The specificty and sensitivity of resting state functional MRI (rs-fMRI) measurements depend on pre-processing choices, such as the parcellation scheme used to define regions of interest (ROIs). In this study, we critically evaluate the effect of brain parcellations on machine learning models applied to rs-fMRI data. Our experiments reveal a remarkable trend: On average, models with stochastic parcellations consistently perform as well as models with widely used atlases at the same spatial scale. We thus propose an ensemble learning strategy to combine the predictions from models trained on connectivity data extracted using different (e.g., stochastic) parcellations. We further present an implementation of our ensemble learning strategy with a novel 3D Convolutional Neural Network (CNN) approach. The proposed CNN approach takes advantage of the full-resolution 3D spatial structure of rs-fMRI data and fits non-linear predictive models. Our ensemble CNN framework overcomes the limitations of traditional machine learning models for connectomes that often rely on region-based summary statistics and/or linear models. We showcase our approach on a classification (autism patients versus healthy controls) and a regression problem (prediction of subject's age), and report promising results.

Automatic recognition of the historical letters (XI-XVIII centuries) carved on the stoned walls of St.Sophia cathedral in Kyiv (Ukraine) was demonstrated by means of capsule deep learning neural network. It was applied to the image dataset of the carved Glagolitic and Cyrillic letters (CGCL), which was assembled and pre-processed recently for recognition and prediction by machine learning methods (https://www.kaggle.com/yoctoman/graffiti-st-sophia-cathedral-kyiv). CGCL dataset contains >4000 images for glyphs of 34 letters which are hardly recognized by experts even in contrast to notMNIST dataset with the better images of 10 letters taken from different fonts. Despite the much worse quality of CGCL dataset and extremely low number of samples (in comparison to notMNIST dataset) the capsule network model demonstrated much better results than the previously used convolutional neural network (CNN). The validation accuracy (and validation loss) was higher (lower) for capsule network model than for CNN without data augmentation even. The area under curve (AUC) values for receiver operating characteristic (ROC) were also higher for the capsule network model than for CNN model: 0.88-0.93 (capsule network) and 0.50 (CNN) without data augmentation, 0.91-0.95 (capsule network) and 0.51 (CNN) with lossless data augmentation, and similar results of 0.91-0.93 (capsule network) and 0.9 (CNN) in the regime of lossless data augmentation only. The confusion matrixes were much better for capsule network than for CNN model and gave the much lower type I (false positive) and type II (false negative) values in all three regimes of data augmentation. These results supports the previous claims that capsule-like networks allow to reduce error rates not only on MNIST digit dataset, but on the other notMNIST letter dataset and the more complex CGCL handwriting graffiti letter dataset also.

Robot manipulation is increasingly poised to interact with humans in co-shared workspaces. Despite increasingly robust manipulation and control algorithms, failure modes continue to exist whenever models do not capture the dynamics of the unstructured environment. To obtain longer-term horizons in robot automation, robots must develop introspection and recovery abilities. We contribute a set of recovery policies to deal with anomalies produced by external disturbances as well as anomaly classification through the use of non-parametric statistics with memoized variational inference with scalable adaptation. A recovery critic stands atop of a tightly-integrated, graph-based online motion-generation and introspection system that resolves a wide range of anomalous situations. Policies, skills, and introspection models are learned incrementally and contextually in a task. Two task-level recovery policies: re-enactment and adaptation resolve accidental and persistent anomalies respectively. The introspection system uses non-parametric priors along with Markov jump linear systems and memoized variational inference with scalable adaptation to learn a model from the data. Extensive real-robot experimentation with various strenuous anomalous conditions is induced and resolved at different phases of a task and in different combinations. The system executes around-the-clock introspection and recovery and even elicited self-recovery when misclassifications occurred.

Recommender system is an important component of many web services to help users locate items that match their interests. Several studies showed that recommender systems are vulnerable to poisoning attacks, in which an attacker injects fake data to a given system such that the system makes recommendations as the attacker desires. However, these poisoning attacks are either agnostic to recommendation algorithms or optimized to recommender systems that are not graph-based. Like association-rule-based and matrix-factorization-based recommender systems, graph-based recommender system is also deployed in practice, e.g., eBay, Huawei App Store. However, how to design optimized poisoning attacks for graph-based recommender systems is still an open problem. In this work, we perform a systematic study on poisoning attacks to graph-based recommender systems. Due to limited resources and to avoid detection, we assume the number of fake users that can be injected into the system is bounded. The key challenge is how to assign rating scores to the fake users such that the target item is recommended to as many normal users as possible. To address the challenge, we formulate the poisoning attacks as an optimization problem, solving which determines the rating scores for the fake users. We also propose techniques to solve the optimization problem. We evaluate our attacks and compare them with existing attacks under white-box (recommendation algorithm and its parameters are known), gray-box (recommendation algorithm is known but its parameters are unknown), and black-box (recommendation algorithm is unknown) settings using two real-world datasets. Our results show that our attack is effective and outperforms existing attacks for graph-based recommender systems. For instance, when 1% fake users are injected, our attack can make a target item recommended to 580 times more normal users in certain scenarios.

Equality of opportunity (EOP) is an extensively studied conception of fairness in political philosophy. In this work, we map recently proposed notions of algorithmic fairness to economic models of EOP. We formally show that through our proposed mapping, many existing definition of algorithmic fairness, such as predictive value parity and equality of odds, can be interpreted as special cases of EOP. In this respect, our work serves as a unifying moral framework for understanding existing notions of algorithmic fairness. Most importantly, this framework allows us to explicitly spell out the moral assumptions underlying each notion of fairness, and also interpret recent fairness impossibility results in a new light. Last but not least and inspired by luck egalitarian models of EOP, we propose a new, more general family of measures for algorithmic fairness. We empirically show that employing a measure of algorithmic (un)fairness when its underlying moral assumptions are not satisfied, can have devastating consequences on the subjects' welfare.

In this work, we present a comparison of a shallow and a deep learning architecture for the automated segmentation of white matter lesions in MR images of multiple sclerosis patients. In particular, we train and test both methods on early stage disease patients, to verify their performance in challenging conditions, more similar to a clinical setting than what is typically provided in multiple sclerosis segmentation challenges. Furthermore, we evaluate a prototype naive combination of the two methods, which refines the final segmentation. All methods were trained on 32 patients, and the evaluation was performed on a pure test set of 73 cases. Results show low lesion-wise false positives (30%) for the deep learning architecture, whereas the shallow architecture yields the best Dice coefficient (63%) and volume difference (19%). Combining both shallow and deep architectures further improves the lesion-wise metrics (69% and 26% lesion-wise true and false positive rate, respectively).

Doctors often rely on their past experience in order to diagnose patients. For a doctor with enough experience, almost every patient would have similarities to key cases seen in the past, and each new patient could be viewed as a mixture of these key past cases. Because doctors often tend to reason this way, an efficient computationally aided diagnostic tool that thinks in the same way might be helpful in locating key past cases of interest that could assist with diagnosis. This article develops a novel mathematical model to mimic the type of logical thinking that physicians use when considering past cases. The proposed model can also provide physicians with explanations that would be similar to the way they would naturally reason about cases. The proposed method is designed to yield predictive accuracy, computational efficiency, and insight into medical data; the key element is the insight into medical data - in some sense we are automating a complicated process that physicians might perform manually. We finally implemented the result of this work on two publicly available healthcare datasets, for (1) heart disease prediction and (2) breast cancer prediction.

Feature selection can efficiently identify the most informative features with respect to the target feature used in training. However, state-of-the-art vector-based methods are unable to encapsulate the relationships between feature samples into the feature selection process, thus leading to significant information loss. To address this problem, we propose a new graph-based structurally interacting elastic net method for feature selection. Specifically, we commence by constructing feature graphs that can incorporate pairwise relationship between samples. With the feature graphs to hand, we propose a new information theoretic criterion to measure the joint relevance of different pairwise feature combinations with respect to the target feature graph representation. This measure is used to obtain a structural interaction matrix where the elements represent the proposed information theoretic measure between feature pairs. We then formulate a new optimization model through the combination of the structural interaction matrix and an elastic net regression model for the feature subset selection problem. This allows us to a) preserve the information of the original vectorial space, b) remedy the information loss of the original feature space caused by using graph representation, and c) promote a sparse solution and also encourage correlated features to be selected. Because the proposed optimization problem is non-convex, we develop an efficient alternating direction multiplier method (ADMM) to locate the optimal solutions. Extensive experiments on various datasets demonstrate the effectiveness of the proposed method. Keywords: Feature Selection; Graph; Interacting Elastic Net; Sparse; ADMM 1. Introduction There has recently been a rapid growth in both the size and dimension of the data encountered in many real world applications of pattern recognition including image processing, bioinformatics, and financial analysis. Finding useful information and building effective prediction models from such data presents new challenges for machine learning and pattern recognition [1]. One way to overcome this problem is to develop efficient spectral methods including stochastic neighbour embedding [2], elastic embedding methods [3] and feature selection [4] methods to reduce the dimensionality of the data.

Class imbalanced datasets are common in real-world applications that range from credit card fraud detection to rare disease diagnostics. Several popular classification algorithms assume that classes are approximately balanced, and hence build the accompanying objective function to maximize an overall accuracy rate. In these situations, optimizing the overall accuracy will lead to highly skewed predictions towards the majority class. Moreover, the negative business impact resulting from false positives (positive samples incorrectly classified as negative) can be detrimental. Many methods have been proposed to address the class imbalance problem, including methods such as over-sampling, under-sampling and cost-sensitive methods. In this paper, we consider the over-sampling method, where the aim is to augment the original dataset with synthetically created observations of the minority classes. In particular, inspired by the recent advances in generative modelling techniques (e.g., Variational Inference and Generative Adversarial Networks), we introduce a new oversampling technique based on variational autoencoders. Our experiments show that the new method is superior in augmenting datasets for downstream classification tasks when compared to traditional oversampling methods.

Risk scores are simple classification models that let users make quick risk predictions by adding and subtracting a few small numbers. These models are widely used in medicine and criminal justice, but are difficult to learn from data because they need to be calibrated, sparse, use small integer coefficients and obey application-specific constraints. In this paper, we present a new machine learning approach to learn risk scores. We formulate the risk score problem as a mixed integer nonlinear program, and present a new cutting plane algorithm for non-convex settings to efficiently recover its optimal solution. We improve our algorithm with specialized techniques to generate feasible solutions, narrow the optimality gap, and reduce data-related computation. Our approach can fit risk scores in a way that scales linearly in the number of samples, provides a certificate of optimality, and obeys real-world constraints without parameter tuning or post-processing. We illustrate the performance benefits of this approach through an extensive set of numerical experiments, where we compare risk scores built using our approach to those built using heuristic approaches. We also discuss the practical benefits of our approach through an application where we build a customized risk score for ICU seizure prediction in collaboration with the Massachusetts General Hospital.