High-dimensional graphical models are often estimated using regularization that is aimed at reducing the number of edges in a network. In this work, we show how even simpler networks can be produced by aggregating the nodes of the graphical model. We develop a new convex regularized method, called the tree-aggregated graphical lasso or tag-lasso, that estimates graphical models that are both edge-sparse and node-aggregated. The aggregation is performed in a data-driven fashion by leveraging side information in the form of a tree that encodes node similarity and facilitates the interpretation of the resulting aggregated nodes. We provide an efficient implementation of the tag-lasso by using the locally adaptive alternating direction method of multipliers and illustrate our proposal's practical advantages in simulation and in applications in finance and biology.

After challenging the validity of these assumptions in real-world applications, we propose ways to move forward when they are violated. First, we show that group fairness criteria purely based on statistical properties of observed data are fundamentally limited. Revisiting this limitation from a causal viewpoint we develop a more versatile conceptual framework, causal fairness criteria, and first algorithms to achieve them. We also provide tools to analyze how sensitive a believed-to-be causally fair algorithm is to misspecifications of the causal graph. Second, we overcome the assumption that sensitive data is readily available in practice. To this end we devise protocols based on secure multi-party computation to train, validate, and contest fair decision algorithms without requiring users to disclose their sensitive data or decision makers to disclose their models. Finally, we also accommodate the fact that outcome labels are often only observed when a certain decision has been made. We suggest a paradigm shift away from training predictive models towards directly learning decisions to relax the traditional assumption that labels can always be recorded. The main contribution of this thesis is the development of theoretically substantiated and practically feasible methods to move research on fair machine learning closer to real-world applications.

Gliomas are one of the most frequent brain tumors and are classified into high grade and low grade gliomas. The segmentation of various regions such as tumor core, enhancing tumor etc. plays an important role in determining severity and prognosis. Here, we have developed a multi-threshold model based on attention U-Net for identification of various regions of the tumor in magnetic resonance imaging (MRI). We propose a multi-path segmentation and built three separate models for the different regions of interest. The proposed model achieved mean Dice Coefficient of 0.59, 0.72, and 0.61 for enhancing tumor, whole tumor and tumor core respectively on the training dataset. The same model gave mean Dice Coefficient of 0.57, 0.73, and 0.61 on the validation dataset and 0.59, 0.72, and 0.57 on the test dataset.

Machine learning models are used in many sensitive areas where besides predictive accuracy their comprehensibility is also important. Interpretability of prediction models is necessary to determine their biases and causes of errors, and is a necessary prerequisite for users' confidence. For complex state-of-the-art black-box models post-hoc model-independent explanation techniques are an established solution. Popular and effective techniques, such as IME, LIME, and SHAP, use perturbation of instance features to explain individual predictions. Recently, Slack et al. (2020) put their robustness into question by showing that their outcomes can be manipulated due to poor perturbation sampling employed. This weakness would allow dieselgate type cheating of owners of sensitive models who could deceive inspection and hide potentially unethical or illegal biases existing in their predictive models. This could undermine public trust in machine learning models and give rise to legal restrictions on their use. We show that better sampling in these explanation methods prevents malicious manipulations. The proposed sampling uses data generators that learn the training set distribution and generate new perturbation instances much more similar to the training set. We show that the improved sampling increases the robustness of the LIME and SHAP, while previously untested method IME is already the most robust of all.

One-class classification is a challenging subfield of machine learning in which so-called data descriptors are used to predict membership of a class based solely on positive examples of that class, and no counter-examples. A number of data descriptors that have been shown to perform well in previous studies of one-class classification, like the Support Vector Machine (SVM), require setting one or more hyperparameters. There has been no systematic attempt to date to determine optimal default values for these hyperparameters, which limits their ease of use, especially in comparison with hyperparameter-free proposals like the Isolation Forest (IF). We address this issue by determining optimal default hyperparameter values across a collection of 246 one-class classification problems derived from 50 different real-world datasets. In addition, we propose a new data descriptor, Average Localised Proximity (ALP) to address certain issues with existing approaches based on nearest neighbour distances. Finally, we evaluate classification performance using a leave-one-dataset-out procedure, and find strong evidence that ALP outperforms IF and a number of other data descriptors, as well as weak evidence that it outperforms SVM, making ALP a good default choice.

Consider the classical supervised learning problem: we are given data $(y_i,{\boldsymbol x}_i)$, $i\le n$, with $y_i$ a response and ${\boldsymbol x}_i\in {\mathcal X}$ a covariates vector, and try to learn a model $f:{\mathcal X}\to{\mathbb R}$ to predict future responses. Random features methods map the covariates vector ${\boldsymbol x}_i$ to a point ${\boldsymbol \phi}({\boldsymbol x}_i)$ in a higher dimensional space ${\mathbb R}^N$, via a random featurization map ${\boldsymbol \phi}$. We study the use of random features methods in conjunction with ridge regression in the feature space ${\mathbb R}^N$. This can be viewed as a finite-dimensional approximation of kernel ridge regression (KRR), or as a stylized model for neural networks in the so called lazy training regime. We define a class of problems satisfying certain spectral conditions on the underlying kernels, and a hypercontractivity assumption on the associated eigenfunctions. These conditions are verified by classical high-dimensional examples. Under these conditions, we prove a sharp characterization of the error of random features ridge regression. In particular, we address two fundamental questions: $(1)$~What is the generalization error of KRR? $(2)$~How big $N$ should be for the random features approximation to achieve the same error as KRR? In this setting, we prove that KRR is well approximated by a projection onto the top $\ell$ eigenfunctions of the kernel, where $\ell$ depends on the sample size $n$. We show that the test error of random features ridge regression is dominated by its approximation error and is larger than the error of KRR as long as $N\le n^{1-\delta}$ for some $\delta>0$. We characterize this gap. For $N\ge n^{1+\delta}$, random features achieve the same error as the corresponding KRR, and further increasing $N$ does not lead to a significant change in test error.

Disagreements are pervasive in human communication. In this paper we investigate what makes disagreement constructive. To this end, we construct WikiDisputes, a corpus of 7 425 Wikipedia Talk page conversations that contain content disputes, and define the task of predicting whether disagreements will be escalated to mediation by a moderator. We evaluate feature-based models with linguistic markers from previous work, and demonstrate that their performance is improved by using features that capture changes in linguistic markers throughout the conversations, as opposed to averaged values. We develop a variety of neural models and show that taking into account the structure of the conversation improves predictive accuracy, exceeding that of feature-based models. We assess our best neural model in terms of both predictive accuracy and uncertainty by evaluating its behaviour when it is only exposed to the beginning of the conversation, finding that model accuracy improves and uncertainty reduces as models are exposed to more information.

Objectives: To evaluate the consequences of the framing of machine learning risk prediction models. We evaluate how framing affects model performance and model learning in four different approaches previously applied in published artificial-intelligence (AI) models. Setting and participants: We analysed structured secondary healthcare data from 221,283 citizens from four Danish municipalities who were 18 years of age or older. Results: The four models had similar population level performance (a mean area under the receiver operating characteristic curve of 0.73 to 0.82), in contrast to the mean average precision, which varied greatly from 0.007 to 0.385. Correspondingly, the percentage of missing values also varied between framing approaches. The on-clinical-demand framing, which involved samples for each time the clinicians made an early warning score assessment, showed the lowest percentage of missing values among the vital sign parameters, and this model was also able to learn more temporal dependencies than the others. The Shapley additive explanations demonstrated opposing interpretations of SpO2 in the prediction of sepsis as a consequence of differentially framed models. Conclusions: The profound consequences of framing mandate attention from clinicians and AI developers, as the understanding and reporting of framing are pivotal to the successful development and clinical implementation of future AI technology. Model framing must reflect the expected clinical environment. The importance of proper problem framing is by no means exclusive to sepsis prediction and applies to most clinical risk prediction models.

Explainable Artificial Intelligence (XAI) has in recent years become a well-suited framework to generate human understandable explanations of black box models. In this paper, we present a novel XAI visual explanation algorithm denoted SIDU that can effectively localize entire object regions responsible for prediction in a full extend. We analyze its robustness and effectiveness through various computational and human subject experiments. In particular, we assess the SIDU algorithm using three different types of evaluations (Application, Human and Functionally-Grounded) to demonstrate its superior performance. The robustness of SIDU is further studied in presence of adversarial attack on black box models to better understand its performance.

Abstract--Human-Object Interaction (HOI) detection is an important problem to understand how humans interact with objects. In this paper, we explore interactiveness knowledge which indicates whether a human and an object interact with each other or not. We found that interactiveness knowledge can be learned across HOI datasets and bridge the gap between diverse HOI category settings. Our core idea is to exploit an interactiveness network to learn the general interactiveness knowledge from multiple HOI datasets and perform Non-Interaction Suppression (NIS) before HOI classification in inference. On account of the generalization ability of interactiveness, interactiveness network is a transferable knowledge learner and can be cooperated with any HOI detection models to achieve desirable results. We utilize the human instance and body part features together to learn the interactiveness in hierarchical paradigm, i.e., instance-level and body part-level interactivenesses. Thereafter, a consistency task is proposed to guide the learning and extract deeper interactive visual clues. We extensively evaluate the proposed method on HICO-DET, V-COCO, and a newly constructed PaStaNet-HOI dataset. With the learned interactiveness, our method outperforms state-of-the-art HOI detection methods, verifying its efficacy and flexibility.