextual ambiguity and hallucinations in risk-sensitive scenarios. To address these challenges, we present a Domain Knowledge (DK)-Enhanced LLM framework that integrates pretrained LLMs with structured, task-specific insights to perform fraud and concept drift detection. The proposed architecture consists of three main components: (1) a DK-LLM module to detect fake or deceptive conversations; (2) a drift detection unit (OCDD) to determine whether a semantic shift has occurred; and (3) a second DK-LLM module to classify the drift as either benign or fraudulent. We first validate the value of domain knowledge using a fake review dataset and then apply our full framework to SEConvo, a multiturn dialogue dataset that includes various types of fraud and spam attacks. Results show that our system detects fake conversations with high accuracy and effectively classifies the nature of drift. Guided by structured prompts, the LLaMA-based implementation achieves 98% classification accuracy. Comparative studies against zero-shot baselines demonstrate that incorporating domain knowledge and drift awareness significantly improves performance, interpretability, and robustness in high-stakes NLP applications.

This study analyzes tract-level real estate ownership patterns in New York State (NYS) and New York City (NYC) to uncover racial disparities. We use an advanced race/ethnicity imputation model (LSTM+Geo with XGBoost filtering, validated at 89.2% accuracy) to compare the predicted racial composition of property owners to the resident population from census data. We examine both a Full Model (statewide) and a Name-Only LSTM Model (NYC) to assess how incorporating geospatial context affects our predictions and disparity estimates. The results reveal significant inequities: White individuals hold a disproportionate share of properties and property value relative to their population, while Black, Hispanic, and Asian communities are underrepresented as property owners. These disparities are most pronounced in minority-majority neighborhoods, where ownership is predominantly White despite a predominantly non-White population. Corporate ownership (LLCs, trusts, etc.) exacerbates these gaps by reducing owner-occupied opportunities in urban minority communities. We provide a breakdown of ownership vs. population by race for majority-White, -Black, -Hispanic, and -Asian tracts, identify those with extreme ownership disparities, and compare patterns in urban, suburban, and rural contexts. The findings underscore persistent racial inequity in property ownership, reflecting broader historical and socio-economic forces, and highlight the importance of data-driven approaches to address these issues.

LAAS-CNRS, 7 Av du Colonel Roche, 31400, Toulouse, France (e-mail: claude.baron@insa-toulouse.fr)Abstract: Component obsolescence poses significant challenges in industries reliant on electronic components, causing increased costs and disruptions in the security and availability of systems. Accurate obsolescence risk prediction is essential but hindered by a lack of reliable data. This paper proposes a novel approach to forecasting obsolescence risk using zero-shot learning (ZSL) with large language models (LLMs) to address data limitations by leveraging domain-specific knowledge from tabular datasets. Applied to two real-world datasets, the method demonstrates effective risk prediction. A comparative evaluation of four LLMs underscores the importance of selecting the right model for specific forecasting tasks. INTRODUCTION Obsolescence is a significant challenge for industries relying on electronic components and complex systems. It occurs when products become outdated or unavailable due to technological advancements, market changes, or new regulations (International Electrotechnical Commission, 2019), leading to increased maintenance costs, disruptions in the security and availability of systems (Zolghadri et al., 2023), and operational inefficiencies (Mellal, 2020).

This technical report presents submission systems for Task 4 of the DCASE 2025 Challenge. This model incorporates additional audio features (spectral roll-off and chroma features) into the embedding feature extracted from the mel-spectral feature to im-prove the classification capabilities of an audio-tagging model in the spatial semantic segmentation of sound scenes (S5) system. This approach is motivated by the fact that mixed audio often contains subtle cues that are difficult to capture with mel-spectrograms alone. Thus, these additional features offer alterna-tive perspectives for the model. Second, an agent-based label correction system is applied to the outputs processed by the S5 system. This system reduces false positives, improving the final class-aware signal-to-distortion ratio improvement (CA-SDRi) metric. Finally, we refine the training dataset to enhance the classi-fication accuracy of low-performing classes by removing irrele-vant samples and incorporating external data. That is, audio mix-tures are generated from a limited number of data points; thus, even a small number of out-of-class data points could degrade model performance. The experiments demonstrate that the submit-ted systems employing these approaches relatively improve CA-SDRi by up to 14.7% compared to the baseline of DCASE 2025 Challenge Task 4.

Molecular property prediction aims to learn representations that map chemical structures to functional properties. While multimodal learning has emerged as a powerful paradigm to learn molecular representations, prior works have largely overlooked textual and taxonomic information of molecules for representation learning. We introduce TRIDENT, a novel framework that integrates molecular SMILES, textual descriptions, and taxonomic functional annotations to learn rich molecular representations. To achieve this, we curate a comprehensive dataset of molecule-text pairs with structured, multi-level functional annotations. Instead of relying on conventional contrastive loss, TRIDENT employs a volume-based alignment objective to jointly align tri-modal features at the global level, enabling soft, geometry-aware alignment across modalities. Additionally, TRIDENT introduces a novel local alignment objective that captures detailed relationships between molecular substructures and their corresponding sub-textual descriptions. A momentum-based mechanism dynamically balances global and local alignment, enabling the model to learn both broad functional semantics and fine-grained structure-function mappings. TRIDENT achieves state-of-the-art performance on 11 downstream tasks, demonstrating the value of combining SMILES, textual, and taxonomic functional annotations for molecular property prediction.

Automatic fluency assessment (AFA) remains challenging, particularly in capturing speech rhythm, pauses, and disfluencies in non-native speakers. We introduce a chunk-based approach integrating self-supervised learning (SSL) models (Wav2Vec2, HuBERT, and WavLM) selected for their complementary strengths in phonetic, prosodic, and noisy speech modeling, with a hierarchical CNN-BiLSTM framework. Speech is segmented into breath-group chunks using Silero voice activity detection (Silero-VAD), enabling fine-grained temporal analysis while mitigating over-segmentation artifacts. SSL embeddings are fused via a learnable weighted mechanism, balancing acoustic and linguistic features, and enriched with chunk-level fluency markers (e.g., speech rate, pause durations, n-gram repetitions). The CNN-BiLSTM captures local and long-term dependencies across chunks. Evaluated on Avalinguo and Speechocean762, our approach improves F1-score by 2.8 and Pearson correlation by 6.2 points over single SSL baselines on Speechocean762, with gains of 4.2 F1-score and 4.0 Pearson points on Avalinguo, surpassing Pyannote.audio-based segmentation baselines. These findings highlight chunk-based multi-SSL fusion for robust fluency evaluation, though future work should explore generalization to dialects with irregular prosody.