Code review is one of the key processes in the software development lifecycle and is essential to maintain code quality. However, manual code review is subjective and time consuming. Given its rule-based nature, code review is well suited for automation. In recent years, significant efforts have been made to automate this process with the help of artificial intelligence. Recent developments in Large Language Models (LLMs) have also emerged as a promising tool in this area, but these models often lack the logical reasoning capabilities needed to fully understand and evaluate code. To overcome this limitation, this study proposes a hybrid approach that integrates symbolic reasoning techniques with LLMs to automate the code review process. We tested our approach using the CodexGlue dataset, comparing several models, including CodeT5, CodeBERT, and GraphCodeBERT, to assess the effectiveness of combining symbolic reasoning and prompting techniques with LLMs. Our results show that this approach improves the accuracy and efficiency of automated code review.

The rapid development of COVID-19 vaccines has showcased the global community's ability to combat infectious diseases. However, the need for post-licensure surveillance systems has grown due to the limited window for safety data collection in clinical trials and early widespread implementation. This study aims to employ Natural Language Processing (NLP) techniques and Active Learning (AL) to rapidly develop a classifier that detects potential vaccine safety issues from emergency department (ED) notes. ED triage notes, containing expert, succinct vital patient information at the point of entry to health systems, can significantly contribute to timely vaccine safety signal surveillance. While keyword-based classification can be effective, it may yield false positives and demand extensive keyword modifications. This is exacerbated by the infrequency of vaccination-related ED presentations and their similarity to other reasons for ED visits. NLP offers a more accurate and efficient alternative, albeit requiring annotated data, which is often scarce in the medical field. Active learning optimizes the annotation process and the quality of annotated data, which can result in faster model implementation and improved model performance. This work combines active learning, data augmentation, and active learning and evaluation techniques to create a classifier that is used to enhance vaccine safety surveillance from ED triage notes.

Faithfulness and interpretability are essential for deploying deep neural networks (DNNs) in safety-critical domains such as medical imaging. B-cos networks offer a promising solution by replacing standard linear layers with a weight-input alignment mechanism, producing inherently interpretable, class-specific explanations without post-hoc methods. While maintaining diagnostic performance competitive with state-of-the-art DNNs, standard B-cos models suffer from severe aliasing artifacts in their explanation maps, making them unsuitable for clinical use where clarity is essential. In this work, we address these limitations by introducing anti-aliasing strategies using FLCPooling (FLC) and BlurPool (BP) to significantly improve explanation quality. Our experiments on chest X-ray datasets demonstrate that the modified $\text{B-cos}_\text{FLC}$ and $\text{B-cos}_\text{BP}$ preserve strong predictive performance while providing faithful and artifact-free explanations suitable for clinical application in multi-class and multi-label settings. Code available at: GitHub repository (url: https://github.com/mkleinma/B-cos-medical-paper).

Language Models (LMs) typically adhere to a "pre-training and fine-tuning" paradigm, where a universal pre-trained model can be fine-tuned to cater to various specialized domains. Low-Rank Adaptation (LoRA) has gained the most widespread use in LM fine-tuning due to its lightweight computational cost and remarkable performance. Because the proportion of parameters tuned by LoRA is relatively small, there might be a misleading impression that the LoRA fine-tuning data is invulnerable to Membership Inference Attacks (MIAs). However, we identify that utilizing the pre-trained model can induce more information leakage, which is neglected by existing MIAs. Therefore, we introduce LoRA-Leak, a holistic evaluation framework for MIAs against the fine-tuning datasets of LMs. LoRA-Leak incorporates fifteen membership inference attacks, including ten existing MIAs, and five improved MIAs that leverage the pre-trained model as a reference. In experiments, we apply LoRA-Leak to three advanced LMs across three popular natural language processing tasks, demonstrating that LoRA-based fine-tuned LMs are still vulnerable to MIAs (e.g., 0.775 AUC under conservative fine-tuning settings). We also applied LoRA-Leak to different fine-tuning settings to understand the resulting privacy risks. We further explore four defenses and find that only dropout and excluding specific LM layers during fine-tuning effectively mitigate MIA risks while maintaining utility. We highlight that under the "pre-training and fine-tuning" paradigm, the existence of the pre-trained model makes MIA a more severe risk for LoRA-based LMs. We hope that our findings can provide guidance on data privacy protection for specialized LM providers.

Information security is facing increasingly severe challenges, and traditional protection means are difficult to cope with complex and changing threats. In recent years, as an emerging intelligent technology, large language models (LLMs) have shown a broad application prospect in the field of information security. In this paper, we focus on the key role of LLM in information security, systematically review its application progress in malicious behavior prediction, network threat analysis, system vulnerability detection, malicious code identification, and cryptographic algorithm optimization, and explore its potential in enhancing security protection performance. Based on neural networks and Transformer architecture, this paper analyzes the technical basis of large language models and their advantages in natural language processing tasks. It is shown that the introduction of large language modeling helps to improve the detection accuracy and reduce the false alarm rate of security systems. Finally, this paper summarizes the current application results and points out that it still faces challenges in model transparency, interpretability, and scene adaptability, among other issues. It is necessary to explore further the optimization of the model structure and the improvement of the generalization ability to realize a more intelligent and accurate information security protection system.

Glioblastoma, a highly aggressive brain tumor with diverse molecular and pathological features, poses a diagnostic challenge due to its heterogeneity. Accurate diagnosis and assessment of this heterogeneity are essential for choosing the right treatment and improving patient outcomes. Traditional methods rely on identifying specific features in tissue samples, but deep learning offers a promising approach for improved glioblastoma diagnosis. In this paper, we present our approach to the BraTS-Path Challenge 2024. We leverage a pre-trained model and fine-tune it on the BraTS-Path training dataset. Our model demonstrates poor performance on the challenging BraTS-Path validation set, as rigorously assessed by the Synapse online platform. The model achieves an accuracy of 0.392229, a recall of 0.392229, and a F1-score of 0.392229, indicating a consistent ability to correctly identify instances under the target condition. Notably, our model exhibits perfect specificity of 0.898704, showing an exceptional capacity to correctly classify negative cases. Moreover, a Matthews Correlation Coefficient (MCC) of 0.255267 is calculated, to signify a limited positive correlation between predicted and actual values and highlight our model's overall predictive power. Our solution also achieves the second place during the testing phase.

In scenarios where training data is limited due to observation costs or data scarcity, enriching the label information associated with each instance becomes crucial for building high-accuracy classification models. In such contexts, it is often feasible to obtain not only hard labels but also {\it additional supervision}, such as the confidences for the hard labels. This setting naturally raises fundamental questions: {\it What kinds of additional supervision are intrinsically beneficial?} And {\it how do they contribute to improved generalization performance?} To address these questions, we propose a theoretical framework that treats both hard labels and additional supervision as probability distributions, and constructs soft labels through their affine combination. Our theoretical analysis reveals that the essential component of additional supervision is not the confidence score of the assigned hard label, but rather the information of the distribution over the non-hard-labeled classes. Moreover, we demonstrate that the additional supervision and the mixing coefficient contribute to the refinement of soft labels in complementary roles. Intuitively, in the probability simplex, the additional supervision determines the direction in which the deterministic distribution representing the hard label should be adjusted toward the true label distribution, while the mixing coefficient controls the step size along that direction. Through generalization error analysis, we theoretically characterize how the additional supervision and its mixing coefficient affect both the convergence rate and asymptotic value of the error bound. Finally, we experimentally demonstrate that, based on our theory, designing additional supervision can lead to improved classification accuracy, even when utilized in a simple manner.

Biomedical Foundation Models (FMs) are rapidly transforming AI-enabled healthcare research and entering clinical validation. However, their susceptibility to learning non-biological technical features -- including variations in surgical/endoscopic techniques, laboratory procedures, and scanner hardware -- poses risks for clinical deployment. We present the first systematic investigation of pathology FM robustness to non-biological features. Our work (i) introduces measures to quantify FM robustness, (ii) demonstrates the consequences of limited robustness, and (iii) proposes a framework for FM robustification to mitigate these issues. Specifically, we developed PathoROB, a robustness benchmark with three novel metrics, including the robustness index, and four datasets covering 28 biological classes from 34 medical centers. Our experiments reveal robustness deficits across all 20 evaluated FMs, and substantial robustness differences between them. We found that non-robust FM representations can cause major diagnostic downstream errors and clinical blunders that prevent safe clinical adoption. Using more robust FMs and post-hoc robustification considerably reduced (but did not yet eliminate) the risk of such errors. This work establishes that robustness evaluation is essential for validating pathology FMs before clinical adoption and demonstrates that future FM development must integrate robustness as a core design principle. PathoROB provides a blueprint for assessing robustness across biomedical domains, guiding FM improvement efforts towards more robust, representative, and clinically deployable AI systems that prioritize biological information over technical artifacts.

We study the societal impact of pseudo-scientific assumptions for predicting the behavior of people in a straightforward application of machine learning to risk prediction in financial lending. This use case also exemplifies the impact of survival bias in loan return prediction. We analyze the models in terms of their accuracy and social cost, showing that the socially optimal model may not imply a significant accuracy loss for this downstream task. Our results are verified for commonly used learning methods and datasets. Our findings also show that there is a natural dynamic when training models that suffer survival bias where accuracy slightly deteriorates, and whose recall and precision improves with time. These results act as an illusion, leading the observer to believe that the system is getting better, when in fact the model is suffering from increasingly more unfairness and survival bias.

Generating clinical synthetic text represents an effective solution for common clinical NLP issues like sparsity and privacy. This paper aims to conduct a systematic review on generating synthetic medical free-text by formulating quantitative analysis to three research questions concerning (i) the purpose of generation, (ii) the techniques, and (iii) the evaluation methods. We searched PubMed, ScienceDirect, Web of Science, Scopus, IEEE, Google Scholar, and arXiv databases for publications associated with generating synthetic medical unstructured free-text. We have identified 94 relevant articles out of 1,398 collected ones. A great deal of attention has been given to the generation of synthetic medical text from 2018 onwards, where the main purpose of such a generation is towards text augmentation, assistive writing, corpus building, privacy-preserving, annotation, and usefulness. Transformer architectures were the main predominant technique used to generate the text, especially the GPTs. On the other hand, there were four main aspects of evaluation, including similarity, privacy, structure, and utility, where utility was the most frequent method used to assess the generated synthetic medical text. Although the generated synthetic medical text demonstrated a moderate possibility to act as real medical documents in different downstream NLP tasks, it has proven to be a great asset as augmented, complementary to the real documents, towards improving the accuracy and overcoming sparsity/undersampling issues. Yet, privacy is still a major issue behind generating synthetic medical text, where more human assessments are needed to check for the existence of any sensitive information. Despite that, advances in generating synthetic medical text will considerably accelerate the adoption of workflows and pipeline development, discarding the time-consuming legalities of data transfer.