An automated explanation facility for Bayesian conditioning aimed at improving user acceptance of probability-based decision support systems has been developed. The domain-independent facility is based on an information processing perspective on reasoning about conditional evidence that accounts both for biased and normative inferences. Experimental results indicate that the facility is both acceptable to naive users and effective in improving understanding.

This paper presents some ideas and results of using uncertainty management methods in the presence of data in preference to other statistical and machine learning methods. A medical domain is used as a test-bed with data available from a large hospital database system which collects symptom and outcome information about patients. Data is often missing, of many variable types and sample sizes for particular outcomes is not large. Uncertainty management methods are useful for such domains and have the added advantage of allowing for expert modification of belief values originally obtained from data. Methodological considerations for using belief functions on statistical data are dealt with in some detail. Expert opinions are Incorporated at various levels of the project development and results are reported on an application to liver disease diagnosis. Recent results contrasting the use of weights of evidence and logistic regression on another medical domain are also presented.

Associative classification is a recent and rewarding technique which integrates association rule mining and classification to a model for prediction and achieves maximum accuracy. Associative classifiers are especially fit to applications where maximum accuracy is desired to a model for prediction. There are many domains such as medical where the maximum accuracy of the model is desired. Heart disease is a single largest cause of death in developed countries and one of the main contributors to disease burden in developing countries. Mortality data from the registrar general of India shows that heart disease are a major cause of death in India, and in Andhra Pradesh coronary heart disease cause about 30%of deaths in rural areas. Hence there is a need to develop a decision support system for predicting heart disease of a patient. In this paper we propose efficient associative classification algorithm using genetic approach for heart disease prediction. The main motivation for using genetic algorithm in the discovery of high level prediction rules is that the discovered rules are highly comprehensible, having high predictive accuracy and of high interestingness values. Experimental Results show that most of the classifier rules help in the best prediction of heart disease which even helps doctors in their diagnosis decisions.

We consider the problem of sparse estimation in a factor analysis model. A traditional estimation procedure in use is the following two-step approach: the model is estimated by maximum likelihood method and then a rotation technique is utilized to find sparse factor loadings. However, the maximum likelihood estimates cannot be obtained when the number of variables is much larger than the number of observations. Furthermore, even if the maximum likelihood estimates are available, the rotation technique does not often produce a sufficiently sparse solution. In order to handle these problems, this paper introduces a penalized likelihood procedure that imposes a nonconvex penalty on the factor loadings. We show that the penalized likelihood procedure can be viewed as a generalization of the traditional two-step approach, and the proposed methodology can produce sparser solutions than the rotation technique. A new algorithm via the EM algorithm along with coordinate descent is introduced to compute the entire solution path, which permits the application to a wide variety of convex and nonconvex penalties. Monte Carlo simulations are conducted to investigate the performance of our modeling strategy. A real data example is also given to illustrate our procedure.

We investigate the accuracy of the two most common estimators for the maximum expected value of a general set of random variables: a generalization of the maximum sample average, and cross validation. No unbiased estimator exists and we show that it is non-trivial to select a good estimator without knowledge about the distributions of the random variables. We investigate and bound the bias and variance of the aforementioned estimators and prove consistency. The variance of cross validation can be significantly reduced, but not without risking a large bias. The bias and variance of different variants of cross validation are shown to be very problem-dependent, and a wrong choice can lead to very inaccurate estimates.

Multilabel classification is a relatively recent subfield of machine learning. Unlike to the classical approach, where instances are labeled with only one category, in multilabel classification, an arbitrary number of categories is chosen to label an instance. Due to the problem complexity (the solution is one among an exponential number of alternatives), a very common solution (the binary method) is frequently used, learning a binary classifier for every category, and combining them all afterwards. The assumption taken in this solution is not realistic, and in this work we give examples where the decisions for all the labels are not taken independently, and thus, a supervised approach should learn those existing relationships among categories to make a better classification. Therefore, we show here a generic methodology that can improve the results obtained by a set of independent probabilistic binary classifiers, by using a combination procedure with a classifier trained on the co-occurrences of the labels. We show an exhaustive experimentation in three different standard corpora of labeled documents (Reuters-21578, Ohsumed-23 and RCV1), which present noticeable improvements in all of them, when using our methodology, in three probabilistic base classifiers.

The application of machine learning to bioinformatics problems is well established. Less well understood is the application of bioinformatics techniques to machine learning and, in particular, the representation of non-biological data as biosequences. The aim of this paper is to explore the effects of giving amino acid representation to problematic machine learning data and to evaluate the benefits of supplementing traditional machine learning with bioinformatics tools and techniques. The signatures of 60 computer viruses and 60 computer worms were converted into amino acid representations and first multiply aligned separately to identify conserved regions across different families within each class (virus and worm). This was followed by a second alignment of all 120 aligned signatures together so that non-conserved regions were identified prior to input to a number of machine learning techniques. Differences in length between virus and worm signatures after the first alignment were resolved by the second alignment. Our first set of experiments indicates that representing computer malware signatures as amino acid sequences followed by alignment leads to greater classification and prediction accuracy. Our second set of experiments indicates that checking the results of data mining from artificial virus and worm data against known proteins can lead to generalizations being made from the domain of naturally occurring proteins to malware signatures. However, further work is needed to determine the advantages and disadvantages of different representations and sequence alignment methods for handling problematic machine learning data.

Many applications concern sparse signals, for example, detecting anomalies from the differences between consecutive images taken by surveillance cameras. This paper focuses on the problem of recovering a K-sparse signal x in N dimensions. In the mainstream framework of compressed sensing (CS), the vector x is recovered from M non-adaptive linear measurements y = xS, where S (of size N x M) is typically a Gaussian (or Gaussian-like) design matrix, through some optimization procedure such as linear programming (LP). In our proposed method, the design matrix S is generated from an $\alpha$-stable distribution with $\alpha\approx 0$. Our decoding algorithm mainly requires one linear scan of the coordinates, followed by a few iterations on a small number of coordinates which are "undetermined" in the previous iteration. Comparisons with two strong baselines, linear programming (LP) and orthogonal matching pursuit (OMP), demonstrate that our algorithm can be significantly faster in decoding speed and more accurate in recovery quality, for the task of exact spare recovery. Our procedure is robust against measurement noise. Even when there are no sufficient measurements, our algorithm can still reliably recover a significant portion of the nonzero coordinates. To provide the intuition for understanding our method, we also analyze the procedure by assuming an idealistic setting. Interestingly, when K=2, the "idealized" algorithm achieves exact recovery with merely 3 measurements, regardless of N. For general K, the required sample size of the "idealized" algorithm is about 5K.

In many classification systems, sensing modalities have different acquisition costs. It is often {\it unnecessary} to use every modality to classify a majority of examples. We study a multi-stage system in a prediction time cost reduction setting, where the full data is available for training, but for a test example, measurements in a new modality can be acquired at each stage for an additional cost. We seek decision rules to reduce the average measurement acquisition cost. We formulate an empirical risk minimization problem (ERM) for a multi-stage reject classifier, wherein the stage $k$ classifier either classifies a sample using only the measurements acquired so far or rejects it to the next stage where more attributes can be acquired for a cost. To solve the ERM problem, we show that the optimal reject classifier at each stage is a combination of two binary classifiers, one biased towards positive examples and the other biased towards negative examples. We use this parameterization to construct stage-by-stage global surrogate risk, develop an iterative algorithm in the boosting framework and present convergence and generalization results. We test our work on synthetic, medical and explosives detection datasets. Our results demonstrate that substantial cost reduction without a significant sacrifice in accuracy is achievable.

Link prediction is one of the fundamental problems in network analysis. In many applications, notably in genetics, a partially observed network may not contain any negative examples of absent edges, which creates a difficulty for many existing supervised learning approaches. We develop a new method which treats the observed network as a sample of the true network with different sampling rates for positive and negative examples. We obtain a relative ranking of potential links by their probabilities, utilizing information on node covariates as well as on network topology. Empirically, the method performs well under many settings, including when the observed network is sparse. We apply the method to a protein-protein interaction network and a school friendship network.