Chronic obstructive pulmonary disease (COPD) is a major global health concern, with accurate severity assessment crucial for effective management, especially in intensive care units (ICUs). This study presents a novel approach to COPD sever - ity classification using machine learning algorithms applied to the MIMIC - III dataset. Our work presents a new application of the MIMIC - III dataset and con - tributes to the growing field of artificial intelligence in critical care medicine. We developed a model to classify COPD severity based on available ICU parameters, including blood gas measurements and vital signs. Our methodology incorpo - rated semi - supervised learning techniques to leverage unlabeled data, enhancing model robustness. A random forest classifier demonstrated superior performance, achieving 92.51% accuracy and 0.98 ROC AUC distinguishing between mild - to - moderate and severe COPD cases. This approach offers a practical, accurate, and accessible tool for rapid COPD severity assessment in ICU settings, poten - tially improving clinical decision - making and patient outcomes. Future research should focus on external validation and integration into clinical decision support systems to enhance COPD management in the ICUs.

Distributed Denial of Service (DDoS) attacks represent a persistent and evolving threat to modern networked systems, capable of causing large-scale service disruptions. The complexity of such attacks, often hidden within high-dimensional and redundant network traffic data, necessitates robust and intelligent feature selection techniques for effective detection. Traditional methods such as filter-based, wrapper-based, and embedded approaches, each offer strengths but struggle with scalability or adaptability in complex attack environments. In this study, we explore these existing techniques through a detailed comparative analysis and highlight their limitations when applied to large-scale DDoS detection tasks. Building upon these insights, we introduce a novel Generative Adversarial Network-based Feature Selection (GANFS) method that leverages adversarial learning dynamics to identify the most informative features. By training a GAN exclusively on attack traffic and employing a perturbation-based sensitivity analysis on the Discriminator, GANFS effectively ranks feature importance without relying on full supervision. Experimental evaluations using the CIC-DDoS2019 dataset demonstrate that GANFS not only improves the accuracy of downstream classifiers but also enhances computational efficiency by significantly reducing feature dimensionality. These results point to the potential of integrating generative learning models into cybersecurity pipelines to build more adaptive and scalable detection systems.

Deep learning models, especially large Transformers, carry substantial "memory" in their intermediate layers -- an \emph{internal world} that encodes a wealth of relational and contextual knowledge. This work harnesses that internal world for wildfire occurrence prediction by introducing a modular architecture built upon Gemma 3, a state-of-the-art multimodal model. Rather than relying on Gemma 3's original embedding and positional encoding stacks, we develop a custom feed-forward module that transforms tabular wildfire features into the hidden dimension required by Gemma 3's mid-layer Transformer blocks. We freeze these Gemma 3 sub-layers -- thus preserving their pretrained representation power -- while training only the smaller input and output networks. This approach minimizes the number of trainable parameters and reduces the risk of overfitting on limited wildfire data, yet retains the benefits of Gemma 3's broad knowledge. Evaluations on a Moroccan wildfire dataset demonstrate improved predictive accuracy and robustness compared to standard feed-forward and convolutional baselines. Ablation studies confirm that the frozen Transformer layers consistently contribute to better representations, underscoring the feasibility of reusing large-model mid-layers as a learned internal world. Our findings suggest that strategic modular reuse of pretrained Transformers can enable more data-efficient and interpretable solutions for critical environmental applications such as wildfire risk management.

Virtual screening plays a critical role in modern drug discovery by enabling the identification of promising candidate molecules for experimental validation. Traditional machine learning methods such, as Support Vector Machines (SVM) and XGBoost, rely on predefined molecular representations, often leading to information loss and potential bias. In contrast, deep learning approaches-particularly Graph Convolutional Networks (GCNs)-offer a more expressive and unbiased alternative by operating directly on molecular graphs. Meanwhile, Large Language Models (LLMs) have recently demonstrated state-of-the-art performance in drug design, thanks to their capacity to capture complex chemical patterns from large-scale data via attention mechanisms. In this paper, we propose a hybrid architecture that integrates GCNs with LLM-derived embeddings to combine localized structural learning with global chemical knowledge. The LLM embeddings can be precomputed and stored in a molecular feature library, removing the need to rerun the LLM during training or inference and thus maintaining computational efficiency. We found that concatenating the LLM embeddings after each GCN layer-rather than only at the final layer-significantly improves performance, enabling deeper integration of global context throughout the network. The resulting model achieves superior results, with an F1-score of (88.8\%), outperforming standalone GCN (87.9%), XGBoost (85.5%), and SVM (85.4%) baselines.

Reinforcement learning has been shown to improve the performance of large language models. However, traditional approaches like RLHF or RLAIF treat the problem as single-step. As focus shifts toward more complex reasoning and agentic tasks, language models must take multiple steps of text generation, reasoning and environment interaction before generating a solution. We propose a synthetic data generation and RL methodology targeting multi-step optimization scenarios. This approach, called Step-Wise Reinforcement Learning (SWiRL), iteratively generates multi-step reasoning and tool use data, and then learns from that data. It employs a simple step-wise decomposition that breaks each multi-step trajectory into multiple sub-trajectories corresponding to each action by the original model. It then applies synthetic data filtering and RL optimization on these sub-trajectories. We evaluated SWiRL on a number of multi-step tool use, question answering, and mathematical reasoning tasks. Our experiments show that SWiRL outperforms baseline approaches by 21.5%, 12.3%, 14.8%, 11.1%, and 15.3% in relative accuracy on GSM8K, HotPotQA, CofCA, MuSiQue, and BeerQA, respectively. Excitingly, the approach exhibits generalization across tasks: for example, training only on HotPotQA (text question-answering) improves zero-shot performance on GSM8K (a math dataset) by a relative 16.9%.

Instance segmentation plays a pivotal role in medical image analysis by enabling precise localization and delineation of lesions, tumors, and anatomical structures. Although deep learning models such as Mask R-CNN and BlendMask have achieved remarkable progress, their application in high-risk medical scenarios remains constrained by confidence calibration issues, which may lead to misdiagnosis. To address this challenge, we propose a robust quality control framework based on conformal prediction theory. This framework innovatively constructs a risk-aware dynamic threshold mechanism that adaptively adjusts segmentation decision boundaries according to clinical requirements.Specifically, we design a \textbf{calibration-aware loss function} that dynamically tunes the segmentation threshold based on a user-defined risk level $α$. Utilizing exchangeable calibration data, this method ensures that the expected FNR or FDR on test data remains below $α$ with high probability. The framework maintains compatibility with mainstream segmentation models (e.g., Mask R-CNN, BlendMask+ResNet-50-FPN) and datasets (PASCAL VOC format) without requiring architectural modifications. Empirical results demonstrate that we rigorously bound the FDR metric marginally over the test set via our developed calibration framework.

Protein-protein interaction (PPI) prediction plays a pivotal role in deciphering cellular functions and disease mechanisms. To address the limitations of traditional experimental methods and existing computational approaches in cross-modal feature fusion and false-negative suppression, we propose SCMPPI-a novel supervised contrastive multimodal framework. By effectively integrating sequence-based features (AAC, DPC, ESMC-CKSAAP) with network topology (Node2Vec embeddings) and incorporating an enhanced contrastive learning strategy with negative sample filtering, SCMPPI achieves superior prediction performance. Extensive experiments on eight benchmark datasets demonstrate its state-of-the-art accuracy(98.13%) and AUC(99.69%), along with excellent cross-species generalization (AUC>99%). Successful applications in CD9 networks, Wnt pathway analysis, and cancer-specific networks further highlight its potential for disease target discovery, establishing SCMPPI as a powerful tool for multimodal biological data analysis.

In the United States alone accidental home deaths exceed 128,000 per year. Our work aims to enable home robots who respond to emergency scenarios in the home, preventing injuries and deaths. We introduce a new dataset of household emergencies based in the ThreeDWorld simulator. Each scenario in our dataset begins with an instantaneous or periodic sound which may or may not be an emergency. The agent must navigate the multi-room home scene using prior observations, alongside audio signals and images from the simulator, to determine if there is an emergency or not. In addition to our new dataset, we present a modular approach for localizing and identifying potential home emergencies. Underpinning our approach is a novel probabilistic dynamic scene graph (P-DSG), where our key insight is that graph nodes corresponding to agents can be represented with a probabilistic edge. This edge, when refined using Bayesian inference, enables efficient and effective localization of agents in the scene. We also utilize multi-modal vision-language models (VLMs) as a component in our approach, determining object traits (e.g. flammability) and identifying emergencies. We present a demonstration of our method completing a real-world version of our task on a consumer robot, showing the transferability of both our task and our method. Our dataset will be released to the public upon this papers publication.

This important role has led researchers to develop various methods for gathering information about brain activity, resulting in significant advancements in medical signal and image acquisition systems [2]. Among these advancements are functional neuroimaging techniques, such as functional magnetic resonance imaging, magnetoencephalography (MEG), positron emission tomography (PET), and electroencephalography [2]. Among these techniques, electroencephalography stands out due to three key advantages: it is a non-invasive method that allows data generation from any individual, has excellent temporal resolution--effectively capturing events occurring within milliseconds--and is relatively cost-effective compared to other examinations [3]. Electroencephalography monitors the brain's electrical activity through electrodes placed on the scalp, and the resulting data, known as the electroencephalogram (EEG), consists of a time series of electrical potentials that reflect neurological activity [4]. The EEG signal is widely used in the field of neuroscience and has the potential to advance brain-computer interfaces [5], facilitate emotion detection [6], enable classification of sleep stages [7] and help clinicians and researchers in identifying brain diseases, including but not limited to Alzheimer's disease [8], dyslexia [9], schizophrenia [10], Creutzfeldt-Jakob disease [11] and cognitive impairment [12]. Epilepsy, for example, is a neurological disorder characterized by abnormal brain activity that can lead to seizures, unusual behaviors, or even loss of consciousness.

Empirical inference attacks are a popular approach for evaluating the privacy risk of data release mechanisms in practice. While an active attack literature exists to evaluate machine learning models or synthetic data release, we currently lack comparable methods for fixed aggregate statistics, in particular when only a limited number of statistics are released. We here propose an inference attack framework against fixed aggregate statistics and an attribute inference attack called DeSIA. We instantiate DeSIA against the U.S. Census PPMF dataset and show it to strongly outperform reconstruction-based attacks. In particular, we show DeSIA to be highly effective at identifying vulnerable users, achieving a true positive rate of 0.14 at a false positive rate of $10^{-3}$. We then show DeSIA to perform well against users whose attributes cannot be verified and when varying the number of aggregate statistics and level of noise addition. We also perform an extensive ablation study of DeSIA and show how DeSIA can be successfully adapted to the membership inference task. Overall, our results show that aggregation alone is not sufficient to protect privacy, even when a relatively small number of aggregates are being released, and emphasize the need for formal privacy mechanisms and testing before aggregate statistics are released.