Systematic reviews (SRs) are essential for evidence-based guidelines but are often limited by the time-consuming nature of literature screening. We propose and evaluate an in-house system based on Large Language Models (LLMs) for automating both title/abstract and full-text screening, addressing a critical gap in the literature. Using a completed SR on Vitamin D and falls (14,439 articles), the LLM-based system employed prompt engineering for title/abstract screening and Retrieval-Augmented Generation (RAG) for full-text screening. The system achieved an article exclusion rate (AER) of 99.5%, specificity of 99.6%, a false negative rate (FNR) of 0%, and a negative predictive value (NPV) of 100%. After screening, only 78 articles required manual review, including all 20 identified by traditional methods, reducing manual screening time by 95.5%. For comparison, Rayyan, a commercial tool for title/abstract screening, achieved an AER of 72.1% and FNR of 5% when including articles Rayyan considered as undecided or likely to include. Lowering Rayyan's inclusion thresholds improved FNR to 0% but increased screening time. By addressing both screening phases, the LLM-based system significantly outperformed Rayyan and traditional methods, reducing total screening time to 25.5 hours while maintaining high accuracy. These findings highlight the transformative potential of LLMs in SR workflows by offering a scalable, efficient, and accurate solution, particularly for the full-text screening phase, which has lacked automation tools.

Prostate cancer is a leading cause of cancer-related deaths among men. The recent development of high frequency, micro-ultrasound imaging offers improved resolution compared to conventional ultrasound and potentially a better ability to differentiate clinically significant cancer from normal tissue. However, the features of prostate cancer remain subtle, with ambiguous borders with normal tissue and large variations in appearance, making it challenging for both machine learning and humans to localize it on micro-ultrasound images. We propose a novel Mask Enhanced Deeply-supervised Micro-US network, termed MedMusNet, to automatically and more accurately segment prostate cancer to be used as potential targets for biopsy procedures. MedMusNet leverages predicted masks of prostate cancer to enforce the learned features layer-wisely within the network, reducing the influence of noise and improving overall consistency across frames. MedMusNet successfully detected 76% of clinically significant cancer with a Dice Similarity Coefficient of 0.365, significantly outperforming the baseline Swin-M2F in specificity and accuracy (Wilcoxon test, Bonferroni correction, p-value<0.05). While the lesion-level and patient-level analyses showed improved performance compared to human experts and different baseline, the improvements did not reach statistical significance, likely on account of the small cohort. We have presented a novel approach to automatically detect and segment clinically significant prostate cancer on B-mode micro-ultrasound images. Our MedMusNet model outperformed other models, surpassing even human experts. These preliminary results suggest the potential for aiding urologists in prostate cancer diagnosis via biopsy and treatment decision-making.

Gravitational waves (GW), predicted by Einstein's General Theory of Relativity, provide a powerful probe of astrophysical phenomena and fundamental physics. In this work, we propose an unsupervised anomaly detection method using variational autoencoders (VAEs) to analyze GW time-series data. By training on noise-only data, the VAE accurately reconstructs noise inputs while failing to reconstruct anomalies, such as GW signals, which results in measurable spikes in the reconstruction error. The method was applied to data from the LIGO H1 and L1 detectors. Evaluation on testing datasets containing both noise and GW events demonstrated reliable detection, achieving an area under the ROC curve (AUC) of 0.89. This study introduces VAEs as a robust, unsupervised approach for identifying anomalies in GW data, which offers a scalable framework for detecting known and potentially new phenomena in physics.

The application of autonomous robots in high-throughput phenotyping has experienced a significant surge in recent years, driven by the need for precision and efficiency in agricultural tasks [1]. These advanced robotic systems are transforming the field by automating the complex task of phenotyping with unparalleled accuracy. While autonomous solutions in agriculture have been explored for decades [2], recent advancements have pushed the boundaries of this technology, particularly in addressing challenges related to GPS-denied navigation in dense crop environments. For nearly two decades, GPS-based autonomy has been the cornerstone of agricultural robotics. Studies such as [3] and [4] have showcased the use of RTK and GPS-based systems to guide tractors and harvesters with high precision. The GPS coordinates of rows can either be determined during planting or estimated using systems like [5, 6], which provide accurate crop and row location data.

Estimation of patient acuity in the Intensive Care Unit (ICU) is vital to ensure timely and appropriate interventions. Advances in artificial intelligence (AI) technologies have significantly improved the accuracy of acuity predictions. However, prior studies using machine learning for acuity prediction have predominantly relied on electronic health records (EHR) data, often overlooking other critical aspects of ICU stay, such as patient mobility, environmental factors, and facial cues indicating pain or agitation. To address this gap, we present MANGO: the Multimodal Acuity traNsformer for intelliGent ICU Outcomes, designed to enhance the prediction of patient acuity states, transitions, and the need for life-sustaining therapy. We collected a multimodal dataset ICU-Multimodal, incorporating four key modalities: EHR data, wearable sensor data, video of patient's facial cues, and ambient sensor data, which we utilized to train MANGO. The MANGO model employs a multimodal feature fusion network powered by Transformer masked self-attention method, enabling it to capture and learn complex interactions across these diverse data modalities even when some modalities are absent. Our results demonstrated that integrating multiple modalities significantly improved the model's ability to predict acuity status, transitions, and the need for life-sustaining therapy. The best-performing models achieved an area under the receiver operating characteristic curve (AUROC) of 0.76 (95% CI: 0.72-0.79)

Internet connectivity in schools is critical to provide students with the digital literary skills necessary to compete in modern economies. In order for governments to effectively implement digital infrastructure development in schools, accurate internet connectivity information is required. However, traditional survey-based methods can exceed the financial and capacity limits of governments. Open-source Earth Observation (EO) datasets have unlocked our ability to observe and understand socio-economic conditions on Earth from space, and in combination with Machine Learning (ML), can provide the tools to circumvent costly ground-based survey methods to support infrastructure development. In this paper, we present our work on school internet connectivity prediction using EO and ML. We detail the creation of our multi-modal, freely-available satellite imagery and survey information dataset, leverage the latest geographically-aware location encoders, and introduce the first results of using the new European Space Agency phi-lab geographically-aware foundational model to predict internet connectivity in Botswana and Rwanda. We find that ML with EO and ground-based auxiliary data yields the best performance in both countries, for accuracy, F1 score, and False Positive rates, and highlight the challenges of internet connectivity prediction from space with a case study in Kigali, Rwanda. Our work showcases a practical approach to support data-driven digital infrastructure development in low-resource settings, leveraging freely available information, and provide cleaned and labelled datasets for future studies to the community through a unique collaboration between UNICEF and the European Space Agency phi-lab.

The deployment of the Internet of Things (IoT) in smart cities and critical infrastructure has enhanced connectivity and real-time data exchange but introduced significant security challenges. While effective, cryptography can often be resource-intensive for small-footprint resource-constrained (i.e., IoT) devices. Radio Frequency Fingerprinting (RFF) offers a promising authentication alternative by using unique RF signal characteristics for device identification at the Physical (PHY)-layer, without resorting to cryptographic solutions. The challenge is two-fold: how to deploy such RFF in a large scale and for resource-constrained environments. Edge computing, processing data closer to its source, i.e., the wireless device, enables faster decision-making, reducing reliance on centralized cloud servers. Considering a modest edge device, we introduce two truly lightweight Edge AI-based RFF schemes tailored for resource-constrained devices. We implement two Deep Learning models, namely a Convolution Neural Network and a Transformer-Encoder, to extract complex features from the IQ samples, forming device-specific RF fingerprints. We convert the models to TensorFlow Lite and evaluate them on a Raspberry Pi, demonstrating the practicality of Edge deployment. Evaluations demonstrate the Transformer-Encoder outperforms the CNN in identifying unique transmitter features, achieving high accuracy (> 0.95) and ROC-AUC scores (> 0.90) while maintaining a compact model size of 73KB, appropriate for resource-constrained devices.

Recent regulatory proposals for artificial intelligence emphasize fairness requirements for machine learning models. However, precisely defining the appropriate measure of fairness is challenging due to philosophical, cultural and political contexts. Biases can infiltrate machine learning models in complex ways depending on the model's context, rendering a single common metric of fairness insufficient. This ambiguity highlights the need for criteria to guide the selection of context-aware measures, an issue of increasing importance given the proliferation of ever tighter regulatory requirements. To address this, we developed a flowchart to guide the selection of contextually appropriate fairness measures. Twelve criteria were used to formulate the flowchart. This included consideration of model assessment criteria, model selection criteria, and data bias. We also review fairness literature in the context of machine learning and link it to core regulatory instruments to assist policymakers, AI developers, researchers, and other stakeholders in appropriately addressing fairness concerns and complying with relevant regulatory requirements.

A myriad of measures to illustrate performance of predictive artificial intelligence (AI) models have been proposed in the literature. Selecting appropriate performance measures is essential for predictive AI models that are developed to be used in medical practice, because poorly performing models may harm patients and lead to increased costs. We aim to assess the merits of classic and contemporary performance measures when validating predictive AI models for use in medical practice. We focus on models with a binary outcome. We discuss 32 performance measures covering five performance domains (discrimination, calibration, overall, classification, and clinical utility) along with accompanying graphical assessments. The first four domains cover statistical performance, the fifth domain covers decision-analytic performance. We explain why two key characteristics are important when selecting which performance measures to assess: (1) whether the measure's expected value is optimized when it is calculated using the correct probabilities (i.e., a "proper" measure), and (2) whether they reflect either purely statistical performance or decision-analytic performance by properly considering misclassification costs. Seventeen measures exhibit both characteristics, fourteen measures exhibited one characteristic, and one measure possessed neither characteristic (the F1 measure). All classification measures (such as classification accuracy and F1) are improper for clinically relevant decision thresholds other than 0.5 or the prevalence. We recommend the following measures and plots as essential to report: AUROC, calibration plot, a clinical utility measure such as net benefit with decision curve analysis, and a plot with probability distributions per outcome category.

Estimating the expected output quality of generation systems is central to NLG. This paper qualifies the notion that automatic metrics are not as good as humans in estimating system-level quality. Statistically, humans are unbiased, high variance estimators, while metrics are biased, low variance estimators. We compare these estimators by their error in pairwise prediction (which generation system is better?) using the bootstrap. Measuring this error is complicated: predictions are evaluated against noisy, human predicted labels instead of the ground truth, and metric predictions fluctuate based on the test sets they were calculated on. By applying a bias-variance-noise decomposition, we adjust this error to a noise-free, infinite test set setting. Our analysis compares the adjusted error of metrics to humans and a derived, perfect segment-level annotator, both of which are unbiased estimators dependent on the number of judgments collected. In MT, we identify two settings where metrics outperform humans due to a statistical advantage in variance: when the number of human judgments used is small, and when the quality difference between compared systems is small. The data and code to reproduce our analyses are available at https://github.com/johntzwei/metric-statistical-advantage .