Cardiac auscultation is an essential point-of-care method used for the early diagnosis of heart diseases. Automatic analysis of heart sounds for abnormality detection is faced with the challenges of additive noise and sensor-dependent degradation. This paper aims to develop methods to address the cardiac abnormality detection problem when both types of distortions are present in the cardiac auscultation sound. We first mathematically analyze the effect of additive and convolutional noise on short-term filterbank-based features and a Convolutional Neural Network (CNN) layer. Based on the analysis, we propose a combination of linear and logarithmic spectrogram-image features. These 2D features are provided as input to a residual CNN network (ResNet) for heart sound abnormality detection. Experimental validation is performed on an open-access heart sound abnormality detection dataset involving noisy recordings obtained from multiple stethoscope sensors. The proposed method achieves significantly improved results compared to the conventional approaches, with an area under the ROC (receiver operating characteristics) curve (AUC) of 91.36%, F-1 score of 84.09%, and Macc (mean of sensitivity and specificity) of 85.08%. We also show that the proposed method shows the best mean accuracy across different source domains including stethoscope and noise variability, demonstrating its effectiveness in different recording conditions. The proposed combination of linear and logarithmic features along with the ResNet classifier effectively minimizes the impact of background noise and sensor variability for classifying phonocardiogram (PCG) signals. The proposed method paves the way towards developing computer-aided cardiac auscultation systems in noisy environments using low-cost stethoscopes.

We present a novel framework for designing multiplierless kernel machines that can be used on resource-constrained platforms like intelligent edge devices. The framework uses a piecewise linear (PWL) approximation based on a margin propagation (MP) technique and uses only addition/subtraction, shift, comparison, and register underflow/overflow operations. We propose a hardware-friendly MP-based inference and online training algorithm that has been optimized for a Field Programmable Gate Array (FPGA) platform. Our FPGA implementation eliminates the need for DSP units and reduces the number of LUTs. By reusing the same hardware for inference and training, we show that the platform can overcome classification errors and local minima artifacts that result from the MP approximation. Using the FPGA platform, we also show that the proposed multiplierless MP-kernel machine demonstrates superior performance in terms of power, performance, and area compared to other comparable implementations.

Human activity recognition in videos is a challenging problem that has drawn a lot of interest, particularly when the goal requires the analysis of a large video database. AOLME project provides a collaborative learning environment for middle school students to explore mathematics, computer science, and engineering by processing digital images and videos. As part of this project, around 2200 hours of video data was collected for analysis. Because of the size of the dataset, it is hard to analyze all the videos of the dataset manually. Thus, there is a huge need for reliable computer-based methods that can detect activities of interest. My thesis is focused on the development of accurate methods for detecting and tracking objects in long videos. All the models are validated on videos from 7 different sessions, ranging from 45 minutes to 90 minutes. The keyboard detector achieved a very high average precision (AP) of 92% at 0.5 intersection over union (IoU). Furthermore, a combined system of the detector with a fast tracker KCF (159fps) was developed so that the algorithm runs significantly faster without sacrificing accuracy. For a video of 23 minutes having resolution 858X480 @ 30 fps, the detection alone runs at 4.7Xthe real-time, and the combined algorithm runs at 21Xthe real-time for an average IoU of 0.84 and 0.82, respectively. The hand detector achieved average precision (AP) of 72% at 0.5 IoU. The detection results were improved to 81% using optimal data augmentation parameters. The hand detector runs at 4.7Xthe real-time with AP of 81% at 0.5 IoU. The hand detection method was integrated with projections and clustering for accurate proposal generation. This approach reduced the number of false-positive hand detections by 80%. The overall hand detection system runs at 4Xthe real-time, capturing all the activity regions of the current collaborative group.

Background: The learning of genotype-phenotype associations and history of human disease by doing detailed and precise analysis of phenotypic abnormalities can be defined as deep phenotyping. To understand and detect this interaction between phenotype and genotype is a fundamental step when translating precision medicine to clinical practice. The recent advances in the field of machine learning is efficient to predict these interactions between abnormal human phenotypes and genes. Methods: In this study, we developed a framework to predict links between human phenotype ontology (HPO) and genes. The annotation data from the heterogeneous knowledge resources i.e., orphanet, is used to parse human phenotype-gene associations. To generate the embeddings for the nodes (HPO & genes), an algorithm called node2vec was used. It performs node sampling on this graph based on random walks, then learns features over these sampled nodes to generate embeddings. These embeddings were used to perform the downstream task to predict the presence of the link between these nodes using 5 different supervised machine learning algorithms. Results: The downstream link prediction task shows that the Gradient Boosting Decision Tree based model (LightGBM) achieved an optimal AUROC 0.904 and AUCPR 0.784. In addition, LightGBM achieved an optimal weighted F1 score of 0.87. Compared to the other 4 methods LightGBM is able to find more accurate interaction/link between human phenotype & gene pairs.

Least squares estimators, when trained on a few target domain samples, may predict poorly. Supervised domain adaptation aims to improve the predictive accuracy by exploiting additional labeled training samples from a source distribution that is close to the target distribution. Given available data, we investigate novel strategies to synthesize a family of least squares estimator experts that are robust with regard to moment conditions. When these moment conditions are specified using Kullback-Leibler or Wasserstein-type divergences, we can find the robust estimators efficiently using convex optimization. We use the Bernstein online aggregation algorithm on the proposed family of robust experts to generate predictions for the sequential stream of target test samples. Numerical experiments on real data show that the robust strategies may outperform non-robust interpolations of the empirical least squares estimators.

In real world datasets, particular groups are under-represented, much rarer than others, and machine learning classifiers will often preform worse on under-represented populations. This problem is aggravated across many domains where datasets are class imbalanced, with a minority class far rarer than the majority class. Naive approaches to handle under-representation and class imbalance include training sub-population specific classifiers that handle class imbalance or training a global classifier that overlooks sub-population disparities and aims to achieve high overall accuracy by handling class imbalance. In this study, we find that these approaches are vulnerable in class imbalanced datasets with minority sub-populations. We introduced Fair-Net, a branched multitask neural network architecture that improves both classification accuracy and probability calibration across identifiable sub-populations in class imbalanced datasets. Fair-Nets is a straightforward extension to the output layer and error function of a network, so can be incorporated in far more complex architectures. Empirical studies with three real world benchmark datasets demonstrate that Fair-Net improves classification and calibration performance, substantially reducing performance disparity between gender and racial sub-populations.

As machine learning algorithms start to get integrated into the decision-making process of companies and organizations, insurance products will be developed to protect their owners from risk. We introduce the concept of algorithmic insurance and present a quantitative framework to enable the pricing of the derived insurance contracts. We propose an optimization formulation to estimate the risk exposure and price for a binary classification model. Our approach outlines how properties of the model, such as accuracy, interpretability and generalizability, can influence the insurance contract evaluation. To showcase a practical implementation of the proposed framework, we present a case study of medical malpractice in the context of breast cancer detection. Our analysis focuses on measuring the effect of the model parameters on the expected financial loss and identifying the aspects of algorithmic performance that predominantly affect the price of the contract.

In the past decade, there has been much discussion about the issue of biased reporting in clinical research. Despite this attention, there have been limited tools developed for the systematic assessment of qualitative statements made in clinical research, with most studies assessing qualitative statements relying on the use of manual expert raters, which limits their size. Also, previous attempts to develop larger scale tools, such as those using natural language processing, were limited by both their accuracy and the number of categories used for the classification of their findings. With these limitations in mind, this study's goal was to develop a classification algorithm that was both suitably accurate and finely grained to be applied on a large scale for assessing the qualitative sentiment expressed in clinical trial abstracts. Additionally, this study seeks to compare the performance of the proposed algorithm, GAN-BioBERT, to previous studies as well as to expert manual rating of clinical trial abstracts. This study develops a three-class sentiment classification algorithm for clinical trial abstracts using a semi-supervised natural language process model based on the Bidirectional Encoder Representation from Transformers (BERT) model, from a series of clinical trial abstracts annotated by a group of experts in academic medicine. Results: The use of this algorithm was found to have a classification accuracy of 91.3%, with a macro F1-Score of 0.92, which is a significant improvement in accuracy when compared to previous methods and expert ratings, while also making the sentiment classification finer grained than previous studies. The proposed algorithm, GAN-BioBERT, is a suitable classification model for the large-scale assessment of qualitative statements in clinical trial literature, providing an accurate, reproducible tool for the large-scale study of clinical publication trends.

Leads are the driving force of many businesses today. With the advancement of subscription-based business models particularly in the start-up space, the ability to convert leads into paying customers is key to survival. In simple terms, a "lead" represents a potential customer interested in buying your product/service. A significant amount of time, money, and effort is spent by marketing and sales departments on lead management, a concept that we will take to encompass the three key phases of lead generation, qualification, and monetization. Lead generation is the initiation of customer interest or inquiry into the products or services of your business.

Machine learning based data-driven technologies have shown impressive performances in a variety of application domains. Most enterprises use data from multiple sources to provide quality applications. The reliability of the external data sources raises concerns for the security of the machine learning techniques adopted. An attacker can tamper the training or test datasets to subvert the predictions of models generated by these techniques. Data poisoning is one such attack wherein the attacker tries to degrade the performance of a classifier by manipulating the training data. In this work, we focus on label contamination attack in which an attacker poisons the labels of data to compromise the functionality of the system. We develop Gradient-based Data Subversion strategies to achieve model degradation under the assumption that the attacker has limited-knowledge of the victim model. We exploit the gradients of a differentiable convex loss function (residual errors) with respect to the predicted label as a warm-start and formulate different strategies to find a set of data instances to contaminate. Further, we analyze the transferability of attacks and the susceptibility of binary classifiers. Our experiments show that the proposed approach outperforms the baselines and is computationally efficient.