This study proposes a new loss function for deep neural networks, L1-weighted Dice Focal Loss (L1DFL), that leverages L1 norms for adaptive weighting of voxels based on their classification difficulty, towards automated detection and segmentation of metastatic prostate cancer lesions in PET/CT scans. We obtained 380 PSMA [18-F] DCFPyL PET/CT scans of patients diagnosed with biochemical recurrence metastatic prostate cancer. We trained two 3D convolutional neural networks, Attention U-Net and SegResNet, and concatenated the PET and CT volumes channel-wise as input. The performance of our custom loss function was evaluated against the Dice and Dice Focal Loss functions. For clinical significance, we considered a detected region of interest (ROI) as a true positive if at least the voxel with the maximum standardized uptake value falls within the ROI. We assessed the models' performance based on the number of lesions in an image, tumour volume, activity, and extent of spread. The L1DFL outperformed the comparative loss functions by at least 13% on the test set. In addition, the F1 scores of the Dice Loss and the Dice Focal Loss were lower than that of L1DFL by at least 6% and 34%, respectively. The Dice Focal Loss yielded more false positives, whereas the Dice Loss was more sensitive to smaller volumes and struggled to segment larger lesions accurately. They also exhibited network-specific variations and yielded declines in segmentation accuracy with increased tumour spread. Our results demonstrate the potential of L1DFL to yield robust segmentation of metastatic prostate cancer lesions in PSMA PET/CT images. The results further highlight potential complexities arising from the variations in lesion characteristics that may influence automated prostate cancer tumour detection and segmentation. The code is publicly available at: https://github.com/ObedDzik/pca_segment.git.

Natural Language Processing (NLP) has seen remarkable advances in recent years, particularly with the emergence of Large Language Models that have achieved unprecedented performance across many tasks. However, these developments have mainly benefited a small number of high-resource languages such as English. The majority of languages still face significant challenges due to the scarcity of training data and computational resources. To address this issue, this thesis focuses on cross-lingual transfer learning, a research area aimed at leveraging data and models from high-resource languages to improve NLP performance for low-resource languages. Specifically, we focus on Sequence Labeling tasks such as Named Entity Recognition, Opinion Target Extraction, and Argument Mining. The research is structured around three main objectives: (1) advancing data-based cross-lingual transfer learning methods through improved translation and annotation projection techniques, (2) developing enhanced model-based transfer learning approaches utilizing state-of-the-art multilingual models, and (3) applying these methods to real-world problems while creating open-source resources that facilitate future research in low-resource NLP. More specifically, this thesis presents a new method to improve data-based transfer with T-Projection, a state-of-the-art annotation projection method that leverages text-to-text multilingual models and machine translation systems. T-Projection significantly outperforms previous annotation projection methods by a wide margin. For model-based transfer, we introduce a constrained decoding algorithm that enhances cross-lingual Sequence Labeling in zero-shot settings using text-to-text models. Finally, we develop Medical mT5, the first multilingual text-to-text medical model, demonstrating the practical impact of our research on real-world applications.

Image autoregressive (IAR) models have surpassed diffusion models (DMs) in both image quality (FID: 1.48 vs. 1.58) and generation speed. However, their privacy risks remain largely unexplored. To address this, we conduct a comprehensive privacy analysis comparing IARs to DMs. We develop a novel membership inference attack (MIA) that achieves a significantly higher success rate in detecting training images (TPR@FPR=1%: 86.38% for IARs vs. 4.91% for DMs). Using this MIA, we perform dataset inference (DI) and find that IARs require as few as six samples to detect dataset membership, compared to 200 for DMs, indicating higher information leakage. Additionally, we extract hundreds of training images from an IAR (e.g., 698 from VAR-d30). Our findings highlight a fundamental privacy-utility trade-off: while IARs excel in generation quality and speed, they are significantly more vulnerable to privacy attacks. This suggests that incorporating techniques from DMs, such as per-token probability modeling using diffusion, could help mitigate IARs' privacy risks. Our code is available at https://github.com/sprintml/privacy_attacks_against_iars.

ABSTRACT Survival analysis, a vital tool for predicting the time to event, has been used in many domains such as healthcare, criminal justice, and finance. Like classification tasks, survival analysis can exhibit bias against disadvantaged groups, often due to biases inherent in data or algorithms . Several studies in both the IS and CS communities have attempted to address fairness in survival analysis . However, existing methods often overlook the importance of prediction fairness at pre - defined evaluation time points, which is crucial in real - world applications where decision making often hinge s on specific time frames . To address this critical research gap, we introduce a new fairness concept: equalized odds (EO) in survival analysis, which emphasize s prediction fairness at pre - defined time points . To achieve th e EO fairness in survival analysis, we propose a Conditional Mutual Information Augmentation ( CMIA) approach, which features a novel fairness regularization term based on conditional mutual information and a n innovative censored data augmentation technique. Our CMIA approach can effectively balance prediction accuracy and fairness, and it is applicable to various survival models. W e evaluate the CMIA approach against several state - of - the - art methods within three different application domains, and the results demonstrate that CMIA consistently reduces prediction disparit y while maintaining good accuracy and significantly outperform s the other competing methods across multiple datasets and survival models (e.g., linear COX, deep AFT) . Keywords: survival analysis, equalized odds, fairness, pre - defined evaluation time points, conditional mutual information, cen sore d data augmentation 2 Fairness in Survival Analysis: A Novel Conditional Mutual Information Augmentation Approach 1. INTRODUCTION Survival analysis is a set of statistical methods designed to model data where the outcome of interest is the time to the occurrence of a particular event (P . It is widely applied across many domains, such as healthcare (Khuri et al., 2005; Reddy et al., 2015), education (Ameri et al., 2016), business intelligence (Li et al., 2016; Rakesh et al., 2016), etc . In these applications, survival analysis provide s likelihood estimation for the occurrence of event s over time, which is useful for a lot of crucial decision making.

Artificial intelligence (AI) is increasingly being utilized to optimize magnetic resonance imaging (MRI) protocols. Given that image details are critical for diagnostic accuracy, optimizing MRI acquisition protocols is essential for enhancing image quality. While medical physicists are responsible for this optimization, the variability in equipment usage and the wide range of MRI protocols in clinical settings pose significant challenges. This study aims to validate the application of AI in optimizing MRI protocols using dynamic data from clinical practice, specifically DICOM metadata. To achieve this, four MRI spine exam databases were created, with the target attribute being the binary classification of image quality (good or bad). Five AI models were trained to identify trends in acquisition parameters that influence image quality, grounded in MRI theory. These trends were analyzed using SHAP graphs. The models achieved F1 performance ranging from 77% to 93% for datasets containing 292 or more instances, with the observed trends aligning with MRI theory. The models effectively reflected the practical realities of clinical MRI settings, offering a valuable tool for medical physicists in quality control tasks. In conclusion, AI has demonstrated its potential to optimize MRI protocols, supporting medical physicists in improving image quality and enhancing the efficiency of quality control in clinical practice.

Web refresh crawling is the problem of keeping a cache of web pages fresh, that is, having the most recent copy available when a page is requested, given a limited bandwidth available to the crawler. Under the assumption that the change and request events, resp., to each web page follow independent Poisson processes, the optimal scheduling policy was derived by Azar et al. 2018. In this paper, we study an extension of this problem where side information indicating content changes, such as various types of web pings, for example, signals from sitemaps, content delivery networks, etc., is available. Incorporating such side information into the crawling policy is challenging, because (i) the signals can be noisy with false positive events and with missing change events; and (ii) the crawler should achieve a fair performance over web pages regardless of the quality of the side information, which might differ from web page to web page. We propose a scalable crawling algorithm which (i) uses the noisy side information in an optimal way under mild assumptions; (ii) can be deployed without heavy centralized computation; (iii) is able to crawl web pages at a constant total rate without spikes in the total bandwidth usage over any time interval, and automatically adapt to the new optimal solution when the total bandwidth changes without centralized computation. Experiments clearly demonstrate the versatility of our approach.

Machine learning algorithms that learn black-box predictive models (which cannot be directly interpreted) are increasingly used to make predictions affecting the lives of people. It is important that users understand the predictions of such models, particularly when the model outputs a negative prediction for the user (e.g. denying a loan). Counterfactual explanations provide users with guidance on how to change some of their characteristics to receive a different, positive classification by a predictive model. For example, if a predictive model rejected a loan application from a user, a counterfactual explanation might state: If your salary was {\pounds}50,000 (rather than your current {\pounds}35,000), then your loan would be approved. This paper proposes two novel contributions: (a) a novel multi-objective Evolutionary Algorithm (EA) for counterfactual generation based on lexicographic optimisation, rather than the more popular Pareto dominance approach; and (b) an extension to the definition of the objective of validity for a counterfactual, based on measuring the resilience of a counterfactual to violations of monotonicity constraints which are intuitively expected by users; e.g., intuitively, the probability of a loan application to be approved would monotonically increase with an increase in the salary of the applicant. Experiments involving 15 experimental settings (3 types of black box models times 5 datasets) have shown that the proposed lexicographic optimisation-based EA is very competitive with an existing Pareto dominance-based EA; and the proposed extension of the validity objective has led to a substantial increase in the validity of the counterfactuals generated by the proposed EA.

Early identification of cognitive concerns is critical but often hindered by subtle symptom presentation. This study developed and validated a fully automated, multi-agent AI workflow using LLaMA 3 8B to identify cognitive concerns in 3,338 clinical notes from Mass General Brigham. The agentic workflow, leveraging task-specific agents that dynamically collaborate to extract meaningful insights from clinical notes, was compared to an expert-driven benchmark. Both workflows achieved high classification performance, with F1-scores of 0.90 and 0.91, respectively. The agentic workflow demonstrated improved specificity (1.00) and achieved prompt refinement in fewer iterations. Although both workflows showed reduced performance on validation data, the agentic workflow maintained perfect specificity. These findings highlight the potential of fully automated multi-agent AI workflows to achieve expert-level accuracy with greater efficiency, offering a scalable and cost-effective solution for detecting cognitive concerns in clinical settings.

Smishing is a social engineering attack using SMS containing malicious content to deceive individuals into disclosing sensitive information or transferring money to cybercriminals. Smishing attacks have surged by 328%, posing a major threat to mobile users, with losses exceeding \$54.2 million in 2019. Despite its growing prevalence, the issue remains significantly under-addressed. This paper presents a novel hybrid machine learning model for detecting Bangla smishing texts, combining Bidirectional Encoder Representations from Transformers (BERT) with Convolutional Neural Networks (CNNs) for enhanced character-level analysis. Our model addresses multi-class classification by distinguishing between Normal, Promotional, and Smishing SMS. Unlike traditional binary classification methods, our approach integrates BERT's contextual embeddings with CNN's character-level features, improving detection accuracy. Enhanced by an attention mechanism, the model effectively prioritizes crucial text segments. Our model achieves 98.47% accuracy, outperforming traditional classifiers, with high precision and recall in Smishing detection, and strong performance across all categories.

Accurate detection of traffic anomalies is crucial for effective urban traffic management and congestion mitigation. We use the Spatiotemporal Generative Adversarial Network (STGAN) framework combining Graph Neural Networks and Long Short-Term Memory networks to capture complex spatial and temporal dependencies in traffic data. We apply STGAN to real-time, minute-by-minute observations from 42 traffic cameras across Gothenburg, Sweden, collected over several months in 2020. The images are processed to compute a flow metric representing vehicle density, which serves as input for the model. Training is conducted on data from April to November 2020, and validation is performed on a separate dataset from November 14 to 23, 2020. Our results demonstrate that the model effectively detects traffic anomalies with high precision and low false positive rates. The detected anomalies include camera signal interruptions, visual artifacts, and extreme weather conditions affecting traffic flow.