Recent advancements in Large Language Models (LLMs) and their increased accessibility have made it easier than ever for students to automatically generate texts, posing new challenges for educational institutions. To enforce norms of academic integrity and ensure students' learning, learning analytics methods to automatically detect LLM-generated text appear increasingly appealing. This paper benchmarks the performance of different state-of-the-art detectors in educational contexts, introducing a novel dataset, called Generative Essay Detection in Education (GEDE), containing over 900 student-written essays and over 12,500 LLM-generated essays from various domains. To capture the diversity of LLM usage practices in generating text, we propose the concept of contribution levels, representing students' contribution to a given assignment. These levels range from purely human-written texts, to slightly LLM-improved versions, to fully LLM-generated texts, and finally to active attacks on the detector by "humanizing" generated texts. We show that most detectors struggle to accurately classify texts of intermediate student contribution levels, like LLM-improved human-written texts. Detectors are particularly likely to produce false positives, which is problematic in educational settings where false suspicions can severely impact students' lives. Our dataset, code, and additional supplementary materials are publicly available at https://github.com/lukasgehring/Assessing-LLM-Text-Detection-in-Educational-Contexts.

The introduction of 5G and the Open Radio Access Network (O-RAN) architecture has enabled more flexible and intelligent network deployments. However, the increased complexity and openness of these architectures also introduce novel security challenges, such as data manipulation attacks on the semi-standardised Shared Data Layer (SDL) within the O-RAN platform through malicious xApps. In particular, malicious xApps can exploit this vulnerability by introducing subtle Unicode-wise alterations (hypoglyphs) into the data that are being used by traditional machine learning (ML)-based anomaly detection methods. These Unicode-wise manipulations can potentially bypass detection and cause failures in anomaly detection systems based on traditional ML, such as AutoEncoders, which are unable to process hypoglyphed data without crashing. We investigate the use of Large Language Models (LLMs) for anomaly detection within the O-RAN architecture to address this challenge. We demonstrate that LLM-based xApps maintain robust operational performance and are capable of processing manipulated messages without crashing. While initial detection accuracy requires further improvements, our results highlight the robustness of LLMs to adversarial attacks such as hypoglyphs in input data. There is potential to use their adaptability through prompt engineering to further improve the accuracy, although this requires further research. Additionally, we show that LLMs achieve low detection latency (under 0.07 seconds), making them suitable for Near-Real-Time (Near-RT) RIC deployments.

Simulators have revolutionized scientific practice across the natural sciences. By generating data that reliably approximate real-world phenomena, they enable scientists to accelerate hypothesis testing and optimize experimental designs [1, 2]. This is perhaps best illustrated by AlphaFold, a Nobel-prize winning simulator in chemistry that predicts protein structures from amino acid sequences, enabling rapid prototyping of molecular interactions, drug targets, and protein functions [1]. In the behavioral sciences, a reliable participant simulator--a system capable of producing human-like behavior across cognitive tasks--would represent a similarly transformative advance [3]. Recently, Binz et al. introduced Centaur, a large language model (LLM) fine-tuned on human data from 160 experiments, proposing its use not only as a model of cognition but also as a participant simulator for "in silico prototyping of experimental studies" [4], e.g., to advance automated cognitive science [3, 5]. Although Centaur demonstrates strong predictive accuracy, its generative behavior-- a critical criterion for a participant simulator--systematically diverges from human data. This suggests that, while Centaur is a significant step toward predicting human behavior, it does not yet meet the standards of a reliable participant simulator or an accurate model of cognition. A core criterion for any behavioral simulator is its ability to generate behavioral patterns observed in experiments.

Invasive ductal carcinoma (IDC) is the most prevalent form of breast cancer, and early, accurate diagnosis is critical to improving patient survival rates by guiding treatment decisions. Combining medical expertise with artificial intelligence (AI) holds significant promise for enhancing the precision and efficiency of IDC detection. In this work, we propose a human-in-the-loop (HITL) deep learning system designed to detect IDC in histopathology images. The system begins with an initial diagnosis provided by a high-performance EfficientNetV2S model, offering feedback from AI to the human expert. Medical professionals then review the AI-generated results, correct any misclassified images, and integrate the revised labels into the training dataset, forming a feedback loop from the human back to the AI. This iterative process refines the model's performance over time. The EfficientNetV2S model itself achieves state-of-the-art performance compared to existing methods in the literature, with an overall accuracy of 93.65\%. Incorporating the human-in-the-loop system further improves the model's accuracy using four experimental groups with misclassified images. These results demonstrate the potential of this collaborative approach to enhance AI performance in diagnostic systems. This work contributes to advancing automated, efficient, and highly accurate methods for IDC detection through human-AI collaboration, offering a promising direction for future AI-assisted medical diagnostics.

Though intelligent agents are supposed to improve human experience (or make it more efficient), it is hard from a human perspective to grasp the ethical values which are explicitly or implicitly embedded in an agent behaviour. This is the well-known problem of alignment, which refers to the challenge of designing AI systems that align with human values, goals and preferences. This problem is particularly challenging since most human ethical considerations refer to \emph{incommensurable} (i.e. non-measurable and/or incomparable) values and criteria. Consider, for instance, a medical agent prescribing a treatment to a cancerous patient. How could it take into account (and/or weigh) incommensurable aspects like the value of a human life and the cost of the treatment? Now, the alignment between human and artificial values is possible only if we define a common space where a metric can be defined and used. This paper proposes to extend to ethics the conventional Anything2vec approach, which has been successful in plenty of similar and hard-to-quantify domains (ranging from natural language processing to recommendation systems and graph analysis). This paper proposes a way to map an automatic agent decision-making (or control law) strategy to a multivariate vector representation, which can be used to compare and assess the alignment with human values. The Ethics2Vec method is first introduced in the case of an automatic agent performing binary decision-making. Then, a vectorisation of an automatic control law (like in the case of a self-driving car) is discussed to show how the approach can be extended to automatic control settings.

AI has the potential to augment human decision making. However, even high-performing models can produce inaccurate predictions when deployed. These inaccuracies, combined with automation bias, where humans overrely on AI predictions, can result in worse decisions. Selective prediction, in which potentially unreliable model predictions are hidden from users, has been proposed as a solution. This approach assumes that when AI abstains and informs the user so, humans make decisions as they would without AI involvement. To test this assumption, we study the effects of selective prediction on human decisions in a clinical context. We conducted a user study of 259 clinicians tasked with diagnosing and treating hospitalized patients. We compared their baseline performance without any AI involvement to their AI-assisted accuracy with and without selective prediction. Our findings indicate that selective prediction mitigates the negative effects of inaccurate AI in terms of decision accuracy. Compared to no AI assistance, clinician accuracy declined when shown inaccurate AI predictions (66% [95% CI: 56%-75%] vs. 56% [95% CI: 46%-66%]), but recovered under selective prediction (64% [95% CI: 54%-73%]). However, while selective prediction nearly maintains overall accuracy, our results suggest that it alters patterns of mistakes: when informed the AI abstains, clinicians underdiagnose (18% increase in missed diagnoses) and undertreat (35% increase in missed treatments) compared to no AI input at all. Our findings underscore the importance of empirically validating assumptions about how humans engage with AI within human-AI systems.

Accurate and interpretable bearing fault classification is critical for ensuring the reliability of rotating machinery, particularly under variable operating conditions where domain shifts can significantly degrade model performance. This study proposes a physics-informed multimodal convolutional neural network (CNN) with a late fusion architecture, integrating vibration and motor current signals alongside a dedicated physics-based feature extraction branch. The model incorporates a novel physics-informed loss function that penalizes physically implausible predictions based on characteristic bearing fault frequencies - Ball Pass Frequency Outer (BPFO) and Ball Pass Frequency Inner (BPFI) - derived from bearing geometry and shaft speed. Comprehensive experiments on the Paderborn University dataset demonstrate that the proposed physics-informed approach consistently outperforms a non-physics-informed baseline, achieving higher accuracy, reduced false classifications, and improved robustness across multiple data splits. To address performance degradation under unseen operating conditions, three transfer learning (TL) strategies - Target-Specific Fine-Tuning (TSFT), Layer-Wise Adaptation Strategy (LAS), and Hybrid Feature Reuse (HFR) - are evaluated. Results show that LAS yields the best generalization, with additional performance gains when combined with physics-informed modeling. Validation on the KAIST bearing dataset confirms the framework's cross-dataset applicability, achieving up to 98 percent accuracy. Statistical hypothesis testing further verifies significant improvements (p < 0.01) in classification performance. The proposed framework demonstrates the potential of integrating domain knowledge with data-driven learning to achieve robust, interpretable, and generalizable fault diagnosis for real-world industrial applications.

Proteins are essential macromolecules responsible for the structural and functional mechanisms of living things. Phage structural proteins are a subclass of the protein family corresponding to the bacteriophages, which are the most prevalent kind of biological creatures [1]. The PVPs are mainly associated with building structural constituents of the bacteriophage [2], such as the baseplate and head as shown in Figure 1, enabling efficient host-phage binding for genome transfer. The amino acid sequences, particularly those involved in structure synthesis, exhibit significant diversity among phages and their respective groups [3]. Consequently, characterizing these sequences becomes a challenging yet crucial task, as the shortage of annotations for phage proteins has emerged as a hindrance in numerous research studies focused on phage genomics [4]. With the advent of high-throughput sequencing technology, rapid additions of sequences are being observed in standard biological databases [6] as shown in Figure 1, giving rise to the need for proper annotation of the sequences. Enhancement of annotations for the phage family is vital for exploring effective anti-bacterial drug synthesis [7, 8], disease diagnosis [9], food production [10], bacterial genome remodeling [11], etc. Traditionally, mass spectrometry and protein array techniques [12, 13] were utilized for characterizing these proteins. However, these methods are associated with significant time, labor, and computational expenses [1]. Similarly, alignment-based methods do not always work well with PVP categorization due to the lack of collinearity [14] in viral genomes, resulting from factors such as horizontal gene transfer, high mutation rates, etc., leading to dissimilar sequences 2 Figure 1 Structural constituents of Phage

This study explores the intersection of electroencephalography (EEG) microstates and Large Language Models (LLMs) to enhance the assessment of cognitive load states. By utilizing EEG microstate features, the research aims to fine-tune LLMs for improved predictions of distinct cognitive states, specifically 'Rest' and 'Load'. The experimental design is delineated in four comprehensive stages: dataset collection and preprocessing, microstate segmentation and EEG backfitting, feature extraction paired with prompt engineering, and meticulous LLM model selection and refinement. Employing a supervised learning paradigm, the LLM is trained to identify cognitive load states based on EEG microstate features integrated into prompts, producing accurate discrimination of cognitive load. A curated dataset, linking EEG features to specified cognitive load conditions, underpins the experimental framework. The results indicate a significant improvement in model performance following the proposed fine-tuning, showcasing the potential of EEG-informed LLMs in cognitive neuroscience and cognitive AI applications. This approach not only contributes to the understanding of brain dynamics but also paves the way for advancements in machine learning techniques applicable to cognitive load and cognitive AI research.

Reliable seizure detection is critical for diagnosing and managing epilepsy, yet clinical workflows remain dependent on time-consuming manual EEG interpretation. While machine learning has shown promise, existing approaches often rely on dataset-specific optimisations, limiting their real-world applicability and reproducibility. Here, we introduce an innovative, open-source machine-learning framework that enables robust and generalisable seizure detection across varied clinical datasets. We evaluate our approach on two publicly available EEG datasets that differ in patient populations and electrode configurations. To enhance robustness, the framework incorporates an automated pre-processing pipeline to standardise data and a majority voting mechanism, in which multiple models independently assess each second of EEG before reaching a final decision. We train, tune, and evaluate models within each dataset, assessing their cross-dataset transferability. Our models achieve high within-dataset performance (AUC 0.904+/-0.059 for CHB-MIT and 0.864+/-0.060 for TUSZ) and demonstrate strong generalisation across datasets despite differences in EEG setups and populations (AUC 0.615+/-0.039 for models trained on CHB-MIT and tested on TUSZ and 0.762+/-0.175 in the reverse case) without any post-processing. Furthermore, a mild post-processing improved the within-dataset results to 0.913+/-0.064 and 0.867+/-0.058 and cross-dataset results to 0.619+/-0.036 and 0.768+/-0.172. These results underscore the potential of, and essential considerations for, deploying our framework in diverse clinical settings. By making our methodology fully reproducible, we provide a foundation for advancing clinically viable, dataset-agnostic seizure detection systems. This approach has the potential for widespread adoption, complementing rather than replacing expert interpretation, and accelerating clinical integration.