Predictions oflifetimes of dynamically allocated objects can be used to improve time and space efficiency of dynamic memory management in computer programs. Barrett and Zorn [1993] used a simple lifetime predictor and demonstrated this improvement on a variety of computer programs. In this paper, we use decision trees to do lifetime prediction on the same programs and show significantly better prediction. Our method also has the advantage that during training we can use a large number of features and let the decision tree automatically choose the relevant subset.

The mortality related to cervical cancer can be substantially reduced through early detection and treatment. However, current detection techniques, such as Pap smear and colposcopy, fail to achieve a concurrently high sensitivity and specificity. In vivo fluorescence spectroscopy is a technique which quickly, noninvasively and quantitatively probes the biochemical and morphological changes that occur in precancerous tissue. RBF ensemble algorithms based on such spectra provide automated, and near realtime implementation of pre-cancer detection in the hands of nonexperts. The results are more reliable, direct and accurate than those achieved by either human experts or multivariate statistical algorithms. 1 Introduction Cervical carcinoma is the second most common cancer in women worldwide, exceeded only by breast cancer (Ramanujam et al., 1996). The mortality related to cervical cancer can be reduced if this disease is detected at the precancerous state, known as squamous intraepitheliallesion (SIL). Currently, a Pap smear is used to 982 K. Turner, N. Ramanujam, R. Richards-Kortum and J. Ghosh screen for cervical cancer {Kurman et al., 1994}. In a Pap test, a large number of cells obtained by scraping the cervical epithelium are smeared onto a slide which is then fixed and stained for cytologic examination.

We compare different methods to combine predictions from neural networks trained on different bootstrap samples of a regression problem. One of these methods, introduced in [6] and which we here call balancing, is based on the analysis of the ensemble generalization error into an ambiguity term and a term incorporating generalization performances of individual networks. We show how to estimate these individual errors from the residuals on validation patterns. Weighting factors for the different networks follow from a quadratic programming problem. On a real-world problem concerning the prediction of sales figures and on the well-known Boston housing data set, balancing clearly outperforms other recently proposed alternatives as bagging [1] and bumping [8]. 1 EARLY STOPPING AND BOOTSTRAPPING Stopped training is a popular strategy to prevent overfitting in neural networks.

I describe a querying criterion that attempts to minimize the error of a learner by minimizing its estimated squared bias. I describe experiments with locally-weighted regression on two simple problems, and observe that this "bias-only" approach outperforms the more common "variance-only" exploration approach, even in the presence of noise.

The mortality related to cervical cancer can be substantially reduced through early detection and treatment. However, current detection techniques, such as Pap smear and colposcopy, fail to achieve a concurrently high sensitivity and specificity. In vivo fluorescence spectroscopy is a technique which quickly, noninvasively and quantitatively probes the biochemical and morphological changes that occur in precancerous tissue. RBF ensemble algorithms based on such spectra provide automated, and near realtime implementation of pre-cancer detection in the hands of nonexperts. The results are more reliable, direct and accurate than those achieved by either human experts or multivariate statistical algorithms. 1 Introduction Cervical carcinoma is the second most common cancer in women worldwide, exceeded only by breast cancer (Ramanujam et al., 1996). The mortality related to cervical cancer can be reduced if this disease is detected at the precancerous state, known as squamous intraepitheliallesion (SIL). Currently, a Pap smear is used to 982 K. Turner, N. Ramanujam, R. Richards-Kortum and J. Ghosh screen for cervical cancer {Kurman et al., 1994}. In a Pap test, a large number of cells obtained by scraping the cervical epithelium are smeared onto a slide which is then fixed and stained for cytologic examination.

I describe a querying criterion that attempts to minimize the error of a learner by minimizing its estimated squared bias. I describe experiments with locally-weighted regression on two simple problems, and observe that this "bias-only" approach outperforms the more common "variance-only" exploration approach, even in the presence of noise.

Predictions oflifetimes of dynamically allocated objects can be used to improve time and space efficiency of dynamic memory management in computer programs. Barrett and Zorn [1993] used a simple lifetime predictor and demonstrated this improvement on a variety of computer programs. In this paper, we use decision trees to do lifetime prediction on the same programs and show significantly better prediction. Our method also has the advantage that during training we can use a large number of features and let the decision tree automatically choose the relevant subset.

We compare different methods to combine predictions from neural networkstrained on different bootstrap samples of a regression problem. One of these methods, introduced in [6] and which we here call balancing, is based on the analysis of the ensemble generalization errorinto an ambiguity term and a term incorporating generalization performances of individual networks. We show how to estimate these individual errors from the residuals on validation patterns.Weighting factors for the different networks follow from a quadratic programming problem. On a real-world problem concerning the prediction of sales figures and on the well-known Boston housing data set, balancing clearly outperforms other recently proposedalternatives as bagging [1] and bumping [8]. 1 EARLY STOPPING AND BOOTSTRAPPING Stopped training is a popular strategy to prevent overfitting in neural networks. The complete data set is split up into a training and a validation set.

I describe a querying criterion that attempts to minimize the error of a learner by minimizing its estimated squared bias. I describe experiments with locally-weighted regression on two simple problems, andobserve that this "bias-only" approach outperforms the more common "variance-only" exploration approach, even in the presence of noise.

The mortality related to cervical cancer can be substantially reduced throughearly detection and treatment. However, current detection techniques, such as Pap smear and colposcopy, fail to achieve a concurrently high sensitivity and specificity. In vivo fluorescence spectroscopy is a technique which quickly, noninvasively andquantitatively probes the biochemical and morphological changes that occur in precancerous tissue. RBF ensemble algorithms based on such spectra provide automated, and near realtime implementationof pre-cancer detection in the hands of nonexperts. Theresults are more reliable, direct and accurate than those achieved by either human experts or multivariate statistical algorithms. 1 Introduction Cervical carcinoma is the second most common cancer in women worldwide, exceeded onlyby breast cancer (Ramanujam et al., 1996). The mortality related to cervical cancer can be reduced if this disease is detected at the precancerous state, known as squamous intraepitheliallesion (SIL).