We consider the problem of identifying patterns in a data set that exhibit anomalous behavior, often referred to as anomaly detection. In most anomaly detection algorithms, the dissimilarity between data samples is calculated by a single criterion, such as Euclidean distance. However, in many cases there may not exist a single dissimilarity measure that captures all possible anomalous patterns. In such a case, multiple criteria can be defined, and one can test for anomalies by scalarizing the multiple criteria using a linear combination of them. If the importance of the different criteria are not known in advance, the algorithm may need to be executed multiple times with different choices of weights in the linear combination. In this paper, we introduce a novel non-parametric multi-criteria anomaly detection method using Pareto depth analysis (PDA). PDA uses the concept of Pareto optimality to detect anomalies under multiple criteria without having to run an algorithm multiple times with different choices of weights. The proposed PDA approach scales linearly in the number of criteria and is provably better than linear combinations of the criteria.

In this paper we apply boosting to learn complex non-linear local visual feature representations, drawing inspiration from its successful application to visual object detection. The main goal of local feature descriptors is to distinctively represent a salient image region while remaining invariant to viewpoint and illumination changes. This representation can be improved using machine learning, however, past approaches have been mostly limited to learning linear feature mappings in either the original input or a kernelized input feature space. While kernelized methods have proven somewhat effective for learning non-linear local feature descriptors, they rely heavily on the choice of an appropriate kernel function whose selection is often difficult and non-intuitive. We propose to use the boosting-trick to obtain a non-linear mapping of the input to a high-dimensional feature space. The non-linear feature mapping obtained with the boosting-trick is highly intuitive. We employ gradient-based weak learners resulting in a learned descriptor that closely resembles the well-known SIFT. As demonstrated in our experiments, the resulting descriptor can be learned directly from intensity patches achieving state-of-the-art performance.

Glioblastoma is a highly aggressive and malignant brain tumor type that requires early diagnosis and prompt intervention. Due to its heterogeneity in appearance, developing automated detection approaches is challenging. To address this challenge, Artificial Intelligence (AI)-driven approaches in healthcare have generated interest in efficiently diagnosing and evaluating brain tumors. The Brain Tumor Segmentation Challenge (BraTS) is a platform for developing and assessing automated techniques for tumor analysis using high-quality, clinically acquired MRI data. In our approach, we utilized a multi-scale, attention-guided and hybrid U-Net-shaped model -- GLIMS -- to perform 3D brain tumor segmentation in three regions: Enhancing Tumor (ET), Tumor Core (TC), and Whole Tumor (WT). The multi-scale feature extraction provides better contextual feature aggregation in high resolutions and the Swin Transformer blocks improve the global feature extraction at deeper levels of the model. The segmentation mask generation in the decoder branch is guided by the attention-refined features gathered from the encoder branch to enhance the important attributes. Moreover, hierarchical supervision is used to train the model efficiently. Our model's performance on the validation set resulted in 92.19, 87.75, and 83.18 Dice Scores and 89.09, 84.67, and 82.15 Lesion-wise Dice Scores in WT, TC, and ET, respectively. The code is publicly available at https://github.com/yaziciz/GLIMS.

Overparameterized neural networks are loosely characterized as networks that have a very high fitting (or memorization) capacity with respect to their training data. Although capable of memorization of their training data, these networks intriguingly achieve very low test error close to their training error rates [1, 2]. Meanwhile, sparse neural networks have shown similar or better generalization performance than their dense counterparts while having higher parameter efficiency [3]. With increasing availability of hardware and software that support sparse computational operations [4, 5], there has been a growing interest in finding sparse sub-networks within large overparameterized models to either improve generalization performance or to gain computational efficiency at the same performance level [6, 7, 8, 3]. Earlier works on creating efficient sparse sub-networks include the now popular pruning technique [9]. These were motivated by the desire to achieve compute efficiency in resource constraint applications by finding smaller networks within a larger network space without losing task performance quality [10]. The original pruning technique involves fully training a larger network on some task, discarding the task-irrelevant connections, and then fine-tuning the remaining sparse sub-network on the task to achieve the a level of performance near that of the larger network. Connections were originally pruned based on loss Hessians [9, 11]. Later on, other techniques were proposed such as the removal of weak connections [12] based on weight value thresholds.

Causal Representation Learning (CRL) aims at identifying high-level causal factors and their relationships from high-dimensional observations, e.g., images. While most CRL works focus on learning causal representations in a single environment, in this work we instead propose a first step towards learning causal representations from temporal sequences of images that can be adapted in a new environment, or composed across multiple related environments. In particular, we introduce DECAF, a framework that detects which causal factors can be reused and which need to be adapted from previously learned causal representations. Our approach is based on the availability of intervention targets, that indicate which variables are perturbed at each time step. Experiments on three benchmark datasets show that integrating our framework with four state-of-the-art CRL approaches leads to accurate representations in a new environment with only a few samples.

Graph neural networks (GNNs) have attracted significant attention for their outstanding performance in graph learning and node classification tasks. However, their vulnerability to adversarial attacks, particularly through susceptible nodes, poses a challenge in decision-making. The need for robust graph summarization is evident in adversarial challenges resulting from the propagation of attacks throughout the entire graph. In this paper, we address both performance and adversarial robustness in graph input by introducing the novel technique SHERD (Subgraph Learning Hale through Early Training Representation Distances). SHERD leverages information from layers of a partially trained graph convolutional network (GCN) to detect susceptible nodes during adversarial attacks using standard distance metrics. The method identifies "vulnerable (bad)" nodes and removes such nodes to form a robust subgraph while maintaining node classification performance. Through our experiments, we demonstrate the increased performance of SHERD in enhancing robustness by comparing the network's performance on original and subgraph inputs against various baselines alongside existing adversarial attacks. Our experiments across multiple datasets, including citation datasets such as Cora, Citeseer, and Pubmed, as well as microanatomical tissue structures of cell graphs in the placenta, highlight that SHERD not only achieves substantial improvement in robust performance but also outperforms several baselines in terms of node classification accuracy and computational complexity.

Uncertainty Quantification aims to determine when the prediction from a Machine Learning model is likely to be wrong. Computer Vision research has explored methods for determining epistemic uncertainty (also known as model uncertainty), which should correspond with generalisation error. These methods theoretically allow to predict misclassifications due to inter-subject variability. We applied a variety of Uncertainty Quantification methods to predict misclassifications for a Motor Imagery Brain Computer Interface. Deep Ensembles performed best, both in terms of classification performance and cross-subject Uncertainty Quantification performance. However, we found that standard CNNs with Softmax output performed better than some of the more advanced methods.

The impact of using artificial intelligence (AI) to guide patient care or operational processes is an interplay of the AI model's output, the decision-making protocol based on that output, and the capacity of the stakeholders involved to take the necessary subsequent action. Estimating the effects of this interplay before deployment, and studying it in real time afterwards, are essential to bridge the chasm between AI model development and achievable benefit. To accomplish this, the Data Science team at Stanford Health Care has developed a Testing and Evaluation (T&E) mechanism to identify fair, useful and reliable AI models (FURM) by conducting an ethical review to identify potential value mismatches, simulations to estimate usefulness, financial projections to assess sustainability, as well as analyses to determine IT feasibility, design a deployment strategy, and recommend a prospective monitoring and evaluation plan. We report on FURM assessments done to evaluate six AI guided solutions for potential adoption, spanning clinical and operational settings, each with the potential to impact from several dozen to tens of thousands of patients each year. We describe the assessment process, summarize the six assessments, and share our framework to enable others to conduct similar assessments. Of the six solutions we assessed, two have moved into a planning and implementation phase. Our novel contributions - usefulness estimates by simulation, financial projections to quantify sustainability, and a process to do ethical assessments - as well as their underlying methods and open source tools, are available for other healthcare systems to conduct actionable evaluations of candidate AI solutions.

Cancer is one of the diseases that kill the most women in the world, with breast cancer being responsible for the highest number of cancer cases and consequently deaths. However, it can be prevented by early detection and, consequently, early treatment. Any development for detection or perdition this kind of cancer is important for a better healthy life. Many studies focus on a model with high accuracy in cancer prediction, but sometimes accuracy alone may not always be a reliable metric. This study implies an investigative approach to studying the performance of different machine learning algorithms based on boosting to predict breast cancer focusing on the recall metric. Boosting machine learning algorithms has been proven to be an effective tool for detecting medical diseases. The dataset of the University of California, Irvine (UCI) repository has been utilized to train and test the model classifier that contains their attributes. The main objective of this study is to use state-of-the-art boosting algorithms such as AdaBoost, XGBoost, CatBoost and LightGBM to predict and diagnose breast cancer and to find the most effective metric regarding recall, ROC-AUC, and confusion matrix. Furthermore, our study is the first to use these four boosting algorithms with Optuna, a library for hyperparameter optimization, and the SHAP method to improve the interpretability of our model, which can be used as a support to identify and predict breast cancer. We were able to improve AUC or recall for all the models and reduce the False Negative for AdaBoost and LigthGBM the final AUC were more than 99.41\% for all models.

The Internet of Medical Things (IoMT) transcends traditional medical boundaries, enabling a transition from reactive treatment to proactive prevention. This innovative method revolutionizes healthcare by facilitating early disease detection and tailored care, particularly in chronic disease management, where IoMT automates treatments based on real-time health data collection. Nonetheless, its benefits are countered by significant security challenges that endanger the lives of its users due to the sensitivity and value of the processed data, thereby attracting malicious interests. Moreover, the utilization of wireless communication for data transmission exposes medical data to interception and tampering by cybercriminals. Additionally, anomalies may arise due to human errors, network interference, or hardware malfunctions. In this context, anomaly detection based on Machine Learning (ML) is an interesting solution, but it comes up against obstacles in terms of explicability and protection of privacy. To address these challenges, a new framework for Intrusion Detection Systems (IDS) is introduced, leveraging Artificial Neural Networks (ANN) for intrusion detection while utilizing Federated Learning (FL) for privacy preservation. Additionally, eXplainable Artificial Intelligence (XAI) methods are incorporated to enhance model explanation and interpretation. The efficacy of the proposed framework is evaluated and compared with centralized approaches using multiple datasets containing network and medical data, simulating various attack types impacting the confidentiality, integrity, and availability of medical and physiological data. The results obtained offer compelling evidence that the FL method performs comparably to the centralized method, demonstrating high performance. Additionally, it affords the dual advantage of safeguarding privacy and providing model explanation.