Nowadays, there has been a growing trend in the field of high-energy physics (HEP), in both its experimental and phenomenological studies, to incorporate machine learning (ML) and its specialized branch, deep learning (DL). This review paper provides a thorough illustration of these applications using different ML and DL approaches. The first part of the paper examines the basics of various particle physics types and establishes guidelines for assessing particle physics alongside the available learning models. Next, a detailed classification is provided for representing Jets that are reconstructed in high-energy collisions, mainly in proton-proton collisions at well-defined beam energies. This section covers various datasets, preprocessing techniques, and feature extraction and selection methods. The presented techniques can be applied to future hadron-hadron colliders (HHC), such as the high-luminosity LHC (HL-LHC) and the future circular collider - hadron-hadron (FCChh). The authors then explore several AI techniques analyses designed specifically for both image and point-cloud (PC) data in HEP. Additionally, a closer look is taken at the classification associated with Jet tagging in hadron collisions. In this review, various state-of-the-art (SOTA) techniques in ML and DL are examined, with a focus on their implications for HEP demands. More precisely, this discussion addresses various applications in extensive detail, such as Jet tagging, Jet tracking, particle classification, and more. The review concludes with an analysis of the current state of HEP using DL methodologies. It highlights the challenges and potential areas for future research, which are illustrated for each application.

Artificial intelligence (AI) systems increasingly match or surpass human experts in biomedical signal interpretation. However, their effective integration into clinical practice requires more than high predictive accuracy. Clinicians must discern \textit{when} and \textit{why} to trust algorithmic recommendations. This work presents an application-grounded user study with eight professional sleep medicine practitioners, who score nocturnal arousal events in polysomnographic data under three conditions: (i) manual scoring, (ii) black-box (BB) AI assistance, and (iii) transparent white-box (WB) AI assistance. Assistance is provided either from the \textit{start} of scoring or as a post-hoc quality-control (\textit{QC}) review. We systematically evaluate how the type and timing of assistance influence event-level and clinically most relevant count-based performance, time requirements, and user experience. When evaluated against the clinical standard used to train the AI, both AI and human-AI teams significantly outperform unaided experts, with collaboration also reducing inter-rater variability. Notably, transparent AI assistance applied as a targeted QC step yields median event-level performance improvements of approximately 30\% over black-box assistance, and QC timing further enhances count-based outcomes. While WB and QC approaches increase the time required for scoring, start-time assistance is faster and preferred by most participants. Participants overwhelmingly favor transparency, with seven out of eight expressing willingness to adopt the system with minor or no modifications. In summary, strategically timed transparent AI assistance effectively balances accuracy and clinical efficiency, providing a promising pathway toward trustworthy AI integration and user acceptance in clinical workflows.

The operational capabilities and application domains of AI-enabled autonomous systems have expanded significantly in recent years due to advances in robotics and machine learning (ML). Demonstrating the safety of autonomous systems rigorously is critical for their responsible adoption but it is challenging as it requires robust methodologies that can handle novel and uncertain situations throughout the system lifecycle, including detecting out-of-distribution (OoD) data. Thus, OOD detection is receiving increased attention from the research, development and safety engineering communities. This comprehensive review analyses OOD detection techniques within the context of safety assurance for autonomous systems, in particular in safety-critical domains. We begin by defining the relevant concepts, investigating what causes OOD and exploring the factors which make the safety assurance of autonomous systems and OOD detection challenging. Our review identifies a range of techniques which can be used throughout the ML development lifecycle and we suggest areas within the lifecycle in which they may be used to support safety assurance arguments. We discuss a number of caveats that system and safety engineers must be aware of when integrating OOD detection into system lifecycles. We conclude by outlining the challenges and future work necessary for the safe development and operation of autonomous systems across a range of domains and applications.

Since the seminal work of TabPFN, research on tabular foundation models (TFMs) based on in-context learning (ICL) has challenged long-standing paradigms in machine learning. Without seeing any real-world data, models pretrained on purely synthetic datasets generalize remarkably well across diverse datasets, often using only a moderate number of in-context examples. This shifts the focus in tabular machine learning from model architecture design to the design of synthetic datasets, or, more precisely, to the prior distributions that generate them. Yet the guiding principles for prior design remain poorly understood. This work marks the first attempt to address the gap. We systematically investigate and identify key properties of synthetic priors that allow pretrained TFMs to generalize well. Based on these insights, we introduce Mitra, a TFM trained on a curated mixture of synthetic priors selected for their diversity, distinctiveness, and performance on real-world tabular data. Mitra consistently outperforms state-of-the-art TFMs, such as TabPFNv2 and TabICL, across both classification and regression benchmarks, with better sample efficiency.

In precision-sensitive classification tasks, false positives carry severe operational consequences. For example, when a text safety classifier incorrectly flags 10% of benign user queries as unsafe, it blocks legitimate queries from being processed, degrading the experience for millions of users and potentially driving them away from the service. Similarly, in hallucination detection within Retrieval-Augmented Generation (RAG) pipelines, when factually correct responses are incorrectly flagged as hallucinated, the system triggers regeneration or self-correction mechanisms, adding unnecessary computational overhead and latency that frustrates users waiting for responses. These deployment realities demand classifiers that operate at extremely low false positive rates--often below 1%--while maintaining acceptable recall. Large language models are increasingly deployed for such precision-critical classification tasks through specialized safety guardrails like Llama Guard (Inan et al., 2023) and ShieldGemma (Zeng et al., 2024), as well as hallucination detection systems (Huang et al., 2025). Recently, reasoning-augmented approaches have emerged as a promising direction: GuardReasoner (Liu et al., 2025) incorporates chain-of-thought reasoning for safety classification, while Lynx (Ravi et al., 2024) leverages reasoning for hallucination detection in RAG

Abstract--Falls among elderly and disabled individuals remain a leading cause of injury and mortality worldwide, necessitating robust, accurate, and privacy-aware fall detection systems. Traditional fall detection approaches, whether centralized or point-wise, often struggle with key challenges such as limited gener-alizability, data privacy concerns, and variability in individual movement behaviors. T o address these limitations, we propose EPFL--an Ensembled Penalized Federated Learning framework that integrates continual learning, personalized modeling, and a novel Specialized Weighted Aggregation (SW A) strategy. EPFL leverages wearable sensor data to capture sequential motion patterns while preserving user privacy through homomorphic encryption and federated training. Unlike existing federated models, EPFL incorporates both penalized local training and ensemble-based inference to improve inter-client consistency and adaptability to behavioral differences. Extensive experiments on a benchmark fall detection dataset demonstrate the effectiveness of our approach, achieving a Recall of 88.31% and an F1-score of 89.94%, significantly outperforming both centralized and baseline models. This work presents a scalable, secure, and accurate solution for real-world fall detection in healthcare settings, with strong potential for continuous improvement via its adaptive feedback mechanism. Due to changes in traditional family structures, the number of older individuals living alone has significantly increased over the past few decades [1]. According to the report from World Health Organization (WHO) [2], falls are the second leading cause of unintentional injury deaths worldwide, with particularly high morbidity among individuals aged 60 and older. Resulting in severe injuries, including fractures, head trauma, and even death, falls can significantly decline the quality of life of older adults [3]. Considering this, the need for effective monitoring and fall detection systems has been raised by this change aiming to ensure the safety of seniors. Falls can have long-term impacts on individuals, including significant disability-adjusted life years (DAL Ys) and high financial costs. According to the report [2], falls cause over 38 million DAL Ys lost annually worldwide. In Canada, a 20% reduction in falls could save approximately US$120 million each year. Considering the severe injuries, potential fatalities and other additional costs resulting from sudden falls [4], fall detection is a critical research area, especially for the elderly and individuals with disabilities.

To fix the 'bias in, bias out' problem in fair machine learning, it is important to steer feature distributions of data or internal representations of Large Language Models (LLMs) to ideal ones that guarantee group-fair outcomes. Previous work on fair generative models and representation steering could greatly benefit from provable fairness guarantees on the model output. We define a distribution as ideal if the minimizer of any cost-sensitive risk on it is guaranteed to have exact group-fair outcomes (e.g., demographic parity, equal opportunity)-in other words, it has no fairness-utility trade-off. We formulate an optimization program for optimal steering by finding the nearest ideal distribution in KL-divergence, and provide efficient algorithms for it when the underlying distributions come from well-known parametric families (e.g., normal, log-normal). Empirically, our optimal steering techniques on both synthetic and real-world datasets improve fairness without diminishing utility (and sometimes even improve utility). We demonstrate affine steering of LLM representations to reduce bias in multi-class classification, e.g., occupation prediction from a short biography in Bios dataset (De-Arteaga et al.). Furthermore, we steer internal representations of LLMs towards desired outputs so that it works equally well across different groups.

Large Language Models (LLMs) continue to exhibit vulnerabilities despite deliberate safety alignment efforts, posing significant risks to users and society. To safeguard against the risk of policy-violating content, system-level moderation via external guard models-designed to monitor LLM inputs and outputs and block potentially harmful content-has emerged as a prevalent mitigation strategy. Existing approaches of training guard models rely heavily on extensive human curated datasets and struggle with out-of-distribution threats, such as emerging harmful categories or jailbreak attacks. To address these limitations, we propose RSafe, an adaptive reasoning-based safeguard that conducts guided safety reasoning to provide robust protection within the scope of specified safety policies. RSafe operates in two stages: 1) guided reasoning, where it analyzes safety risks of input content through policy-guided step-by-step reasoning, and 2) reinforced alignment, where rule-based RL optimizes its reasoning paths to align with accurate safety prediction. This two-stage training paradigm enables RSafe to internalize safety principles to generalize safety protection capability over unseen or adversarial safety violation scenarios. During inference, RSafe accepts user-specified safety policies to provide enhanced safeguards tailored to specific safety requirements.

Linear and quadratic optimization are crucial in numerous real-world applications, ranging from training machine learning models to solving integer linear programs. Recently, learning-to-optimize methods (L2O) for linear (LPs) or quadratic programs (QPs) using message-passing graph neural networks (MPNNs) have gained traction, promising lightweight, data-driven proxies for solving such optimization problems. For example, they replace the costly computation of strong branching scores in branch-and-bound solvers, thereby reducing the need to solve many such optimization problems. However, robust L2O MPNNs remain challenging in data-scarce settings, especially when addressing complex optimization problems such as QPs. This work introduces a principled approach to data augmentation tailored for QPs via MPNNs. Our method leverages theoretically justified data augmentation techniques to generate diverse yet optimality-preserving instances. Furthermore, we integrate these augmentations into a self-supervised contrastive learning framework, thereby pretraining MPNNs for improved performance on L2O tasks. Extensive experiments demonstrate that our approach improves generalization in supervised scenarios and facilitates effective transfer learning to related optimization problems.

Multi-omics data integration is crucial for understanding complex diseases, yet limited sample sizes, noise, and heterogeneity often reduce predictive power. To address these challenges, we introduce Omics-GAN, a Generative Adversarial Network (GAN)-based framework designed to generate high-quality synthetic multi-omics profiles while preserving biological relationships. We evaluated Omics-GAN on three omics types (mRNA, miRNA, and DNA methylation) using the ROSMAP cohort for Alzheimer's disease (AD) and TCGA datasets for colon and liver cancer. A support vector machine (SVM) classifier with repeated 5-fold cross-validation demonstrated that synthetic datasets consistently improved prediction accuracy compared to original omics profiles. The AUC of SVM for mRNA improved from 0.72 to 0.74 in AD, and from 0.68 to 0.72 in liver cancer. Synthetic miRNA enhanced classification in colon cancer from 0.59 to 0.69, while synthetic methylation data improved performance in liver cancer from 0.64 to 0.71. Boxplot analyses confirmed that synthetic data preserved statistical distributions while reducing noise and outliers. Feature selection identified significant genes overlapping with original datasets and revealed additional candidates validated by GO and KEGG enrichment analyses. Finally, molecular docking highlighted potential drug repurposing candidates, including Nilotinib for AD, Atovaquone for liver cancer, and Tecovirimat for colon cancer. Omics-GAN enhances disease prediction, preserves biological fidelity, and accelerates biomarker and drug discovery, offering a scalable strategy for precision medicine applications.