Patient-reported outcomes (PROs) directly collected from cancer patients being treated with radiation therapy play a vital role in assisting clinicians in counseling patients regarding likely toxicities. Precise prediction and evaluation of symptoms or health status associated with PROs are fundamental to enhancing decision-making and planning for the required services and support as patients transition into survivorship. However, the raw PRO data collected from hospitals exhibits some intrinsic challenges such as incomplete item reports and imbalance patient toxicities. To the end, in this study, we explore various machine learning techniques to predict patient outcomes related to health status such as pain levels and sleep discomfort using PRO datasets from a cancer photon/proton therapy center. Specifically, we deploy six advanced machine learning classifiers -- Random Forest (RF), XGBoost, Gradient Boosting (GB), Support Vector Machine (SVM), Multi-Layer Perceptron with Bagging (MLP-Bagging), and Logistic Regression (LR) -- to tackle a multi-class imbalance classification problem across three prevalent cancer types: head and neck, prostate, and breast cancers. To address the class imbalance issue, we employ an oversampling strategy, adjusting the training set sample sizes through interpolations of in-class neighboring samples, thereby augmenting minority classes without deviating from the original skewed class distribution. Our experimental findings across multiple PRO datasets indicate that the RF and XGB methods achieve robust generalization performance, evidenced by weighted AUC and detailed confusion matrices, in categorizing outcomes as mild, intermediate, and severe post-radiation therapy. These results underscore the models' effectiveness and potential utility in clinical settings.

Ensuring the quality and reliability of Metal Additive Manufacturing (MAM) components is crucial, especially in the Laser Powder Bed Fusion (L-PBF) process, where melt pool defects such as keyhole, balling, and lack of fusion can significantly compromise structural integrity. This study presents SL-RF+ (Sequentially Learned Random Forest with Enhanced Sampling), a novel Sequential Learning (SL) framework for melt pool defect classification designed to maximize data efficiency and model accuracy in data-scarce environments. SL-RF+ utilizes RF classifier combined with Least Confidence Sampling (LCS) and Sobol sequence-based synthetic sampling to iteratively select the most informative samples to learn from, thereby refining the model's decision boundaries with minimal labeled data. Results show that SL-RF+ outperformed traditional machine learning models across key performance metrics, including accuracy, precision, recall, and F1 score, demonstrating significant robustness in identifying melt pool defects with limited data. This framework efficiently captures complex defect patterns by focusing on high-uncertainty regions in the process parameter space, ultimately achieving superior classification performance without the need for extensive labeled datasets. While this study utilizes pre-existing experimental data, SL-RF+ shows strong potential for real-world applications in pure sequential learning settings, where data is acquired and labeled incrementally, mitigating the high costs and time constraints of sample acquisition.

The performance of active learning algorithms can be improved in two ways. The often used and intuitive way is by reducing the overall error rate within the test set. The second way is to ensure that correct predictions are not forgotten when the training set is increased in between rounds. The former is measured by the accuracy of the model and the latter is captured in negative flips between rounds. Negative flips are samples that are correctly predicted when trained with the previous/smaller dataset and incorrectly predicted after additional samples are labeled. In this paper, we discuss improving the performance of active learning algorithms both in terms of prediction accuracy and negative flips. The first observation we make in this paper is that negative flips and overall error rates are decoupled and reducing one does not necessarily imply that the other is reduced. Our observation is important as current active learning algorithms do not consider negative flips directly and implicitly assume the opposite. The second observation is that performing targeted active learning on subsets of the unlabeled pool has a significant impact on the behavior of the active learning algorithm and influences both negative flips and prediction accuracy. We then develop ROSE - a plug-in algorithm that utilizes a small labeled validation set to restrict arbitrary active learning acquisition functions to negative flips within the unlabeled pool. We show that integrating a validation set results in a significant performance boost in terms of accuracy, negative flip rate reduction, or both.

Chest X-rays (CXRs) often display various diseases with disparate class frequencies, leading to a long-tailed, multi-label data distribution. In response to this challenge, we explore the Pruned MIMIC-CXR-LT dataset, a curated collection derived from the MIMIC-CXR dataset, specifically designed to represent a long-tailed and multi-label data scenario. We introduce LTCXNet, a novel framework that integrates the ConvNeXt model, ML-Decoder, and strategic data augmentation, further enhanced by an ensemble approach. We demonstrate that LTCXNet improves the performance of CXR interpretation across all classes, especially enhancing detection in rarer classes like `Pneumoperitoneum' and `Pneumomediastinum' by 79\% and 48\%, respectively. Beyond performance metrics, our research extends into evaluating fairness, highlighting that some methods, while improving model accuracy, could inadvertently affect fairness across different demographic groups negatively. This work contributes to advancing the understanding and management of long-tailed, multi-label data distributions in medical imaging, paving the way for more equitable and effective diagnostic tools.

Mining machinery operating in variable environments faces high wear and unpredictable stress, challenging Predictive Maintenance (PdM). This paper introduces the Edge Sensor Network for Predictive Maintenance (ESN-PdM), a hierarchical inference framework across edge devices, gateways, and cloud services for real-time condition monitoring. The system dynamically adjusts inference locations--on-device, on-gateway, or on-cloud--based on trade-offs among accuracy, latency, and battery life, leveraging Tiny Machine Learning (TinyML) techniques for model optimization on resource-constrained devices. Performance evaluations showed that on-sensor and on-gateway inference modes achieved over 90\% classification accuracy, while cloud-based inference reached 99\%. On-sensor inference reduced power consumption by approximately 44\%, enabling up to 104 hours of operation. Latency was lowest for on-device inference (3.33 ms), increasing when offloading to the gateway (146.67 ms) or cloud (641.71 ms). The ESN-PdM framework provides a scalable, adaptive solution for reliable anomaly detection and PdM, crucial for maintaining machinery uptime in remote environments. By balancing accuracy, latency, and energy consumption, this approach advances PdM frameworks for industrial applications.

Chronic kidney disease (CKD) is a significant public health challenge, often progressing to end-stage renal disease (ESRD) if not detected and managed early. Early intervention, warranted by silent disease progression, can significantly reduce associated morbidity, mortality, and financial burden. In this study, we propose a novel approach to modeling CKD progression using a combination of machine learning techniques and classical statistical models. Building on the work of Liu et al. (2023), we evaluate linear models, tree-based methods, and deep learning models to extract novel predictors for CKD progression, with feature importance assessed using Shapley values. These newly identified predictors, integrated with established clinical features from the Kidney Failure Risk Equation, are then applied within the framework of Cox proportional hazards models to predict CKD progression.

During surgical training, real-time feedback from trainers to trainees is important for preventing errors and enhancing long-term skill acquisition. Accurately predicting the effectiveness of this feedback, specifically whether it leads to a change in trainee behavior, is crucial for developing methods for improving surgical training and education. However, relying on human annotations to assess feedback effectiveness is laborious and prone to biases, underscoring the need for an automated, scalable, and objective method. Creating such an automated system poses challenges, as it requires an understanding of both the verbal feedback delivered by the trainer and the visual context of the real-time surgical scene. To address this, we propose a method that integrates information from transcribed verbal feedback and corresponding surgical video to predict feedback effectiveness. Our findings show that both transcribed feedback and surgical video are individually predictive of trainee behavior changes, and their combination achieves an AUROC of 0.70+/-0.02, improving prediction accuracy by up to 6.6%. Additionally, we introduce self-supervised fine-tuning as a strategy for enhancing surgical video representation learning, which is scalable and further enhances prediction performance. Our results demonstrate the potential of multi-modal learning to advance the automated assessment of surgical feedback.

Label imbalance and homophily-heterophily mixture are the fundamental problems encountered when applying Graph Neural Networks (GNNs) to Graph Fraud Detection (GFD) tasks. Existing GNN-based GFD models are designed to augment graph structure to accommodate the inductive bias of GNNs towards homophily, by excluding heterophilic neighbors during message passing. In our work, we argue that the key to applying GNNs for GFD is not to exclude but to {\em distinguish} neighbors with different labels. Grounded in this perspective, we introduce Partitioning Message Passing (PMP), an intuitive yet effective message passing paradigm expressly crafted for GFD. Specifically, in the neighbor aggregation stage of PMP, neighbors with different classes are aggregated with distinct node-specific aggregation functions. By this means, the center node can adaptively adjust the information aggregated from its heterophilic and homophilic neighbors, thus avoiding the model gradient being dominated by benign nodes which occupy the majority of the population. We theoretically establish a connection between the spatial formulation of PMP and spectral analysis to characterize that PMP operates an adaptive node-specific spectral graph filter, which demonstrates the capability of PMP to handle heterophily-homophily mixed graphs. Extensive experimental results show that PMP can significantly boost the performance on GFD tasks.

Artificial Intelligence is rapidly embedding itself within militaries, economies, and societies, reshaping their very foundations. Given the depth and breadth of its consequences, it has never been more pressing to understand how to ensure that AI systems are safe, ethical, and have a positive societal impact. This book aims to provide a comprehensive approach to understanding AI risk. Our primary goals include consolidating fragmented knowledge on AI risk, increasing the precision of core ideas, and reducing barriers to entry by making content simpler and more comprehensible. The book has been designed to be accessible to readers from diverse backgrounds. You do not need to have studied AI, philosophy, or other such topics. The content is skimmable and somewhat modular, so that you can choose which chapters to read. We introduce mathematical formulas in a few places to specify claims more precisely, but readers should be able to understand the main points without these.

Artificial Intelligence (AI) in materials science is driving significant advancements in the discovery of advanced materials for energy applications. The recent GNoME protocol identifies over 380,000 novel stable crystals. From this, we identify over 33,000 materials with potential as energy materials forming the Energy-GNoME database. Leveraging Machine Learning (ML) and Deep Learning (DL) tools, our protocol mitigates cross-domain data bias using feature spaces to identify potential candidates for thermoelectric materials, novel battery cathodes, and novel perovskites. Classifiers with both structural and compositional features identify domains of applicability, where we expect enhanced accuracy of the regressors. Such regressors are trained to predict key materials properties like, thermoelectric figure of merit (zT), band gap (Eg), and cathode voltage ($\Delta V_c$). This method significantly narrows the pool of potential candidates, serving as an efficient guide for experimental and computational chemistry investigations and accelerating the discovery of materials suited for electricity generation, energy storage and conversion.