Radiological imaging is central to diagnosis, treatment planning, and clinical decision-making. Vision-language foundation models have spurred interest in automated radiology report generation (RRG), but safe deployment requires reliable clinical evaluation of generated reports. Existing metrics often rely on surface-level similarity or behave as black boxes, lacking interpretability. We introduce ICARE (Interpretable and Clinically-grounded Agent-based Report Evaluation), an interpretable evaluation framework leveraging large language model agents and dynamic multiple-choice question answering (MCQA). Two agents, each with either the ground-truth or generated report, generate clinically meaningful questions and quiz each other. Agreement on answers captures preservation and consistency of findings, serving as interpretable proxies for clinical precision and recall. By linking scores to question-answer pairs, ICARE enables transparent, and interpretable assessment. Clinician studies show ICARE aligns significantly more with expert judgment than prior metrics. Perturbation analyses confirm sensitivity to clinical content and reproducibility, while model comparisons reveal interpretable error patterns.

This review presents a comprehensive survey and benchmark of pulse shape discrimination (PSD) algorithms for radiation detection, classifying nearly sixty methods into statistical (time-domain, frequency-domain, neural network-based) and prior-knowledge (machine learning, deep learning) paradigms. We implement and evaluate all algorithms on two standardized datasets: an unlabeled set from a 241Am-9Be source and a time-of-flight labeled set from a 238Pu-9Be source, using metrics including Figure of Merit (FOM), F1-score, ROC-AUC, and inter-method correlations. Our analysis reveals that deep learning models, particularly Multi-Layer Perceptrons (MLPs) and hybrid approaches combining statistical features with neural regression, often outperform traditional methods. We discuss architectural suitabilities, the limitations of FOM, alternative evaluation metrics, and performance across energy thresholds. Accompanying this work, we release an open-source toolbox in Python and MATLAB, along with the datasets, to promote reproducibility and advance PSD research.

Pan-cancer classification using transcriptomic (RNA-Seq) data can inform tumor subtyping and therapy selection, but is challenging due to extremely high dimensionality and limited sample sizes. In this study, we propose a novel deep learning framework that uses a class-conditional variational autoencoder (cVAE) to augment training data for pan-cancer gene expression classification. Using 801 tumor RNA-Seq samples spanning 5 cancer types from The Cancer Genome Atlas (TCGA), we first perform feature selection to reduce 20,531 gene expression features to the 500 most variably expressed genes. A cVAE is then trained on this data to learn a latent representation of gene expression conditioned on cancer type, enabling the generation of synthetic gene expression samples for each tumor class. We augment the training set with these cVAE-generated samples (doubling the dataset size) to mitigate overfitting and class imbalance. A two-layer multilayer perceptron (MLP) classifier is subsequently trained on the augmented dataset to predict tumor type. The augmented framework achieves high classification accuracy (~98%) on a held-out test set, substantially outperforming a classifier trained on the original data alone. We present detailed experimental results, including VAE training curves, classifier performance metrics (ROC curves and confusion matrix), and architecture diagrams to illustrate the approach. The results demonstrate that cVAE-based synthetic augmentation can significantly improve pan-cancer prediction performance, especially for underrepresented cancer classes.

Large-scale tuberculosis (TB) screening is limited by the high cost and operational complexity of traditional diagnostics, creating a need for artificial-intelligence solutions. We propose DeepGB-TB, a non-invasive system that instantly assigns TB risk scores using only cough audio and basic demographic data. The model couples a lightweight one-dimensional convolutional neural network for audio processing with a gradient-boosted decision tree for tabular features. Its principal innovation is a Cross-Modal Bidirectional Cross-Attention module (CM-BCA) that iteratively exchanges salient cues between modalities, emulating the way clinicians integrate symptoms and risk factors. To meet the clinical priority of minimizing missed cases, we design a Tuberculosis Risk-Balanced Loss (TRBL) that places stronger penalties on false-negative predictions, thereby reducing high-risk misclassifications. DeepGB-TB is evaluated on a diverse dataset of 1,105 patients collected across seven countries, achieving an AUROC of 0.903 and an F1-score of 0.851, representing a new state of the art. Its computational efficiency enables real-time, offline inference directly on common mobile devices, making it ideal for low-resource settings. Importantly, the system produces clinically validated explanations that promote trust and adoption by frontline health workers. By coupling AI innovation with public-health requirements for speed, affordability, and reliability, DeepGB-TB offers a tool for advancing global TB control.

Machine learning models trained on Earth observation data, such as satellite imagery, have demonstrated significant promise in predicting household-level wealth indices, enabling the creation of high-resolution wealth maps that can be leveraged across multiple causal trials. However, because standard training objectives prioritize overall predictive accuracy, these predictions inherently suffer from shrinkage toward the mean, leading to attenuated estimates of causal treatment effects and limiting their utility in policy. Existing debiasing methods, such as Prediction-Powered Inference, can handle this attenuation bias but require additional fresh ground-truth data at the downstream stage of causal inference, which restricts their applicability in data-scarce environments. Here, we introduce and evaluate two correction methods -- linear calibration correction and Tweedie's correction -- that substantially reduce prediction bias without relying on newly collected labeled data. Linear calibration corrects bias through a straightforward linear transformation derived from held-out calibration data, whereas Tweedie's correction leverages empirical Bayes principles to directly address shrinkage-induced biases by exploiting score functions derived from the model's learning patterns. Through analytical exercises and experiments using Demographic and Health Survey data, we demonstrate that the proposed methods meet or outperform existing approaches that either require (a) adjustments to training pipelines or (b) additional labeled data. These approaches may represent a promising avenue for improving the reliability of causal inference when direct outcome measures are limited or unavailable, enabling a "one map, many trials" paradigm where a single upstream data creation team produces predictions usable by many downstream teams across diverse ML pipelines.

Discovering causal relationships in complex multivariate time series is a fundamental scientific challenge. Traditional methods often falter, either by relying on restrictive linear assumptions or on conditional independence tests that become uninformative in the presence of intricate, non-linear dynamics. This paper proposes a new paradigm, shifting from statistical testing to pattern recognition. We hypothesize that a causal link creates a persistent and learnable asymmetry in the flow of information through a system's temporal graph, even when clear conditional independencies are obscured. We introduce Temporal Dependency to Causality (TD2C), a supervised learning framework that operationalizes this hypothesis. TD2C learns to recognize these complex causal signatures from a rich set of information-theoretic and statistical descriptors. Trained exclusively on a diverse collection of synthetic time series, TD2C demonstrates remarkable zero-shot generalization to unseen dynamics and established, realistic benchmarks. Our results show that TD2C achieves state-of-the-art performance, consistently outperforming established methods, particularly in high-dimensional and non-linear settings. By reframing the discovery problem, our work provides a robust and scalable new tool for uncovering causal structures in complex systems.

Motivated by canonical problems in medical diagnostics, we propose and study properties of an objective function that uniformly bounds uncertainties in quantities of interest extracted from classifiers and related data analysis tools. We begin by adopting a set-theoretic perspective to show how two main tasks in diagnostics -- classification and prevalence estimation -- can be recast in terms of a variation on the confusion (or error) matrix ${\boldsymbol {\rm P}}$ typically considered in supervised learning. We then combine arguments from conditional probability with the Gershgorin circle theorem to demonstrate that the largest Gershgorin radius $\boldsymbol ρ_m$ of the matrix $\mathbb I-\boldsymbol {\rm P}$ (where $\mathbb I$ is the identity) yields uniform error bounds for both classification and prevalence estimation. In a two-class setting, $\boldsymbol ρ_m$ is minimized via a measure-theoretic ``water-leveling'' argument that optimizes an appropriately defined partition $U$ generating the matrix ${\boldsymbol {\rm P}}$. We also consider an example that illustrates the difficulty of generalizing the binary solution to a multi-class setting and deduce relevant properties of the confusion matrix.

Multi-class classification annotations have significantly advanced AI applications, with truth inference serving as a critical technique for aggregating noisy and biased annotations. Existing state-of-the-art methods typically model each annotator's expertise using a confusion matrix. However, these methods suffer from two widely recognized issues: 1) when most annotators label only a few tasks, or when classes are imbalanced, the estimated confusion matrices are unreliable, and 2) a single confusion matrix often remains inadequate for capturing each annotator's full expertise patterns across all tasks. To address these issues, we propose a novel confusion-matrix-based method, PTBCC (ProtoType learning-driven Bayesian Classifier Combination), to introduce a reliable and richer annotator estimation by prototype learning. Specifically, we assume that there exists a set $S$ of prototype confusion matrices, which capture the inherent expertise patterns of all annotators. Rather than a single confusion matrix, the expertise per annotator is extended as a Dirichlet prior distribution over these prototypes. This prototype learning-driven mechanism circumvents the data sparsity and class imbalance issues, ensuring a richer and more flexible characterization of annotators. Extensive experiments on 11 real-world datasets demonstrate that PTBCC achieves up to a 15% accuracy improvement in the best case, and a 3% higher average accuracy while reducing computational cost by over 90%.

Machine learning (ML) has rapidly grown in popularity, becoming vital to many industries. Currently, the research on code smells in ML applications lacks tools and studies that address the identification and validity of ML-specific code smells. This work investigates suitable methods and tools to design and develop a static code analysis tool (MLpylint) based on code smell criteria. This research employed the Design Science Methodology. In the problem identification phase, a literature review was conducted to identify ML-specific code smells. In solution design, a secondary literature review and consultations with experts were performed to select methods and tools for implementing the tool. We evaluated the tool on data from 160 open-source ML applications sourced from GitHub. We also conducted a static validation through an expert survey involving 15 ML professionals. The results indicate the effectiveness and usefulness of the MLpylint. We aim to extend our current approach by investigating ways to introduce MLpylint seamlessly into development workflows, fostering a more productive and innovative developer environment.

In physical human-robot collaboration (pHRC) settings, humans and robots collaborate directly in shared environments. Robots must analyze interactions with objects to ensure safety and facilitate meaningful workflows. One critical aspect is human/object detection, where the contacted object is identified. Past research introduced binary machine learning classifiers to distinguish between soft and hard objects. This study improves upon those results by evaluating three-class human/object detection models, offering more detailed contact analysis. A dataset was collected using the Franka Emika Panda robot manipulator, exploring preprocessing strategies for time-series analysis. Models including LSTM, GRU, and Transformers were trained on these datasets. The best-performing model achieved 91.11\% accuracy during real-time testing, demonstrating the feasibility of multi-class detection models. Additionally, a comparison of preprocessing strategies suggests a sliding window approach is optimal for this task.