Osteoporosis is a widespread and chronic metabolic bone disease that often remains undiagnosed and untreated due to limited access to bone mineral density (BMD) tests like Dual-energy X-ray absorptiometry (DXA). In response to this challenge, current advancements are pivoting towards detecting osteoporosis by examining alternative indicators from peripheral bone areas, with the goal of increasing screening rates without added expenses or time. In this paper, we present a method to predict osteoporosis using hand and wrist X-ray images, which are both widely accessible and affordable, though their link to DXA-based data is not thoroughly explored. We employ a sophisticated image segmentation model that utilizes a mixture of probabilistic U-Net decoders, specifically designed to capture predictive uncertainty in the segmentation of the ulna, radius, and metacarpal bones. This model is formulated as an optimal transport (OT) problem, enabling it to handle the inherent uncertainties in image segmentation more effectively. Further, we adopt a self-supervised learning (SSL) approach to extract meaningful representations without the need for explicit labels, and move on to classify osteoporosis in a supervised manner. Our method is evaluated on a dataset with 192 individuals, cross-referencing their verified osteoporosis conditions against the standard DXA test. With a notable classification score, this integration of uncertainty-aware segmentation and self-supervised learning represents a pioneering effort in leveraging vision-based techniques for the early detection of osteoporosis from peripheral skeletal sites.

Predictive process monitoring focuses on forecasting future states of ongoing process executions, such as predicting the outcome of a particular case. In recent years, the application of machine learning models in this domain has garnered significant scientific attention. When using historical execution data, which may contain biases or exhibit unfair behavior, these biases may be encoded into the trained models. Consequently, when such models are deployed to make decisions or guide interventions for new cases, they risk perpetuating this unwanted behavior. This work addresses group fairness in predictive process monitoring by investigating independence, i.e. ensuring predictions are unaffected by sensitive group membership. We explore independence through metrics for demographic parity such as $\Delta$DP, as well as recently introduced, threshold-independent distribution-based alternatives. Additionally, we propose a composite loss functions existing of binary cross-entropy and a distribution-based loss (Wasserstein) to train models that balance predictive performance and fairness, and allow for customizable trade-offs. The effectiveness of both the fairness metrics and the composite loss functions is validated through a controlled experimental setup.

Purpose: Subarachnoid haemorrhage is a potentially fatal consequence of intracranial aneurysm rupture, however, it is difficult to predict if aneurysms will rupture. Prophylactic treatment of an intracranial aneurysm also involves risk, hence identifying rupture-prone aneurysms is of substantial clinical importance. This systematic review aims to evaluate the performance of machine learning algorithms for predicting intracranial aneurysm rupture risk. Methods: MEDLINE, Embase, Cochrane Library and Web of Science were searched until December 2023. Studies incorporating any machine learning algorithm to predict the risk of rupture of an intracranial aneurysm were included. Risk of bias was assessed using the Prediction Model Risk of Bias Assessment Tool (PROBAST). PROSPERO registration: CRD42023452509. Results: Out of 10,307 records screened, 20 studies met the eligibility criteria for this review incorporating a total of 20,286 aneurysm cases. The machine learning models gave a 0.66-0.90 range for performance accuracy. The models were compared to current clinical standards in six studies and gave mixed results. Most studies posed high or unclear risks of bias and concerns for applicability, limiting the inferences that can be drawn from them. There was insufficient homogenous data for a meta-analysis. Conclusions: Machine learning can be applied to predict the risk of rupture for intracranial aneurysms. However, the evidence does not comprehensively demonstrate superiority to existing practice, limiting its role as a clinical adjunct. Further prospective multicentre studies of recent machine learning tools are needed to prove clinical validation before they are implemented in the clinic.

The popularisation of applying AI in businesses poses significant challenges relating to ethical principles, governance, and legal compliance. Although businesses have embedded AI into their day-to-day processes, they lack a unified approach for mitigating its potential risks. This paper introduces a framework ensuring that AI must be ethical, controllable, viable, and desirable. Balancing these factors ensures the design of a framework that addresses its trade-offs, such as balancing performance against explainability. A successful framework provides practical advice for businesses to meet regulatory requirements in sectors such as finance and healthcare, where it is critical to comply with standards like GPDR and the EU AI Act. Different case studies validate this framework by integrating AI in both academic and practical environments. For instance, large language models are cost-effective alternatives for generating synthetic opinions that emulate attitudes to environmental issues. These case studies demonstrate how having a structured framework could enhance transparency and maintain performance levels as shown from the alignment between synthetic and expected distributions. This alignment is quantified using metrics like Chi-test scores, normalized mutual information, and Jaccard indexes. Future research should explore the framework's empirical validation in diverse industrial settings further, ensuring the model's scalability and adaptability.

The integration of fully homomorphic encryption (FHE) in federated learning (FL) has led to significant advances in data privacy. However, during the aggregation phase, it often results in performance degradation of the aggregated model, hindering the development of robust representational generalization. In this work, we propose a novel multimodal quantum federated learning framework that utilizes quantum computing to counteract the performance drop resulting from FHE. For the first time in FL, our framework combines a multimodal quantum mixture of experts (MQMoE) model with FHE, incorporating multimodal datasets for enriched representation and task-specific learning. Our MQMoE framework enhances performance on multimodal datasets and combined genomics and brain MRI scans, especially for underrepresented categories. Our results also demonstrate that the quantum-enhanced approach mitigates the performance degradation associated with FHE and improves classification accuracy across diverse datasets, validating the potential of quantum interventions in enhancing privacy in FL.

Multi-modal large language models (MLLMs), such as GPT-4o, excel at integrating text and visual data but face systematic challenges when interpreting ambiguous or incomplete visual stimuli. This study leverages statistical modeling to analyze the factors driving these errors, using a dataset of geometric stimuli characterized by features like 3D, rotation, and missing face/side. We applied parametric methods, non-parametric methods, and ensemble techniques to predict classification errors, with the non-linear gradient boosting model achieving the highest performance (AUC=0.85) during cross-validation. Feature importance analysis highlighted difficulties in depth perception and reconstructing incomplete structures as key contributors to misclassification. These findings demonstrate the effectiveness of statistical approaches for uncovering limitations in MLLMs and offer actionable insights for enhancing model architectures by integrating contextual reasoning mechanisms.

Timely and accurate assessments of building damage are crucial for effective response and recovery in the aftermath of earthquakes. Conventional preliminary damage assessments (PDA) often rely on manual door-to-door inspections, which are not only time-consuming but also pose significant safety risks. To safely expedite the PDA process, researchers have studied the applicability of satellite imagery processed with heuristic and machine learning approaches. These approaches output binary or, more recently, multiclass damage states at the scale of a block or a single building. However, the current performance of such approaches limits practical applicability. To address this limitation, we introduce a metadata-enriched, transformer based framework that combines high-resolution post-earthquake satellite imagery with building-specific metadata relevant to the seismic performance of the structure. Our model achieves state-of-the-art performance in multiclass post-earthquake damage identification for buildings from the Turkey-Syria earthquake on February 6, 2023. Specifically, we demonstrate that incorporating metadata, such as seismic intensity indicators, soil properties, and SAR damage proxy maps not only enhances the model's accuracy and ability to distinguish between damage classes, but also improves its generalizability across various regions. Furthermore, we conducted a detailed, class-wise analysis of feature importance to understand the model's decision-making across different levels of building damage. This analysis reveals how individual metadata features uniquely contribute to predictions for each damage class. By leveraging both satellite imagery and metadata, our proposed framework enables faster and more accurate damage assessments for precise, multiclass, building-level evaluations that can improve disaster response and accelerate recovery efforts for affected communities.

One of the issues faced by the maintainers of popular open source software is the triage of newly reported issues. Many of the issues submitted to issue trackers are questions. Many people ask questions on issue trackers about their problem instead of using a proper QA website like StackOverflow. This may seem insignificant but for many of the big projects with thousands of users, this leads to spamming of the issue tracker. Reading and labeling these unrelated issues manually is a serious time consuming task and these unrelated questions add to the burden. In fact, most often maintainers demand to not submit questions in the issue tracker. To address this problem, first, we leveraged dozens of patterns to clean text of issues, we removed noises like logs, stack traces, environment variables, error messages, etc. Second, we have implemented a classification-based approach to automatically label unrelated questions. Empirical evaluations on a dataset of more than 102,000 records show that our approach can label questions with an accuracy of over 81%.

Large language models (LLMs) have been shown to be effective on tabular prediction tasks in the low-data regime, leveraging their internal knowledge and ability to learn from instructions and examples. However, LLMs can fail to generate predictions that satisfy group fairness, that is, produce equitable outcomes across groups. Critically, conventional debiasing approaches for natural language tasks do not directly translate to mitigating group unfairness in tabular settings. In this work, we systematically investigate four empirical approaches to improve group fairness of LLM predictions on tabular datasets, including fair prompt optimization, soft prompt tuning, strategic selection of few-shot examples, and self-refining predictions via chain-of-thought reasoning. Through experiments on four tabular datasets using both open-source and proprietary LLMs, we show the effectiveness of these methods in enhancing demographic parity while maintaining high overall performance. Our analysis provides actionable insights for practitioners in selecting the most suitable approach based on their specific requirements and constraints.

Numerical N-body simulations are commonly used to explore stability regions around exoplanets, offering insights into the possible existence of satellites and ring systems. This study aims to utilize Machine Learning (ML) techniques to generate predictive maps of stable regions surrounding a hypothetical planet. The approach can also be extended to planet-satellite systems, planetary ring systems, and other similar configurations. A dataset was generated using 10^5 numerical simulations, each incorporating nine orbital features for the planet and a test particle in a star-planet-test particle system. The simulations were classified as stable or unstable based on stability criteria, requiring particles to remain stable over a timespan equivalent to 10,000 orbital periods of the planet. Various ML algorithms were tested and fine-tuned through hyperparameter optimization to determine the most effective predictive model. Tree-based algorithms showed comparable accuracy in performance. The best-performing model, using the Extreme Gradient Boosting (XGBoost) algorithm, achieved an accuracy of 98.48%, with 94% recall and precision for stable particles and 99% for unstable particles. ML algorithms significantly reduce the computational time required for three-body simulations, operating approximately 100,000 times faster than traditional numerical methods. Predictive models can generate entire stability maps in less than a second, compared to the days required by numerical simulations. The results from the trained ML models will be made accessible through a public web interface, enabling broader scientific applications.