Traditionally, pathological analysis and diagnosis are performed by manually eyeballing glass slide specimens under a microscope by an expert. The whole slide image is the digital specimen produced from the glass slide. Whole slide image enabled specimens to be observed on a computer screen and led to computational pathology where computer vision and artificial intelligence are utilized for automated analysis and diagnosis. With the current computational advancement, the entire whole slide image can be analyzed autonomously without human supervision. However, the analysis could fail or lead to wrong diagnosis if the whole slide image is affected by tissue artifacts such as tissue fold or air bubbles depending on the severity. Existing artifact detection methods rely on experts for severity assessment to eliminate artifact affected regions from the analysis. This process is time consuming, exhausting and undermines the goal of automated analysis or removal of artifacts without evaluating their severity, which could result in the loss of diagnostically important data. Therefore, it is necessary to detect artifacts and then assess their severity automatically. In this paper, we propose a system that incorporates severity evaluation with artifact detection utilizing convolutional neural networks. The proposed system uses DoubleUNet to segment artifacts and an ensemble network of six fine tuned convolutional neural network models to determine severity. This method outperformed current state of the art in accuracy by 9 percent for artifact segmentation and achieved a strong correlation of 97 percent with the evaluation of pathologists for severity assessment. The robustness of the system was demonstrated using our proposed heterogeneous dataset and practical usability was ensured by integrating it with an automated analysis system.

Model selection is a necessary step in unsupervised machine learning. Despite numerous criteria and metrics, model selection remains subjective. A high degree of subjectivity may lead to questions about repeatability and reproducibility of various machine learning studies and doubts about the robustness of models deployed in the real world. Yet, the impact of modelers' preferences on model selection outcomes remains largely unexplored. This study uses the Hidden Markov Model as an example to investigate the subjectivity involved in model selection. We asked 33 participants and three Large Language Models (LLMs) to make model selections in three scenarios. Results revealed variability and inconsistencies in both the participants' and the LLMs' choices, especially when different criteria and metrics disagree. Sources of subjectivity include varying opinions on the importance of different criteria and metrics, differing views on how parsimonious a model should be, and how the size of a dataset should influence model selection. The results underscore the importance of developing a more standardized way to document subjective choices made in model selection processes.

We introduce Dagma-DCE, an interpretable and model-agnostic scheme for differentiable causal discovery. Current non- or over-parametric methods in differentiable causal discovery use opaque proxies of ``independence'' to justify the inclusion or exclusion of a causal relationship. We show theoretically and empirically that these proxies may be arbitrarily different than the actual causal strength. Juxtaposed to existing differentiable causal discovery algorithms, \textsc{Dagma-DCE} uses an interpretable measure of causal strength to define weighted adjacency matrices. In a number of simulated datasets, we show our method achieves state-of-the-art level performance. We additionally show that \textsc{Dagma-DCE} allows for principled thresholding and sparsity penalties by domain-experts. The code for our method is available open-source at https://github.com/DanWaxman/DAGMA-DCE, and can easily be adapted to arbitrary differentiable models.

Their Machine learning models underpin many modern financial systems rapid success has been in no small part due to the development of for use cases such as fraud detection and churn prediction. Most self-supervised learning (SSL) methods such as autoregressive [27] are based on supervised learning with hand-engineered features, and masked [13] language modelling which have allowed models which relies heavily on the availability of labelled data. Large selfsupervised to learn contextual representations of input tokens without relying generative models have shown tremendous success on labels. in natural language processing and computer vision, yet so far While these methods have already been successfully used with they haven't been adapted to multivariate time series of financial different modalities such as natural language [4, 11, 22, 27, 28], transactions. In this paper, we present a generative pretraining computer vision [26, 30], audio [3, 12], and tabular data [1, 20, 31] method that can be used to obtain contextualised embeddings of there has been little work to adapt them to the case of multivariate financial transactions. Benchmarks on public datasets demonstrate time series data. One example of such data modality of particular that it outperforms state-of-the-art self-supervised methods on a interest in this work is streams of financial transactions - sequences range of downstream tasks. We additionally perform large-scale of events representing transfers of funds between two entities. Each pretraining of an embedding model using a corpus of data from 180 event can be described by a set of numerical or categorical features, issuing banks containing 5.1 billion transactions and apply it to the such as the timestamp, card number, transaction amount, merchant card fraud detection problem on hold-out datasets.

This research introduces a novel approach, MBO-NB, that leverages Migrating Birds Optimization (MBO) coupled with Naive Bayes as an internal classifier to address feature selection challenges in text classification having large number of features. Focusing on computational efficiency, we preprocess raw data using the Information Gain algorithm, strategically reducing the feature count from an average of 62221 to 2089. Our experiments demonstrate MBO-NB's superior effectiveness in feature reduction compared to other existing techniques, emphasizing an increased classification accuracy. The successful integration of Naive Bayes within MBO presents a well-rounded solution. In individual comparisons with Particle Swarm Optimization (PSO), MBO-NB consistently outperforms by an average of 6.9% across four setups. This research offers valuable insights into enhancing feature selection methods, providing a scalable and effective solution for text classification

This study examines the impact of class-imbalanced data on deep learning models and proposes a technique for data balancing by generating synthetic data for the minority class. Unlike random-based oversampling, our method prioritizes balancing the informative regions by identifying high entropy samples. Generating well-placed synthetic data can enhance machine learning algorithms accuracy and efficiency, whereas poorly-placed ones may lead to higher misclassification rates. We introduce an algorithm that maximizes the probability of generating a synthetic sample in the correct region of its class by optimizing the class posterior ratio. Additionally, to maintain data topology, synthetic data are generated within each minority sample's neighborhood. Our experimental results on forty-one datasets demonstrate the superior performance of our technique in enhancing deep-learning models.

Pulmonary nodules may be an early manifestation of lung cancer, the leading cause of cancer-related deaths among both men and women. Numerous studies have established that deep learning methods can yield high-performance levels in the detection of lung nodules in chest X-rays. However, the lack of gold-standard public datasets slows down the progression of the research and prevents benchmarking of methods for this task. To address this, we organized a public research challenge, NODE21, aimed at the detection and generation of lung nodules in chest X-rays. While the detection track assesses state-of-the-art nodule detection systems, the generation track determines the utility of nodule generation algorithms to augment training data and hence improve the performance of the detection systems. This paper summarizes the results of the NODE21 challenge and performs extensive additional experiments to examine the impact of the synthetically generated nodule training images on the detection algorithm performance.

Anticancer peptides (ACPs) are a class of molecules that have gained significant attention in the field of cancer research and therapy. ACPs are short chains of amino acids, the building blocks of proteins, and they possess the ability to selectively target and kill cancer cells. One of the key advantages of ACPs is their ability to selectively target cancer cells while sparing healthy cells to a greater extent. This selectivity is often attributed to differences in the surface properties of cancer cells compared to normal cells. That is why ACPs are being investigated as potential candidates for cancer therapy. ACPs may be used alone or in combination with other treatment modalities like chemotherapy and radiation therapy. While ACPs hold promise as a novel approach to cancer treatment, there are challenges to overcome, including optimizing their stability, improving selectivity, and enhancing their delivery to cancer cells, continuous increasing in number of peptide sequences, developing a reliable and precise prediction model. In this work, we propose an efficient transformer-based framework to identify anticancer peptides for by performing accurate a reliable and precise prediction model. For this purpose, four different transformer models, namely ESM, ProtBert, BioBERT, and SciBERT are employed to detect anticancer peptides from amino acid sequences. To demonstrate the contribution of the proposed framework, extensive experiments are carried on widely-used datasets in the literature, two versions of AntiCp2, cACP-DeepGram, ACP-740. Experiment results show the usage of proposed model enhances classification accuracy when compared to the state-of-the-art studies. The proposed framework, ESM, exhibits 96.45 of accuracy for AntiCp2 dataset, 97.66 of accuracy for cACP-DeepGram dataset, and 88.51 of accuracy for ACP-740 dataset, thence determining new state-of-the-art.

Semantic segmentation methods have advanced significantly. Still, their robustness to real-world perturbations and object types not seen during training remains a challenge, particularly in safety-critical applications. We propose a novel approach to improve the robustness of semantic segmentation techniques by leveraging the synergy between label-to-image generators and image-to-label segmentation models. Specifically, we design Robusta, a novel robust conditional generative adversarial network to generate realistic and plausible perturbed images that can be used to train reliable segmentation models. We conduct in-depth studies of the proposed generative model, assess the performance and robustness of the downstream segmentation network, and demonstrate that our approach can significantly enhance the robustness in the face of real-world perturbations, distribution shifts, and out-of-distribution samples. Our results suggest that this approach could be valuable in safety-critical applications, where the reliability of perception modules such as semantic segmentation is of utmost importance and comes with a limited computational budget in inference. We release our code at https://github.com/ENSTA-U2IS/robusta.

Introducing HyperSense, our co-designed hardware and software system efficiently controls Analog-to-Digital Converter (ADC) modules' data generation rate based on object presence predictions in sensor data. Addressing challenges posed by escalating sensor quantities and data rates, HyperSense reduces redundant digital data using energy-efficient low-precision ADC, diminishing machine learning system costs. Leveraging neurally-inspired HyperDimensional Computing (HDC), HyperSense analyzes real-time raw low-precision sensor data, offering advantages in handling noise, memory-centricity, and real-time learning. Our proposed HyperSense model combines high-performance software for object detection with real-time hardware prediction, introducing the novel concept of Intelligent Sensor Control. Comprehensive software and hardware evaluations demonstrate our solution's superior performance, evidenced by the highest Area Under the Curve (AUC) and sharpest Receiver Operating Characteristic (ROC) curve among lightweight models. Hardware-wise, our FPGA-based domain-specific accelerator tailored for HyperSense achieves a 5.6x speedup compared to YOLOv4 on NVIDIA Jetson Orin while showing up to 92.1% energy saving compared to the conventional system. These results underscore HyperSense's effectiveness and efficiency, positioning it as a promising solution for intelligent sensing and real-time data processing across diverse applications.