Differential privacy (DP) is applied when fine-tuning pre-trained large language models (LLMs) to limit leakage of training examples. While most DP research has focused on improving a model's privacy-utility tradeoff, some find that DP can be unfair to or biased against underrepresented groups. In this work, we show the impact of DP on bias in LLMs through empirical analysis. Differentially private training can increase the model bias against protected groups w.r.t AUC-based bias metrics. DP makes it more difficult for the model to differentiate between the positive and negative examples from the protected groups and other groups in the rest of the population. Our results also show that the impact of DP on bias is not only affected by the privacy protection level but also the underlying distribution of the dataset.

This study explored how lifestyle, personal background, and family history contribute to the risk of developing Alcohol Use Disorder (AUD). Survey data from the All of Us Program was utilized to extract information on AUD status, lifestyle, personal background, and family history for 6,016 participants. Key determinants of AUD were identified using decision trees including annual income, recreational drug use, length of residence, sex/gender, marital status, education level, and family history of AUD. Data visualization and Chi-Square Tests of Independence were then used to assess associations between identified factors and AUD. Afterwards, machine learning techniques including decision trees, random forests, and Naive Bayes were applied to predict an individual's likelihood of developing AUD. Random forests were found to achieve the highest accuracy (82%), compared to Decision Trees and Naive Bayes. Findings from this study can offer insights that help parents, healthcare professionals, and educators develop strategies to reduce AUD risk, enabling early intervention and targeted prevention efforts.

Large Language Models (LLMs) have revolutionized natural language processing, yet they struggle with inconsistent reasoning, particularly in novel domains and complex logical sequences. This research introduces Proof of Thought, a framework that enhances the reliability and transparency of LLM outputs. Our approach bridges LLM-generated ideas with formal logic verification, employing a custom interpreter to convert LLM outputs into First Order Logic constructs for theorem prover scrutiny. Central to our method is an intermediary JSON-based Domain-Specific Language, which by design balances precise logical structures with intuitive human concepts. This hybrid representation enables both rigorous validation and accessible human comprehension of LLM reasoning processes. Key contributions include a robust type system with sort management for enhanced logical integrity, explicit representation of rules for clear distinction between factual and inferential knowledge, and a flexible architecture that allows for easy extension to various domain-specific applications. We demonstrate Proof of Thought's effectiveness through benchmarking on StrategyQA and a novel multimodal reasoning task, showing improved performance in open-ended scenarios. By providing verifiable and interpretable results, our technique addresses critical needs for AI system accountability and sets a foundation for human-in-the-loop oversight in high-stakes domains.

The proliferation of fake news on digital platforms has underscored the need for robust and scalable detection mechanisms. Traditional methods often fall short in handling large and diverse datasets due to limitations in scalability and accuracy. In this paper, we propose NexusIndex, a novel framework and model that enhances fake news detection by integrating advanced language models, an innovative FAISSNexusIndex layer, and attention mechanisms. Our approach leverages multi-model embeddings to capture rich contextual and semantic nuances, significantly improving text interpretation and classification accuracy. By transforming articles into high-dimensional embeddings and indexing them efficiently, NexusIndex facilitates rapid similarity searches across extensive collections of news articles. The FAISSNexusIndex layer further optimizes this process, enabling real-time detection and enhancing the system's scalability and performance. Our experimental results demonstrate that NexusIndex outperforms state-of-the-art methods in efficiency and accuracy across diverse datasets.

We developed a rapid scanning optical microscope, termed "BlurryScope", that leverages continuous image acquisition and deep learning to provide a cost-effective and compact solution for automated inspection and analysis of tissue sections. BlurryScope integrates specialized hardware with a neural network-based model to quickly process motion-blurred histological images and perform automated pathology classification. This device offers comparable speed to commercial digital pathology scanners, but at a significantly lower price point and smaller size/weight, making it ideal for fast triaging in small clinics, as well as for resourcelimited settings. To demonstrate the proof-of-concept of BlurryScope, we implemented automated classification of human epidermal growth factor receptor 2 (HER2) scores on immunohistochemically (IHC) stained breast tissue sections, achieving concordant results with those obtained from a high-end digital scanning microscope. We evaluated this approach by scanning HER2-stained tissue microarrays (TMAs) at a continuous speed of 5,000 µm/s, which introduces bidirectional motion blur artifacts. These compromised images were then used to train our network models. Using a test set of 284 unique patient cores, we achieved blind testing accuracies of 79.3% and 89.7% for 4-class (0, 1+, 2+, 3+) and 2-class (0/1+, 2+/3+) HER2 score classification, respectively. BlurryScope automates the entire workflow, from image scanning to stitching and cropping of regions of interest, as well as HER2 score classification. We believe BlurryScope has the potential to enhance the current pathology infrastructure in resource-scarce environments, save diagnostician time and bolster cancer identification and classification across various clinical environments.

This paper conducts a comprehensive study of the learning curves of kernel ridge regression (KRR) under minimal assumptions. Our contributions are three-fold: 1) we analyze the role of key properties of the kernel, such as its spectral eigen-decay, the characteristics of the eigenfunctions, and the smoothness of the kernel; 2) we demonstrate the validity of the Gaussian Equivalent Property (GEP), which states that the generalization performance of KRR remains the same when the whitened features are replaced by standard Gaussian vectors, thereby shedding light on the success of previous analyzes under the Gaussian Design Assumption; 3) we derive novel bounds that improve over existing bounds across a broad range of setting such as (in)dependent feature vectors and various combinations of eigen-decay rates in the over/underparameterized regimes.

Safety is a paramount concern of large language models (LLMs) in their open deployment. To this end, safeguard methods aim to enforce the ethical and responsible use of LLMs through safety alignment or guardrail mechanisms. However, we found that the malicious attackers could exploit false positives of safeguards, i.e., fooling the safeguard model to block safe content mistakenly, leading to a new denial-of-service (DoS) attack on LLMs. Specifically, by software or phishing attacks on user client software, attackers insert a short, seemingly innocuous adversarial prompt into to user prompt templates in configuration files; thus, this prompt appears in final user requests without visibility in the user interface and is not trivial to identify. By designing an optimization process that utilizes gradient and attention information, our attack can automatically generate seemingly safe adversarial prompts, approximately only 30 characters long, that universally block over 97\% of user requests on Llama Guard 3. The attack presents a new dimension of evaluating LLM safeguards focusing on false positives, fundamentally different from the classic jailbreak.

Federated learning (FL) is a promising machine learning paradigm that collaborates with client models to capture global knowledge. However, deploying FL models in real-world scenarios remains unreliable due to the coexistence of in-distribution data and unexpected out-of-distribution (OOD) data, such as covariate-shift and semantic-shift data. Current FL researches typically address either covariate-shift data through OOD generalization or semantic-shift data via OOD detection, overlooking the simultaneous occurrence of various OOD shifts. In this work, we propose FOOGD, a method that estimates the probability density of each client and obtains reliable global distribution as guidance for the subsequent FL process. Firstly, SM3D in FOOGD estimates score model for arbitrary distributions without prior constraints, and detects semantic-shift data powerfully. Then SAG in FOOGD provides invariant yet diverse knowledge for both local covariate-shift generalization and client performance generalization. In empirical validations, FOOGD significantly enjoys three main advantages: (1) reliably estimating non-normalized decentralized distributions, (2) detecting semantic shift data via score values, and (3) generalizing to covariate-shift data by regularizing feature extractor. The prejoct is open in https://github.com/XeniaLLL/FOOGD-main.git.

Over the past two decades, tools from network science have been leveraged to characterize the organization of both structural and functional networks of the brain. One such measure of network organization is hub node identification. Hubs are specialized nodes within a network that link distinct brain units corresponding to specialized functional processes. Conventional methods for identifying hub nodes utilize different types of centrality measures and participation coefficient to profile various aspects of nodal importance. These methods solely rely on the functional connectivity networks constructed from functional magnetic resonance imaging (fMRI), ignoring the structure-function coupling in the brain. In this paper, we introduce a graph signal processing (GSP) based hub detection framework that utilizes both the structural connectivity and the functional activation to identify hub nodes. The proposed framework models functional activity as graph signals on the structural connectivity. Hub nodes are then detected based on the premise that hub nodes are sparse, have higher level of activity compared to their neighbors, and the non-hub nodes' activity can be modeled as the output of a graph-based filter. Based on these assumptions, an optimization framework, GraFHub, is formulated to learn the coefficients of the optimal polynomial graph filter and detect the hub nodes. The proposed framework is evaluated on both simulated data and resting state fMRI (rs-fMRI) data from Human Connectome Project (HCP).

We introduce VEMOCLAP: Video EMOtion Classifier using Pretrained features, the first readily available and open-source web application that analyzes the emotional content of any user-provided video. We improve our previous work, which exploits open-source pretrained models that work on video frames and audio, and then efficiently fuse the resulting pretrained features using multi-head cross-attention. Our approach increases the state-of-the-art classification accuracy on the Ekman-6 video emotion dataset by 4.3% and offers an online application for users to run our model on their own videos or YouTube videos. We invite the readers to try our application at serkansulun.com/app.