Background and Objectives: Reproducibility is a major challenge in developing machine learning (ML)-based solutions in computational pathology (CompPath). The NCI Imaging Data Commons (IDC) provides >120 cancer image collections according to the FAIR principles and is designed to be used with cloud ML services. Here, we explore its potential to facilitate reproducibility in CompPath research. Methods: Using the IDC, we implemented two experiments in which a representative ML-based method for classifying lung tumor tissue was trained and/or evaluated on different datasets. To assess reproducibility, the experiments were run multiple times with separate but identically configured instances of common ML services. Results: The AUC values of different runs of the same experiment were generally consistent. However, we observed small variations in AUC values of up to 0.045, indicating a practical limit to reproducibility. Conclusions: We conclude that the IDC facilitates approaching the reproducibility limit of CompPath research (i) by enabling researchers to reuse exactly the same datasets and (ii) by integrating with cloud ML services so that experiments can be run in identically configured computing environments.

Maximum mean discrepancy (MMD) refers to a general class of nonparametric two-sample tests that are based on maximizing the mean difference over samples from one distribution $P$ versus another $Q$, over all choices of data transformations $f$ living in some function space $\mathcal{F}$. Inspired by recent work that connects what are known as functions of $\textit{Radon bounded variation}$ (RBV) and neural networks (Parhi and Nowak, 2021, 2023), we study the MMD defined by taking $\mathcal{F}$ to be the unit ball in the RBV space of a given smoothness order $k \geq 0$. This test, which we refer to as the $\textit{Radon-Kolmogorov-Smirnov}$ (RKS) test, can be viewed as a generalization of the well-known and classical Kolmogorov-Smirnov (KS) test to multiple dimensions and higher orders of smoothness. It is also intimately connected to neural networks: we prove that the witness in the RKS test -- the function $f$ achieving the maximum mean difference -- is always a ridge spline of degree $k$, i.e., a single neuron in a neural network. This allows us to leverage the power of modern deep learning toolkits to (approximately) optimize the criterion that underlies the RKS test. We prove that the RKS test has asymptotically full power at distinguishing any distinct pair $P \not= Q$ of distributions, derive its asymptotic null distribution, and carry out extensive experiments to elucidate the strengths and weakenesses of the RKS test versus the more traditional kernel MMD test.

Out-of-distribution (OOD) detection is essential for the safe deployment of AI. Particularly, OOD detectors should generalize effectively across diverse scenarios. To improve upon the generalizability of existing OOD detectors, we introduce a highly versatile OOD detector, called Neural Collapse inspired OOD detector (NC-OOD). We extend the prevalent observation that in-distribution (ID) features tend to form clusters, whereas OOD features are far away. Particularly, based on the recent observation, Neural Collapse, we further demonstrate that ID features tend to cluster in proximity to weight vectors. From our extended observation, we propose to detect OOD based on feature proximity to weight vectors. To further rule out OOD samples, we leverage the observation that OOD features tend to reside closer to the origin than ID features. Extensive experiments show that our approach enhances the generalizability of existing work and can consistently achieve state-of-the-art OOD detection performance across a wide range of OOD Benchmarks over different classification tasks, training losses, and model architectures. Machine learning models deployed in practice will inevitably encounter samples that deviate from the training distribution. As a classifier cannot make meaningful predictions on test samples that belong to unseen classes during training, it is important to actively detect and handle Out-of-Distribution (OOD) samples. Considering the diverse application scenarios, an effective OOD detector should generalize across classification tasks of different input resolutions, number of classes, classification accuracy, as well as classifiers under different training schemes and architectures. Since Nguyen et al. (2015) reveals that neural networks tend to be over-confident on OOD samples, an extensive body of research has been focused on developing effective OOD detection algorithms.

Biometry has proved its capability in terms of recognition accuracy. Now, it is widely used for automated border control with the biometric passport, to unlock a smartphone or a computer with a fingerprint or a face recognition algorithm. While identity verification is widely democratized, pure identification with no additional clues is still a work in progress. The identification difficulty depends on the population size, as the larger the group is, the larger the confusion risk. For collision prevention, biometric traits must be sufficiently distinguishable to scale to considerable groups, and algorithms should be able to capture their differences accurately. Most biometric works are purely experimental, and it is impossible to extrapolate the results to a smaller or a larger group. In this work, we propose a theoretical analysis of the distinguishability problem, which governs the error rates of biometric systems. We demonstrate simple relationships between the population size and the number of independent bits necessary to prevent collision in the presence of noise. This work provides the lowest lower bound for memory requirements. The results are very encouraging, as the biometry of the whole Earth population can fit in a regular disk, leaving some space for noise and redundancy.

We propose a dual-stream multi-scale vision transformer (DS-MSHViT) architecture that processes RGB and optical flow inputs for efficient sewer defect classification. Unlike existing methods that combine the predictions of two separate networks trained on each modality, we jointly train a single network with two branches for RGB and motion. Our key idea is to use self-attention regularization to harness the complementary strengths of the RGB and motion streams. The motion stream alone struggles to generate accurate attention maps, as motion images lack the rich visual features present in RGB images. To facilitate this, we introduce an attention consistency loss between the dual streams. By leveraging motion cues through a self-attention regularizer, we align and enhance RGB attention maps, enabling the network to concentrate on pertinent input regions. We evaluate our data on a public dataset as well as cross-validate our model performance in a novel dataset. Our method outperforms existing models that utilize either convolutional neural networks (CNNs) or multi-scale hybrid vision transformers (MSHViTs) without employing attention regularization between the two streams.

Supervised learning models have been used in various domains such as lending, college admission, face recognition, natural language processing, etc. However, they may inherit pre-existing biases from training data and exhibit discrimination against protected social groups. Various fairness notions have been proposed to address unfairness issues. In this work, we focus on Equalized Loss (EL), a fairness notion that requires the expected loss to be (approximately) equalized across different groups. Imposing EL on the learning process leads to a non-convex optimization problem even if the loss function is convex, and the existing fair learning algorithms cannot properly be adopted to find the fair predictor under the EL constraint. This paper introduces an algorithm that can leverage off-the-shelf convex programming tools (e.g., CVXPY) to efficiently find the global optimum of this non-convex optimization. In particular, we propose the ELminimizer algorithm, which finds the optimal fair predictor under EL by reducing the non-convex optimization to a sequence of convex optimization problems. We theoretically prove that our algorithm finds the global optimal solution under certain conditions. Then, we support our theoretical results through several empirical studies.

Discriminatively trained, deterministic neural networks are the de facto choice for classification problems. However, even though they achieve state-of-the-art results on in-domain test sets, they tend to be overconfident on out-of-distribution (OOD) data. For instance, ReLU networks -- a popular class of neural network architectures -- have been shown to almost always yield high confidence predictions when the test data are far away from the training set, even when they are trained with OOD data. We overcome this problem by adding a term to the output of the neural network that corresponds to the logit of an extra class, that we design to dominate the logits of the original classes as we move away from the training data.This technique provably prevents arbitrarily high confidence on far-away test data while maintaining a simple discriminative point-estimate training. Evaluation on various benchmarks demonstrates strong performance against competitive baselines on both far-away and realistic OOD data.

Deep learning models are widely used in critical applications, highlighting the need for pre-deployment model understanding and improvement. Visual concept-based methods, while increasingly used for this purpose, face challenges: (1) most concepts lack interpretability, (2) existing methods require model knowledge, often unavailable at run time. Additionally, (3) there lacks a no-code method for post-understanding model improvement. Addressing these, we present InterVLS. The system facilitates model understanding by discovering text-aligned concepts, measuring their influence with model-agnostic linear surrogates. Employing visual analytics, InterVLS offers concept-based explanations and performance insights. It enables users to adjust concept influences to update a model, facilitating no-code model improvement. We evaluate InterVLS in a user study, illustrating its functionality with two scenarios. Results indicates that InterVLS is effective to help users identify influential concepts to a model, gain insights and adjust concept influence to improve the model. We conclude with a discussion based on our study results.

The pursuit of fairness in machine learning models has emerged as a critical research challenge in different applications ranging from bank loan approval to face detection. Despite the widespread adoption of artificial intelligence algorithms across various domains, concerns persist regarding the presence of biases and discrimination within these models. To address this pressing issue, this study introduces a novel method called "The Fairness Stitch (TFS)" to enhance fairness in deep learning models. This method combines model stitching and training jointly, while incorporating fairness constraints. In this research, we assess the effectiveness of our proposed method by conducting a comprehensive evaluation of two well-known datasets, CelebA and UTKFace. We systematically compare the performance of our approach with the existing baseline method. Our findings reveal a notable improvement in achieving a balanced trade-off between fairness and performance, highlighting the promising potential of our method to address bias-related challenges and foster equitable outcomes in machine learning models. This paper poses a challenge to the conventional wisdom of the effectiveness of the last layer in deep learning models for de-biasing.

Ensuring fairness in decision-making systems within Human-Cyber-Physical-Systems (HCPS) is a pressing concern, particularly when diverse individuals, each with varying behaviors and expectations, coexist within the same application space, influenced by a shared set of control actions in the system. The long-term adverse effects of these actions further pose the challenge, as historical experiences and interactions shape individual perceptions of fairness. This paper addresses the challenge of fairness from an equity perspective of adverse effects, taking into account the dynamic nature of human behavior and evolving preferences while recognizing the lasting impact of adverse effects. We formally introduce the concept of Fairness-in-Adverse-Effects (FinA) within the HCPS context. We put forth a comprehensive set of five formulations for FinA, encompassing both the instantaneous and long-term aspects of adverse effects. To empirically validate the effectiveness of our FinA approach, we conducted an evaluation within the domain of smart homes, a pertinent HCPS application. The outcomes of our evaluation demonstrate that the adoption of FinA significantly enhances the overall perception of fairness among individuals, yielding an average improvement of 66.7% when compared to the state-of-the-art method.