SEOUL – South Korean health authorities raised new concerns about the novel coronavirus after reporting last month that dozens of patients who had recovered from the illness later tested positive again. The findings suggested that some people who survived COVID-19 could become reinfected with the virus that causes it, potentially complicating efforts to lift quarantine restrictions and to produce a vaccine. But after weeks of research, they now say that such test results appear to be "false positives" caused by lingering -- but likely not infectious -- bits of the virus. South Korea had reported more than 350 such cases as of Wednesday, according to the Korea Centers for Disease Control and Prevention (KCDC). As more and more South Koreans were released from treatment for COVID-19, authorities discovered a disturbing trend.

Early detection of patients vulnerable to infections acquired in the hospital environment is a challenge in current health systems given the impact that such infections have on patient mortality and healthcare costs. This work is focused on both the identification of risk factors and the prediction of healthcare-associated infections in intensive-care units by means of machine-learning methods. The aim is to support decision making addressed at reducing the incidence rate of infections. In this field, it is necessary to deal with the problem of building reliable classifiers from imbalanced datasets. We propose a clustering-based undersampling strategy to be used in combination with ensemble classifiers. A comparative study with data from 4616 patients was conducted in order to validate our proposal. We applied several single and ensemble classifiers both to the original dataset and to data preprocessed by means of different resampling methods. The results were analyzed by means of classic and recent metrics specifically designed for imbalanced data classification. They revealed that the proposal is more efficient in comparison with other approaches.

Business processes are prone to unexpected changes, as process workers may suddenly or gradually start executing a process differently in order to adjust to changes in workload, season, or other external factors. Early detection of business process changes enables managers to identify and act upon changes that may otherwise affect process performance. Business process drift detection refers to a family of methods to detect changes in a business process by analyzing event logs extracted from the systems that support the execution of the process. Existing methods for business process drift detection are based on an explorative analysis of a potentially large feature space and in some cases they require users to manually identify specific features that characterize the drift. Depending on the explored feature space, these methods miss various types of changes. Moreover, they are either designed to detect sudden drifts or gradual drifts but not both. This paper proposes an automated and statistically grounded method for detecting sudden and gradual business process drifts under a unified framework. An empirical evaluation shows that the method detects typical change patterns with significantly higher accuracy and lower detection delay than existing methods, while accurately distinguishing between sudden and gradual drifts.

For the purpose of this narrative review, we searched PubMed and MEDLINE databases with no date restriction using search terms related to AI and medicine and cardiology subspecialties. Articles were reviewed and selected for inclusion on the basis of relevance. This article highlights that the role of ML in cardiovascular medicine is rapidly emerging, and mounting evidence indicates it will power the new tools that drive the field. Among other uses, AI has been deployed to interpret echocardiograms, to automatically identify heart rhythms from an ECG, to uniquely identify an individual using the ECG as a biometric signal, and to detect the presence of heart disease such as left ventricular dysfunction from the surface ECG.6x6Attia, Z.I., Kapa, S., Lopez-Jimenez, F. et al.

Many data sets contain an inherent multilevel structure, for example, because of repeated measurements of the same observational units. Taking this structure into account is critical for the accuracy and calibration of any statistical analysis performed on such data. However, the large number of possible model configurations hinders the use of multilevel models in practice. In this work, we propose a flexible framework for efficiently assessing differences between the levels of given grouping variables in the data. The assessed group heterogeneity is valuable in choosing the relevant group coefficients to consider in a multilevel model. Our empirical evaluations demonstrate that the framework can reliably identify relevant multilevel components in both simulated and real data sets.

Ridge regression (RR) is a regularization technique that penalizes the L2-norm of the coefficients in linear regression. One of the challenges of using RR is the need to set a hyperparameter ($\alpha$) that controls the amount of regularization. Cross-validation is typically used to select the best $\alpha$ from a set of candidates. However, efficient and appropriate selection of $\alpha$ can be challenging, particularly where large amounts of data are analyzed. Because the selected $\alpha$ depends on the scale of the data and predictors, it is not straightforwardly interpretable. Here, we propose to reparameterize RR in terms of the ratio $\gamma$ between the L2-norms of the regularized and unregularized coefficients. This approach, called fractional RR (FRR), has several benefits: the solutions obtained for different $\gamma$ are guaranteed to vary, guarding against wasted calculations, and automatically span the relevant range of regularization, avoiding the need for arduous manual exploration. We provide an algorithm to solve FRR, as well as open-source software implementations in Python and MATLAB (https://github.com/nrdg/fracridge). We show that the proposed method is fast and scalable for large-scale data problems, and delivers results that are straightforward to interpret and compare across models and datasets.

Crowdsourcing is a popular approach to collect annotations for unlabeled data instances. It involves collecting a large number of annotations from several, often naive untrained annotators for each data instance which are then combined to estimate the ground truth. Further, annotations for constructs such as affect are often multi-dimensional with annotators rating multiple dimensions, such as valence and arousal, for each instance. Most annotation fusion schemes however ignore this aspect and model each dimension separately. In this work we address this by proposing a generative model for multi-dimensional annotation fusion, which models the dimensions jointly leading to more accurate ground truth estimates. The model we propose is applicable to both global and time series annotation fusion problems and treats the ground truth as a latent variable distorted by the annotators. The model parameters are estimated using the Expectation-Maximization algorithm and we evaluate its performance using synthetic data and real emotion corpora as well as on an artificial task with human annotations

In this paper, we study the problem of fair classification in the presence of prior probability shifts, where the training set distribution differs from the test set. This phenomenon can be observed in the yearly records of several real-world datasets, such as recidivism records and medical expenditure surveys. If unaccounted for, such shifts can cause the predictions of a classifier to become unfair towards specific population subgroups. While the fairness notion called Proportional Equality (PE) accounts for such shifts, a procedure to ensure PE-fairness was unknown. In this work, we propose a method, called CAPE, which provides a comprehensive solution to the aforementioned problem. CAPE makes novel use of prevalence estimation techniques, sampling and an ensemble of classifiers to ensure fair predictions under prior probability shifts. We introduce a metric, called prevalence difference (PD), which CAPE attempts to minimize in order to ensure PE-fairness. We theoretically establish that this metric exhibits several desirable properties. We evaluate the efficacy of CAPE via a thorough empirical evaluation on synthetic datasets. We also compare the performance of CAPE with several popular fair classifiers on real-world datasets like COMPAS (criminal risk assessment) and MEPS (medical expenditure panel survey). The results indicate that CAPE ensures PE-fair predictions, while performing well on other performance metrics.

The federal government has received plenty of well-deserved flack for slow-rolling the national launch of diagnostic tests for Covid-19. First came the flawed swab-based tests from the Centers for Disease Control and Prevention, followed by a chaotic, lost month of regulatory tango that prevented independent tests from getting scaled and out the door. So when interest arose in a different kind of testing--antibody blood tests, which are used to find evidence of past infection, not a current diagnosis--the US Food and Drug Administration was under pressure to hurry things along. In mid-March, the agency loosened its rules, declaring via an update to its emergency use guidance that antibody tests could be sold without seeking the agency's approval, provided that manufacturers did their own validation. Now FDA officials are walking back that decision.

The right to be forgotten states that a data owner has the right to erase her data from an entity storing it. In the context of machine learning (ML), the right to be forgotten requires an ML model owner to remove the data owner's data from the training set used to build the ML model, a process known as machine unlearning. While originally designed to protect the privacy of the data owner, we argue that machine unlearning may leave some imprint of the data in the ML model and thus create unintended privacy risks. In this paper, we perform the first study on investigating the unintended information leakage caused by machine unlearning. We propose a novel membership inference attack which leverages the different outputs of an ML model's two versions to infer whether the deleted sample is part of the training set. Our experiments over five different datasets demonstrate that the proposed membership inference attack achieves strong performance. More importantly, we show that our attack in multiple cases outperforms the classical membership inference attack on the original ML model, which indicates that machine unlearning can have counterproductive effects on privacy. We notice that the privacy degradation is especially significant for well-generalized ML models where classical membership inference does not perform well. We further investigate two mechanisms to mitigate the newly discovered privacy risks and show that the only effective mechanism is to release the predicted label only. We believe that our results can help improve privacy in practical implementation of machine unlearning.