False positives in pedestrian detection remain a challenge that has yet to be effectively resolved. To address this issue, this paper proposes a Full-stage Refined Proposal (FRP) algorithm aimed at eliminating these false positives within a two-stage CNN-based pedestrian detection framework. The main innovation of this work lies in employing various pedestrian feature re-evaluation strategies to filter out low-quality pedestrian proposals during both the training and testing stages. Specifically, in the training phase, the Training mode FRP algorithm (TFRP) introduces a novel approach for validating pedestrian proposals to effectively guide the model training process, thereby constructing a model with strong capabilities for false positive suppression. During the inference phase, two innovative strategies are implemented: the Classifier-guided FRP (CFRP) algorithm integrates a pedestrian classifier into the proposal generation pipeline to yield high-quality proposals through pedestrian feature evaluation, and the Split-proposal FRP (SFRP) algorithm vertically divides all proposals, sending both the original and the sub-region proposals to the subsequent subnetwork to evaluate their confidence scores, filtering out those with lower sub-region pedestrian confidence scores. As a result, the proposed algorithm enhances the model's ability to suppress pedestrian false positives across all stages. Various experiments conducted on multiple benchmarks and the SY-Metro datasets demonstrate that the model, supported by different combinations of the FRP algorithm, can effectively eliminate false positives to varying extents. Furthermore, experiments conducted on embedded platforms underscore the algorithm's effectiveness in enhancing the comprehensive pedestrian detection capabilities of the small pedestrian detector in resource-constrained edge devices.

The reliability of affective state estimation using EEG data is in question, given the variability in reported performance and the lack of standardized evaluation protocols. To investigate this, we reviewed 101 studies, focusing on the widely used DEAP dataset for emotion recognition. Our analysis revealed widespread methodological issues that include data leakage from improper segmentation, biased feature selection, flawed hyperparameter optimization, neglect of class imbalance, and insufficient methodological reporting. Notably, we found that nearly 87% of the reviewed papers contained one or more of these errors. Moreover, through experimental analysis, we observed that such methodological flaws can inflate the classification accuracy by up to 46%. These findings reveal fundamental gaps in standardized evaluation practices and highlight critical deficiencies in the peer review process for machine learning applications in neuroscience, emphasizing the urgent need for stricter methodological standards and evaluation protocols.

Federated Learning (FL) allows the training of deep neural networks in a distributed and privacy-preserving manner. However, this concept suffers from malfunctioning updates sent by the attending clients that cause global model performance degradation. Reasons for this malfunctioning might be technical issues, disadvantageous training data, or malicious attacks. Most of the current defense mechanisms are meant to require impractical prerequisites like knowledge about the number of malfunctioning updates, which makes them unsuitable for real-world applications. To counteract these problems, we introduce a novel method called Angular Support for Malfunctioning Client Resilience (ASMR), that dynamically excludes malfunctioning clients based on their angular distance. Our novel method does not require any hyperparameters or knowledge about the number of malfunctioning clients.

Access to comprehensive flight operations data remains severely restricted in aviation due to commercial sensitivity and competitive considerations, hindering the development of predictive models for operational planning. This paper investigates whether synthetic data can effectively replace real operational data for training machine learning models in pre-tactical aviation scenarios-predictions made hours to days before operations using only scheduled flight information. We evaluate four state-of-the-art synthetic data generators on three prediction tasks: aircraft turnaround time, departure delays, and arrival delays. Using a Train on Synthetic, Test on Real (TSTR) methodology on over 1.7 million European flight records, we first validate synthetic data quality through fidelity assessments, then assess both predictive performance and the preservation of operational relationships. Our results show that advanced neural network architectures, specifically transformer-based generators, can retain 94-97% of real-data predictive performance while maintaining feature importance patterns informative for operational decision-making. Our analysis reveals that even with real data, prediction accuracy is inherently limited when only scheduled information is available-establishing realistic baselines for pre-tactical forecasting. These findings suggest that high-quality synthetic data can enable broader access to aviation analytics capabilities while preserving commercial confidentiality, though stakeholders must maintain realistic expectations about pre-tactical prediction accuracy given the stochastic nature of flight operations.

Arrhythmia is a common cardiac condition that can precipitate severe complications without timely intervention. While continuous monitoring is essential for timely diagnosis, conventional approaches such as electrocardiogram and wearable devices are constrained by their reliance on specialized medical expertise and patient discomfort from their contact nature. Existing contactless monitoring, primarily designed for healthy subjects, face significant challenges when analyzing reflected signals from arrhythmia patients due to disrupted spatial stability and temporal consistency. In this paper, we introduce mCardiacDx, a radar-driven contactless system that accurately analyzes reflected signals and reconstructs heart pulse waveforms for arrhythmia monitoring and diagnosis. The key contributions of our work include a novel precise target localization (PTL) technique that locates reflected signals despite spatial disruptions, and an encoder-decoder model that transforms these signals into HPWs, addressing temporal inconsistencies. Our evaluation on a large dataset of healthy subjects and arrhythmia patients shows that both mCardiacDx and PTL outperform state-of-the-art approach in arrhythmia monitoring and diagnosis, also demonstrating improved performance in healthy subjects.

In recent years, large language models (LLMs) have demonstrated significant potential in constructing passage retrieval datasets. However, existing methods still face limitations in expressing cross-doc query needs and controlling annotation quality. To address these issues, this paper proposes a bidirectional generation pipeline, which aims to generate 3-level hierarchical queries for both intra-doc and cross-doc scenarios and mine additional relevance labels on top of direct mapping annotation. The pipeline introduces two query generation methods: bottom-up from single-doc text and top-down from multi-doc titles. The bottom-up method uses LLMs to disassemble and generate structured queries at both sentence-level and passage-level simultaneously from intra-doc passages. The top-down approach incorporates three key financial elements--industry, topic, and time--to divide report titles into clusters and prompts LLMs to generate topic-level queries from each cluster. For relevance annotation, our pipeline not only relies on direct mapping annotation from the generation relationship but also implements an indirect positives mining method to enrich the relevant query-passage pairs. Using this pipeline, we constructed a Financial Passage Retrieval Generated dataset (FinCPRG) from almost 1.3k Chinese financial research reports, which includes hierarchical queries and rich relevance labels. Through evaluations of mined relevance labels, bench-marking and training experiments, we assessed the quality of FinCPRG and validated its effectiveness as a passage retrieval dataset for both training and benchmarking.

Most human proteins remain undrugged, over 96% of human proteins remain unexploited by approved therapeutics. While structure-based virtual screening promises to expand the druggable proteome, existing methods lack atomic-level precision and fail to predict binding fitness, limiting translational impact. We present AuroBind, a scalable virtual screening framework that fine-tunes a custom atomic-level structural model on million-scale chemogenomic data. AuroBind integrates direct preference optimization, self-distillation from high-confidence complexes, and a teacher-student acceleration strategy to jointly predict ligand-bound structures and binding fitness. The proposed models outperform state-of-the-art models on structural and functional benchmarks while enabling 100,000-fold faster screening across ultra-large compound libraries. In a prospective screen across ten disease-relevant targets, AuroBind achieved experimental hit rates of 7-69%, with top compounds reaching sub-nanomolar to picomolar potency. For the orphan GPCRs GPR151 and GPR160, AuroBind identified both agonists and antagonists with success rates of 16-30%, and functional assays confirmed GPR160 modulation in liver and prostate cancer models. AuroBind offers a generalizable framework for structure-function learning and high-throughput molecular screening, bridging the gap between structure prediction and therapeutic discovery.

Large Language Models (LLMs) fine-tuned to align with human values often exhibit alignment drift, producing unsafe or policy-violating completions when exposed to adversarial prompts, decoding perturbations, or paraphrased jailbreaks. While prior work has behaviorally characterized alignment failure, little is known about the training-time belief sources underlying these failures. We introduce TraceAlign, a unified framework for tracing unsafe completions back to their root causes in the model's training corpus. Central to our approach is the Belief Conflict Index (BCI), which quantifies semantic inconsistency between generated spans and aligned policies, based on retrieved training documents using suffix-array matching. We propose three complementary interventions: (i) TraceShield, an inference-time safety filter that refuses completions with high-BCI spans, (ii) Contrastive Belief Deconfliction Loss, a contrastive fine-tuning objective penalizing high-BCI continuations during DPO, and (iii) Prov-Decode, a provenance-aware decoding strategy that vetoes beam expansions predicted to yield high-BCI spans. Together, these defenses reduce alignment drift by up to 85% on our curated Alignment Drift Benchmark (ADB) while preserving utility on standard tasks, with delta less than 0.2 and improved refusal quality. We further derive a theoretical upper bound on drift likelihood via suffix-array span statistics, linking memorization frequency and length to adversarial reactivation risk. TraceAlign thus provides the first scalable, traceable, and grounded toolkit for understanding and mitigating alignment failures at source. To encourage further exploration and development, we open-source our implementation at: https://anonymous.4open.science/r/tracealign-2DA7

This paper develops a hybrid quantum approach for graph-based semi-supervised learning to enhance performance in scenarios where labeled data is scarce. We introduce two enhanced quantum models, the Improved Laplacian Quantum Semi-Supervised Learning (ILQSSL) and the Improved Poisson Quantum Semi-Supervised Learning (IPQSSL), that incorporate advanced label propagation strategies within variational quantum circuits. These models utilize QR decomposition to embed graph structure directly into quantum states, thereby enabling more effective learning in low-label settings. We validate our methods across four benchmark datasets like Iris, Wine, Heart Disease, and German Credit Card -- and show that both ILQSSL and IPQSSL consistently outperform leading classical semi-supervised learning algorithms, particularly under limited supervision. Beyond standard performance metrics, we examine the effect of circuit depth and qubit count on learning quality by analyzing entanglement entropy and Randomized Benchmarking (RB). Our results suggest that while some level of entanglement improves the model's ability to generalize, increased circuit complexity may introduce noise that undermines performance on current quantum hardware. Overall, the study highlights the potential of quantum-enhanced models for semi-supervised learning, offering practical insights into how quantum circuits can be designed to balance expressivity and stability. These findings support the role of quantum machine learning in advancing data-efficient classification, especially in applications constrained by label availability and hardware limitations.

All-day smart glasses are likely to emerge as platforms capable of continuous contextual sensing, uniquely positioning them for unprecedented assistance in our daily lives. Integrating the multi-modal AI agents required for human memory enhancement while performing continuous sensing, however, presents a major energy efficiency challenge for all-day usage. Achieving this balance requires intelligent, context-aware sensor management. Our approach, EgoTrigger, leverages audio cues from the microphone to selectively activate power-intensive cameras, enabling efficient sensing while preserving substantial utility for human memory enhancement. EgoTrigger uses a lightweight audio model (YAMNet) and a custom classification head to trigger image capture from hand-object interaction (HOI) audio cues, such as the sound of a drawer opening or a medication bottle being opened. In addition to evaluating on the QA-Ego4D dataset, we introduce and evaluate on the Human Memory Enhancement Question-Answer (HME-QA) dataset. Our dataset contains 340 human-annotated first-person QA pairs from full-length Ego4D videos that were curated to ensure that they contained audio, focusing on HOI moments critical for contextual understanding and memory. Our results show EgoTrigger can use 54% fewer frames on average, significantly saving energy in both power-hungry sensing components (e.g., cameras) and downstream operations (e.g., wireless transmission), while achieving comparable performance on datasets for an episodic memory task. We believe this context-aware triggering strategy represents a promising direction for enabling energy-efficient, functional smart glasses capable of all-day use -- supporting applications like helping users recall where they placed their keys or information about their routine activities (e.g., taking medications).