Early identification of patients at risk of cardiovascular diseases (CVD) is crucial for effective preventive care, reducing healthcare burden, and improving patients' quality of life. This study demonstrates the potential of retinal optical coherence tomography (OCT) imaging combined with fundus photographs for identifying future adverse cardiac events. We used data from 977 patients who experienced CVD within a 5-year interval post-image acquisition, alongside 1,877 control participants without CVD, totaling 2,854 subjects. We propose a novel binary classification network based on a Multi-channel Variational Autoencoder (MCVAE), which learns a latent embedding of patients' fundus and OCT images to classify individuals into two groups: those likely to develop CVD in the future and those who are not. Our model, trained on both imaging modalities, achieved promising results (AUROC 0.78 +/- 0.02, accuracy 0.68 +/- 0.002, precision 0.74 +/- 0.02, sensitivity 0.73 +/- 0.02, and specificity 0.68 +/- 0.01), demonstrating its efficacy in identifying patients at risk of future CVD events based on their retinal images. This study highlights the potential of retinal OCT imaging and fundus photographs as cost-effective, non-invasive alternatives for predicting cardiovascular disease risk. The widespread availability of these imaging techniques in optometry practices and hospitals further enhances their potential for large-scale CVD risk screening. Our findings contribute to the development of standardized, accessible methods for early CVD risk identification, potentially improving preventive care strategies and patient outcomes.

Large Vision-Language Models (LVLMs) demonstrate impressive capabilities in generating detailed and coherent responses from visual inputs. However, they are prone to generate hallucinations due to an over-reliance on language priors. To address this issue, we investigate the language priors in LVLMs and make two key observations: (1) Even when predicting the tokens associated with image-related part-of-speech (POS), models increasingly rely on linguistic priors as the token sequences grow, thereby amplifying hallucinations. (2) Methods that directly calibrate LVLM's output distribution to mitigate language priors can lead to a degradation in text quality or even exacerbate hallucinations. Based on these findings, we propose a novel method, Summary-Guided Decoding (SGD). This method naturally encourages the model to focus more on image information by reducing the text context through summaries, while controlling only the image-related POS tokens to maintain text quality. Through experiments, we demonstrate that SGD achieves state-of-the-art performance on object hallucination benchmarks. Furthermore, in terms of the trade-off between precision and recall, SGD achieves Pareto optimality among the existing methods. Lastly, we observe that although existing methods struggle to balance the reduction of object hallucinations with maintaining text quality, SGD demonstrates robustness in handling this challenge.

A central question in human immunology is how a patient's repertoire of T cells impacts disease. Here, we introduce a method to infer the causal effects of T cell receptor (TCR) sequences on patient outcomes using observational TCR repertoire sequencing data and clinical outcomes data. Our approach corrects for unobserved confounders, such as a patient's environment and life history, by using the patient's immature, pre-selection TCR repertoire. The pre-selection repertoire can be estimated from nonproductive TCR data, which is widely available. It is generated by a randomized mutational process, V(D)J recombination, which provides a natural experiment. We show formally how to use the pre-selection repertoire to draw causal inferences, and develop a scalable neural-network estimator for our identification formula. Our method produces an estimate of the effect of interventions that add a specific TCR sequence to patient repertoires. As a demonstration, we use it to analyze the effects of TCRs on COVID-19 severity, uncovering potentially therapeutic TCRs that are (1) observed in patients, (2) bind SARS-CoV-2 antigens in vitro and (3) have strong positive effects on clinical outcomes.

Multimodal Large Language Models (MLLMs) have recently received substantial interest, which shows their emerging potential as general-purpose models for various vision-language tasks. MLLMs involve significant external knowledge within their parameters; however, it is challenging to continually update these models with the latest knowledge, which involves huge computational costs and poor interpretability. Retrieval augmentation techniques have proven to be effective plugins for both LLMs and MLLMs. In this study, we propose multimodal adaptive Retrieval-Augmented Bootstrapping Language-Image Pre-training (RA-BLIP), a novel retrieval-augmented framework for various MLLMs. Considering the redundant information within vision modality, we first leverage the question to instruct the extraction of visual information through interactions with one set of learnable queries, minimizing irrelevant interference during retrieval and generation. Besides, we introduce a pre-trained multimodal adaptive fusion module to achieve question text-to-multimodal retrieval and integration of multimodal knowledge by projecting visual and language modalities into a unified semantic space. Furthermore, we present an Adaptive Selection Knowledge Generation (ASKG) strategy to train the generator to autonomously discern the relevance of retrieved knowledge, which realizes excellent denoising performance. Extensive experiments on open multimodal question-answering datasets demonstrate that RA-BLIP achieves significant performance and surpasses the state-of-the-art retrieval-augmented models.

Large language models (LLMs) have demonstrated impressive performance on several tasks and are increasingly deployed in real-world applications. However, especially in high-stakes settings, it becomes vital to know when the output of an LLM may be unreliable. Depending on whether an answer is trustworthy, a system can then choose to route the question to another expert, or otherwise fall back on a safe default behavior. In this work, we study the extent to which LLMs can reliably indicate confidence in their answers, and how this notion of confidence can translate into downstream accuracy gains. We propose Self-REF, a lightweight training strategy to teach LLMs to express confidence in whether their answers are correct in a reliable manner. Self-REF introduces confidence tokens into the LLM, from which a confidence score can be extracted. Compared to conventional approaches such as verbalizing confidence and examining token probabilities, we demonstrate empirically that confidence tokens show significant improvements in downstream routing and rejection learning tasks.

As relevant examples such as the future criminal detection software [1] show, fairness of AI-based and social domain affecting decision support tools constitutes an important area of research. In this contribution, we investigate the applications of AI to socioeconomically relevant infrastructures such as those of water distribution networks (WDNs), where fairness issues have yet to gain a foothold. To establish the notion of fairness in this domain, we propose an appropriate definition of protected groups and group fairness in WDNs as an extension of existing definitions. We demonstrate that typical methods for the detection of leakages in WDNs are unfair in this sense. Further, we thus propose a remedy to increase the fairness which can be applied even to non-differentiable ensemble classification methods as used in this context.

Large Language Models (LLMs) are increasingly used in a variety of important applications, yet their safety and reliability remain as major concerns. Various adversarial and jailbreak attacks have been proposed to bypass the safety alignment and cause the model to produce harmful responses. We introduce Self-supervised Prompt INjection (SPIN) which can detect and reverse these various attacks on LLMs. As our self-supervised prompt defense is done at inference-time, it is also compatible with existing alignment and adds an additional layer of safety for defense. Our benchmarks demonstrate that our system can reduce the attack success rate by up to 87.9%, while maintaining the performance on benign user requests. In addition, we discuss the situation of an adaptive attacker and show that our method is still resilient against attackers who are aware of our defense.

Statistical watermarking techniques are well-established for sequentially decoded language models (LMs). However, these techniques cannot be directly applied to order-agnostic LMs, as the tokens in order-agnostic LMs are not generated sequentially. In this work, we introduce Pattern-mark, a pattern-based watermarking framework specifically designed for order-agnostic LMs. We develop a Markov-chain-based watermark generator that produces watermark key sequences with high-frequency key patterns. Correspondingly, we propose a statistical pattern-based detection algorithm that recovers the key sequence during detection and conducts statistical tests based on the count of high-frequency patterns. Our extensive evaluations on order-agnostic LMs, such as ProteinMPNN and CMLM, demonstrate Pattern-mark's enhanced detection efficiency, generation quality, and robustness, positioning it as a superior watermarking technique for order-agnostic LMs.

Natural Language Processing (NLP) is a vital computational method for addressing language processing, analysis, and generation. NLP tasks form the core of many daily applications, from automatic text correction to speech recognition. While significant research has focused on NLP tasks for the English language, less attention has been given to Modern Standard Arabic and Dialectal Arabic. Globalization has also contributed to the rise of Code-Switching (CS), where speakers mix languages within conversations and even within individual words (intra-word CS). This is especially common in Arab countries, where people often switch between dialects or between dialects and a foreign language they master. CS between Arabic and English is frequent in Egypt, especially on social media. Consequently, a significant amount of code-switched content can be found online. Such code-switched data needs to be investigated and analyzed for several NLP tasks to tackle the challenges of this multilingual phenomenon and Arabic language challenges. No work has been done before for several integral NLP tasks on Arabic-English CS data. In this work, we focus on the Named Entity Recognition (NER) task and other tasks that help propose a solution for the NER task on CS data, e.g., Language Identification. This work addresses this gap by proposing and applying state-of-the-art techniques for Modern Standard Arabic and Arabic-English NER. We have created the first annotated CS Arabic-English corpus for the NER task. Also, we apply two enhancement techniques to improve the NER tagger on CS data using CS contextual embeddings and data augmentation techniques. All methods showed improvements in the performance of the NER taggers on CS data. Finally, we propose several intra-word language identification approaches to determine the language type of a mixed text and identify whether it is a named entity or not.

Spatiotemporal graph neural networks (STGNNs) have shown promising results in many domains, from forecasting to epidemiology. However, understanding the dynamics learned by these models and explaining their behaviour is significantly more complex than for models dealing with static data. Inspired by Koopman theory, which allows a simpler description of intricate, nonlinear dynamical systems, we introduce an explainability approach for temporal graphs. We present two methods to interpret the STGNN's decision process and identify the most relevant spatial and temporal patterns in the input for the task at hand. The first relies on dynamic mode decomposition (DMD), a Koopman-inspired dimensionality reduction method. The second relies on sparse identification of nonlinear dynamics (SINDy), a popular method for discovering governing equations, which we use for the first time as a general tool for explainability. We show how our methods can correctly identify interpretable features such as infection times and infected nodes in the context of dissemination processes.