This study examines the impact of class-imbalanced data on deep learning models and proposes a technique for data balancing by generating synthetic data for the minority class. Unlike random-based oversampling, our method prioritizes balancing the informative regions by identifying high entropy samples. Generating well-placed synthetic data can enhance machine learning algorithms accuracy and efficiency, whereas poorly-placed ones may lead to higher misclassification rates. We introduce an algorithm that maximizes the probability of generating a synthetic sample in the correct region of its class by optimizing the class posterior ratio. Additionally, to maintain data topology, synthetic data are generated within each minority sample's neighborhood. Our experimental results on forty-one datasets demonstrate the superior performance of our technique in enhancing deep-learning models.

Pulmonary nodules may be an early manifestation of lung cancer, the leading cause of cancer-related deaths among both men and women. Numerous studies have established that deep learning methods can yield high-performance levels in the detection of lung nodules in chest X-rays. However, the lack of gold-standard public datasets slows down the progression of the research and prevents benchmarking of methods for this task. To address this, we organized a public research challenge, NODE21, aimed at the detection and generation of lung nodules in chest X-rays. While the detection track assesses state-of-the-art nodule detection systems, the generation track determines the utility of nodule generation algorithms to augment training data and hence improve the performance of the detection systems. This paper summarizes the results of the NODE21 challenge and performs extensive additional experiments to examine the impact of the synthetically generated nodule training images on the detection algorithm performance.

Anticancer peptides (ACPs) are a class of molecules that have gained significant attention in the field of cancer research and therapy. ACPs are short chains of amino acids, the building blocks of proteins, and they possess the ability to selectively target and kill cancer cells. One of the key advantages of ACPs is their ability to selectively target cancer cells while sparing healthy cells to a greater extent. This selectivity is often attributed to differences in the surface properties of cancer cells compared to normal cells. That is why ACPs are being investigated as potential candidates for cancer therapy. ACPs may be used alone or in combination with other treatment modalities like chemotherapy and radiation therapy. While ACPs hold promise as a novel approach to cancer treatment, there are challenges to overcome, including optimizing their stability, improving selectivity, and enhancing their delivery to cancer cells, continuous increasing in number of peptide sequences, developing a reliable and precise prediction model. In this work, we propose an efficient transformer-based framework to identify anticancer peptides for by performing accurate a reliable and precise prediction model. For this purpose, four different transformer models, namely ESM, ProtBert, BioBERT, and SciBERT are employed to detect anticancer peptides from amino acid sequences. To demonstrate the contribution of the proposed framework, extensive experiments are carried on widely-used datasets in the literature, two versions of AntiCp2, cACP-DeepGram, ACP-740. Experiment results show the usage of proposed model enhances classification accuracy when compared to the state-of-the-art studies. The proposed framework, ESM, exhibits 96.45 of accuracy for AntiCp2 dataset, 97.66 of accuracy for cACP-DeepGram dataset, and 88.51 of accuracy for ACP-740 dataset, thence determining new state-of-the-art.

Semantic segmentation methods have advanced significantly. Still, their robustness to real-world perturbations and object types not seen during training remains a challenge, particularly in safety-critical applications. We propose a novel approach to improve the robustness of semantic segmentation techniques by leveraging the synergy between label-to-image generators and image-to-label segmentation models. Specifically, we design Robusta, a novel robust conditional generative adversarial network to generate realistic and plausible perturbed images that can be used to train reliable segmentation models. We conduct in-depth studies of the proposed generative model, assess the performance and robustness of the downstream segmentation network, and demonstrate that our approach can significantly enhance the robustness in the face of real-world perturbations, distribution shifts, and out-of-distribution samples. Our results suggest that this approach could be valuable in safety-critical applications, where the reliability of perception modules such as semantic segmentation is of utmost importance and comes with a limited computational budget in inference. We release our code at https://github.com/ENSTA-U2IS/robusta.

Introducing HyperSense, our co-designed hardware and software system efficiently controls Analog-to-Digital Converter (ADC) modules' data generation rate based on object presence predictions in sensor data. Addressing challenges posed by escalating sensor quantities and data rates, HyperSense reduces redundant digital data using energy-efficient low-precision ADC, diminishing machine learning system costs. Leveraging neurally-inspired HyperDimensional Computing (HDC), HyperSense analyzes real-time raw low-precision sensor data, offering advantages in handling noise, memory-centricity, and real-time learning. Our proposed HyperSense model combines high-performance software for object detection with real-time hardware prediction, introducing the novel concept of Intelligent Sensor Control. Comprehensive software and hardware evaluations demonstrate our solution's superior performance, evidenced by the highest Area Under the Curve (AUC) and sharpest Receiver Operating Characteristic (ROC) curve among lightweight models. Hardware-wise, our FPGA-based domain-specific accelerator tailored for HyperSense achieves a 5.6x speedup compared to YOLOv4 on NVIDIA Jetson Orin while showing up to 92.1% energy saving compared to the conventional system. These results underscore HyperSense's effectiveness and efficiency, positioning it as a promising solution for intelligent sensing and real-time data processing across diverse applications.

Global financial crime activity is driving demand for machine learning solutions in fraud prevention. However, prevention systems are commonly serviced to financial institutions in isolation, and few provisions exist for data sharing due to fears of unintentional leaks and adversarial attacks. Collaborative learning advances in finance are rare, and it is hard to find real-world insights derived from privacy-preserving data processing systems. In this paper, we present a collaborative deep learning framework for fraud prevention, designed from a privacy standpoint, and awarded at the recent PETs Prize Challenges. We leverage latent embedded representations of varied-length transaction sequences, along with local differential privacy, in order to construct a data release mechanism which can securely inform externally hosted fraud and anomaly detection models. We assess our contribution on two distributed data sets donated by large payment networks, and demonstrate robustness to popular inference-time attacks, along with utility-privacy trade-offs analogous to published work in alternative application domains.

This project explores adversarial training techniques to develop fairer Deep Neural Networks (DNNs) to mitigate the inherent bias they are known to exhibit. DNNs are susceptible to inheriting bias with respect to sensitive attributes such as race and gender, which can lead to life-altering outcomes (e.g., demographic bias in facial recognition software used to arrest a suspect). We propose a robust optimization problem, which we demonstrate can improve fairness in several datasets, both synthetic and real-world, using an affine linear model. Leveraging second order information, we are able to find a solution to our optimization problem more efficiently than a purely first order method.

Out-of-distribution (OOD) detection plays a crucial role in ensuring the security of neural networks. Existing works have leveraged the fact that In-distribution (ID) samples form a subspace in the feature space, achieving state-of-the-art (SOTA) performance. However, the comprehensive characteristics of the ID subspace still leave under-explored. Recently, the discovery of Neural Collapse ($\mathcal{NC}$) sheds light on novel properties of the ID subspace. Leveraging insight from $\mathcal{NC}$, we observe that the Principal Angle between the features and the ID feature subspace forms a superior representation for measuring the likelihood of OOD. Building upon this observation, we propose a novel $\mathcal{NC}$-inspired OOD scoring function, named Entropy-enhanced Principal Angle (EPA), which integrates both the global characteristic of the ID subspace and its inner property. We experimentally compare EPA with various SOTA approaches, validating its superior performance and robustness across different network architectures and OOD datasets.

Self-supervised learning (SSL) has become the de facto training paradigm of large models where pre-training is followed by supervised fine-tuning using domain-specific data and labels. Hypothesizing that SSL models would learn more generic, hence less biased, representations, this study explores the impact of pre-training and fine-tuning strategies on fairness (i.e., performing equally on different demographic breakdowns). Motivated by human-centric applications on real-world timeseries data, we interpret inductive biases on the model, layer, and metric levels by systematically comparing SSL models to their supervised counterparts. Our findings demonstrate that SSL has the capacity to achieve performance on par with supervised methods while significantly enhancing fairness--exhibiting up to a 27% increase in fairness with a mere 1% loss in performance through self-supervision. Ultimately, this work underscores SSL's potential in human-centric computing, particularly high-stakes, data-scarce application domains like healthcare.

We investigate whether general-domain large language models such as GPT-4 Turbo can perform risk stratification and predict post-operative outcome measures using a description of the procedure and a patient's clinical notes derived from the electronic health record. We examine predictive performance on 8 different tasks: prediction of ASA Physical Status Classification, hospital admission, ICU admission, unplanned admission, hospital mortality, PACU Phase 1 duration, hospital duration, and ICU duration. Few-shot and chain-of-thought prompting improves predictive performance for several of the tasks. We achieve F1 scores of 0.50 for ASA Physical Status Classification, 0.81 for ICU admission, and 0.86 for hospital mortality. Performance on duration prediction tasks were universally poor across all prompt strategies. Current generation large language models can assist clinicians in perioperative risk stratification on classification tasks and produce high-quality natural language summaries and explanations.