Sparse autoencoders (SAEs) are a popular method for interpreting concepts represented in large language model (LLM) activations. However, there is a lack of evidence regarding the validity of their interpretations due to the lack of a ground truth for the concepts used by an LLM, and a growing number of works have presented problems with current SAEs. One alternative source of evidence would be demonstrating that SAEs improve performance on downstream tasks beyond existing baselines. We test this by applying SAEs to the real-world task of LLM activation probing in four regimes: data scarcity, class imbalance, label noise, and covariate shift. Due to the difficulty of detecting concepts in these challenging settings, we hypothesize that SAEs' basis of interpretable, concept-level latents should provide a useful inductive bias. However, although SAEs occasionally perform better than baselines on individual datasets, we are unable to design ensemble methods combining SAEs with baselines that consistently outperform ensemble methods solely using baselines. Additionally, although SAEs initially appear promising for identifying spurious correlations, detecting poor dataset quality, and training multi-token probes, we are able to achieve similar results with simple non-SAE baselines as well. Though we cannot discount SAEs' utility on other tasks, our findings highlight the shortcomings of current SAEs and the need to rigorously evaluate interpretability methods on downstream tasks with strong baselines.

Machine learning algorithms are used in diverse domains, many of which face significant challenges due to data imbalance. Studies have explored various approaches to address the issue, like data preprocessing, cost-sensitive learning, and ensemble methods. Generative Adversarial Networks (GANs) showed immense potential as a data preprocessing technique that generates good quality synthetic data. This study employs a systematic mapping methodology to analyze 3041 papers on GAN-based sampling techniques for imbalanced data sourced from four digital libraries. A filtering process identified 100 key studies spanning domains such as healthcare, finance, and cybersecurity. Through comprehensive quantitative analysis, this research introduces three categorization mappings as application domains, GAN techniques, and GAN variants used to handle the imbalanced nature of the data. GAN-based over-sampling emerges as an effective preprocessing method. Advanced architectures and tailored frameworks helped GANs to improve further in the case of data imbalance. GAN variants like vanilla GAN, CTGAN, and CGAN show great adaptability in structured imbalanced data cases. Interest in GANs for imbalanced data has grown tremendously, touching a peak in recent years, with journals and conferences playing crucial roles in transmitting foundational theories and practical applications. While with these advances, none of the reviewed studies explicitly explore hybridized GAN frameworks with diffusion models or reinforcement learning techniques. This gap leads to a future research idea develop innovative approaches for effectively handling data imbalance.

Unmasking Societal Biases in Respiratory Support for ICU Patients through Social Determinants of Health Mira Moukheiber 1, Lama Moukheiber 1, Dana Moukheiber 1 and Hyung-Chul Lee 2, 1 Massachusetts Institute of Technology 2 Seoul National University College of Medicine, Seoul National University Hospital, Department of Anesthesiology and Pain Medicine vital@snu.ac.kr Abstract In critical care settings, where precise and timely interventions are crucial for health outcomes, evaluating disparities in patient outcomes is important. Current approaches often fall short in comprehensively understanding and evaluating the impact of respiratory support interventions on individuals affected by social determinants of health. Attributes such as gender, race, and age are commonly assessed and essential, but provide only a partial view of the complexities faced by diverse populations. In this study, we focus on two clinically motivated tasks: prolonged mechanical ventilation and successful weaning. We also perform fairness audits on the models' predictions across demographic groups and social determinants of health to better understand the health inequities in respiratory interventions in the intensive care unit. We also release a temporal benchmark dataset, verified by clinical experts, to enable benchmarking of clinical respiratory intervention tasks. 1 Introduction Critically-ill patients often find themselves in the intensive care unit (ICU) seeking specialized support for respiratory distress [ Doyle et al., 1995; Ware and Matthay, 2000 ] . Despite advances in supportive treatments, the in-hospital mortality rate remains 40% for conditions such as acute lung injury and acute respiratory distress syndrome [ Rubenfeld et al., 2005; Sweatt and Levitt, 2014 ] .

It has been 100 years since statistical process control (SPC) or statistical process monitoring (SPM) was first introduced for production processes and later applied to service, healthcare, and other industries. The techniques applied to SPM applications are mostly statistically oriented. Recent advances in Artificial Intelligence (AI) have reinvigorated the imagination of adopting AI for SPM applications. This manuscript begins with a concise review of the historical development of the statistically based SPM methods. Next, this manuscript explores AI and Machine Learning (ML) algorithms and methods applied in various SPM applications, addressing quality characteristics of univariate, multivariate, profile, and image. These AI methods can be classified into the following categories: classification, pattern recognition, time series applications, and generative AI. Specifically, different kinds of neural networks, such as artificial neural networks (ANN), convolutional neural networks (CNN), recurrent neural networks (RNN), and generative adversarial networks (GAN), are among the most implemented AI methods impacting SPM. Finally, this manuscript outlines a couple of future directions that harness the potential of the Large Multimodal Model (LMM) for advancing SPM research and applications in complex systems. The ultimate objective is to transform statistical process monitoring (SPM) into smart process control (SMPC), where corrective actions are autonomously implemented to either prevent quality issues or restore process performance.

Large Language models (LLMs) have achieved encouraging results in tabular data generation. However, existing approaches require fine-tuning, which is computationally expensive. This paper explores an alternative: prompting a fixed LLM with in-context examples. We observe that using randomly selected in-context examples hampers the LLM's performance, resulting in sub-optimal generation quality. To address this, we propose a novel in-context learning framework: TabGen-ICL, to enhance the in-context learning ability of LLMs for tabular data generation. TabGen-ICL operates iteratively, retrieving a subset of real samples that represent the residual between currently generated samples and true data distributions. This approach serves two purposes: locally, it provides more effective in-context learning examples for the LLM in each iteration; globally, it progressively narrows the gap between generated and real data. Extensive experiments on five real-world tabular datasets demonstrate that TabGen-ICL significantly outperforms the random selection strategy. Specifically, it reduces the error rate by a margin of $3.5\%-42.2\%$ on fidelity metrics. We demonstrate for the first time that prompting a fixed LLM can yield high-quality synthetic tabular data. The code is provided in the \href{https://github.com/fangliancheng/TabGEN-ICL}{link}.

Autonomous driving is at a critical stage in revolutionizing transportation systems and reshaping societal norms. More than 1,400 self-driving cars, trucks, and other vehicles are currently in operation or testing in the U.S. (Etherington 2019), and 4.5 million autonomous vehicles are expected to run on U.S. roads by 2030 (Meyer 2023). While autonomous driving is promising in improving traffic efficiency and personal mobility, safety is a prerequisite of all possible achievements and is becoming the first priority in practice (Du et al. 2020). In October 2023, Cruise, one of the leading autonomous driving companies, was ordered by California to stop operations of driverless cars in the state after one of Cruise's cars struck a pedestrian in San Francisco (Kerr 2023). The rare incident involved a woman who was first hit by a human driver and then thrown onto the road in front of a Cruise vehicle. The Cruise vehicle then rolled over the pedestrian and finally stopped on top of her, causing serious injuries. Such an accident reflects one of the greatest challenges in autonomous driving: the safety of an autonomous car is largely determined by the ability to detect and react to rare scenarios rather than common normal situations, which have been well considered during development. Although rare in a long-tailed distribution, unusual driving scenarios do happen and can have large impact on driving safety. To mitigate the impact of abnormal ego behaviors when outside the design domains, a detection system for anomalous driving scenarios is necessary, the output of which can be potentially used as a high-level decision for motion planning.

In this paper we present the symbol and bit error rate performance of the weak signal digital communications system. We investigate orthogonal multiple frequency shift keying modulation scheme with supervised machine learning demodulation approach using simple dense end-to-end artificial neural network. We focus on the interference immunity over an additive white Gaussian noise with average signal-to-noise ratios from -20 dB to 0 dB.

Vision foundation models (VFMs) are pre-trained on extensive image datasets to learn general representations for diverse types of data. These models can subsequently be fine-tuned for specific downstream tasks, significantly boosting performance across a broad range of applications. However, existing vision foundation models that claim to be applicable to various clinical tasks are mostly pre-trained on 3D computed tomography (CT), which benefits from the availability of extensive 3D CT databases. Significant differences between CT and magnetic resonance imaging (MRI) in imaging principles, signal characteristics, and data distribution may hinder their practical performance and versatility in MRI-specific applications. Here, we propose Triad, a vision foundation model for 3D MRI. Triad adopts a widely used autoencoder architecture to learn robust representations from 131,170 3D MRI volumes and uses organ-independent imaging descriptions to constrain the semantic distribution of the visual modality. The above pre-training dataset is called Triad-131K, which is currently the largest 3D MRI pre-training dataset. We evaluate Triad across three tasks, namely, organ/tumor segmentation, organ/cancer classification, and medical image registration, in two data modalities (within-domain and out-of-domain) settings using 25 downstream datasets. By initializing models with Triad's pre-trained weights, nnUNet-Triad improves segmentation performance by 2.51% compared to nnUNet-Scratch across 17 datasets. Swin-B-Triad achieves a 3.97% improvement over Swin-B-Scratch in classification tasks across five datasets. SwinUNETR-Triad improves by 4.00% compared to SwinUNETR-Scratch in registration tasks across two datasets. Our study demonstrates that pre-training can improve performance when the data modalities and organs of upstream and downstream tasks are consistent.

To deploy machine learning models in the real world, researchers have proposed many OOD detection algorithms to help models identify unknown samples during the inference phase and prevent them from making untrustworthy predictions. Unlike methods that rely on extra data for outlier exposure training, post hoc methods detect Out-of-Distribution (OOD) samples by developing scoring functions, which are model agnostic and do not require additional training. However, previous post hoc methods may fail to capture the geometric cues embedded in network representations. Thus, in this study, we propose a novel score function based on the optimal transport theory, named OTOD, for OOD detection. We utilize information from features, logits, and the softmax probability space to calculate the OOD score for each test sample. Our experiments show that combining this information can boost the performance of OTOD with a certain margin. Experiments on the CIFAR-10 and CIFAR-100 benchmarks demonstrate the superior performance of our method. Notably, OTOD outperforms the state-of-the-art method GEN by 7.19% in the mean FPR@95 on the CIFAR-10 benchmark using ResNet-18 as the backbone, and by 12.51% in the mean FPR@95 using WideResNet-28 as the backbone. In addition, we provide theoretical guarantees for OTOD. The code is available in https://github.com/HengGao12/OTOD.

Non-small cell lung cancer (NSCLC) remains a major global health challenge, with high post-surgical recurrence rates underscoring the need for accurate pathological response predictions to guide personalized treatments. Although artificial intelligence models show promise in this domain, their clinical adoption is limited by the lack of medically grounded guidance during training, often resulting in non-explainable intrinsic predictions. To address this, we propose Doctor-in-the-Loop, a novel framework that integrates expert-driven domain knowledge with explainable artificial intelligence techniques, directing the model toward clinically relevant anatomical regions and improving both interpretability and trustworthiness. Our approach employs a gradual multi-view strategy, progressively refining the model's focus from broad contextual features to finer, lesion-specific details. By incorporating domain insights at every stage, we enhance predictive accuracy while ensuring that the model's decision-making process aligns more closely with clinical reasoning. Evaluated on a dataset of NSCLC patients, Doctor-in-the-Loop delivers promising predictive performance and provides transparent, justifiable outputs, representing a significant step toward clinically explainable artificial intelligence in oncology.