Given the increasing complexity of omics datasets, a key challenge is not only improving classification performance but also enhancing the transparency and reliability of model decisions. Effective model performance and feature selection are fundamental for explainability and reliability. In many cases, high dimensional omics datasets suffer from limited number of samples due to clinical constraints, patient conditions, phenotypes rarity and others conditions. Current omics based classification models often suffer from narrow interpretability, making it difficult to discern meaningful insights where trust and reproducibility are critical. This study presents a machine learning based classification framework that integrates feature selection with data augmentation techniques to achieve high standard classification accuracy while ensuring better interpretability. Using the publicly available dataset (E MTAB 8026), we explore a bootstrap analysis in six binary classification scenarios to evaluate the proposed model's behaviour. We show that the proposed pipeline yields cross validated perfomance on small dataset that is conserved when the trained classifier is applied to a larger test set. Our findings emphasize the fundamental balance between accuracy and feature selection, highlighting the positive effect of introducing synthetic data for better generalization, even in scenarios with very limited samples availability.

Generative models can unintentionally memorize training data, posing significant privacy risks. This paper addresses the memorization phenomenon in time series imputation models, introducing the Loss-Based with Reference Model (LBRM) algorithm. The LBRM method leverages a reference model to enhance the accuracy of membership inference attacks, distinguishing between training and test data. Our contributions are twofold: first, we propose an innovative method to effectively extract and identify memorized training data, significantly improving detection accuracy. On average, without fine-tuning, the AUROC improved by approximately 40\%. With fine-tuning, the AUROC increased by approximately 60\%. Second, we validate our approach through membership inference attacks on two types of architectures designed for time series imputation, demonstrating the robustness and versatility of the LBRM approach in different contexts. These results highlight the significant enhancement in detection accuracy provided by the LBRM approach, addressing privacy risks in time series imputation models.

Traditional human reliability analysis (HRA) methods, such as IDHEAS-ECA, rely on expert judgment and empirical rules that often overlook the cognitive underpinnings of human error. Moreover, conducting human-in-the-loop experiments for advanced nuclear power plants is increasingly impractical due to novel interfaces and limited operational data. This study proposes a cognitive-mechanistic framework (COGMIF) that enhances the IDHEAS-ECA methodology by integrating an ACT-R-based human digital twin (HDT) with TimeGAN-augmented simulation. The ACT-R model simulates operator cognition, including memory retrieval, goal-directed procedural reasoning, and perceptual-motor execution--under high-fidelity scenarios derived from a high-temperature gas-cooled reactor (HTGR) simulator. To overcome the resource constraints of large-scale cognitive modeling, TimeGAN is trained on ACT-R-generated time-series data to produce high-fidelity synthetic operator behavior datasets. These simulations are then used to drive IDHEAS-ECA assessments, enabling scalable, mechanism-informed estimation of human error probabilities (HEPs). Comparative analyses with SPAR-H and sensitivity assessments demonstrate the robustness and practical advantages of the proposed COGMIF. This work offers a credible and computationally efficient pathway to integrate cognitive theory into industrial HRA practices. Keywords: Human Reliability, Human Digital Twins, IDHEAS-ECA, TimeGAN, Bayesian 1 Introduction Human reliability analysis (HRA) plays a pivotal role in the safety assessment of complex socio-technical systems, particularly in high-risk domains such as nuclear power generation [1]. As a fundamental component of probabilistic risk assessment (PRA), HRA aims to estimate the likelihood of human error under specific operational contexts, thereby supporting risk-informed decision-making and the design of resilient safety systems. Over the past decades, a range of structured methodologies, such as the standardized plant analysis risk-human reliability analysis (SPAR-H) [2], the technique for human error rate prediction (THERP) [3], and more recently, the integrated human event analysis system for event and condition assessment (IDHEAS-ECA) [4], have been developed to quantify human error probabilities (HEPs). While these frameworks offer operational utility, they are primarily grounded in expert judgment, predefined performance shaping factors (PSFs), and empirically derived databases, often lacking a mechanistic understanding of the cognitive processes that drive operator actions and errors. Furthermore, traditional HRA approaches are highly dependent on two major data sources: (1) retrospective analysis of operational events, and (2) human-in-the-loop (HITL) simulation experiments conducted in controlled environments.

Membership Inference Attacks (MIAs) have recently been employed to determine whether a specific text was part of the pre-training data of Large Language Models (LLMs). However, existing methods often misinfer non-members as members, leading to a high false positive rate, or depend on additional reference models for probability calibration, which limits their practicality. To overcome these challenges, we introduce a novel framework called Automatic Calibration Membership Inference Attack (ACMIA), which utilizes a tunable temperature to calibrate output probabilities effectively. This approach is inspired by our theoretical insights into maximum likelihood estimation during the pre-training of LLMs. We introduce ACMIA in three configurations designed to accommodate different levels of model access and increase the probability gap between members and non-members, improving the reliability and robustness of membership inference. Extensive experiments on various open-source LLMs demonstrate that our proposed attack is highly effective, robust, and generalizable, surpassing state-of-the-art baselines across three widely used benchmarks. Our code is available at: Github. 1 Introduction Large Language Models (LLMs), pre-trained on massive text corpora, have shown impressive human-level language understanding, reasoning, and decision-making capabilities [4, 28, 1, 23]. However, their tendency to memorize training data also introduces significant ethical and security concerns [14, 31, 2, 21, 22].

--Machine learning (ML)-based intrusion detection systems (IDS) are vulnerable to adversarial attacks. It is crucial for an IDS to learn to recognize adversarial examples before malicious entities exploit them. In this paper, we generated adversarial samples using the Jacobian Saliency Map Attack (JSMA). We validate the generalization and scalability of the adversarial samples to tackle a broad range of real attacks on Industrial Control Systems (ICS). We evaluated the impact by assessing multiple attacks generated using the proposed method. The model trained with adversarial samples detected attacks with 95% accuracy on real-world attack data not used during training. The study was conducted using an operational secure water treatment (SWaT) testbed. Industrial control systems (ICS) comprise a significant portion of any state or nation's critical infrastructure (CI). Examples of such systems include water treatment plants and electric power grids, where an ICS regulates the physical processes. The physical processes consist of two primary parts: monitoring and controlling. The monitoring part maintains processes and ensures they are operating properly by measuring various signals acquired from sensors.

Oysters are ecologically and commercially important species that require frequent monitoring to track population demographics (e.g. abundance, growth, mortality). Current methods of monitoring oyster reefs often require destructive sampling methods and extensive manual effort. Therefore, they are suboptimal for small-scale or sensitive environments. A recent alternative, the ODYSSEE model, was developed to use deep learning techniques to identify live oysters using video or images taken in the field of oyster reefs to assess abundance. The validity of this model in identifying live oysters on a reef was compared to expert and non-expert annotators. In addition, we identified potential sources of prediction error. Although the model can make inferences significantly faster than expert and non-expert annotators (39.6 s, $2.34 \pm 0.61$ h, $4.50 \pm 1.46$ h, respectively), the model overpredicted the number of live oysters, achieving lower accuracy (63\%) in identifying live oysters compared to experts (74\%) and non-experts (75\%) alike. Image quality was an important factor in determining the accuracy of the model and the annotators. Better quality images improved human accuracy and worsened model accuracy. Although ODYSSEE was not sufficiently accurate, we anticipate that future training on higher-quality images, utilizing additional live imagery, and incorporating additional annotation training classes will greatly improve the model's predictive power based on the results of this analysis. Future research should address methods that improve the detection of living vs. dead oysters.

Multimodal learning, which integrates diverse data sources such as images, text, and structured data, has proven superior to unimodal counterparts in high-stakes decision-making. However, while performance gains remain the gold standard for evaluating multimodal systems, concerns around bias and robustness are frequently overlooked. In this context, this paper explores two key research questions (RQs): (i) RQ1 examines whether adding a modality con-sistently enhances performance and investigates its role in shaping fairness measures, assessing whether it mitigates or amplifies bias in multimodal models; (ii) RQ2 investigates the impact of missing modalities at inference time, analyzing how multimodal models generalize in terms of both performance and fairness. Our analysis reveals that incorporating new modalities during training consistently enhances the performance of multimodal models, while fairness trends exhibit variability across different evaluation measures and datasets. Additionally, the absence of modalities at inference degrades performance and fairness, raising concerns about its robustness in real-world deployment. We conduct extensive experiments using multimodal healthcare datasets containing images, time series, and structured information to validate our findings.

Model averaging (MA) and ensembling play a crucial role in statistical and machine learning practice. When multiple candidate models are considered, MA techniques can be used to weight and combine them, often resulting in improved predictive accuracy and better estimation stability compared to model selection (MS) methods. In this paper, we address two challenges in combining least squares estimators from both theoretical and practical perspectives. We first establish several oracle inequalities for least squares MA via minimizing a Mallows' $C_p$ criterion under an arbitrary candidate model set. Compared to existing studies, these oracle inequalities yield faster excess risk and directly imply the asymptotic optimality of the resulting MA estimators under milder conditions. Moreover, we consider candidate model construction and investigate the problem of optimal all-subset combination for least squares estimators, which is an important yet rarely discussed topic in the existing literature. We show that there exists a fundamental limit to achieving the optimal all-subset MA risk. To attain this limit, we propose a novel Mallows-type MA procedure based on a dimension-adaptive $C_p$ criterion. The implicit ensembling effects of several MS procedures are also revealed and discussed. We conduct several numerical experiments to support our theoretical findings and demonstrate the effectiveness of the proposed Mallows-type MA estimator.

This paper proposes a scalable and interpretable framework for lane-wise highway traffic anomaly detection, leveraging multi-modal time series data extracted from surveillance cameras. Unlike traditional sensor-dependent methods, our approach uses AI-powered vision models to extract lane-specific features, including vehicle count, occupancy, and truck percentage, without relying on costly hardware or complex road modeling. We introduce a novel dataset containing 73,139 lane-wise samples, annotated with four classes of expert-validated anomalies: three traffic-related anomalies (lane blockage and recovery, foreign object intrusion, and sustained congestion) and one sensor-related anomaly (camera angle shift). Our multi-branch detection system integrates deep learning, rule-based logic, and machine learning to improve robustness and precision. Extensive experiments demonstrate that our framework outperforms state-of-the-art methods in precision, recall, and F1-score, providing a cost-effective and scalable solution for real-world intelligent transportation systems.

Knowledge Graphs have become increasingly popular due to their wide usage in various downstream applications, including information retrieval, chatbot development, language model construction, and many others. Link prediction (LP) is a crucial downstream task for knowledge graphs, as it helps to address the problem of the incompleteness of the knowledge graphs. However, previous research has shown that knowledge graphs, often created in a (semi) automatic manner, are not free from social biases. These biases can have harmful effects on downstream applications, especially by leading to unfair behavior toward minority groups. To understand this issue in detail, we develop a framework -- AuditLP -- deploying fairness metrics to identify biased outcomes in LP, specifically how occupations are classified as either male or female-dominated based on gender as a sensitive attribute. We have experimented with the sensitive attribute of age and observed that occupations are categorized as young-biased, old-biased, and age-neutral. We conduct our experiments on a large number of knowledge triples that belong to 21 different geographies extracted from the open-sourced knowledge graph, Wikidata. Our study shows that the variance in the biased outcomes across geographies neatly mirrors the socio-economic and cultural division of the world, resulting in a transparent partition of the Global North from the Global South.