Diabetes, particularly Type 2 diabetes (T2D), poses a substantial global health burden, compounded by its associated complications such as cardiovascular diseases, kidney failure, and vision impairment. Early detection of T2D is critical for improving healthcare outcomes and optimizing resource allocation. In this study, we address the gap in early T2D detection by leveraging machine learning (ML) techniques on gene expression data obtained from T2D patients. Our primary objective was to enhance the accuracy of early T2D detection through advanced ML methodologies and increase the model's trustworthiness using the explainable artificial intelligence (XAI) technique. Analyzing the biological mechanisms underlying T2D through gene expression datasets represents a novel research frontier, relatively less explored in previous studies. While numerous investigations have focused on utilizing clinical and demographic data for T2D prediction, the integration of molecular insights from gene expression datasets offers a unique and promising avenue for understanding the pathophysiology of the disease. By employing six ML classifiers on data sourced from NCBI's Gene Expression Omnibus (GEO), we observed promising performance across all models. Notably, the XGBoost classifier exhibited the highest accuracy, achieving 97%. Our study addresses a notable gap in early T2D detection methodologies, emphasizing the importance of leveraging gene expression data and advanced ML techniques.

In order to address issues with manual vote counting during election procedures, this study intends to examine the viability of using advanced image processing techniques for automated voter counting. The study aims to shed light on how automated systems that utilize cutting-edge technologies like OpenCV, CVZone, and the MOG2 algorithm could greatly increase the effectiveness and openness of electoral operations. The empirical findings demonstrate how automated voter counting can enhance voting processes and rebuild public confidence in election outcomes, particularly in places where trust is low. The study also emphasizes how rigorous metrics, such as the F1 score, should be used to systematically compare the accuracy of automated systems against manual counting methods. This methodology enables a detailed comprehension of the differences in performance between automated and human counting techniques by providing a nuanced assessment. The incorporation of said measures serves to reinforce an extensive assessment structure, guaranteeing the legitimacy and dependability of automated voting systems inside the electoral sphere.

Stylometry aims to distinguish authors by analyzing literary traits assumed to reflect semi-conscious choices distinct from elements like genre or theme. However, these components often overlap, complicating text classification based solely on feature distributions. While some literary properties, such as thematic content, are likely to manifest as correlations between adjacent text units, others, like authorial style, may be independent thereof. We introduce a hypothesis-testing approach to evaluate the influence of sequentially correlated literary properties on text classification, aiming to determine when these correlations drive classification. Using a multivariate binary distribution, our method models sequential correlations between text units as a stochastic process, assessing the likelihood of clustering across varying adjacency scales. This enables us to examine whether classification is dominated by sequentially correlated properties or remains independent. In experiments on a diverse English prose corpus, our analysis integrates traditional and neural embeddings within supervised and unsupervised frameworks. Results demonstrate that our approach effectively identifies when textual classification is not primarily influenced by sequentially correlated literary properties, particularly in cases where texts differ in authorial style or genre rather than by a single author within a similar genre.

The personalization techniques of diffusion models succeed in generating specific concepts but also pose threats to copyright protection and illegal use. Model Watermarking is an effective method to prevent the unauthorized use of subject-driven or style-driven image generation, safeguarding concept copyrights. However, under the goal of concept-oriented protection, current watermarking schemes typically add watermarks to all images rather than applying them in a refined manner targeted at specific concepts. Additionally, the personalization techniques of diffusion models can easily remove watermarks. Existing watermarking methods struggle to achieve fine-grained watermark embedding with a few images of specific concept and prevent removal of watermarks through personalized fine-tuning. Therefore, we introduce a novel concept-oriented watermarking framework that seamlessly embeds imperceptible watermarks into the concept of diffusion models. We conduct extensive experiments and ablation studies to verify our framework. Our code is available at https://anonymous.4open.science/r/Conceptwm-4EB3/.

We propose a new approach for fine-grained uncertainty quantification (UQ) using a collision matrix. For a classification problem involving $K$ classes, the $K\times K$ collision matrix $S$ measures the inherent (aleatoric) difficulty in distinguishing between each pair of classes. In contrast to existing UQ methods, the collision matrix gives a much more detailed picture of the difficulty of classification. We discuss several possible downstream applications of the collision matrix, establish its fundamental mathematical properties, as well as show its relationship with existing UQ methods, including the Bayes error rate. We also address the new problem of estimating the collision matrix using one-hot labeled data. We propose a series of innovative techniques to estimate $S$. First, we learn a contrastive binary classifier which takes two inputs and determines if they belong to the same class. We then show that this contrastive classifier (which is PAC learnable) can be used to reliably estimate the Gramian matrix of $S$, defined as $G=S^TS$. Finally, we show that under very mild assumptions, $G$ can be used to uniquely recover $S$, a new result on stochastic matrices which could be of independent interest. Experimental results are also presented to validate our methods on several datasets.

We introduce a new method for learning Bayesian neural networks, treating them as a stack of multivariate Bayesian linear regression models. The main idea is to infer the layerwise posterior exactly if we know the target outputs of each layer. We define these pseudo-targets as the layer outputs from the forward pass, updated by the backpropagated gradients of the objective function. The resulting layerwise posterior is a matrix-normal distribution with a Kronecker-factorized covariance matrix, which can be efficiently inverted. Our method extends to the stochastic mini-batch setting using an exponential moving average over natural-parameter terms, thus gradually forgetting older data. The method converges in few iterations and performs as well as or better than leading Bayesian neural network methods on various regression, classification, and out-of-distribution detection benchmarks.

This book is about conformal prediction and related inferential techniques that build on permutation tests and exchangeability. These techniques are useful in a diverse array of tasks, including hypothesis testing and providing uncertainty quantification guarantees for machine learning systems. Much of the current interest in conformal prediction is due to its ability to integrate into complex machine learning workflows, solving the problem of forming prediction sets without any assumptions on the form of the data generating distribution. Since contemporary machine learning algorithms have generally proven difficult to analyze directly, conformal prediction's main appeal is its ability to provide formal, finite-sample guarantees when paired with such methods. The goal of this book is to teach the reader about the fundamental technical arguments that arise when researching conformal prediction and related questions in distribution-free inference. Many of these proof strategies, especially the more recent ones, are scattered among research papers, making it difficult for researchers to understand where to look, which results are important, and how exactly the proofs work. We hope to bridge this gap by curating what we believe to be some of the most important results in the literature and presenting their proofs in a unified language, with illustrations, and with an eye towards pedagogy.

Over an extensive duration, administrators and clinicians have endeavoured to predict Emergency Department (ED) visits with precision, aiming to optimise resource distribution. Despite the proliferation of diverse AI-driven models tailored for precise prognostication, this task persists as a formidable challenge, besieged by constraints such as restrained generalisability, susceptibility to overfitting and underfitting, scalability issues, and complex fine-tuning hyper-parameters. In this study, we introduce a novel Meta-learning Gradient Booster (Meta-ED) approach for precisely forecasting daily ED visits and leveraging a comprehensive dataset of exogenous variables, including socio-demographic characteristics, healthcare service use, chronic diseases, diagnosis, and climate parameters spanning 23 years from Canberra Hospital in ACT, Australia. The proposed Meta-ED consists of four foundational learners-Catboost, Random Forest, Extra Tree, and lightGBoost-alongside a dependable top-level learner, Multi-Layer Perceptron (MLP), by combining the unique capabilities of varied base models (sub-learners). Our study assesses the efficacy of the Meta-ED model through an extensive comparative analysis involving 23 models. The evaluation outcomes reveal a notable superiority of Meta-ED over the other models in accuracy at 85.7% (95% CI ;85.4%, 86.0%) and across a spectrum of 10 evaluation metrics. Notably, when compared with prominent techniques, XGBoost, Random Forest (RF), AdaBoost, LightGBoost, and Extra Tree (ExT), Meta-ED showcases substantial accuracy enhancements of 58.6%, 106.3%, 22.3%, 7.0%, and 15.7%, respectively. Furthermore, incorporating weather-related features demonstrates a 3.25% improvement in the prediction accuracy of visitors' numbers. The encouraging outcomes of our study underscore Meta-ED as a foundation model for the precise prediction of daily ED visitors.

Reconstructing compositional 3D representations of scenes, where each object is represented with its own 3D model, is a highly desirable capability in robotics and augmented reality. However, most existing methods rely heavily on strong appearance priors for object discovery, therefore only working on those classes of objects on which the method has been trained, or do not allow for object manipulation, which is necessary to scan objects fully and to guide object discovery in challenging scenarios. We address these limitations with a novel interaction-guided and class-agnostic method based on object displacements that allows a user to move around a scene with an RGB-D camera, hold up objects, and finally outputs one 3D model per held-up object. Our main contribution to this end is a novel approach to detecting user-object interactions and extracting the masks of manipulated objects. On a custom-captured dataset, our pipeline discovers manipulated objects with 78.3% precision at 100% recall and reconstructs them with a mean chamfer distance of 0.90cm. Compared to Co-Fusion, the only comparable interaction-based and class-agnostic baseline, this corresponds to a reduction in chamfer distance of 73% while detecting 99% fewer false positives.

Objective: Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by unpredictable flares. This study aimed to develop a novel proteomics-based risk prediction model specifically for Asian SLE populations to enhance personalized disease management and early intervention. Methods: A longitudinal cohort study was conducted over 48 weeks, including 139 SLE patients monitored every 12 weeks. Patients were classified into flare (n = 53) and non-flare (n = 86) groups. Baseline plasma samples underwent data-independent acquisition (DIA) proteomics analysis, and phenome-wide Mendelian randomization (PheWAS) was performed to evaluate causal relationships between proteins and clinical predictors. Logistic regression (LR) and random forest (RF) models were used to integrate proteomic and clinical data for flare risk prediction. Results: Five proteins (SAA1, B4GALT5, GIT2, NAA15, and RPIA) were significantly associated with SLE Disease Activity Index-2K (SLEDAI-2K) scores and 1-year flare risk, implicating key pathways such as B-cell receptor signaling and platelet degranulation. SAA1 demonstrated causal effects on flare-related clinical markers, including hemoglobin and red blood cell counts. A combined model integrating clinical and proteomic data achieved the highest predictive accuracy (AUC = 0.769), surpassing individual models. SAA1 was highlighted as a priority biomarker for rapid flare discrimination. Conclusion: The integration of proteomic and clinical data significantly improves flare prediction in Asian SLE patients. The identification of key proteins and their causal relationships with flare-related clinical markers provides valuable insights for proactive SLE management and personalized therapeutic approaches.