Multimodal data arise in various applications where information about the same phenomenon is acquired from multiple sensors and across different imaging modalities. Learning from multimodal data is of great interest in machine learning and statistics research as this offers the possibility of capturing complementary information among modalities. Multimodal modeling helps to explain the interdependence between heterogeneous data sources, discovers new insights that may not be available from a single modality, and improves decision-making. Recently, coupled matrix-tensor factorization has been introduced for multimodal data fusion to jointly estimate latent factors and identify complex interdependence among the latent factors. However, most of the prior work on coupled matrix-tensor factors focuses on unsupervised learning and there is little work on supervised learning using the jointly estimated latent factors. This paper considers the multimodal tensor data classification problem. A Coupled Support Tensor Machine (C-STM) built upon the latent factors jointly estimated from the Advanced Coupled Matrix Tensor Factorization (ACMTF) is proposed. C-STM combines individual and shared latent factors with multiple kernels and estimates a maximal-margin classifier for coupled matrix tensor data. The classification risk of C-STM is shown to converge to the optimal Bayes risk, making it a statistically consistent rule. C-STM is validated through simulation studies as well as a simultaneous EEG-fMRI analysis. The empirical evidence shows that C-STM can utilize information from multiple sources and provide a better classification performance than traditional single-mode classifiers.

Histopathological image analysis is the gold standard to diagnose cancer. Carcinoma is a subtype of cancer that constitutes more than 80% of all cancer cases. Squamous cell carcinoma and adenocarcinoma are two major subtypes of carcinoma, diagnosed by microscopic study of biopsy slides. However, manual microscopic evaluation is a subjective and time-consuming process. Many researchers have reported methods to automate carcinoma detection and classification. The increasing use of artificial intelligence (AI) in the automation of carcinoma diagnosis also reveals a significant rise in the use of deep network models. In this systematic literature review, we present a comprehensive review of the state-of-the-art approaches reported in carcinoma diagnosis using histopathological images. Studies are selected from well-known databases with strict inclusion/exclusion criteria. We have categorized the articles and recapitulated their methods based on specific organs of carcinoma origin. Further, we have summarized pertinent literature on AI methods, highlighted critical challenges and limitations, and provided insights on future research direction in automated carcinoma diagnosis. Out of 101 articles selected, most of the studies experimented on private datasets with varied image sizes, obtaining accuracy between 63% and 100%. Overall, this review highlights the need for a generalized AI-based carcinoma diagnostic system. Additionally, it is desirable to have accountable approaches to extract microscopic features from images of multiple magnifications that should mimic pathologists' evaluations.

Removing the bias and variance of multicentre data has always been a challenge in large scale digital healthcare studies, which requires the ability to integrate clinical features extracted from data acquired by different scanners and protocols to improve stability and robustness. Previous studies have described various computational approaches to fuse single modality multicentre datasets. However, these surveys rarely focused on evaluation metrics and lacked a checklist for computational data harmonisation studies. In this systematic review, we summarise the computational data harmonisation approaches for multi-modality data in the digital healthcare field, including harmonisation strategies and evaluation metrics based on different theories. In addition, a comprehensive checklist that summarises common practices for data harmonisation studies is proposed to guide researchers to report their research findings more effectively. Last but not least, flowcharts presenting possible ways for methodology and metric selection are proposed and the limitations of different methods have been surveyed for future research.

The application of Deep Neural Networks (DNNs) to a broad variety of tasks demands methods for coping with the complex and opaque nature of these architectures. The analysis of performance can be pursued in two ways. On one side, model interpretation techniques aim at "opening the box" to assess the relationship between the input, the inner layers, and the output. For example, saliency and attention models exploit knowledge of the architecture to capture the essential regions of the input that have the most impact on the inference process and output. On the other hand, models can be analysed as "black boxes", e.g., by associating the input samples with extra annotations that do not contribute to model training but can be exploited for characterizing the model response. Such performance-driven meta-annotations enable the detailed characterization of performance metrics and errors and help scientists identify the features of the input responsible for prediction failures and focus their model improvement efforts. This paper presents a structured survey of the tools that support the "black box" analysis of DNNs and discusses the gaps in the current proposals and the relevant future directions in this research field.

Modern face recognition systems (FRS) still fall short when the subjects are wearing facial masks, a common theme in the age of respiratory pandemics. An intuitive partial remedy is to add a mask detector to flag any masked faces so that the FRS can act accordingly for those low-confidence masked faces. In this work, we set out to investigate the potential vulnerability of such FRS, equipped with a mask detector, on large-scale masked faces. As existing face recognizers and mask detectors have high performance in their respective tasks, it is a challenge to simultaneously fool them and preserve the transferability of the attack. To this end, we devise realistic facial masks that exhibit partial face patterns (i.e., faced masks) and stealthily add adversarial textures that can not only lead to significant performance deterioration of the SOTA deep learning-based FRS, but also remain undetected by the SOTA facial mask detector, thus successfully fooling both systems at the same time. The proposed method unveils the vulnerability of the FRS when dealing with masked faces wearing faced masks.

To assess fetal health during pregnancy, doctors use the gestational age (GA) calculation based on the Crown Rump Length (CRL) measurement in order to check for fetal size and growth trajectory. However, GA estimation based on CRL, requires proper positioning of calipers on the fetal crown and rump view, which is not always an easy plane to find, especially for an inexperienced sonographer. Finding a slightly oblique view from the true CRL view could lead to a different CRL value and therefore incorrect estimation of GA. This study presents an AI-based method for a quality assessment of the CRL view by verifying 7 clinical scoring criteria that are used to verify the correctness of the acquired plane. We show how our proposed solution achieves high accuracy on the majority of the scoring criteria when compared to an expert. We also show that if such scoring system is used, it helps identify poorly acquired images accurately and hence may help sonographers acquire better images which could potentially lead to a better assessment of conditions such as Intrauterine Growth Restriction (IUGR).

The issue of fairness in machine learning stems from the fact that historical data often displays biases against specific groups of people which have been underprivileged in the recent past, or still are. In this context, one of the possible approaches is to employ fair representation learning algorithms which are able to remove biases from data, making groups statistically indistinguishable. In this paper, we instead develop a fair representation learning algorithm which is able to map individuals belonging to different groups in a single group. This is made possible by training a pair of Normalizing Flow models and constraining them to not remove information about the ground truth by training a ranking or classification model on top of them. The overall, ``chained'' model is invertible and has a tractable Jacobian, which allows to relate together the probability densities for different groups and ``translate'' individuals from one group to another. We show experimentally that our methodology is competitive with other fair representation learning algorithms. Furthermore, our algorithm achieves stronger invariance w.r.t. the sensitive attribute.

Kernel methods provide a principled approach to nonparametric learning. While their basic implementations scale poorly to large problems, recent advances showed that approximate solvers can efficiently handle massive datasets. A shortcoming of these solutions is that hyperparameter tuning is not taken care of, and left for the user to perform. Hyperparameters are crucial in practice and the lack of automated tuning greatly hinders efficiency and usability. In this paper, we work to fill in this gap focusing on kernel ridge regression based on the Nystr\"om approximation. After reviewing and contrasting a number of hyperparameter tuning strategies, we propose a complexity regularization criterion based on a data dependent penalty, and discuss its efficient optimization. Then, we proceed to a careful and extensive empirical evaluation highlighting strengths and weaknesses of the different tuning strategies. Our analysis shows the benefit of the proposed approach, that we hence incorporate in a library for large scale kernel methods to derive adaptively tuned solutions.

Backdoor attacks have been widely studied to hide the misclassification rules in the normal models, which are only activated when the model is aware of the specific inputs (i.e., the trigger). However, despite their success in the conventional Euclidean space, there are few studies of backdoor attacks on graph structured data. In this paper, we propose a new type of backdoor which is specific to graph data, called neighboring backdoor. Considering the discreteness of graph data, how to effectively design the triggers while retaining the model accuracy on the original task is the major challenge. To address such a challenge, we set the trigger as a single node, and the backdoor is activated when the trigger node is connected to the target node. To preserve the model accuracy, the model parameters are not allowed to be modified. Thus, when the trigger node is not connected, the model performs normally. Under these settings, in this work, we focus on generating the features of the trigger node. Two types of backdoors are proposed: (1) Linear Graph Convolution Backdoor which finds an approximation solution for the feature generation (can be viewed as an integer programming problem) by looking at the linear part of GCNs. (2) Variants of existing graph attacks. We extend current gradient-based attack methods to our backdoor attack scenario. Extensive experiments on two social networks and two citation networks datasets demonstrate that all proposed backdoors can achieve an almost 100\% attack success rate while having no impact on predictive accuracy.

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