With the advance of high-throughput genotyping and sequencing technologies, it becomes feasible to comprehensive evaluate the role of massive genetic predictors in disease prediction. There exists, therefore, a critical need for developing appropriate statistical measurements to access the combined effects of these genetic variants in disease prediction. Predictiveness curve is commonly used as a graphical tool to measure the predictive ability of a risk prediction model on a single continuous biomarker. Yet, for most complex diseases, risk prediciton models are formed on multiple genetic variants. We therefore propose a multi-marker predictiveness curve and provide a non-parametric method to construct the curve for case-control studies. We further introduce a global predictiveness U and a partial predictiveness U to summarize prediction curve across the whole population and sub-population of clinical interest, respectively. We also demonstrate the connections of predictiveness curve with ROC curve and Lorenz curve. Through simulation, we compared the performance of the predictiveness U to other three summary indices: R square, Total Gain, and Average Entropy, and showed that Predictiveness U outperformed the other three indexes in terms of unbiasedness and robustness. Moreover, we simulated a series of rare-variants disease model, found partial predictiveness U performed better than global predictiveness U. Finally, we conducted a real data analysis, using predictiveness curve and predictiveness U to evaluate a risk prediction model for Nicotine Dependence.

Tweets provides valuable semantic context for earth observation tasks and serves as a complementary modality to remote sensing imagery. In building function classification (BFC), tweets are often collected using geographic heuristics and labeled via external databases, an inherently weakly supervised process that introduces both label noise and sentence level feature noise (e.g., irrelevant or uninformative tweets). While label noise has been widely studied, the impact of sentence level feature noise remains underexplored, largely due to the lack of clean benchmark datasets for controlled analysis. In this work, we propose a method for generating a synthetic oracle dataset using LLM, designed to contain only tweets that are both correctly labeled and semantically relevant to their associated buildings. This oracle dataset enables systematic investigation of noise impacts that are otherwise difficult to isolate in real-world data. To assess its utility, we compare model performance using Naive Bayes and mBERT classifiers under three configurations: real vs. synthetic training data, and cross-domain generalization. Results show that noise in real tweets significantly degrades the contextual learning capacity of mBERT, reducing its performance to that of a simple keyword-based model. In contrast, the clean synthetic dataset allows mBERT to learn effectively, outperforming Naive Bayes Bayes by a large margin. These findings highlight that addressing feature noise is more critical than model complexity in this task. Our synthetic dataset offers a novel experimental environment for future noise injection studies and is publicly available on GitHub.

Central bank communication plays a critical role in shaping economic expectations and monetary policy effectiveness. This study applies supervised machine learning techniques to classify the sentiment of press releases from the Bank of Thailand, addressing gaps in research that primarily focus on lexicon-based approaches. My findings show that supervised learning can be an effective method, even with smaller datasets, and serves as a starting point for further automation. However, achieving higher accuracy and better generalization requires a substantial amount of labeled data, which is time-consuming and demands expertise. Using models such as Na\"ive Bayes, Random Forest and SVM, this study demonstrates the applicability of machine learning for central bank sentiment analysis, with English-language communications from the Thai Central Bank as a case study.

This paper examines the critical role of Graph Neural Networks (GNNs) in data preparation for generative artificial intelligence (GenAI) systems, with a particular focus on addressing and mitigating biases. We present a comparative analysis of three distinct methods for bias mitigation: data sparsification, feature modification, and synthetic data augmentation. Through experimental analysis using the german credit dataset, we evaluate these approaches using multiple fairness metrics, including statistical parity, equality of opportunity, and false positive rates. Our research demonstrates that while all methods improve fairness metrics compared to the original dataset, stratified sampling and synthetic data augmentation using GraphSAGE prove particularly effective in balancing demographic representation while maintaining model performance. The results provide practical insights for developing more equitable AI systems while maintaining model performance.

The existing biclustering algorithms for finding feature relation based biclusters often depend on assumptions like monotonicity or linearity. Though a few algorithms overcome this problem by using density-based methods, they tend to miss out many biclusters because they use global criteria for identifying dense regions. The proposed method, RelDenClu uses the local variations in marginal and joint densities for each pair of features to find the subset of observations, which forms the bases of the relation between them. It then finds the set of features connected by a common set of observations, resulting in a bicluster. To show the effectiveness of the proposed methodology, experimentation has been carried out on fifteen types of simulated datasets. Further, it has been applied to six real-life datasets. For three of these real-life datasets, the proposed method is used for unsupervised learning, while for other three real-life datasets it is used as an aid to supervised learning. For all the datasets the performance of the proposed method is compared with that of seven different state-of-the-art algorithms and the proposed algorithm is seen to produce better results. The efficacy of proposed algorithm is also seen by its use on COVID-19 dataset for identifying some features (genetic, demographics and others) that are likely to affect the spread of COVID-19.

Recent breakthroughs in single-cell technology have ushered in unparalleled opportunities to decode the molecular intricacy of intricate biological systems, especially those linked to diseases unique to humans. However, these progressions have also ushered in novel obstacles-specifically, the efficient annotation of extensive, long-tailed single-cell data pertaining to disease conditions. To effectively surmount this challenge, we introduce Celler, a state-of-the-art generative pre-training model crafted specifically for the annotation of single-cell data. Celler incorporates two groundbreaking elements: First, we introduced the Gaussian Inflation (GInf) Loss function. By dynamically adjusting sample weights, GInf Loss significantly enhances the model's ability to learn from rare categories while reducing the risk of overfitting for common categories. Secondly, we introduce an innovative Hard Data Mining (HDM) strategy into the training process, specifically targeting the challenging-to-learn minority data samples, which significantly improved the model's predictive accuracy. Additionally, to further advance research in this field, we have constructed a large-scale single-cell dataset: Celler-75, which encompasses 40 million cells distributed across 80 human tissues and 75 specific diseases. This dataset provides critical support for comprehensively exploring the potential of single-cell technology in disease research. Our code is available at https://github.com/AI4science-ym/HiCeller.

This research introduces an innovative method for identifying credit card fraud by combining the SMOTE-KMEANS technique with an ensemble machine learning model. The proposed model was benchmarked against traditional models such as logistic regression, decision trees, random forests, and support vector machines. Performance was evaluated using metrics, including accuracy, recall, and area under the curve (AUC). The results demonstrated that the proposed model achieved superior performance, with an AUC of 0.96 when combined with the SMOTE-KMEANS algorithm. This indicates a significant improvement in detecting fraudulent transactions while maintaining high precision and recall. The study also explores the application of different oversampling techniques to enhance the performance of various classifiers. The findings suggest that the proposed method is robust and effective for classification tasks on balanced datasets. Future research directions include further optimization of the SMOTE-KMEANS approach and its integration into existing fraud detection systems to enhance financial security and consumer protection.

In this work, we propose a metric called "Number of Thoughts (NofT)" to determine the difficulty of tasks pre-prompting and support Large Language Models (LLMs) in production contexts. By setting thresholds based on the number of thoughts, this metric can discern the difficulty of prompts and support more effective prompt routing. A 2% decrease in latency is achieved when routing prompts from the MathInstruct dataset through quantized, distilled versions of Deepseek with 1.7 billion, 7 billion, and 14 billion parameters. Moreover, this metric can be used to detect adversarial prompts used in prompt injection attacks with high efficacy. The Number of Thoughts can inform a classifier that achieves 95% accuracy in adversarial prompt detection.

Reliable drug safety reference databases are essential for pharmacovigilance, yet existing resources like SIDER are outdated and static. We introduce PVLens, an automated system that extracts labeled safety information from FDA Structured Product Labels (SPLs) and maps terms to MedDRA. In validation against 97 drug labels, PVLens achieved an F1 score of 0.882, with high recall (0.983) and moderate precision (0.799). By offering a scalable, more accurate and continuously updated alternative to SIDER, PVLens enhances real-time pharamcovigilance with improved accuracy and contemporaneous insights. Keywords: Pharmacovigilance, Natural Language Processing (NLP), Drug Safety, ADR 1 Introduction A clear understanding of known adverse effects, along with continuous surveillance for emerging safety concerns, is essential for patients, healthcare professionals, and pharmacovigilance (PV) scientists.

Advancements in retrieving accessible information have evolved faster in the last few years compared to the decades since the internet's creation. Search engines, like Google, have been the number one way to find relevant data. They have always relied on the user's abilities to find the best information in its billions of links and sources at everybody's fingertips. The advent of large language models (LLMs) has completely transformed the field of information retrieval. The LLMs excel not only at retrieving relevant knowledge but also at summarizing it effectively, making information more accessible and consumable for users. On top of it, the rise of AI Agents has introduced another aspect to information retrieval i.e. dynamic information retrieval which enables the integration of real-time data such as weather forecasts, and financial data with the knowledge base to curate context-aware knowledge. However, despite these advancements the agents remain susceptible to issues of bias and fairness, challenges deeply rooted within the knowledge base and training of LLMs. This study introduces a novel approach to bias-aware knowledge retrieval by leveraging agentic framework and the innovative use of bias detectors as tools to identify and highlight inherent biases in the retrieved content. By empowering users with transparency and awareness, this approach aims to foster more equitable information systems and promote the development of responsible AI.